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| 1 | 假膜性结肠炎的CT诊断显示文摘 | Schulze M Fritz J Joanoviciu SD Horger M Tbingen 曹毅媛(译) 胡道予(校) | 2009 | 放射学实践2009，24，5： | 4 |
| 2 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 3 | 4D Design and Simulation Technologies and Process Design Patterns to Support Lean Construction Methods显示文摘The objective of this ongoing joint research program is to determine how 3D/4D modeling, simulation and visualization of Products (buildings), Organizations and Processes (POP) can support lean construction. Initial findings suggest that Process Design Pattern may have the potential to intuitively support ICT based lean construction. We initiated a 'Process Archeology' in order to reveal the requirements for tools that can support the planning, simulation and control of lean construction methods. First findings show that existing tools provide only limited support and therefore, we started to develop new methodologies and technologies to overcome these shortcomings. Through the introduction of Process Design Patterns, we intent to establish process thinking in the interdisciplinary POP design. Optimized construction processes may be synthesized with semi-automatic methods by applying Process Design Patterns on building structures. By providing process templates that integrate problem solution and expert knowledge, Process Design Patterns may have the potential to ensure high quality process models. | Manfred Breit Manfred Vogel Fritz Hubi Fabian Mrki Micheal Raps | 2008 | Tsinghua Science and Technology2008，13，S1： | 2 |
| 4 | Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting显示文摘瞄准:如果与推延的 portasystemic 有关的 T 房间激活通过 RANKL 依赖的小径引起调停骨破折的骨头损失,学习。如果用 rapamycin 的 T 房间抑制将在老鼠免于骨头损失,我们也调查了。方法:推延的 Portasystemic 在男 Sprague-Dawley 老鼠和 rapamycin 被执行 0.1 mg/kg 被管饲法为 15 wk 管理。老鼠收到了 powderized 食物并且补加喂在骨头作文上阻止营养不良的效果。重量获得和生长在推延的动物在外科以后被恢复。在结束,骨头周转和量的骨头组织学的生物化学的参数被估计。T 房间激活,煽动性的 cytokine 生产,和 RANKL 依赖的小径的标记被测量。另外, IGF-1 和性腺机能减退的角色被调查。结果:推延的 Portasystemic 引起了是 RANKL 独立人士的低周转骨质疏松症。包括 IL-1, IL-6 和 TNFalpha,骨头再吞 cytokine 层次没在浆液和 TNFalpha 被增加, RANKL 表示不起来在 PBMC 调整了。推延的 Portasystemic 增加了传播 CD8+T 房间人口。Rapamycin 减少了传播 CD8+T 房间人口,增加了 CD8+CD25+T 规章的房间人口并且改进了骨头周转的所有参数。结论:推延的 portasystemic 引起的骨质疏松症可以被 rapamycin 部分在肝的骨营养不良的老鼠模型改善。 | Schalk W van der Merwe Maria M Conradie Robert Bond Brenda J Olivier Elongo Fritz Martin Nieuwoudt Rhena Delport Tomas Slavik Gert Engelbrecht Del Kahn Enid G Shephard Maritha J Kotze Nico P de Villiers Stephen Hough | 2006 | World Journal of Gastroenterology2006，12，28： | 2 |
| 5 | Translating biomolecular recognition into nanomechanics显示文摘 | Fritz J Bailer M K Lang H P | 2000 | Science2000，288，： | 1 |
| 6 | Genistein action in the prepubertal mammary gland in a chemoprevention model显示文摘 | COTRONEO M S WANG J FRITZ W A | 2002 | Carcinogenesis2002，23，9： | 1 |
| 7 | The use of MODIS datato derive acreage estimations for larger fields: A casestudy in the south-western Rostov region of Russia显示文摘 | Fritz S Massart M Savin I | 2008 | International Journal of Applied Earth Observation andGeoinformation Modem Methods in Crop YieldForecasting and Crop Area Estimation2008，10，4： | 1 |
| 8 | Reconnaissance of the July10,2000,Payatas Landfill Failure显示文摘 | Merry S M Jr E K Fritz W U | 2005 | Journal of Perfor-mance of Constructed Facilities ASCE2005，19，2： | 1 |
| 9 | Localization and toxic effects of cadmium, copper and uranium in AzoUa显示文摘 | Sela M Tel-Or E Fritz E | 1988 | Plant Physiology1988，88，1： | 1 |
| 10 | Small-scale deceit:deception as a marker of two-,three-,and four-year-olds' early theories of mind显示文摘 | Fritz A S Hala S | 1989 | Child Development1989，，6： | 1 |
| 11 | The effect of mild hypothermia on plasma fentanyl concentration and biotransformation in juvenile pigs显示文摘 | Fritz H G Holzmayr M Walter B | 2005 | Anesth Analg2005，100，4： | 1 |
| 12 | The prognostic significance of proliferating cell nuclear antigen,epidermal growth factor receptor,and mdr gene expression in colorectal cancer显示文摘 | Mayer A Takimoto M Fritz E | 1993 | Cancer1993，71，8： | 1 |
| 13 | Onset and characteristics of the midcycle surge in bioactive and immunoactive luteinizing 显示文摘 | FRITZ M A MCLACHLAN R L COHEN N L | 2003 | Fert Sterl2003，12，2： | 1 |
| 14 | Soluble interleukin-2 receptors are released from activated human lymphoid cells in vitro显示文摘 | Rubin L A Kurman C C Fritz M E | 1985 | J Immunol1985，135，5： | 1 |
| 15 | Hugoniot data for iron 显示文摘 | Brown J M Fritz J N Hixson R S | 2000 | J Appl Phys2000，88，9： | 1 |
| 16 | A method to compare and improve land cover datasets: Application to the GLC-2000 and MODIS land cover products 显示文摘 | See L M Fritz S | 2006 | IEEE Transactions on Geoscienee and Remote Sensing2006，44，： | 1 |
| 17 | The role of intestinal P glycoprotein in the interaction of digoxin and rifampin 显示文摘 | Greiner B Eichelbaum M Fritz P | 1999 | J Clin Invest1999，104，： | 1 |
| 18 | Flat pearls from biofabrication of ofganized composite on inorganit substrates 显示文摘 | Fritz M Belcher A M Radmacher M | 1994 | Nature1994，371，： | 1 |
| 19 | Perlustrin, a Haliotis laevigata (abalone) nacre protein, is homologous to the insulin like growth factor binding protein N terminal module of vertebrates显示文摘 | WEISS IM GOHRING W FRITZ M | 2001 | Biochem Biophys Res Commun2001，285，2： | 1 |
| 20 | Impact of heart valve decellulafization on 3-D ultrastructure, immunogenicity and thrombo- genicity 显示文摘 | Zhou J Fritze O Schleicher M | 2010 | Biomaterials2010，31，9： | 1 |
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