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| 1 | Interpreting sedimentation dynamics at Longxi catchment in the Three Gorges Area,China,using Cs-137 activity,particle size and rainfall erosivity显示文摘Reservoir sedimentation dynamics were interpreted using Cs-137 activity,particle size and rainfall erosivity analysis in conjunction with sediment profile coring.Two sediment cores were retrieved from the Changshou reservoir of Chongqing,which was dammed in 1956 at the outlet of Longxi catchment in the Three Gorges Area using a gravity corer equipped with an acrylic tube with an inner diameter of 6 cm.The extracted cores were sectioned at 2 cm intervals.All sediment core samples were dried,sieved(<2 mm) and weighed.137 Cs activity was measured by γ-ray spectrometry.The particle size of the core samples was measured using laser particlesize granulometry.Rainfall erosivity was calculated using daily rainfall data from meteorological records and information on soil conservation history was collated to help interpret temporal sedimentation trends.The peak fallout of 137 Cs in 1963 appeared at a depth of 84 cm in core A and 56 cm in core B.The peaks of sand contents were related to the peaks of rainfall erosivity which were recorded in 1982,1989,1998 and 2005,respectively.Sedimentation rates were calculated according to the sediment profile chronological controls of 1956,1963,1982,1989,1998 and 2005.The highest sedimentation rate was around 2.0 cm?a^(-1) between 1982 and 1988 when the Chinese national reform and the Household Responsibility System were implemented,leading to accelerated soil erosion in the Longxi catchment.Since 1990 s,andparticularly since 2005,sedimentation rates clearly decreased,since a number of soil conservation programs have been carried out in the catchment.The combined use of 137 Cs chronology,particle size and rainfall erosivity provided a simple basis for reconstructing reservoir sedimentation dynamics in the context of both physical processes and soil restoration.Its advantages include avoiding the need for full blown sediment yield reconstruction and the concomitant consideration of core correlation and corrections for autochthonous inputs and reservoir trap efficiency. | GAO Jin-zhang LONG Yi ZHANG Xin-bao Collins Adrian L HE Xiu-bin ZHANG Yun-qi SHI Zhong-lin | 2016 | Journal of Mountain Science2016，13，5： | 6 |
| 2 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 3 | Mediastinal node staging by positron emission tomographycomputed tomography and selective endoscopic ultrasound with fine needle aspiration for patients with upper gastrointestinal cancer:Results from a regional centre显示文摘AIM To investigate the impact of endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA) and positron emission tomography-computed tomography(PET-CT) in the nodal staging of upper gastrointestinal(GI) cancer in a tertiary referral centre.METHODS We performed a retrospective review of prospectively recorded data held on all patients with a diagnosis of upper GI cancer made between January 2009 and December 2015. Only those patients who had both a PET-CT and EUS with FNA sampling of a mediastinal node distant from the primary tumour were included. Using a positive EUS-FNA result as the gold standard for lymph node involvement, the sensitivity, specificity, positive and negative predictive values(PPV and NPV) and accuracy of PET-CT in the staging of mediastinal lymph nodes were calculated. The impact on therapeutic strategy of adding EUS-FNA to PET-CT was assessed.RESULTS One hundred and twenty one patients were included. Sixty nine patients had a diagnosis of oesophageal adenocarcinoma(Thirty one of whom were junctional), forty eight had oesophageal squamous cell carcinoma and four had gastric adenocarcinoma. The FNA results were inadequate in eleven cases and the PET-CT findings were indeterminate in two cases, therefore thirteen patients(10.7%) were excluded from further analysis. There was concordance between PET-CT and EUS-FNA findings in seventy one of the remaining one hundred and eight patients(65.7%). The sensitivity, specificity, PPV and NPV values of PET-CT were 92.5%, 50%, 52.1% and 91.9% respectively. There was discordance between PET-CT and EUS-FNA findings in thirty seven out of one hundred and eight patients(34.3%). MDT discussion led to a radical treatment pathway in twenty seven of these cases, after the final tumour stage was altered as a direct consequence of the EUS-FNA findings. Of these patients, fourteen(51.9%) experienced clinical remission of a median of nine months(range three to forty two months). CONCLUSION EUS-FNA leads to altered staging of upper GI cancer, resulting in more patients receiving radical treatment that would have been the case using PET-CT staging alone. | Chris Harrington Lyn Smith Jennifer Bisland Elisabet López González Neil Jamieson Stuart Paterson Adrian John Stanley | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，1： | 4 |
