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| 1 | Simplified criteria for diagnosing superficial esophageal squamous neoplasms using Narrow Band Imaging magnifying endoscopy显示文摘AIM To simplify the diagnostic criteria for superficial esophageal squamous cell carcinoma(SESCC) on Narrow Band Imaging combined with magnifying endoscopy(NBI-ME).METHODS This study was based on the post-hoc analysis of a randomized controlled trial. We performed NBI-ME for 147 patients with present or a history of squamous cell carcinoma in the head and neck, or esophagus between January 2009 and June 2011. Two expert endoscopistsdetected 89 lesions that were suspicious for SESCC lesions, which had been prospectively evaluated for the following 6 NBI-ME findings in real time: 'intervascular background coloration'; 'proliferation of intrapapillary capillary loops(IPCL)'; and 'dilation', 'tortuosity', 'change in caliber', and 'various shapes(VS)' of IPCLs(i.e., Inoue's tetrad criteria). The histologic examination of specimens was defined as the gold standard for diagnosis. A stepwise logistic regression analysis was used to identify candidates for the simplified criteria from among the 6 NBI-ME findings for diagnosing SESCCs. We evaluated diagnostic performance of the simplified criteria compared with that of Inoue's criteria.RESULTS Fifty-four lesions(65%) were histologically diagnosed as SESCCs and the others as low-grade intraepithelial neoplasia or inflammation. In the univariate analysis, proliferation, tortuosity, change in caliber, and VS were significantly associated with SESCC(P < 0.01). The combination of VS and proliferation was statistically extracted from the 6 NBI-ME findings by using the stepwise logistic regression model. We defined the combination of VS and proliferation as simplified dyad criteria for SESCC. The areas under the curve of the simplified dyad criteria and Inoue's tetrad criteria were 0.70 and 0.73, respectively. No significant difference was shown between them. The sensitivity, specificity, and accuracy of diagnosis for SESCC were 77.8%, 57.1%, 69.7% and 51.9%, 80.0%, 62.9% for the simplified dyad criteria and Inoue's tetrad criteria, respectively.CONCLUSION The combination of proliferation and VS may serve as simplified criteria for the diagnosis of SESCC using NBIME. | Akira Dobashi Kenichi Goda Noboru Yoshimura Tomohiko R Ohya Masayuki Kato Kazuki Sumiyama Masato Matsushima Shinichi Hirooka Masahiro Ikegami Hisao Tajiri | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 2 | Analysis on Temperature Distributions in Single Cell of Polymer Electrolyte Fuel Cell When Operated in High Temperature Range显示文摘 | Akira Nishimura Kotaro Osada Takuro Tsunoda Masato Yoshimura Masafumi Hirota Eric Hu | 2016 | Journal of Energy and Power Engineering2016，10，8： | 5 |
| 3 | Numerical Analysis of Temperature Distributions in Single Cell of Polymer Electrolyte Fuel Cell when Operated in Elevated Temperature Range显示文摘 | Akira Nishimura Kanji Patoriki Zamami Masato Yoshimura Masafumi Hirota Mohan Lal Kolhe | 2017 | Journal of Energy and Power Engineering2017，11，6： | 4 |
| 4 | Impact of Thickness of Polymer Electrolyte Membrane on Temperature Distributions in Single Cell of Polymer Electrolyte Fuel Cell Operated at High Temperature显示文摘 | Akira Nishimura Yusuke Sato Masato Yoshimura Satoru Kamiya Masafumi Hirota | 2018 | Journal of Energy and Power Engineering2018，12，2： | 4 |
| 5 | Protocol for laparoscopic cholecystectomy: Is it rocket science?显示文摘Laparoscopic cholecystectomy(LC) does not require advanced techniques, and its performance has therefore rapidly spread worldwide. However, the rate of biliary injuries has not decreased. The concept of the critical view of safety(CVS) was first documented two decades ago. Unexpected injuries are principally due to misidentification of human factors. The surgeon's assumption is a major cause of misidentification, and a high level of experience alone is not sufficient for successful LC. We herein describe tips and pitfalls of LC in detail and discuss various technical considerations.Finally, based on a review of important papers and our own experience, we summarize the following mandatory protocol for safe LC:(1) consideration that a high level of experience alone is not enough;(2) recognition of the plateau involving the common hepatic duct and hepatic hilum;(3) blunt dissection until CVS exposure;(4) Calot's triangle clearance in the overhead view;(5) Calot's triangle clearance in the view from underneath;(6) dissection of the posterior right side of Calot's triangle;(7) removal of the gallbladder body; and(8) positive CVS exposure. We believe that adherence to this protocol will ensure successful and beneficial LC worldwide, even in patients with inflammatory changes and rare anatomies. | Tomohide Hori Fumitaka Oike Hiroaki Furuyama Takafumi Machimoto Yoshio Kadokawa Toshiyuki Hata Shigeru Kato Daiki Yasukawa Yuki Aisu Maho Sasaki Yusuke Kimura Yuichiro Takamatsu Masato Naito Masaya Nakauchi Takahiro Tanaka Daigo Gunji Kiyokuni Nakamura Kiyoko Sato Masahiro Mizuno Taku Iida Shintaro Yagi Shinji Uemoto Tsunehiro Yoshimura | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 6 | Impact of Relative Humidity of Supply Gas on Temperature Distributions in Single Cell of Polymer Electrolyte Fuel Cell When Operated at High Temperature显示文摘 | Akira Nishimura Masato Yoshimura Satoru Kamiya Masafumi Hirota Eric Hu | 2017 | Journal of Energy and Power Engineering2017，11，11： | 2 |
