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| 1 | Mechanisms underlying feed intolerance in the critically ill: Implications for treatment显示文摘Malnutrition is associated with poor outcomes in critically ill patients. Although nutritional support is yet to be proven to improve mortality in non-malnourished critically ill patients, early enteral feeding is considered best practice. However, enteral feeding is often limited by delayed gastric emptying. The best method to clinically identify delayed gastric emptying and feed intolerance is unclear. Gastric residual volume (GRV) measured at the bedside is widely used as a surrogate marker for gastric emptying, but the value of GRV measurement has recently been disputed. While the mechanisms underlying delayed gastric emptying require further investigation, recent research has given a better appreciation of the pathophysiology. A number of pharmacological strategies are available to improve the success of feeding. Recent data suggest a combination of intravenous metoclopramide and erythromycin to be the most successful treatment, but novel drug therapies should be explored. Simpler methods to access the duodenum and more distal small bowel for feed delivery are also under investigation. This review summarises current understanding of the factors responsible for, and mechanisms underlying feed intolerance in critical illness, together with the evidence for current practices. Areas requiring further research are also highlighted. | Adam Deane Marianne J Chapman Robert J Fraser Laura K Bryant Carly Burgstad Nam Q Nguyen | 2007 | World Journal of Gastroenterology2007，13，29： | 18 |
| 2 | Endogenous Glucagon-Like Peptide-1 Slows Gastric Emptying in Healthy Subjects, Attenuating Postprandial Glycemia显示文摘 | Adam M. Deane Nam Q. Nguyen Julie E. Stevens Robert J. L. Fraser Richard H. Holloway Laura K. Besanko Carly Burgstad Karen L. Jones Marianne J. Chapman Chris K. Rayner Michael Horowitz | 2010 | The Journal of Clinical Endocrinology & Metabolism2010，，1： | 1 |
| 3 | Experimental Study of Desalination Using Direct Contact Membrane Distillation: A New Approach to Flux Enhancement 显示文摘 | Tzahi Y Cath V Dean Adams | 2004 | JMembrSci2004，228，1： | 1 |
| 4 | Market structure and the pass-through of the federal funds rate显示文摘 | Robert M. Adams Dean F. Amel | 2010 | Journal of Banking and Finance2010，，5： | 1 |
| 5 | Sleep during and following critical illness:A narrative review显示文摘Sleep is a complex process influenced by biological and environmental factors.Disturbances of sleep quantity and quality occur frequently in the critically ill and remain prevalent in survivors for at least 12 mo.Sleep disturbances are associated with adverse outcomes across multiple organ systems but are most strongly linked to delirium and cognitive impairment.This review will outline the predisposing and precipitating factors for sleep disturbance,categorised into patient,environmental and treatment-related factors.The objective and subjective methodologies used to quantify sleep during critical illness will be reviewed.While polysomnography remains the gold-standard,its use in the critical care setting still presents many barriers.Other methodologies are needed to better understand the pathophysiology,epidemiology and treatment of sleep disturbance in this population.Subjective outcome measures,including the Richards-Campbell Sleep Questionnaire,are still required for trials involving a greater number of patients and provide valuable insight into patients’experiences of disturbed sleep.Finally,sleep optimisation strategies are reviewed,including intervention bundles,ambient noise and light reduction,quiet time,and the use of ear plugs and eye masks.While drugs to improve sleep are frequently prescribed to patients in the ICU,evidence supporting their effectiveness is lacking. | Laurie Showler Yasmine Ali Abdelhamid Jeremy Goldin Adam M Deane | 2023 | World Journal of Critical Care Medicine2023，12，3： | 1 |
| 6 | CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver显示文摘 | Ye Htun Oo Vanessa Banz Dean Kavanagh Evaggelia Liaskou David R. Withers Elizabeth Humphreys Gary M. Reynolds Laura Lee-Turner Neena Kalia Stefan G. Hubscher Paul Klenerman Bertus Eksteen David H. Adams | 2012 | Journal of Hepatology2012，，5： | 1 |
| 7 | Postpancreatectomy Hemorrhage: Diagnosis and Treatment: An Analysis in 1669 Consecutive Pancreatic Resections显示文摘 | Emre F. Yekebas Lars Wolfram Guellue Cataldegirmen Christian R. Habermann Dean Bogoevski Alexandra M. Koenig Jussuf Kaifi Paulus G. Schurr Michael Bubenheim Claus Nolte-Ernsting Gerhard Adam Jakob R. Izbicki | 2007 | Annals of Surgery2007，，2： | 1 |
| 8 | Pressure Measurements and Attenuation in a Hybrid Mul- titube Pulse Detonation Turbine System 显示文摘 | Adam Rasheed Furman Anthony H Dean Anthony J | 2009 | Journal : Propulsion and Power2009，25，1： | 1 |
| 9 | The use of sequential pattern mining to predict next prescribed medications显示文摘 | Aileen P. Wright Adam T. Wright Allison B. McCoy Dean F. Sittig | 2014 | Journal of Biomedical Informatics2014，，： | 1 |
| 10 | Postpancreatectomy Hemorrhage: Diagnosis and Treatment: An Analysis in 1669 Consecutive Pancreatic Resections显示文摘 | Emre F. Yekebas Lars Wolfram Guellue Cataldegirmen Christian R. Habermann Dean Bogoevski Alexandra M. Koenig Jussuf Kaifi Paulus G. Schurr Michael Bubenheim Claus Nolte-Ernsting Gerhard Adam Jakob R. Izbicki | 2007 | Annals of Surgery2007，，2： | 1 |
| 11 | Comparisons between intragastric and small intestinal delivery of enteral nutrition in the critically ill:a systematic review and meta-analysis显示文摘 | Deane Adam M Rupinder D Day Andrew G | | 0，，03： | 1 |
