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| 1 | New discovery of fossil cycad-like plants from the Middle Jurassic of West Liaoning,China显示文摘 | WANG Yongdong ZHANG Wu ZHENG Shaolin SAIKI Keni'chi LI Nan | 2005 | Chinese Science Bulletin2005，50，16： | 8 |
| 2 | Enzyme-digested Colla Corii Asini(E’jiao) prevents hydrogen peroxide-induced cell death and accelerates amyloid beta clearance in neuronal-like PC12 cells显示文摘As an aging-associated degenerative disease,Alzheimer’s disease is characterized by the deposition of amyloid beta(Aβ),oxidative stress,inflammation,dysfunction and loss of cholinergic neurons.Colla Corii Asini(CCA)is a traditional Chinese medicine which has been used for feebleness-related diseases and anti-aging.CCA might delay aging-induced degenerative changes in neurons.In the present study,we evaluated antioxidant activity,cytoprotective effects,and Aβremovability of enzyme-digested Colla Corii Asini(CCAD).Oxygen radical absorbance capacity(ORAC)activity assay showed that,as compared to gelatins from the skin of porcine,bovine and cold water fish,CCA exhibited the highest ORAC activity.The ORAC activity of CCA and CCAD was increased gradually by the length of time in storage.Ultrastructure analysis by scanning electron microscopy showed that among CCA manufactured in 2008,2013,2017 and gelatin from cold water fish skin,CCA manufactured in 2008 presented the smoothest surface structure.We further tested the protective effects of CCAD(manufactured in 2008)and enzyme-digested gelatin from cold water fish skin(FGD)on hydrogen peroxide(H2O2)-induced cell death in nerve growth factor-differentiated neuronal-like PC12 cells.Presto blue assay showed that both FGD and CCAD at 0.5 mg/m L increased cell viability in H2O2-treated neuronal-like PC12 cells.The protection of CCAD was significantly superior to that of FGD.Acetylcholinesterase(Ach E)assay showed that both FGD and CCAD inhibited Ach E activity in nerve growth factor-differentiated neuronal-like PC12 cells to 89.1%and 74.5%of that in non-treated cells,respectively.The data suggest that CCAD might be able to increase the neurotransmitter acetylcholine.Although CCAD inhibited Ach E activity in neuronal-like PC12 cells,CCAD prevented H2O2-induced abnormal deterioration of Ach E.ELISA and neprilysin activity assay results indicated that CCAD reduced amyloid beta accumulation and increased neprilysin activity in Aβ1–42-treated neuronal-like PC12 cells,suggesting that CCAD can enhance Aβclearance.Our results suggest that CCA might be useful for preventing and treating Alzheimer’s disease. | Li Xiao Feng Liao Ryoji Ide Tetsuro Horie Yumei Fan Chikako Saiki Nobuhiko Miwa | 2020 | Neural Regeneration Research2020，15，12： | 6 |
| 3 | HIV/AIDS in Asia:The Shape of Epidemics and Their Molecular Epidemiology显示文摘The Asia-Pacific region is a home to 60% of the population in the world and to approximately one quarter of people with HIV/AIDS. Close to a million of people has been infected and a half million people died of AIDS annually in Asia,becoming the second largest epicenter of global AIDS epidemic. Molecular epidemiology has been useful tool to track a course of HIV spread. In-depth knowledge from the studies on molecular epidemiology elucidates the dynamics of HIV spread and the interrelationship of epidemics in the different regions in Asia. | Rie Uenishi Saiki Hase Tee Kok Keng Shigeru Kusagawa Yutaka Takebe | 2007 | Virologica Sinica2007，22，6： | 4 |
