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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | Glucocorticoid receptor β:iewⅠ显示文摘 | Alessandra V George P Chrousos | 1999 | TEM1999，10，8： | 1 |
| 3 | Final height in girls with central idiopathic precocious puberty treated with gonadotropin-releasing hormone analog and oxandrolone 显示文摘 | Alessandra V Simona P Marta V | 2006 | J Clin Endoerinol Etab2006，91，4： | 1 |
| 4 | Randomized trials of radiotherapy alone versus comined chemotherapy and radiotherapy in stage Ⅲ a and Ⅲ b nonsmall cell lung cancer:a meta-analysis显示文摘 | Armando P Alessandra C | 1995 | Cancer1995，76，4： | 1 |
| 5 | Broadband spectral analysis of blood pressure and HRV in very elderly subjects显示文摘 | Alessandra F | 1997 | Hypertension1997，30，： | 1 |
| 6 | Financial Constraints to Innovation in the UK:Evidence from CIS2and CIS3显示文摘 | Alessandra Stoneman P | 2008 | Oxford Economic Papers2008，，4： | 1 |
| 7 | Repartition effect of aromatic polyaniline coatings on the separation of bioactive peptides in capillary electrophoresis显示文摘 | ALESSANDRA B SERGEY A P ANTHONY P F T PIER G R | 2002 | Electrophoresis2002，23，2： | 1 |
| 8 | 6,7-Dihydroxy-1,2,3,4-tetrahydroisoquinoline formation by iron mediated dopamine oxidation:a nivel route to endogenous neurotoxins under oxidative stress condition显示文摘 | Alessandra N Alessandro P Giuseppe P | 1999 | Tetrahedron Letters1999，40，14： | 1 |
| 9 | Enantioselective 1,3-dipolar cycloadditions of unsaturated aldehydes promoted by apoly( ethylene glycol)-supported organic catalyst显示文摘 | Alessandra P M aurizio B M auro C e t a l | 2004 | E ur J Org Chem2004，344，： | 1 |
| 10 | Changes of flavonoids,vitamin Cand antioxidant capacity in minimally processed citrus segments and juices during storage显示文摘 | ALESSANDRA D C ANTONIO P VINCENZO V | 2004 | Food Chemistry2004，84，： | 1 |
| 11 | Evidence for a biphasic apoptotic pathway induced by melatonin in MCF-7 breast cancer cells显示文摘 | Alessandra C Sara P Fabrizio D A | 2009 | J Pineal Res2009，46，3： | 1 |
| 12 | Financial constraints to inno- vation in the UK: Evidence from CIS2 and CIS3显示文摘 | Alessandra C Stoneman P | 2008 | Oxf- ord Economic Papers2008，60，4： | 1 |
| 13 | MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3 显示文摘 | Fasanaro P D'Alessandra Y Di S | 2008 | J Biol Chem2008，283，15： | 1 |
| 14 | Nerve growth factor promotes angiogenesis and arteriogenesis in ischemic hindlimbs显示文摘 | Costanza E Maria BS Alessandra P | 2002 | Circulation2002，，17： | 1 |
| 15 | 3-(4-{{Benzyl(methyl)amino}methyl}phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer′s disease therapy 显示文摘 | Lorna P Angela R Alessandra B | 2003 | J Med Chem2003，46，12： | 1 |
| 16 | Lineage specificity of the evolutionary dynamics of the mtDNA D-loop region in rodents 显示文摘 | Alessandra Larizza Graziano P esole Aurelio Reyes | 2002 | J Mol Evol2002，54，： | 1 |
| 17 | Circulating miRNAs are new and sensitive biomarkers of myocardial infarction显示文摘 | D'Alessandra Y Devanna P Limana F | | 0，，22： | 1 |
| 18 | MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine-kinase ligand Ephrin-A3显示文摘 | FASANARO P D'ALESSANDRA Y DI STEFANO V | | 0，，23： | 1 |
| 19 | Circulating mieroR- NAs are new and sensitive biomarkers of myneardial inthretion 显示文摘 | D'Alessandra Y Devanna P Limana F | 2010 | Eur Heart J2010，31，22： | 1 |
| 20 | Pulse high-volume hae- mofiltration for treatment of severe sepsis : effects on hemody namics and survival 显示文摘 | Ranistha R Alessandra B Pasquale P | 2005 | Critical Care2005，9，4： | 1 |
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