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| 1 | Association between polymorphisms in the Toll-like receptor 4,CD14,and CARD15/NOD2and inflammatory bowel disease in the Greek population显示文摘AIM: Crohn's disease(CD)and ulcerative colitis(UC)are multifactorial diseases with a significant genetic background.Apart from CARD15/NOD2 gene, evidence is accumulating that molecules related to the innate immune response such as CD14 or Toll-like receptor 4 (TLR4), are involved in their pathogenesis. In further exploring the genetic background of these diseases, we investigated the variations in the CARD15/NOD2 gene (Arg702Trp,Gly908Arg and Leu1007fsinsC), and polymorphisms in the TLR4 gene (Asp299Gly and Thr399Ile) as well as in the promoter of the CD14 gene (T/C at position -159) in Greek patients with CD and UC.METHODS: DNA was obtained from 120 patients with CD,85 with UC and 100 healthy individuals. Genotyping was performed by allele specific PCR or by PCR-RFLP analysis.RESULTS: The 299Gly allele frequency of the TLR4 gene and the T allele and TT genotype frequendes of the CD14 promoter were significantly higher in CD patients only compared to healthy individuals (P = 0.026<0.05; P = 0.0048<0.01 and P= 0.047<0.05 respectively). Concerning the NOD2/CARD15mutations the overall presence in CD patients was significantly higher than that in UC patients or in controls.Additionally, 51.67% of the CD patients were carriers of a TLR4 and/or CD14 polymorphic allele and at least one variant of the NOD2/CARD15, compared to 27% of the UC patients. It should be pointed out that both frequencies significantly increased as compared with the 10% frequency of multiple carriers found in healthy controls. A possible interaction of the NOD2/CARD15 with TLR4 and especially CD14, increased the risk of developing inflammatory bowel disease (IBD).CONCLUSION: Our results indicate that co-existence of a mutation in either the TLR4 or CD14 gene, and in NOD2/CARD15is associated with an increased susceptibility to developing CD compared to UC, and to developing either CD or UC compared to healthy individuals. | Maria Gazouli Gerassimos Mantzaris Athanassios Kotsinas Panayotis Zacharatos Efstathios Papalambros Athanassios Archimandritis John Ikonomopoulos Vassilis G Gorgoulis | 2005 | World Journal of Gastroenterology2005，11，5： | 17 |
| 2 | Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease显示文摘AIM: To validate novel single nucleotide polymorphisms (SNPs) in Greek patients with Crohn's disease (CD).METHODS: A total of 120 patients with CD, 85 patients with UC, and 100 unrelated healthy controls were genotyped. Genotyping was performed by allele-specific PCR or by PCR-RFLP analysis.RESULTS: Our results showed that the 1672T and -207C alleles were obviously over-represented in CD patients only (P<0.01 and P<0.05, respectively) compared to the control population. The G113A polymorphism was completely absent in our studied population. The odds ratio for the carriage of the TC haplotype was 2.21 for CD patients as compared with controls. Additionally, the frequency of the TC haplotype was increased in patients with ileocolitis or colitis, and was mainly associated with the fibrostenotic phenotype of the disease. Furthermore, when the TC haplotype was compared jointly with the carriage of at least one mutation of the NOD2/CARD15 gene, there was an increased risk for CD, but not for UC, compared to controls. Regarding the location of the disease, the concomitant presence of the TC haplotype and NOD2/CARD15 mutations was mainly associated with ileocolitis or ileitis. CONCLUSION: Collectively, our results suggest that the 1672T variant of the OCTN1 gene and the -207C variant of the OCTN2 gene represent risk factors for CD in the Greek population. | Maria Gazouli Gerassimos Mantzaris Athanassios J Archimandritis George Nasioulas Nicholas P Anagnou | 2005 | World Journal of Gastroenterology2005，11，47： | 12 |
