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30篇 您的检索式:作者名="Bubenheim"
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1Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer.Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki 2006World Journal of Gastroenterology2006,12,40:3
2Autologous serum for isolation and expansion of human mesenchymal stem cells for clinical use显示文摘Stute N Holtz K Bubenheim M 0,,:2
3Para‐aortic lymph node sampling in pancreatic head adenocarcinoma显示文摘L. Schwarz R. M. Lupinacci M. Svrcek M. Lesurtel M. Bubenheim H. Vuarnesson P. Balladur F. Paye 2014Br J Surg2014,,5:2
4Autologous serum for isolation and expandsion of hum an mesenchymal stem cells for clinical use显示文摘StuteN HoltzK Bubenheim M 2004ExpHematol2004,32,:1
5Autologous serum for isolation and expansion of human mesenchymal stem cells for clinical use 显示文摘Stute N Holtz K Bubenheim M 2004Exp Hematol2004,32,12:1
6Postpancreatectomy Hemorrhage: Diagnosis and Treatment: An Analysis in 1669 Consecutive Pancreatic Resections显示文摘Emre F. Yekebas Lars Wolfram Guellue Cataldegirmen Christian R. Habermann Dean Bogoevski Alexandra M. Koenig Jussuf Kaifi Paulus G. Schurr Michael Bubenheim Claus Nolte-Ernsting Gerhard Adam Jakob R. Izbicki 2007Annals of Surgery2007,,2:1
7Non-invasive ventilation and weaning in chronic hypercapnic respiratory failure patients : a randomized multicenter trial显示文摘Girault C Bubenheim M Abroug F 2011Am J Respir Crit Care Med2011,184,5:1
8Autologous serum for isolation and expansion of human mesenchymal stem cells for clinical use显示文摘Stute N Holtz K Bubenheim M 2004Exp Hematol2004,32,12:1
9Autologous serum for isolation and expansion of human mesenchymal stem cells for clinical use显示文摘STUTE N HOLTZ K BUBENHEIM M 2004Exp Hematol2004,32,:1
10Postpancreatectomy Hemorrhage: Diagnosis and Treatment: An Analysis in 1669 Consecutive Pancreatic Resections显示文摘Emre F. Yekebas Lars Wolfram Guellue Cataldegirmen Christian R. Habermann Dean Bogoevski Alexandra M. Koenig Jussuf Kaifi Paulus G. Schurr Michael Bubenheim Claus Nolte-Ernsting Gerhard Adam Jakob R. Izbicki 2007Annals of Surgery2007,,2:1
11Autologous serum for isolation and expansion of human mesenchymal stem cells for clinical use 显示文摘Stute N Holtz K Bubenheim M 2004Exp Hematol2004,32,12:1
12Postpancreatectomy Hemorrhage: Diagnosis and Treatment: An Analysis in 1669 Consecutive Pancreatic Resections显示文摘Emre F. Yekebas Lars Wolfram Guellue Cataldegirmen Christian R. Habermann Dean Bogoevski Alexandra M. Koenig Jussuf Kaifi Paulus G. Schurr Michael Bubenheim Claus Nolte-Ernsting Gerhard Adam Jakob R. Izbicki 2007Annals of Surgery2007,,2:1
13Autologous serum for isolation and expansion of human mesenchymal stem cells for clinical use显示文摘 HOLTZ K BUBENHEIM M 2004Exp Hematol2004,32,12:1
14Autologous serum for isolation and expansion of human mesenchymal stem cells for clinical use显示文摘Stute N Holtz K Bubenheim M 2004Exp Hematol2004,32,12:1
15Autologous serum for isolation and expansion of human mesenchymal stem cells for clinical use显示文摘Stute N Hohz K Bubenheim M 2004Exp Hematol2004,32,12:1
16Quinoa:An emerging new crop with potential for CELSS显示文摘Schlick G Bubenheim D L 0,,:1
17Autologous serum for isolation and expansion of human mesenchymal stem cells for clinical use 显示文摘STUTE N HOLTZ K BUBENHEIM M 2004Exp Hematol2004,32,12:1
18Albumin Limits Mesenteric Endothelial Dysfunction and Inflammatory Response in Cardiopulmonary Bypass显示文摘Fabien Doguet Fabienne Tamion Vincent Le Guillou Michael Bubenheim Christian Thuillez Vincent Richard Jean Paul Bessou 2012Artificial Organs2012,,11:1
19Induced abnormality in Mir-and earth grown super dwarf wheat显示文摘Bubenheim D L Stieber J Campbell W F Salisbury F B Levinski M Sytchev V Pdolsky I Chemova L 2003Advances in Space Research2003,31,:1
20Autologous serum for isola-tion and expansion of human mesenchymal stem cells for clinicaluse显示文摘Stute N Holtz K Bubenheim M 2004Exp Hematol2004,32,12:1
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