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| 1 | Pre-osteoblastic MC3T3-E1 cells promote breast cancer growth in bone in a murine xenograft model显示文摘The bones are the most common sites of breast cancer metastasis. Upon arrival within the bone microenvironment, breast cancer cells coordinate the activities of stromal cells, resulting in an increase in osteoclast activity and bone matrix degradation. In late stages of bone metastasis, breast cancer cells induce apoptosis in osteoblasts, which further exacerbates bone loss. However, in early stages, breast cancer cells induce osteoblasts to secrete inflammatory cytokines purported to drive tumor progression. To more thoroughly evaluate the role of osteoblasts in early stages of breast cancer metastasis to the bones, we used green fluorescent protein-labeled human breast cancer cell lines MDA-MB-231 and MDA-MB-435, which both induce osteolysis after intra-femoral injection in athymic mice, and the murine pre-osteoblastic cell line MC3T3-E1 to modulate osteoblast populations at the sites of breast cancer metastasis. Breast cancer cells were injected directly into the femur with or without equal numbers of MC3T3-E1 cells. Tumors grew significantly larger when co-injected with breast cancer cells and MC3T3-E1 cells than injected with breast cancer cells alone. Osteolysis was induced in both groups, indicating that MC3T3-E1 cells did not block the ability of breast cancer cells to cause bone destruction. MC3T3-E1 cells promoted tumor growth out of the bone into the extraosseous stroma. These data suggest that breast cancer cells and osteoblasts communicate during early stages of bone metastasis and promote tumor growth. | Thomas M. Bodenstine Benjamin H. Beck Xuemei Cao Leah M. Cook Aimen Ismail J. Kent Powers Andrea M. Mastro Danny R. Welch | 2011 | Chinese Journal of Cancer2011，30，3： | 5 |
| 2 | Hyperelastic Approach for Composite Reinforcement Forming Simulations 显示文摘 | Aimene Y Hagege B Sidoroff F Vidal-Salle E Boissel P Dridi S | 2008 | Int J Mater2008，1，： | 1 |
| 3 | 种植支持无牙颌固定修复体材料对种植体及其修复体存留率的影响:系统性回顾及Meta分析显示文摘目的:评估无牙颌种植固定修复体的材料对其种植体及其修复体临床存留率的影响。文献检索:根据PRISMA声明(系统性回顾及Meta分析优先报告的条目).用电子数据库手动检索相关文献。检索范围为种植支持无牙颌固定修复体的临床研究,且研究的样本量不少于10人。本研究主要目的是评估不同修复体材料对种植体支持无牙颌固定修复种植体存留率及修复体存留率的影响。结果:共检索到文献2254篇.其中41篇文献入选。统计结果显示不同常用修复材料的无牙颌种植修复种植体存留率为:金属烤瓷修复体:97%(95%CI[0.96;0.98]).全瓷修复体:99%(95%CI[0.98;1.00]).金属烤塑修复体:97%(95%CI[0.96;0.98]).三组有显著性差异(P=0.0337)。而修复体存留率为:金属烤瓷修复体:95%(95%CI[0.89;0.97]).全瓷修复体:97%(95%CI[0.92;0.99]).金属烤塑修复体:97%(95%CI[0.95;0.98]).三者无显著性差异(P=0.3796)。三种修复体的饰面崩瓷率从低到高依次为金属烤瓷修复体:8%(95%CI[O.O30.20]).全瓷修复体15%(95%CI[0.06:0.32]).金属烤塑修复体:22%(95%CI[0.13;0.33])。进一步将修复体材料细分为5个亚组(非贵金属烤瓷,氧化错烤瓷.贵金属烤塑.非贵金属烤塑.PMMA)进行种植体及修复体存留率的统计。与上述结果类似.不同常用修复材料的种植体存留率有显著性差异(P=0.0126).而修复体存留率无显著性差异。结论:修复体材料的选择似乎对种植支持无牙颌固定修复的种植体及修复体存留率在临床上无明显影响。种植体支持的无牙颌修复体有较高的崩瓷率.仅修复体的存留率这一个参数难以描述该种修复材料实际的临床效果.参考价值有限。本研究纳入文献数量有限.在选择氧化错烤瓷或金属烤塑作为种植无牙颌修复体时,建议临床医师要慎重。 | Aimen Bagegni Samir Abou-Ayash Gerta Rucker Ahmad Algamy Wael Att 高文莫(译) 耿威(审) | 2020 | 中国口腔医学继续教育杂志2020，23，1： | 1 |
| 4 | Reactive lymphoid hyperplasia of the liver and pancreas. A report of two cases and a comprehensive review of the literature显示文摘 | Aimen Amer Sebastian Mafeld Danish Saeed Wissam Al-Jundi Beate Haugk Richard Charnley Steven White | 2011 | Clinics and Research in Hepatology and Gastroenterology2011，，4： | 1 |
| 5 | The role of ultrasonographyin fetal surgery and invasive procedures显示文摘 | Aimen F shaaban Heung Bae kim Ross Milner | 1999 | Seminars in Roentgenology1999，34，1： | 1 |
| 6 | Increased Neurotrophin Production in a Penicillium chrysogenum-Induced Allergic Asthma Model in Mice显示文摘 | Yong Joo Chung Aimen Farraj Najwa Haykal Coates Stephen H. Gavett Marsha D. W. Ward | 2007 | Journal of Toxicology and Environmental Health, Part A2007，，： | 1 |
| 7 | Adenoviral-mediated gene transfer of insulin-like growth factor 1 enhances wound healing and induces angiogenesis显示文摘 | Swathi Balaji Maria LeSaint Sukanta S. Bhattacharya Chad Moles Yashu Dhamija Mykia Kidd Louis D. Le Alice King Aimen Shaaban Timothy M. Crombleholme Paul Bollyky Sundeep G. Keswani | 2014 | Journal of Surgical Research2014，，： | 1 |
