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| 1 | 青藏高原中部土壤水中稳定同位素变化显示文摘根据 1 998年夏季测得的青藏高原中部那曲地区降水和土壤水中稳定同位素 ,分析了不同层位土壤剖面中稳定同位素的变化规律及与水分迁移的关系。研究结果发现 ,土壤表层水中δ1 8O受降水中δ1 8O的直接影响 ,并且与降水中δ1 8O有相同的变化趋势 ,而地下水中δ1 8O受降水中δ1 8O的直接影响不明显 ,变化幅度很小 ,表明地下水并非直接来源于当年夏季的降水 ,可能代表了多年降水的平均状态。不同土壤剖面水中δ1 8O的变化反映了降水向地下逐渐渗浸的过程。表层土壤水中δ1 8O受降水的影响最为明显 ,而向下土壤水中δ1 8O受地下水δ1 8O的影响增强 ,显示出地下水在土壤水分活动中起着活跃的作用。 | 田立德 姚檀栋 M TSUJIMURA 孙维贞 | 2002 | 土壤学报2002，39，3： | 54 |
| 2 | 青藏高原那曲河流域降水及河流水体中氧稳定同位素研究显示文摘根据青藏高原中部那曲河流域 1 998年夏季测得的上下游中稳定同位素的日变化 ,并与同期观测的流域降水中稳定同位素比较 ,分析了河水中δ18O的变化特征 ,初步研究了该流域的稳定同位素水文循环过程。河水中δ18O的变化幅度远小于降水 ,它是降水中δ18O、降水量以及地表蒸发过程共同作用的结果。研究发现湖水对于稳定同位素变化起着显著的调节作用。 | 田立德 姚檀栋 沈永平 杨梅学 叶柏生 Atu.siNUMAGUTI Maki TSUJIMURA | 2002 | 水科学进展2002，13，2： | 43 |
| 3 | 机车车辆铝合金复合材料制动盘的开发显示文摘目前新干线电动车组使用的制动盘材料主要是Ni—Cr—Mo低合金铸铁。最近开发了高强度材料如铸铁─铸钢双层材料和高耐热裂的锻钢,并投入了实际使用。但这些钢铁材料并未很有效地减小簧下质量。这样,开始注意陶瓷颗粒分散铝合金复合材料。这种材料比钢铁材料轻得多,并在一般的试验条件下具有良好的耐磨性。本文探索了使用这种材料的轻型制动盘的可能性。Sic(碳化硅)颗粒分散铝合金复合材料制动盘已经安装在电动车组上,并由两日本铁路公司在100N新干线电动车组和“Win350”试验车上进行试验。 | 姚永康 Taro TSUJIMURA | 1996 | 国外机车车辆工艺1996，，4： | 13 |
| 4 | Cyclooxygenase-2 expression after preoperative chemoradiotherapy correlates with more frequent esophageal cancer recurrence显示文摘AIM: To investigate the relationship between cycloo- xygenase-2 (COX-2), and vascular endothelial growth factor (VEGF), and to determine the clinical significance of this relationship in esophageal cancer patients undergoing chemoradiotherapy (CRT). METHODS: Immunohistochemical staining was used to evaluate COX-2 and VEGF expression in 40 patients with histologically-confirmed esophageal squamous carcinoma (ESCC) who were undergoing preoperative CRT. RESULTS: Fourteen out of 40 ESCC patients showed a pathological complete response (CR) after CRT. COX-2 and VEGF protein expressions were observed in the cytoplasm of 17 and 13 tumors, respectively, with null expression in 9 and 13 tumors, respectively. COX-2 expression was strongly correlated with VEGF expression (P < 0.05). There were also significant associations between COX-2 expression, tumor recurrence, and lymph-node involvement (P = 0.0277 and P = 0.0095, respectively). COX-2 expression and VEGF expression had significant prognostic value for disease-free survival (log-rank test; P = 0.0073 and P = 0.0341, respectively), but not for overall survival, as assessed by univariate analysis. CONCLUSION: Our results suggest that COX-2 expression correlates with VEGF expression and might be a useful prognostic factor for more frequent tumor recurrence in ESCC patients undergoing neoadjuvant CRT. These findings support the use of anti-angiogenic COX-2 inhibitors in the treatment of ESCC. | Reigetsu Yoshikawa Yoshinori Fujiwara Kenji Koishi Syoudou Kojima Tomohiro Matsumoto Hidenori Yanagi Takehira Yamamura Tomoko Hashimoto-Tamaoki Takashi Nishigami Tohru Tsujimura | 2007 | World Journal of Gastroenterology2007，13，16： | 9 |