| 4 | Stem cell therapy for central nerve system injuries: glial cells hold the key显示文摘Mammalian adult central nerve system(CNS) injuries are devastating because of the intrinsic difficulties for effective neuronal regeneration. The greatest problem to be overcome for CNS recovery is the poor regeneration of neurons and myelin-forming cells, oligodendrocytes. Endogenous neural progenitors and transplanted exogenous neuronal stem cells can be the source for neuronal regeneration. However, because of the harsh local microenvironment, they usually have very low efficacy for functional neural regeneration which cannot compensate for the loss of neurons and oligodendrocytes. Glial cells(including astrocytes, microglia, oligodendrocytes and NG2 glia) are the majority of cells in CNS that provide support and protection for neurons. Inside the local microenvironment, glial cells largely influence local and transplanted neural stem cells survival and fates. This review critically analyzes current finding of the roles of glial cells in CNS regeneration, and highlights strategies for regulating glial cells' behavior to create a permissive microenvironment for neuronal stem cells. | Li Xiao Chikako Saiki Ryoji Ide | 2014 | Neural Regeneration Research2014，9，13： | 3 |
| 5 | 距骨多糖(APS)和距骨类黄酮(AF)对正常老鼠和瘤变老鼠的淋巴因子激活杀伤细胞(LAK)和天然杀伤细胞(NK)的细胞毒性的影响(英文)显示文摘使用WST方法研究了APS和AF分别对LAK和NK细胞的抗瘤变活性的影响 结果表明 :在APS(或AF)和rIL 2的协同作用下 ,LAK细胞的抗瘤变活性显著增强 ;单独使用APS能增加NK细胞的细胞毒性 ;如果将单独使用的rIL 2的剂量增加到 2 0倍 ,可以减轻癌症病人在接受针对LAK细胞的顺势疗法时引起的毒副作用 。 | 钟鸣 张德山 Murata J Saiki I 山本格 | 2001 | 四川大学学报(自然科学版)2001，38，5： | 3 |
| 6 | Image-based autonomous navigation of Hayabusa2 using artificial landmarks: The design and brief in-flight results of the first landing on asteroid Ryugu显示文摘Hayabusa2 is an asteroid sample return mission carried out by the Japan Aerospace Exploration Agency.The spacecraft was launched in 2014 and arrived at the target asteroid Ryugu on June 27,2018.During the 1.5-year proximity phase,several critical operations(including two landing/sampling operations)were successfully performed.They were based on autonomous image-based descent and landing techniques.This paper describes an imagebased autonomous navigation scheme of the Hayabusa2 mission using artificial landmarks named target markers(TMs).Its basic algorithm,and the in-flight results of the first touchdown and its rehearsal,are shown. | Naoko Ogawa Fuyuto Terui Yuya Mimasu Kent Yoshikawa Go Ono Seiji Yasuda Kota Matsushima Tetsuya Masuda Hiroki Hihara Junpei Sano Takashi Matsuhisa Satoshi Danno Manabu Yamada Yasuhiro Yokota Yuto Takei Takanao Saiki Yuichi Tsuda | 2020 | Astrodynamics2020，4，2： | 2 |
| 7 | A subgrid-scale model based on the estimation of unresolved scales of turbulence显示文摘 | Domaradzki J A Saiki E M | 1997 | Phys Fluids1997，9，7： | 2 |
| 8 | Inhibitory of chitin heparinoids on the lung metastasis of B16-BL6 melanoma显示文摘 | Murata J Saiki I Nishimura S | 1989 | Jpn J Cancer Res1989，80，9： | 2 |
| 9 | The deep-space multi-object orbit determination system and its application to Hayabusa2’s asteroid proximity operations显示文摘The deep-space multi-object orbit determination system(DMOODS)and its application in the asteroid proximity operation of the Hayabusa2 mission are described.DMOODS was developed by the Japan Aerospace Exploration Agency(JAXA)for the primary purpose of determining the trajectory of deep-space spacecraft for JAXA’s planetary missions.The weighted least-squares batch filter is used for the orbit estimator of DMOODS.The orbit estimator supports more than 10 data types,some of which are used for relative trajectory measurements between multiple space objects including natural satellites and small bodies.This system consists of a set of computer programs running on Linux-based consumer PCs on the ground,which are used for orbit determination and the generation of radiometric tracking data,such as delta differential one-way ranging and doppler tracking data.During the asteroid proximity phase of Hayabusa2,this system played an essential role in operations that had very strict navigation requirements or operations in which few optical data were obtained owing to special constraints on the spacecraft attitude or distance from the asteroid.One example is orbit determination during the solar conjunction phase,in which the navigation accuracy is degraded by the effect of the solar corona.The large range bias caused by the solar corona was accurately estimated with DMOODS by combining light detection and ranging(LIDAR)and ranging measurements in the superior solar conjunction phase of Hayabusa2.For the orbiting operations of target markers and the MINERVA-II2 rover,the simultaneous estimation of six trajectories of four artificial objects and a natural object was made by DMOODS.This type of simultaneous orbit determination of multi-artificial objects in deep-space has never been accomplished before. | Hiroshi Takeuchi Kent Yoshikawa Yuto Takei Yusuke Oki Shota Kikuchi Hitoshi Ikeda Stefania Soldini Naoko Ogawa Yuya Mimasu Go Ono Fuyuto Terui Naoya Sakatani Manabu Yamada Toru Kouyama Shingo Kameda Takanao Saiki Yuichi Tsuda | 2020 | Astrodynamics2020，4，4： | 2 |
