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| 1 | Maintenance for healed erosive esophagitis:PhaseⅢcomparison of vonoprazan with lansoprazole显示文摘AIM To compare vonoprazan 10 and 20 mg vs lansoprazole 15 mg as maintenance therapy in healed erosive esophagitis(EE).METHODS A total of 607 patients aged ≥ 20 years, with endoscopically-confirmed healed EE following 8 wk of treatment with vonoprazan 20 mg once daily, were randomized 1:1:1 to receive lansoprazole 15 mg(n = 201), vonoprazan 10 mg(n = 202), or vonoprazan 20 mg(n = 204), once daily. The primary endpoint of the study was the rate of endoscopically-confirmed EE recurrence during a 24-wk maintenance period. The secondary endpoint was the EE recurrence rate at Week 12 during maintenance treatment. Additional efficacy endpoints included the incidence of heartburn and acid reflux, and the EE healing rate 4 wk after the initiation of maintenance treatment. Safety endpoints comprised adverse events(AEs), vital signs, electrocardiogram findings, clinical laboratory results, serum gastrin and pepsinogen Ⅰ/Ⅱ levels, and gastric mucosa histopathology results.RESULTS Rates of EE recurrence during the 24-wk maintenance period were 16.8%, 5.1%, and 2.0% with lansoprazole 15 mg, vonoprazan 10 mg, and vonoprazan 20 mg, respectively. Vonoprazan was shown to be non-inferior to lansoprazole 15 mg(P < 0.0001 for both doses). In a post-hoc analysis, EE recurrence at Week 24 was significantly reduced with vonoprazan at both the 10 mg and the 20 mg dose vs lansoprazole 15 mg(5.1% vs 16.8%, P = 0.0002, and 2.0% vs 16.8%, P < 0.0001, respectively); by contrast, the EE recurrence rate did not differ significantly between the two doses of vonoprazan(P = 0.1090). The safety profiles of vonoprazan 10 and 20 mg were similar to that of lansoprazole 15 mg in patients with healed EE. Treatment-related AEs were reported in 11.4%, 10.4%, and 10.3% of patients in the lansoprazole 15 mg, vonoprazan 10 mg, and vonoprazan 20 mg arms, respectively.CONCLUSION Our findings confirm the non-inferiority of vonoprazan 10 and 20 mg to lansoprazole 15 mg as maintenance therapy for patients with healed EE. | Kiyoshi Ashida Katsuhiko Iwakiri Naoki Hiramatsu Yuuichi Sakurai Tetsuharu Hori Kentarou Kudou Akira Nishimura Eiji Umegaki | 2018 | World Journal of Gastroenterology2018，24，14： | 18 |
| 2 | Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer显示文摘AIM: To investigate the prognostic role of KRAS and BRAF mutations after adjustment for microsatellite instability(MSI) status in Japanese colorectal cancer(CRC) population.METHODS: We assessed KRAS and BRAF mutations and MSI status in 813 Japanese patients with curatively resected, stage Ⅰ-Ⅲ CRC and examined associations of these mutations with disease-free survival(DFS) and overall survival(OS) using uni- and multivariate Cox proportional hazards models.RESULTS: KRAS and BRAF mutations were detected in 312(38%) of 812 and 40(5%) of 811 tumors, respectively. KRAS mutations occurred more frequently in females than in males(P = 0.02), while the presence of BRAF mutations was significantly associated with the female gender(P = 0.006), proximal tumor location(P < 0.001), mucinous or poorly differentiated histology(P < 0.001), and MSI-high tumors(P < 0.001). After adjusting for relevant variables, including MSI status, KRAS mutations were associated with poorer DFS(HR = 1.35; 95%CI: 1.03-1.75) and OS(HR = 1.46; 95%CI: 1.09-1.97). BRAF mutations were poor prognostic factors for DFS(HR = 2.20; 