| 4 | Genetic determination of irritable bowel syndrome显示文摘急躁的肠症候群(IBS ) 是普通功能的胃肠的混乱。根据罗马 III 标准, IBS 在下列症状的与二联系的以前的 3 瞬间或更多期间每月为至少 3 d 被定义为周期性的腹的疼痛或不快:有澄清,在凳子的频率与一个变化联系的发作或与一个变化联系处于良好的竟技状态的发作或凳子的外观的改进。在 IBS 关于基因贡献正在种证据,然而, IBS 的精确病原学仍然是未知的。基因影响的评估基于成双的研究,家庭聚集和基因流行病学调查。大多数研究比在 dizygotic 为在单合子显著地更大的 IBS 显示出一个词语索引。研究的多数证明了家庭聚集可以代表暴露到基因因素的类似的环境,以及影响。而没有特定的基因与 IBS 联合被识别了,最近的研究在血清素的倡导者区域注意了多型性的重要性再入伍拿 transporter 基因,G蛋白质贝它 3 子单元基因( C825T ),缩胆囊素受体( CCKAR 基因 779T >C ),并且高制片人的肿瘤坏死因素遗传型。进一步的研究是必要的决定基因因素怎么在 IBS 病人影响临床的表明和 therapeutical 反应。 | Cristina Hotoleanu Radu Popp Adrian Pavel Trifa Laurentiu Nedelcu Dan L Dumitrascu | 2008 | World Journal of Gastroenterology2008，14，43： | 4 |
| 5 | Testosterone,cardiomyopathies,and heart failure:a narrative review显示文摘Testosterone exerts an important regulation of cardiovascular function through genomic and nongenomic pathways. It produces several changes in cardiomyocytes, the main actor of cardiomyopathies, which are characterized by pathological remodeling, eventually leading to heart failure. Testosterone is involved in contractility, in the energy metabolism of myocardial cells, apoptosis, and the remodeling process. In myocarditis, testosterone directly promotes the type of inflammation that leads to fibrosis, and influences viremia with virus localization. At the same time, testosterone exerts cardioprotective effects that have been observed in different studies. There is increasing evidence that low endogenous levels of testosterone have a negative impact in some cardiomyopathies and a protective impact in others. This review focuses on the interrelationships between testosterone and cardiomyopathies and heart failure. | Rodica Diaconu Ionuţ Donoiu Oana Mirea Tudor Adrian Bălşeanu | 2021 | Asian Journal of Andrology2021，23，4： | 2 |
| 6 | Generation of DNA profiles from fabrics without DNA extraction 显示文摘 | Adrian L Vera P Yuvaneswari C S | 2010 | Forensic Sci Int(Genetics)2010，4，： | 1 |
| 7 | The role of transforming growth factor-beta (TGF- beta) during ovarian follicular development in sheep 显示文摘 | JENNIFER L J ADRIAN H B KAREN L R | 2004 | Reproductive Biology and Endocrinology2004，2，： | 1 |
| 8 | Si/Si1-xGex/Si low-loss waveguides fabricated using selective epitaxial growth显示文摘 | ADRIAN Vonsovici SOUREN P VESCAN L | 2001 | Proceeding of SPIE2001，，4293： | 1 |
| 9 | 'Pretty Prudent' or Rhetorically Responsive? The American Public’s Support for Military Action显示文摘 | Drury A Cooper Overby L Marvin Ang Adrian Li Yitan | 2010 | Political Research Quarterly2010，，1： | 1 |
| 10 | Measurement and prediction of spin losses in the EHL point contacts of the full toroidal variator显示文摘 | JONATHON N ADRIAN L | 2004 | Transient Processes in Tribology2004，43，： | 1 |
| 11 | Boron- modified phenolic resins for high performance applications显示文摘 | Mohamed O A Adriane L Temisha M | 2003 | Polymer2003，44，24： | 1 |
| 12 | Bacterial dehalorespiration with chlorinated benzenes显示文摘 | Adrian L Szewzyk U Wecke J | 2000 | Nature2000，408，： | 1 |
| 13 | Comparison of acetate and propionate uptake by polyphosphate accumulating organisms and glycogen accumulating organisms显示文摘 | Oehmen Adrian Yuan Zhiguo Blackall Linda L | 2005 | Biotechnology and Bioengineering2005，91，2： | 1 |
| 14 | Cyclooxygenase-independent chemoprevention with an aspirin derivative in a rat model of colonic adenocarcinoma显示文摘 | Adrian W Webb M Pamela L | 1998 | Life Sci1998，62，23： | 1 |
| 15 | HPLC analysis of grapevine phytoalexins coupling photodiode array detection and fluorometry显示文摘 | JEANDET P BREUIL A C ADRIAN M WESTON L A DEBORD S MEUNIER P MAUME G BESSIS R | 1997 | Analytical Chemistry1997，69，24： | 1 |
| 16 | 3D structure of Alzheimer's amyloid-β(1-42) fibrils显示文摘 | L(U)HRS T RITTER C ADRIAN M | 2005 | Proc Natl Acad Sci USA2005，102，17： | 1 |
| 17 | Bacterial dehalorespiration with chlorinated benzenes显示文摘 | ADRIAN L SZEWZYK U WECKE J | 2000 | Nature2000，408，： | 1 |
| 18 | Heat-Stress Response of Maize Mitochondria 显示文摘 | ADRIAN A L PAUL H B DINAKAR B | 1998 | Plant Physiology1998，116，3： | 1 |
| 19 | Physiological responses to temperature and irradiance in Spirogyra ( Zygnematales : Charophyceae) 显示文摘 | Graham J M Lembi C A Adrian H L | 1995 | J Phycol1995，31，： | 1 |
| 20 | Dechlorination of PCE in the presence of Fe~ enhanced by a mixed culture containing two dehalococcoides strains显示文摘 | Rosenthal H Adrian L Steiof M | 2004 | Chemosphere2004，55，： | 1 |
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