| 5 | Persistent CXCR4 expression after preoperative chemoradiotherapy predicts early recurrence and poor prognosis in esophageal cancer显示文摘AIM: To study the effect of CXC chemokine receptor-4 (CXCR4) expression on disease progression and prognosis in esophageal cancer. METHODS: CXCR4 expression was evaluated in 37 patients with histologically confirmed esophageal squamous carcinomas (ESCC) undergoing preoperative chemoradiotherapy (CRT) by immunohistochemical staining. RESULTS: Eleven out of 37 ESCC patients showed a pathological complete response (CR) after CRT. CXCR4 protein expression was observed in cell cytoplasms of 13 tumors, and null expression was seen in 13 tumors. Distant recurrence was significantly more common in patients with positive CXCR4 expression (P = 0.0318). After a median follow-up time of 31.6 mo, 19 patients progressed (12 of 19 expressed positive CXCR4) and 11 died (10 of 11 expressed positive CXCR4). Overall survival was significantly correlated with lymph node metastasis (952.1 ± 53.8 d in negative group vs 475.1 ± 56.2 d in positive group, P = 0.023), distant metastasis (874.0 ± 60.4 d in negative group vs 434.9 ± 75.2 d in positive group, P = 0.014) and CRT (811.5 ± 51.2 d in responder group vs 459.6 ± 94.0 d in non-responder group, P = 0.00038) and further with an absence ofCXCR4 expression or no residual tumor (959.8 ± 51.0 d in null expression or no tumor group vs 412.0 ± 57.1 d in positive expression group, P = 0.0001). CONCLUSION: Persistent positive CXCR4 expression is implicated in tumor aggressiveness and poor prognosis in ESCC after CRT, and preoperative CRT may improve the prognosis of ESCC via CXCL12-CXCR4 signaling pathway. | Kenji Koishi Reigetsu Yoshikawa Tohru Tsujimura Tomoko Hashimoto-Tamaoki Syoudou Kojima Hidenori Yanagi Takehira Yamamura Yoshinori Fujiwara | 2006 | World Journal of Gastroenterology2006，12，47： | 9 |
| 6 | Disease control by regulation of P-glycoprotein on lymphocytes in patients with rheumatoid arthritis显示文摘The main purpose of treatment of rheumatoid arthritis(RA) with disease modifying antirheumatic drugs(DMARDs) is to control activation of lymphocytes,although some patients do not respond adequately to such treatment. Among various mechanisms of multidrug resistance, P-glycoprotein(P-gp), a member of ATP-binding cassette transporters, causes drugresistance by efflux of intracellular drugs. Certain stimuli,such as tumor necrosis factor-α, activate lymphocytes and induce P-gp expression on lymphocytes, as evident in active RA. Studies from our laboratories showed spontaneous nuclear accumulation of human Y-boxbinding protein-1, a multidrug resistance 1 transcription factor, in unstimulated lymphocytes, and surface overexpression of P-gp on peripheral lymphocytes of RA patients with high disease activity. The significant correlation between P-gp expression level and RA disease activity is associated with active efflux of drugs from the lymphocyte cytoplasm and in drugresistance.However, the use of biological agents that reduce P-gp expression as well as P-gp antagonists(e.g., cyclosporine) can successfully reduce