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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | Intestinal duplication in adulthood: A rare entity, difficult to diagnose显示文摘Duplications of the alimentary tract (ATD) are rare congenital anomalies often found early in life. They may occur anywhere in the intestinal tract but the ileum is the most frequently affected site. Clinical presentation of ATD in adults is variable and because these lesions occur so infrequently they are rarely suspected. In the present report we describe a case of ileal duplication in a 61-year-old patient with Crohn’s disease. Despite various radiological investigations and medical consultations, the diagnosis was only made on the surgical specimen. | Cristina Fiorani Rosa Scaramuzzo Alessandra Lazzaro Livia Biancone Giampiero Palmieri Achille L Gaspari Giuseppe Sica | 2011 | World Journal of Gastrointestinal Surgery2011，3，8： | 6 |
| 3 | Radiological response and inflammation scores predict tumour recurrence in patients treated with transarterial chemoembolization before liver transplantation显示文摘AIM To investigate the prognostic value of the radiological response after transarterial chemoembolization(TACE)and inflammatory markers in patients affected by hepatocellular carcinoma(HCC)awaiting liver transplantation(LT).METHODS We retrospectively evaluated the preoperative pre dictors of HCC recurrence in 70 patients treated with conventional(n=16)or doxorubicin-eluting bead TACE(n=54)before LT.The patient and tumour characteristics,including the static and dynamic alpha-fetoprotein,neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio( LR)measurements,were recorded.Treatment response was classified according to the modified Response Evaluation Criteria in Solid Tumours(m RECIST)and the European Association for the Study of the Liver(EASL)criteria as complete response(CR),partial response( R),stable disease o progressive disease.After examination of the explanted livers,histological necrosis was classified as complete(100%of the cumulative tumour area),partia(50%-99%)or minimal(<50%)and was correlated with the preoperative radiological findings.RESULTS According to the pre-TACE radiological evaluation,22/70(31.4%)and 12/70(17.1%)patients were beyond Milan and University of San Francisco(UCSF)criteria,respectively.After TACE procedures,the objective response(CR+ R)rates were 71.4%and 70.0%according to m RECIST and EASL criteria,respectively.The agreement between the two guidelines in defining the radiological response was rated as very good both for the overall and target lesion response(weighted k-value:0.98 and 0.93,respectively).Complete and partial histological necrosis were achieved in 14/70(20.0%)and 28/70(40.0%)patients,respectively.Using histopathology as the reference standard,m RECIST criteria correctly classified necrosis in 72.9%(51/70)of patients and EASL criteria in 68.6%(48/70)of cases.The m RECIST non-response to TACE[Exp(b)=9.2, =0.012],exceeding UCSF criteria before TACE[Exp(b)=4.7, =0.033]and a preoperative LR>150[Exp(b)=5.9, =0.046]were independent predictors of tumour recurrence.CONCLUSION The radiological response and inflammatory markers are predictive of tumour recurrence and allow the proper selection of TACE-treated candidates for LT. | Daniele Nicolini Andrea Agostini Roberto Montalti Federico Mocchegiani Cinzia Mincarelli Alessandra Mandolesi Nicola L Robertson Roberto Candelari Andrea Giovagnoni Marco Vivarelli | 2017 | World Journal of Gastroenterology2017，23，20： | 4 |
| 4 | A metaanalysis of laparoscopic cholecystectomy in patients with cirrhosis显示文摘 | Alessandra Puggioni Linda L Wong | 2003 | Journal of the American College of Surgeons2003，，6： | 2 |
| 5 | Enantioselective 1,3-dipolar cycloadditions of unsaturated aldehydes promoted by apoly( ethylene glycol)-supported organic catalyst显示文摘 | Alessandra P M aurizio B M auro C e t a l | 2004 | E ur J Org Chem2004，344，： | 1 |
| 6 | Present and future of recombinant gonadotropins in reproductive medicine 显示文摘 | Vincenzo D L Maria M C Alessandra D S | 2012 | Curr Pharmac Biotech2012，13，3： | 1 |
| 7 | Fingerprint classification by directional image partitioning显示文摘 | Raffaele C Alessandra L Dario M | 1999 | IEEE Transactions on Pattern Analysis and Machine Intelligence1999，21，5： | 1 |
| 8 | 显示文摘 | Eliangela M T Alessandra L D R Antonio J F C | 2005 | Macromol Symp2005，229，： | 1 |
| 9 | Effect of biodegradable chelating agents on heavy metals phytoextraction with Mirabilis jalapa and on its associated bacteria显示文摘 | Alessia C Alessandra C Tiziana L | 2007 | European journal of soil biology2007，43，： | 1 |
| 10 | Clonal relationships among avian Escherichia coli isolates determined by enterobacterial repetitive intergenic consensus (ERIC) - PCR显示文摘 | WANDERLEY D D S ALESSANDRA F MARCELO L | 2002 | Veterinary Microbiology2002，89，： | 1 |
| 11 | Probabilistic approach for determining Salmonella spp. and L. monocytogenes concentration in pork meat from presence/absence microbiological data显示文摘 | Antonio Valero Marta Hernandez Alessandra De Cesare Gerardo Manfreda Rosa Maria García-Gimeno Patricia González-García David Rodríguez Lázaro | 2014 | International Journal of Food Microbiology2014，，： | 1 |
| 12 | Detection of genetically modified soybean using peptide nucleic acids (PNAs)and microarray technology显示文摘 | Andrea G Alessandra M Francesca L | 2005 | Journal of Agricultural and Food Chemistry2005，52，14： | 1 |
| 13 | Survey on LBP based texture descriptors for image classification显示文摘 | Loris N Alessandra L Sheryl B | 2012 | Expert Systems with Applications2012，39，： | 1 |
| 14 | Identification of ciprofloxacinresistant Campylobacter jejuni and analysis of the gyrA gene by the light cycler mutation assay 显示文摘 | Anna MD Ida L Alessandra C | 2004 | Mol Cell Probe2004，18，： | 1 |
| 15 | Effect of prolonged application times on the durability of resin-dentin bonds显示文摘 | Alessandra R Paula De Vieira L C | | 0，，06： | 1 |
| 16 | The Brazilian audit tfibunal's role in improving the federal environmental licensing process 显示文摘 | Luiz H L Alessandra M | 2010 | Environmental Impact Assessment Review2010，30，6： | 1 |
| 17 | An ensemble of support vector machines for predicting the membrane protein type directly from the amino acid sequence显示文摘 | Loris N Alessandra L | 2008 | Amino Acids2008，35，3： | 1 |
| 18 | TLR9 is localized in the endoplasmic reticulum prior to stimulation显示文摘 | Cynthia AL Margaret NK Alessandra M ChangWoo L Michael JK David MS | 2004 | J Immunol2004，173，： | 1 |
| 19 | Diagnostic potential of plasmatic microRNA signatures in stable and unstable angina 显示文摘 | D'Alessandra Y Carena MC Spazzafumo L | 2013 | PLoS One2013，8，80： | 1 |
| 20 | Contact profilometry and correspondence analysis to correlate surface properties and cell adhesion in vitro of uncoated and coated Ti and Ti6Al4V disks 显示文摘 | Andrea B Marco G Alessandra L | 2004 | Biomaterials2004，25，12： | 1 |
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