| 12 | Postpancreatectomy Hemorrhage: Diagnosis and Treatment: An Analysis in 1669 Consecutive Pancreatic Resections显示文摘 | Emre F. Yekebas Lars Wolfram Guellue Cataldegirmen Christian R. Habermann Dean Bogoevski Alexandra M. Koenig Jussuf Kaifi Paulus G. Schurr Michael Bubenheim Claus Nolte-Ernsting Gerhard Adam Jakob R. Izbicki | 2007 | Annals of Surgery2007，，2： | 1 |
| 13 | Experimental study of desalination using direct contact membrane distillation : A new approach to flux enhancement 显示文摘 | Cath Tzahi Y Dean Adams V Childress Amy E | 2004 | Journal of Membrane Science2004，228，1： | 1 |
| 14 | An algebraic approach to IP traceback显示文摘 | Drew Dean Adam Stubblefield | 2002 | ACM Transactions on Information and System Security2002，5，2： | 1 |
| 15 | Experimental study of desali- nation using direct contact membrane distillation:A new approach to flux enhancement 显示文摘 | Tzahi Y Cath V Dean Adams | 2004 | J Membr Sci2004，228，1： | 1 |
| 16 | Neutrophil kinetics and function after major trauma:A systematic review显示文摘BACKGROUND Immune dysfunction following major traumatic injury is complex and strongly associated with significant morbidity and mortality through the development of multiple organ dysfunction syndrome(MODS),persistent inflammation,immunosuppression,and catabolism syndrome and sepsis.Neutrophils are thought to be a pivotal mediator in the development of immune dysfunction.AIM To provide a review with a systematic approach of the recent literature describing neutrophil kinetics and functional changes after major trauma in humans and discuss hypotheses as to the mechanisms of the observed neutrophil dysfunction in this setting.METHODS Medline,Embase and PubMed were searched on January 15,2021.Papers were screened by two reviewers and those included had their reference list hand searched for additional papers of interest.Inclusion criteria were adults>18 years old,with an injury severity score>12 requiring admission to an intensive care unit.Papers that analysed major trauma patients as a subgroup were included.RESULTS Of 107 papers screened,48 were included in the review.Data were heterogeneous and most studies had a moderate to significant risk of bias owing to their observational nature and small sample sizes.Key findings included a persistently elevated neutrophil count,stereotyped alterations in cell-surface markers of activation,and the elaboration of heterogeneous and immunosuppressive populations of cells in the circulation.Some of these changes correlate with clinical outcomes such as MODS and secondary infection.Neutrophil phenotype remains a promising avenue for the development of predictive markers for immune dysfunction.CONCLUSION Understanding of neutrophil phenotypes after traumatic injury is expanding.A greater emphasis on incorporating functional and clinically significant markers,greater uniformity in study design and assessment of extravasated neutrophils may facilitate risk stratification in patients affected by major trauma. | Liam DB Finlay Andrew Conway Morris Adam M Deane Alexander JT Wood | 2021 | World Journal of Critical Care Medicine2021，10，5： | 1 |
| 17 | Functional strength training in cerebral palsy:a pilot study of a group circuit training class for children aged 4-8 years显示文摘 | Blundell SW Shepherd RB Dean CM Adams RD Cahill BM | | 0，，01： | 1 |
| 18 | Initial experience with an intravenous P2Y 12 platelet receptor antagonist in patients undergoing percutaneous coronary intervention: Results from a 2-part, phase II, multicenter, randomized, placebo- and active-controlled trial显示文摘 | Adam B. Greenbaum Cindy L. Grines John A. Bittl Richard C. Becker Dean J. Kereiakes Ian C. Gilchrist Jane Clegg Jill E. Stankowski Donna R. Grogan Robert A. Harrington Hakan Emanuelsson W. Douglas Weaver | 2006 | American Heart Journal2006，，3： | 1 |
| 19 | Nutrient stimulation of mesenteric blood flow-implications for older critically ill patients显示文摘Nutrient ingestion induces a substantial increase in mesenteric blood flow. In older persons(aged ≥ 65 years), particularly those with chronic medical conditions, the cardiovascular compensatory response may be inadequate to maintain systemic blood pressure during mesenteric blood pooling, leading to postprandial hypotension. In older ambulatory persons, postprandial hypotension is an important pathophysiological condition associated with an increased propensity for syncope, falls, coronary vascular events, stroke and death. In older critically ill patients, the administration of enteral nutrition acutely increases mesenteric blood flow, but whether this pathophysiological response is protective, or precipitates mesenteric ischaemia, is unknown. There are an increasing number of older patients surviving admission to intensive care units, who are likely to be at increased risk of postprandial hypotension, both during, and after, their stay in hospital. In this review, we describe the prevalence, impact and mechanisms of postprandial hypotension in older people and provide an overview of the impact of postprandial hypotension on feeding prescriptions in older critically ill patients. Finally, we provide evidence that postprandial hypotension is likely to be an unrecognised problem in older survivors of critical illness and discuss potential options for management. | Thu AN Nguyen Yasmine Ali Abdelhamid Liza K Phillips Leeanne S Chapple Michael Horowitz Karen L Jones Adam M Deane | 2017 | World Journal of Critical Care Medicine2017，6，1： | 1 |
| 20 | Trust and Social Collateral显示文摘 | Karlan Dean Markus Mobius Tanya Rosenblat and Adam Szeidl | 2009 | Quarterly Journal of Economics2009，124，3： | 1 |
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