| 10 | Esophageal carcinoma originating in the surface epithelium with immunohistochemically proven esophageal gland duct differentiation: A case report显示文摘A case of esophageal carcinoma exclusively composed of adenocarcinoma simulating an esophageal gland duct in a 61-year-old man is presented. The tumor arose as a slightly elevated lesion in the middle intrathoracic esophagus. It was almost completely overlaid with nonneoplastic stratified squamous epithelial cells. Beneath the overlying surface epithelium, an adenocarcinoma that was bilayered in structure diffusely invaded both the mucosal and submucosal layers. Although the tumor consisted exclusively of adenocarcinomatous cells, a keratinizing squamous cell carcinoma component was focally observed. The invasive carcinoma was focally continuous with the small area of the surface squamous epithelial layer, which was confirmed to be neoplastic by immunohistochemistry. Morphological and immunohistochemical examinations suggested that the adenocarcinomatous component arose from the esophageal surface epithelium and clearly differentiated into an esophageal gland duct. It is important to consider the possibility of this type of adenocarcinoma when diagnosing a ductal or glandular lesion of the esophagus in small biopsy specimens. | Hiromi Tamura Hirotsugu Saiki Takahiro Amano Masashi Yamamoto Shiro Hayashi Hiroka Ando Reiko Doi Tsutomu Nishida Katsumi Yamamoto Shiro Adachi | 2017 | World Journal of Gastroenterology2017，23，21： | 2 |
| 11 | T Cellular basis for the automorphic curvature of rice coleoptiles on a three-dimensional clinostat: possible involvement of reorientation of cortical microtubules 显示文摘 | Saiki M Fujita H Soga K | 2005 | J Plant Res2005，118，： | 1 |
| 12 | ZD1839,a selective epidermal growth factor receptor tyrosine kinase inhibitor,shows antimetastatic activity using a hepatocellular carcinoma model显示文摘 | Matsuo M Sakurai H Saiki I | 2003 | Mol Cancer Ther2003，2，： | 1 |
| 13 | Inhibition by sulfated chitin derivatives of invasion through extracellular matrix and enzymatic degradation by metastatic melanoma cells显示文摘 | Ikao Saiki Jan Murata Motowo Nakajima | 1990 | Cancer Res1990，50，12： | 1 |
| 14 | Primerdirected enzymatic amplification of DNA with a thermostable DNA polymerase显示文摘 | SAIKI RK GELFAND DH STOTTELS A | 1988 | Science1988，239，： | 1 |
| 15 | Association of the Japanese Orthopaedic Association score with the oswestry disability index,roland-morris disability questionnaire,and short-form 36显示文摘 | Fujiwara A Kobayashi N Saiki K | 2003 | Spine2003，28，14： | 1 |
| 16 | Simple and accurate alignment of toric intraocular lenses and evaluation of their rotation errors using anterior segment optical coherence tomography显示文摘 | Watanabe K Negishi K Torii H Saiki M Dogru M Tsubota K | | 0，，01： | 1 |
| 17 | Restoring de novo coenzyme Q biosynthesis in Caenorhabditis elegans coq-3 mutants yields profound rescue compared to exogenous coenzyme Q supplementation显示文摘 | Gomez F Saiki R Chin R Srinivasan C Clarke CF | 2012 | Gene2012，506，： | 1 |
| 18 | Directed enzymatic amplification of DNA with a thermostable DNA polymerase显示文摘 | Saiki R K Bchalf S Faloona F | 1985 | Science1985，230，： | 1 |
| 19 | 显示文摘 | Watanabe T Saiki A Saito K | 2001 | J Appl Phys2001，89，7： | 1 |
| 20 | Primer directed enzymatic amplification of DNA with a thermostable DNA polymerase显示文摘 | Gelfand D H Erlich H A | 1988 | Science1988，239，： | 1 |
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