95%CI: 1.19-4.06) and OS(HR = 2.30; 95%CI: 1.15-4.71). Neither the BRAF by MSI interaction test nor the KRAS by MSI interaction test yielded statistically significant results for DFS and OS.CONCLUSION: KRAS and BRAF mutations are associated with inferior survival, independent of MSI status, inJapanese patients with curatively resected CRC. | Shigenori Kadowaki Miho Kakuta Shuhei Takahashi Akemi Takahashi Yoshiko Arai Yoji Nishimura Toshimasa Yatsuoka Akira Ooki Kensei Yamaguchi Keitaro Matsuo Kei Muro Kiwamu Akagi | 2015 | World Journal of Gastroenterology2015，21，4： | 14 |
| 3 | Analysis on Temperature Distributions in Single Cell of Polymer Electrolyte Fuel Cell When Operated in High Temperature Range显示文摘 | Akira Nishimura Kotaro Osada Takuro Tsunoda Masato Yoshimura Masafumi Hirota Eric Hu | 2016 | Journal of Energy and Power Engineering2016，10，8： | 5 |
| 4 | Numerical Analysis of Temperature Distributions in Single Cell of Polymer Electrolyte Fuel Cell when Operated in Elevated Temperature Range显示文摘 | Akira Nishimura Kanji Patoriki Zamami Masato Yoshimura Masafumi Hirota Mohan Lal Kolhe | 2017 | Journal of Energy and Power Engineering2017，11，6： | 4 |
| 5 | Impact of Thickness of Polymer Electrolyte Membrane on Temperature Distributions in Single Cell of Polymer Electrolyte Fuel Cell Operated at High Temperature显示文摘 | Akira Nishimura Yusuke Sato Masato Yoshimura Satoru Kamiya Masafumi Hirota | 2018 | Journal of Energy and Power Engineering2018，12，2： | 4 |
| 6 | Impact of Relative Humidity of Supply Gas on Temperature Distributions in Single Cell of Polymer Electrolyte Fuel Cell When Operated at High Temperature显示文摘 | Akira Nishimura Masato Yoshimura Satoru Kamiya Masafumi Hirota Eric Hu | 2017 | Journal of Energy and Power Engineering2017，11，11： | 2 |
| 7 | Risk Factors for Metachronous Gastric Cancer in the Remnant Stomach After Early Cancer Surgery显示文摘 | Isao Nozaki Junichirou Nasu Yoshiro Kubo Minoru Tanada Rieko Nishimura Akira Kurita | 2010 | World Journal of Surgery2010，，7： | 2 |
| 8 | Impact of Thickness of Polymer Electrolyte Membrane and Gas Diffusion Layer on Temperature Distributions in Polymer Electrolyte Fuel Cell Operated at Temperature around 90℃显示文摘Polymer Electrolyte Fuel Cell(PEFC)is desired to be operated at temperature around 90℃ for stationary applications during the period from 2020 to 2025 in Japan.It can be expected thinner polymer electrolyte membrane(PEM)and gas diffusion layer(GDL)would promote the power generation performance of PEFC at this temperature.The aim of this study is to understand the impact of thickness of PEM and GDL on the temperature profile of interface between PEM and catalyst layer at the cathode(i.e.,the reaction surface)in a single PEFC with an initial operation temperature(Tini).An 1D multi-plate heat transfer model based on temperature data of separator measured using thermograph in power generation process was developed to evaluate temperature of the reaction surface(Treact).This study investigated the effect of Tini,flow rate and relative humidity of supply gas on Treact distribution.The study finds that when using thin GDL,the even distribution of Treact – Tini is obtained irrespective of thickness of PEM,Tini and relative humidity conditions.Treact – Tini using Nafion 115 is higher than the other thin PEMs irrespective of Tini and relative humidity conditions.It can be concluded that the even temperature distribution could be achieved by using thin PEM and GDL. | Akira Nishimura Yusuke Sato Satoru Kamiya Tatsuya Okado Kouhei Yamamoto Masafumi Hirota Eric Hu | 2019 | Journal of Energy and Power Engineering2019，13，3： | 2 |