the efflux of corticosteroids from lymphocytes in vitro, suggesting that both types of drugs can be used to overcome drug-resistance and improve clinical outcome. We conclude that lymphocytes activated by various stimuli in RA patients with highly active disease acquire P-gpmediated multidrug resistance against corticosteroids and probably some DMARDs, which are substrates of P-gp. Inhibition/reduction of P-gp could overcome such drug resistance. Expression of P-gp on lymphocytes is a promising marker of drug resistance and a suitable therapeutic target to prevent drug resistance in patients with active RA. | Shizuyo Tsujimura Yoshiya Tanaka | 2015 | World Journal of Experimental Medicine2015，5，4： | 8 |
| 7 | Roles and regulation of bone morphogenetic protein-7 in kidney development and diseases显示文摘The gene encoding bone morphogenetic protein-7(BMP7) is expressed in the developing kidney in embryos and also in the mature organ in adults. During kidney development, expression of BMP7 is essential to determine the final number of nephrons in and proper size of the organ. The secreted BMP7 acts on the nephron progenitor cells to exert its dual functions: To maintain and expand the progenitor population and to provide them with competence to respond to differentiation cues, each relying on distinct signaling pathways. Intriguingly, in the adult organ, BMP7 has been implicated in protection against and regeneration from injury. Exogenous administration of recombinant BMP7 to animal models of kidney diseases has shown promising effects in counteracting inflammation, apoptosis and fibrosis evoked upon injury. Although the expression pattern of BMP7 has been well described, the mechanisms by which it is regulated have remained elusive and the processes by which the secretion sites of BMP7 impinge upon its functions in kidney development and diseases have not yet been assessed. Understanding the regulatory mechanisms will pave the way towards gaining better insight into the roles of BMP7, and to achieving desired control of the gene expression as a therapeutic strategy for kidney diseases. | Taro Tsujimura Mana Idei Masahiro Yoshikawa Osamu Takase Keiichi Hishikawa | 2016 | World Journal of Stem Cells2016，8，9： | 6 |
| 8 | 制动盘金属材料的高速摩擦及磨耗特性显示文摘本文介绍了用于新干线车辆上的新式制动材质的高速摩擦特性,并探讨了影响这些特性的某些因素。 | Taro Tsujimura 唐立成 | 1991 | 国外铁道车辆1991，28，5： | 3 |
| 9 | Single-nucleotide polymorphisms in HORMAD1 may be a risk factor for azoospermia caused by meiotic arrest in Japanese patients显示文摘基因机制作为一些男不孕的一个原因被含有,还糟糕被理解。成熟分裂为复制对细菌房间和必需品唯一。synaptonemal 建筑群是为染色体配对,分离和再结合的一个批评部件。因为猛烈雄的老鼠是不肥沃的, Hormad1 为哺乳动物的 gametogenesis 是必要的。在早 pachytene 阶段和 synaptonemal 建筑群的 Hormad1 缺乏的睾丸展览 meiotic 拘捕不能被设想。为了分析人的 HORMAD1 基因缺点与人的精子缺乏被联系的假设,由 meiotic 拘捕引起了, mutational 分析被诊断,精子缺乏源于 meiotic 的 30 个日本人的直接顺序分析在所有编码区域执行拘捕。由顺序分析,三个多型性地点,单个核苷酸多型性 1 (c。163A > G ) , SNP2 (c。501T > G ) 并且 SNP3 (c。918C > T ) ,在 exons 被发现 3, 8 和 10。有精子缺乏和 80 个正常的证明怀孕的、肥沃的人的 30 个病人为 HORMAD1 多型性被分析。SNP1 和 SNP2 与人的精子缺乏由完全的早 meiotic 拘捕引起了被联系(P< 0.05 ) 。我们建议 HORMAD1 让必要 meiotic 在人的精子发生工作。 | Toshinobu Miyamoto Aldra Tsujimura Yasushi Miyagawa Eitetsu Koh Mikio Namiki Michiharu Horikawa Yasuaki Saijo Kazuo Sengoku | 2012 | Asian Journal of Andrology2012，14，4： | 3 |