| 7 | Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein显示文摘 | Li-Fan Lu To-Ha Thai Dinis Pedro Calado Ashutosh Chaudhry Masato Kubo Kentaro Tanaka Gabriel B. Loeb Hana Lee Akihiko Yoshimura Klaus Rajewsky Alexander Y. Rudensky | 2009 | Immunity2009，，1： | 2 |
| 8 | Kidney GATA3^(+) regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury显示文摘FoxP3^(+)regulatory T cells(Tregs)play crucial roles in peripheral immune tolerance.In addition,Tregs that reside or accumulate in nonlymphoid tissues,called tissue Tregs,exhibit tissue-specific functions and contribute to the maintenance of tissue homeostasis and repair.In an experimental mouse model of crescentic glomerulonephritis induced by an anti-glomerular basement membrane antibody,Tregs started to accumulate in the kidney on day 10 of disease onset and remained at high levels(~30–35%of CD4^(+)T cells)during the late stage(days 21–90),which correlated with stable disease control.Treg depletion on day 21 resulted in the relapse of renal dysfunction and an increase in Th1 cells,suggesting that Tregs are essential for disease control during the convalescence stage.The Tregs that accumulated in the kidney showed tissue Treg phenotypes,including high expression of GATA3,ST2(the IL33 receptor subunit),amphiregulin(Areg),and PPARγ.Although T-bet^(+) Tregs and RORγt^(+) Tregs were observed in the kidney,GATA3^(+) Tregs were predominant during the convalescence stage,and a PPARγagonist enhanced the accumulation of GATA3^(+) Tregs in the kidney.To understand the function of specific genes in kidney Tregs,we developed a novel T cell transfer system to T cell-deficient mice.This experiment demonstrates that ST2,Areg,and CCR4 in Tregs play important roles in the accumulation of GATA3^(+) Tregs in the kidney and in the amelioration of renal injury.Our data suggest that GATA3 is important for the recruitment of Tregs into the kidney,which is necessary for convalescence after renal tissue destruction. | Ryota Sakai Minako Ito Kyoko Komai Mana Iizuka-Koga Kazuhiko Matsuo Takashi Nakayama Osamu Yoshie Koichi Amano Hiroshi Nishimasu Osamu Nureki Masato Kubo Akihiko Yoshimura | 2021 | Cellular & Molecular Immunology2021，18，5： | 2 |
| 9 | SOCS pro- teins, cytokine signalling and immune regulation显示文摘 | Kihiko Yoshimura Tetsuji Naka Masato Kubo | 2007 | Nature Rev Imnmnol2007，7，6： | 1 |
| 10 | Metastable- stable phase diagrams in the zirconia- containing systems utilized in solid - oxide fuel cell application 显示文摘 | Masatomo Yashima Masato Kakihana Masahiro Yoshimura | 1996 | Solid State Ionics1996，8688，： | 1 |
| 11 | T Cell Treatment with Small Interfering RNA for Suppressor of Cytokine Signaling 3 Modulates Allergic Airway Responses in a Murine Model of Asthma显示文摘 | Moriwaki Atsushi Inoue Hiromasa Nakano Takako Matsunaga Yuko Matsuno Yukiko Matsumoto Takafumi Fukuyama Satoru Kan-o Keiko Matsumoto Koichiro Tsuda-Eguchi Miyuki Nagakubo Daisuke Yoshie Osamu Yoshimura Akihiko Kubo Masato Nakanishi Yoichi | 2011 | American Journal of Respiratory Cell and Molecular Biology2011，，4： | 1 |
| 12 | Metastable-stable phase diagrams in the zirconia-containing systems utilized in solid-oxide fuel cell application显示文摘 | Masatomo Yashima Masato Kakihana Masahiro Yoshimura | 1996 | Solid State Ionics1996，8688，： | 1 |
| 13 | Primary Hepatic Leiomyosarcoma in a Woman After Renal Transplantation: Report of a Case显示文摘 | Hideto Fujita Masato Kiriyama Taiichi Kawamura Toru Ii Shigeru Takegawa Shotaro Dohba Yasuhiko Kojima Mitsuhiro Yoshimura Akihiko Kobayashi Satoru Ozaki Kishichiro Watanabe | 2002 | Surgery Today2002，，5： | 1 |
| 14 | Preparation of pure perovskite-type BaSnO3 powders by the polymerized complex method at reduced temperature显示文摘 | Chandana Premakumara Udawatte Masato Kakihana Masahiro Yoshimura | 1998 | Solid State Ionics1998，，108： | 1 |
| 15 | T Cell Treatment with Small Interfering RNA for Suppressor of Cytokine Signaling 3 Modulates Allergic Airway Responses in a Murine Model of Asthma显示文摘 | Moriwaki Atsushi Inoue Hiromasa Nakano Takako Matsunaga Yuko Matsuno Yukiko Matsumoto Takafumi Fukuyama Satoru Kan-o Keiko Matsumoto Koichiro Tsuda-Eguchi Miyuki Nagakubo Daisuke Yoshie Osamu Yoshimura Akihiko Kubo Masato Nakanishi Yoichi | 2011 | American Journal of Respiratory Cell and Molecular Biology2011，，4： | 1 |
| 16 | Influence of renin–angiotensin system on serum parathyroid hormone levels in uremic patients显示文摘 | Fumihiko Koiwa Daisuke Komukai Makoto Hirose Ashio Yoshimura Ryoichi Ando Toshifumi Sakaguchi Yasuhiro Komatsu Toshio Shinoda Daijo Inaguma Nobuhiko Joki Hidemi Nishida Masato Ikeda Takashi Shigematsu | 2012 | Clinical and Experimental Nephrology2012，，1： | 1 |
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