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| 1 | Probabilistic approach for open pit bench slope stability analysis——A mine case study显示文摘The geotechnical slope design of an open pit wall starts at the bench scale configuration.At this scale,the rock slope stability is governed primarily by the geological discontinuities within the rock mass and as a result,structurally-controlled failures(e.g.planar,wedge or toppling)are most likely to occur.The probabilistic approach offers a major advantage over the traditional deterministic method in that it accounts for the different degrees of variability and uncertainty often encountered in rock properties.This paper presents a bench slope stability assessment for an open pit mine in Peru using a probabilistic-based approach by coupling a kinematic analysis based on stereographic projection techniques followed by a kinetic analysis by means of the limit equilibrium method.Finally,these two probabilities are combined to provide an overall measure of the probability of failure(PoF)of the bench slope system.The case study is characterized by significant scatter in the geometrical and mechanical properties of the joints.Extensive surface mapping was conducted at 36 different sites following the ISRM suggested procedures.Several direct shear tests were carried out.It is shown that by combining field and laboratory measurements and engineering judgment,the probability density functions(PDF)of the discontinuity parameters can be obtained.These are then used in a Monte Carlo simulation process to compute both kinematic and kinetic probabilities of failure.The overall probability of failure aims to provide the design engineer with a tool to critically evaluate the bench performance from a geotechnical risk perspective and to provide a basis for future bench design optimization. | Christian Obregon Hani Mitri | 2019 | International Journal of Mining Science and Technology2019，29，4： | 3 |
| 2 | Transcutaneous beta-amyloid immunization reduces cerebral beta-amyloid deposits without T cell infiltration and microhemorrhage 显示文摘 | Nikolic WV Bai Y Obregon D | 2007 | Proc Natl Acad Sci USA2007，104，7： | 1 |
| 3 | Rosiglitazone reduces serum homocysteine levels, smooth muscle proliferation , and intimal hyperplasia in Sprague-Dawley rats fed a high methionine diet 显示文摘 | Murthy SN Obregon DF Chsttergoon NN | 2005 | Metabolism2005，54，5： | 1 |
| 4 | Allelic variation of polymorphic locus lytB,encoding a choline-binding protein,from streptococci of the mitis group显示文摘 | MOSCOSO M OBREGON V LOPEZ R | 2005 | Appl Environ Microbiol2005，71，： | 1 |
| 5 | Human alveolar macrophages infected by virulent bacteria expressing SipB are a major source of active interleukin-18 显示文摘 | Obregon C Dreher D Kok M | 2003 | Infection Immunity2003，71，8： | 1 |
| 6 | Prolactin is a component of the human synovial liquid and modulates the growth and chondrogenic differentiation of bone marrow derived mesenchymal stem cells显示文摘 | OGUETA S MUNOZ J OBREGON E | 2002 | Mol Cell Endocrinol2002，190，12： | 1 |
| 7 | Effect of the ingestion of a dietary product containing Lactobacillus johnsonii Lal on Helicobacter pylori colonization in children显示文摘 | Cruchet S Obregon MC Salazar G | 2003 | Nutrition2003，19，9： | 1 |
| 8 | Human alveolar macrophages infected by virulent bacteria expressing SipB are a major source of active interleukin-18 显示文摘 | Obregon C Dreher D Kok M | 2003 | Infect Immun2003，71，8： | 1 |
| 9 | Modulation of neuronal differentiation by CD40 isoforms显示文摘 | Hou H Obregon D Len D | 2008 | Biochem Biophys Res Commun2008，369，2： | 1 |
| 10 | Role of thyroid hormone during early brain development显示文摘 | de Escobar G M Obregon M J del Rey F E | 2004 | Eur J Endocrinol2004，151，3： | 1 |
| 11 | Role of thyroid hormone during early brain develop- ment显示文摘 | Morreale de Escobar G Obregon MJ Escobar del Rey F | 2004 | Eur J Endocrinol2004，151，3： | 1 |
| 12 | Coupling endoplasmic reticulum stress to the cell death program:mechanism of caspase activation显示文摘 | Rao R V Hermel E Castro Obregon S | 2001 | Bio Chem2001，276，33： | 1 |
| 13 | Synthesis and characterization of nanoparticales of a Bi2MoaO:z prepared by co-precipitation method: Langmuir adsorption parame- ters and photocatalytic properties with rhodamine B显示文摘 | Martinez-de la Cruz A Obregon Alfaro S | 2009 | Solid State Sci2009，11，4： | 1 |
| 14 | Airway epithelial IL -15 transforms monocytes into dendritic cells 显示文摘 | Regamey N Obregon C Ferrari-Lacraz S | 2007 | Am J Respir Cell Mol Biol2007，37，1： | 1 |
| 15 | Proinflammatory and vasoactive effects of Abeta in the cerebrovasculature显示文摘 | Townsend KP Obregon D Quadros A | | 0，，： | 1 |
| 16 | Peripheral biomark- ers in Autism: secreted amyloid precursor protein-~ as a probable key player in early diagnosis显示文摘 | Bailey AR Giunta BN Obregon D etal | 2008 | Int J Clin Exp Med2008，，33： | 1 |
| 17 | Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats显示文摘 | Simonides Warner S Mulcahey Michelle A Redout Everaldo M Muller Alice Zuidwijk Marian J Visser Theo J Wassen Frank W J S Crescenzi Alessandra da-Silva Wagner S Harney John Engel Felix B Obregon Maria-Jesús Larsen P Reed Bianco Antonio C Huan | 2008 | Journal of Clinical Investigation2008，，3： | 1 |
| 18 | Synthesis and characterization of 3,-Bi2 MoO6 prepared by co-precipitati- on: Photoassisted degradation of organic dyes under Vis-ir- radiation 显示文摘 | Martinez-de la Cruz A Obregon Alfaro S | 2010 | Journal of Molecular Catalysis A: Chemical2010，320，12： | 1 |
| 19 | Maternal thyroid hormones early in pregnancy and fetal brain development 显示文摘 | de Escobar GM Obregon MJ del Rey FE | 2004 | Best Pract Res Clin Endocrinol Metab2004，18，2： | 1 |
| 20 | Is neuropalsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia显示文摘 | DE MORREALE G E OBREGON M DEL R | 2000 | Journal of Clinical Endocrinology & Metabolism2000，85，11： | 1 |
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