| 10 | SPATA17的单核苷酸多态性可能是日本减速分裂阻滞患者的遗传危险因素显示文摘遗传机制已经成为一些男性患者不育的一个病因。近年来,通过人类睾丸组织的基因芯片分析鉴定了10个与人类精子发生相关的新基因。其中一个是精子发生相关17基因(SPATA17)。为了研究是否SPATA17基因缺陷与减数分裂导致的无精症有关,我们进行了突变分析,将18个日本减数分裂导致的无精症患者的SPATA17编码区域进行了测序,以及统计分析,其中包括18个减数分裂阻滞患者,20个唯支持细胞综合征(SCOS)患者和96个健康对照男性。没有SPATA17发生突变。但是,减数分裂阻滞患者组检测到了3个单核苷酸多态性(cSNPs:SNPI—SNP3)。减数分裂阻滞患者与其他患者的SNP1和SNP2基因型与等位基因频率无明显不同。但是,SNP3的等位基因频率在减数分裂阻滞患者组中明显升高(P〈0.05)。这项研究表明,sPATA17在人类精子发生,尤其是减数分裂中可能起关键性作用。 | Toshinobu Miyamoto Akira Tsujimura Yasushi Miyagawa Eitetsu Koh Naoko Sakugawa Hiroe Miyakawa Hisashi Sato Mikio Namiki Akihiko Okuyama Kazuo Sengoku | 2009 | Asian Journal of Andrology2009，11，5： | 2 |
| 11 | A tutorial survey of job-shop scheduling problems using genetic algorithms, part Ⅱ: Hybrid genetic search strategies显示文摘 | Cheng R Gen M Tsujimura Y | 1999 | Computers & Industrial Engineering1999，35，： | 2 |
| 12 | Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury显示文摘 | ABEMATSU M TSUJIMURA K YAMANO M | 2010 | J Clin Invest2010，120，9： | 1 |
| 13 | A Tutorial Survey of Job-Shop Sheduling Problem Using Genetic Algorithms,Part Ⅱ:Hybrid Genetic Search Strategies显示文摘 | Cheng R Gen M Tsujimura Y | 1999 | Computes & Industrial Engineering1999，33，2： | 1 |
| 14 | Androgen decline in patients with nonobstructive azoospemia after microdissection testicular sperm extraction显示文摘 | Takada S Tsujimura A Ueda T | | 0，，01： | 1 |
| 15 | Necessity of tyrosine 719 and phosphatidylinositol 3'-kinase-mediated signal pathway in constitutive activation and oncogenic potential of c-kit receptor tyrosine kinase with the Asp814Val mutation显示文摘 | Hashimoto K Matsumura I Tsujimura T | 2003 | {H}Blood2003，，3： | 1 |
| 16 | Microdissection testicular sperm extraction:prediction,outcome,and complications显示文摘 | Tsujimura A | 2007 | Int J Urol2007，14，10： | 1 |
| 17 | Identification of a polymorphic gene,BCL2A1,encoding two novel hematopoietic lineage-specific minor histocompatibility antigens显示文摘 | Nishida T Kondo E Miyazaki M Taji H Iida H Tsujimura K Yazaki M Naoe T Morishima Y Kodera Y Kuzushima K Takahashi T | 2003 | J Exp Med2003，197，11： | 1 |
| 18 | Specific differences in gene expression profile revealed by cDNA microarray analysis of glutathione S-transferase placental form (GST-P) immunohistochemically positive rat liver foci and surrounding tissue显示文摘 | Asamoto M Tsujimura K | 2004 | Carcinogenesis2004，25，3： | 1 |
| 19 | Isolation and genetic analysis of Japanese encephalitis virus fi'om a diseased horse in Japan显示文摘 | Yamanaka T Tsujimura K Kondo T | 2006 | J Vet Med Sci2006，68，3： | 1 |
| 20 | Seasonal variation of Microcystis population in sediments of Lake Biwa, Japan显示文摘 | Shigeo Tsujimura Hajime Tsukada Hiroyuki Nakahara | 2000 | Hydrobiologia2000，434，： | 1 |
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