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| 1 | Pharmacological effects of saw palmetto extract in the lower urinary tract显示文摘锯矮棕榈条摘录(SPE ) ,从美国矮子手掌的成熟果浆的一篇摘录,广泛地在欧洲由于良性的 prostatic 增生(BPH ) 为尿机能障碍被用作治疗学的疗法。行动的众多的机制为 SPE 被建议了,包括 5 伪 - reductase 的抑制。今天,伪 1 -adrenoceptor 对手和 muscarinic cholinoceptor 对手通常与对 BPH 第二等的 voiding 症状在人的治疗被使用。在拿 SPE 的病人的 voiding 症状的改进可以在更低的尿道从它的绑定产生到 pharmacologically 相关的受体,例如伪 1 -adrenoceptors, muscarinic cholinoceptors, 1,4-dihyropyridine 受体和 vanilloid 受体。而且, SPE 的口头的管理被显示了在睾丸激素导致的老鼠前列腺稀释伪 1 -adrenoceptors 的起来规定。因此,在临床上相关的剂量的 SPE 可以在更低的尿道在药理学受体上施加直接效果,在有 BPH 和一个 overactive 膀胱的病人的从而改善的尿机能障碍。SPE 没在血与共同管理的药或严肃的不利事件有相互作用生物化学的参数,它的相对安全暗示,甚至与长期的吸入。与 BPH 在人进行的 SPE 的临床的试用(控制安慰剂、活跃控制的试用) 也被考察。这评论应该与 BPH 在病人的治疗贡献 SPE 的药理学效果的理解并且联系更低的尿道症状(LUTS ) 。 | Mayumi SUZUKI Yoshihiko ITO Tomomi FUJINO Masayuki ABE Keizo UMEGAKI Satomi ONOUE Hiroshi NOGUCHI Shizuo YAMADA | 2009 | Acta Pharmacologica Sinica2009，30，3： | 17 |
| 2 | Acid suppressive therapy improved symptoms due to circumferential cervical inlet patch with proton pumps(H^+/K^+-ATPase)显示文摘Cervical inlet patch(CIP), also referred to as esophageal heterotopic gastric mucosa, is regarded as the residue of columnar epithelium of the embryonic esophagus. Narrow band imaging increases the detection rate of CIP. Herein, we present a 55-year-old man with symptomatic circumferential inlet patch. He exhibited globus and dysphagia, and esophagogastroduodenoscopy found cir-cumferential CIP, where im-munohistochemistry revealed the existence of pro-ton pumps(H^+, K^+ -ATPase). His throat symptoms were relieved by acid suppressive therapy with pump inhibitors. This case indicated that CIP should be considered as a differential diagnosis for the cause of globus symptoms in rare cases. | Takanori Yamada Atsushi Tsuji Shunya Onoue Masanao Kaneko Fumihiko Tanioka Satoshi Osawa Yasuhiko Saida | 2017 | World Journal of Clinical Cases2017，5，11： | 3 |
| 3 | Nogo-A and Nogo receptor expression in demyelinating lesions of multiple sclerosis 显示文摘 | Satoh J Onoue H Arima K Yamamura T | 2005 | J Neuropathol Exp Neurol2005，64，2： | 1 |
| 4 | Epithelial-mes-enchymal transition induced by the stromal cell-derived factor-1/CXCR4 system in oral squamous cell carcinoma cells显示文摘 | Onoue T Uchida D Begum NM | | 0，，05： | 1 |
| 5 | Pituitary adenylate cyclase - activating polypeptide and vasoactive intestinal peptide attenuateglutamate - induced nNOS activation and cytotoxicity显示文摘 | Onoue S Endo K Yajima T | 2002 | Regul Pept2002，107，13： | 1 |
| 6 | Expression ofneurotrophin genes in the brain of senescence-accelerated mouse (SAM) during postnataldevelopment显示文摘 | Kaisho Y Miyamoto M Shiho O Onoue H Kitamura Y Nomura S | 1994 | Brain Res1994，647，1： | 1 |
| 7 | CD40 ligand gen and Kawasaki disease显示文摘 | Onouchi Y Onoue S TamariM | 2004 | Eur J Hum Genet2004，12，12： | 1 |
| 8 | Involvement of an autocrine stromal cell derived factor-1/CXCR4 system on the distant metastasis of human oral squamous cell carcinoma 显示文摘 | Uchida D Onoue T Tomizuka Y | 2007 | Mol Cancer Res2007，5，： | 1 |
| 9 | Multidisciplinary mechanical supports improve outcome in a shock patient with cardiac amyloidosis:a case report显示文摘 | Onoue Y Izumiya Y Takashio S | 2012 | Intern Med2012，51，10： | 1 |
| 10 | Imaging intracranial haemangiopericytomas: study of seven cases显示文摘 | M. Akiyama H. Sakai H. Onoue Y. Miyazaki T. Abe | 2004 | Neuroradiology2004，，3： | 1 |
| 11 | Pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide attenuate glutamate-induced nNOS activation and cytotoxicity显示文摘 | Endo K Yajima T et a1 | 2002 | Regul Pept2002，107，： | 1 |
| 12 | CD40 ligand gene and Kawasaki disease显示文摘 | Onouchi Y Onoue S Tamarl M | 2004 | Eur J Hum Genet2004，12，12： | 1 |
| 13 | Erythritol-based dry powder of glucagon for pulmonary adminis- tration 显示文摘 | Endo K Amikawa S Matsumoto A Sahashi N Onoue S | 2005 | lnt J Pharm2005，290，： | 1 |
| 14 | Inhalable sustained-release formulation of long-acting vasoactive intestinal peptide derivative alleviates acute airway inflammation显示文摘 | Satomi Onoue Takuya Matsui Kazuki Kuriyama Kumiko Ogawa Yoshiki Kojo Takahiro Mizumoto Shin-ichiro Karaki Atsukazu Kuwahara Shizuo Yamada | 2012 | Peptides2012，，2： | 1 |
| 15 | Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide attenuate the cigarette smoke extract-induced apoptotic death of rat alveolar L2 cells显示文摘 | Ohmori Y Endo K et a1 | 2004 | Euro J Biochem2004，271，9： | 1 |
| 16 | Preparation of ultrafine RuO2-IrO2-TiO2 oxide particles by a sol-gel process 显示文摘 | TAKASU Y ONOUE S KAMEYAMA K | 1994 | Electrochim Acta1994，39，13： | 1 |
| 17 | Epithelial-mesenchymal transition induced by the stromal cell-derived factor-1/CXCR4 system in oral squamous cell carcinoma cells显示文摘 | Onoue T Uchida D Begum NM | 2006 | Int J Oncol2006，29，5： | 1 |
| 18 | CD40 ligand gen and Kawasaki disease显示文摘 | Onouchi Y Onoue S Tamari M | 2004 | Eur J Hum Genet2004，12，12： | 1 |
| 19 | Serum adipocyte fatty acid-binding protein is independently associated with coronary atherosclerotic burden measured by intravascular ultrasound显示文摘 | Miyoshi T Onoue G Hirohata A | 2010 | Atherosclerosis2010，211，1： | 1 |
| 20 | Epithelial - mesenchymal transition induced by the stromal cell - derived factor - 1/CXCR4 system in oral squamous cell carcinoma cells 显示文摘 | Onoue T Uchida D Begum NM | 2006 | Int J Oncol2006，29，5： | 1 |
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