| 9 | Diffusion Tensor Tractography in the Head-and-Neck Region Using a Clinical 3-T MR Scanner显示文摘 | Masuma Akter Toshinori Hirai Ryosei Minoda Ryuji Murakami Shutaro Saiki Tomoyuki Okuaki Mika Kitajima Hirofumi Fukuoka Akira Sasao Shinichiro Nishimura Eiji Yumoto Kazuo Awai Yasuyuki Yamashita | 2009 | Academic Radiology2009，，7： | 1 |
| 10 | A case of small undifferentiated intramucosal gastric cancer with lymph node metastasis显示文摘 | Junichirou Nasu Shinichiro Hori Akinori Asagi Tomohiro Nishina Yoshio Ikeda Masahito Tanimizu Haruo Iguchi Kenjiro Aogi Akira Kurita Rieko Nishimura | 2010 | Gastric Cancer2010，，4： | 1 |
| 11 | Development of Automatic Welding System for Crawler Crane Latticed Booms 显示文摘 | HIDA Masatoshi OKAMOTO Akira NISHIMURA Toshihiko | 2007 | Research and Develop- ment Robe Steel Engineering Repots2007，，： | 1 |
| 12 | Successful treatment of cerebral hemorrhage using computed tomography angiography in a patient with left-ventricular-assist device显示文摘 | Haruna Morito Takashi Nishimura Masahiko Ando Osamu Kinoshita Motoyuki Hisagi Hideaki Imai Akira Iijima Noboru Motomura Shunei Kyo Minoru Ono | 2012 | Journal of Artificial Organs2012，，1： | 1 |
| 13 | UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients显示文摘 | Masahide Onoue Tomohiro Terada Masahiko Kobayashi Toshiya Katsura Shigemi Matsumoto Kazuhiro Yanagihara Takafumi Nishimura Masashi Kanai Satoshi Teramukai Akira Shimizu Masanori Fukushima Ken-ichi Inui | 2009 | International Journal of Clinical Oncology2009，，2： | 1 |
| 14 | Structure determination of polysaccharides in Aloe arborescensvar 显示文摘 | Akira Yagi Hiroshi Nishimura Takao Shida | 1986 | Planta Med1986，3，： | 1 |
| 15 | Solarthermal aided power generation 显示文摘 | Hu Eric Yang Yongping Nishimura Akira | 2010 | Applied Energy2010，87，9： | 1 |
| 16 | Study of sig nal processing for EMAT显示文摘 | NISHIMURA Y AKIRA S SUZUKI T | 2011 | Materials Science Forum2011，，670： | 1 |
| 17 | Effects of hepatocyte growth factor on E-cadherin-mediated cell-cell adhesion in DU145 prostate cancer cells显示文摘 | Hidenobu Miura Kenji Nishimura Akira Tsujimura Kiyomi Matsumiya Kunio Matsumoto Toshikazu Nakamura Akihiko Okuyama | 2001 | Urology2001，，： | 1 |
| 18 | Dose-Dependent Contribution of CD34-Positive Cell Transplantation to Concurrent Vasculogenesis and Cardiomyogenesis for Functional Regenerative Recovery After Myocardial Infarction显示文摘 | Hiroto Iwasaki Atsuhiko Kawamoto Masakazu Ishikawa Akira Oyamada Shuko Nakamori Hiromi Nishimura Kazuyo Sadamoto Miki Horii Tomoyuki Matsumoto Satoshi Murasawa Toshihiko Shibata Shigefumi Suehiro Takayuki Asahara | 2006 | Circulation2006，，10： | 1 |
| 19 | Increased Infiltration of Tumor Associated Macrophages is Associated With Poor Prognosis of Bladder Carcinoma In Situ After Intravesical Bacillus Calmette-Guerin Instillation显示文摘 | Hitoshi Takayama Kazuo Nishimura Akira Tsujimura Yasutomo Nakai Masashi Nakayama Katsuyuki Aozasa Akihiko Okuyama Norio Nonomura | 2009 | The Journal of Urology2009，，4： | 1 |
| 20 | Clinical application of atrial natriuretic polypeptide in patients with congestive heart failure: beneficial effects on left ventricular function显示文摘 | YOSHIHIKO SAITO KAZUWA NAKAO KAZUNOBU NISHIMURA AKIRA SUGAWARA KEN OKUMURA KENJI OBATA RYUJI SONODA TOSHIHIKO BAN HIROFUMI YASUE HIROO IMURA | 1987 | Circulation1987，，1： | 1 |
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