| 8 | Hypoelastic,hyperelastic,discrete and semi-discrete approaches for textile composite reinforcement forming显示文摘 | BOISSE P AIMENE Y HAMILA N | 2009 | International Journal of Material Forming2009，3，2： | 1 |
| 9 | Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantion in sheep 显示文摘 | KENNETH W LIECHTY AIMEN T C | 2000 | Nat Med2000，6，11： | 1 |
| 10 | Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in uterotransplantation in sheep 显示文摘 | Kenneth W L Tippi C M Aimen F S | 2000 | Nat Med2000，6，11： | 1 |
| 11 | A hyperelastic approach for composite reinforcement large deformation analysis显示文摘 | AIMENE Y VIDAL-SALLE E HAGEGE B | 2010 | Journal of Composite Materials2010，44，1： | 1 |
| 12 | Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantion in sheep显示文摘 | Kenneth W Liechty TC Aimen M | 2000 | Nat Med2000，6，11： | 1 |
| 13 | The Electronic Government of Quebec——The Canadian Experience显示文摘The adoption of technology in all its forms, especially information technology, is effectively achieved by the success of e-government through the quality of public electronic services provided by this type of government. In order to maximize the effectiveness of E-government and realize its vast potential, several fundamental conditions must exist tofacilitate an enabling environment.The main purpose of this study was to provide effective mechanisms and procedures that define the e-government environment in Quebec and to demonstrate their capacity (or lack thereof) for assessing and developing e-governance in Canada. This was achieved through a theoretical analysis of the fundamental indicators of information and communication technology and some critical measures in terms of human, political, legal, and administrative resource capacities to perform this kind of management at the level of Quebec State in Canada. | Aimen Amira Bacha Soumeya | 2019 | Journal of Modern Accounting and Auditing2019，15，3： | 0 |
| 14 | Effects of green tea-and amla extracts on quality and melanosis of Indian white prawn(Fenneropenaeus indicus,Milne Edwards,1837)during chilled storage显示文摘Effect of ethanol extracts of green tea(Camellia sinensis L.)and amla(Phyllanthus emblica Linn)were investigated on quality and melanosis of chilled stored Indian white prawn(Fenneropenaeus indicus)during 28 days.Extracts were subjected to antioxidant assays viz.1,1-diphenyl-2-picryl hydrazyl radical reducing power methods(DPPH),total antioxidant capacity(TAC),total phenolic content(TPC)and ferric reducing antioxidant power(FRAP)to evaluate antioxidant potentiality and fourier-transform infrared spectroscopy(FT-IR)to identify organic constituents.Polyphenol oxidase(PPO)inhibition was assessed to check the efficacy of the extracts as anti-melanogenic agents.Biochemical(total volatile nitrogen,free fatty acid and peroxide values),bacteriological(aerobic counts),melanosis inhibition and sensory quality of chilled stored shrimp were addressed to investigate the efficacy of extracts as preservative and anti-melanogenic remedy.Free reducing power of green tea-and amla extracts were in a range of 28.72-65.67%and 17.38-66.95%,respectively.Phenolic content level was almost same for green tea and amla extract(2.46±0.002 and 2.51±0.036 mg GAE/gram).Total antioxidant capacity of green tea(210.33±4.63 mg EqAsc/g)was slightly higher than that of amla extracts(145.56±1.98 mg EqAsc/g).FRAP value revealed that green tea(477.49±3.25 mgE Fe(II)/g)had more ferric reducing power than amla(324.39±5.85 mgE Fe(II)/g).FT-IR analysis revealed the presence of essential organic bioactive compounds,which play an important role in reducing lipid oxidation and quality loss,and both extracts possess an encouraging PPO inhibition ability.Treatment by green tea-and amla extracts on chilled stored shrimp showed promising effects on biochemical and microbiological parameters followed by melanosis inhibition and enhanced sensory attributes.Treated Indian white prawn with green tea-and amla extract revealed significantly(P<0.05)lower value of biochemical indices and microbial load during chilled storage compared to untreated sample. | Aimen Firdous Einar Ringø Preetham Elumalai | 2021 | Aquaculture and Fisheries2021，6，6： | 0 |
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