| 3 | Hemobilia as the initial manifestation of cholangiocarcinoma in a hemophilia B patient显示文摘Hemobilia is a rare manifestation of hemophilia and is usually iatrogenic following liver biopsy. There are only few reports of spontaneous hemobilia in hemophilia patients. Cholangiocarcinoma is a well-established cause of hemobilia. We describe a case of a 70-year-old male, with known haemophilia B and a past history of papillotomy, who presented with classical symptoms of hemobilia. The initial diagnostic work-up failed to demonstrate a potential cause of bleeding other than the coagulopathy. Three months later, he was readmitted to our hospital with a second episode of hemobilia. During the second work-up, a cholangiocarcinoma was diagnosed both by imaging studies and by a significant elevation of cancer antigen 19-9. Although hemobilia could be attributed to hemophilia, especially in a patient with previous papillotomy, an underlying malignancy of the biliary tree should be suspected. | Anastassios C Manolakis Andreas N Kapsoritakis Antonis D Tsikouras Fotis D Tsiopoulos Athanassios K Psychos Spyros P Potamianos | 2008 | World Journal of Gastroenterology2008，14，26： | 5 |
| 4 | BRCA1 affects global DNA methylation through regulation of DNMT1显示文摘在 CpG 岛的全球 DNA hypomethylation 结合了本地 hypermethylation 是为乳癌的一个特点,然而,位于这个变化下面的机制留下逃犯。在这研究,我们证明 DNMT1,编码 methylation 维护酶,是 BRCA1 的一个 transcriptional 目标。BRCA1 通过一个潜在的 OCT1 地点和绑定绑在 DNMT1 基因的倡导者为维持 transcriptional 被要求在老鼠和人的房间的倡导者的活跃配置。我们进一步证明 BRCA1 的那损害功能在在 premaligant 阶段在一个 BRCA1 变异的老鼠模型检验的纸巾的几种类型导致全球 DNA hypomethylation,印的 genomic 的损失,和一种开的染色质配置。BRCA1 缺乏也与几 protooncogenes 的显著地增加的表达式层次被联系,包括 c-Fos,哈地岬,和 c-Myc,与在肿瘤的一个更高的表达式,当时乳房的上皮的房间显示了的 premalignant 在肿瘤和控制之间的一个中间的状态。在人的临床的样品,有 DNMT1 的减少的层次的 BRCA1 相互关联的减少的表示,和 CpG 岛的减少的 methylation。因此, BRCA1 通过断然调整 DNMT1 表示阻止全球 DNA hypomethylation,并且这为联系 BRCA1 的乳癌形成提供机制之一。 | Vivek Shukla Xavier Coumoul Tyler Lahusen Rui-Hong Wang Xiaoling Xu Athanassios Vassilopoulos Cuiying Xiao Mi-Hye Lee Yan-Gao Man Mutsuko Ouchi Toru Ouchi Chu-Xia Deng | 2010 | Cell Research2010，20，11： | 5 |
| 5 | Intestinal barrier dysfunction in cirrhosis: Current concepts in pathophysiology and clinical implications显示文摘The intestinal lumen is a host place for a wide range of microbiota and sets a unique interplay between local immune system, inflammatory cells and intestinal epithelium, forming a physical barrier against microbial invaders and toxins. Bacterial translocation is the migration of viable or nonviable microorganisms or their pathogen-associated molecular patterns, such as lipopolysaccharide, from the gut lumen to the mesenteric lymph nodes, systemic circulation and other normally sterile extraintestinal sites. A series of studies have shown that translocation of bacteria and their products across the intestinal barrier is a commonplace in patients with liver disease. The deterioration of intestinal barrier integrity and the consulting increased intestinal permeability in cirrhotic patients play a pivotal pathophysiological role in the development of severe complications as high rate of infections, spontaneous bacterial peritonitis, hepatic encephalopathy, hepatorenal syndrome, variceal bleeding, progression of liver injury and hepatocellular carcinoma. Nevertheless, the exact cellular and molecular mechanisms implicated in the phenomenon of microbial translocation in liver cirrhosis have not been fully elucidated yet. | Georgios I Tsiaoussis Stelios F Assimakopoulos Athanassios C Tsamandas Christos K Triantos Konstantinos C Thomopoulos | 2015 | World Journal of Hepatology2015，7，17： | 4 |
| 6 | Optimizing bus services with variable directional and temporal demand using genetic algorithm显示文摘As a major mode choice of commuters for daily travel, bus transit plays an important role in many urban and metropolitan areas. This work proposes a mathematical model to optimize bus service by minimizing total cost and considering a temporally and directionally variable demand. An integrated bus service, consisting of all-stop and stop-skipping services is proposed and optimized subject to directional frequency conservation, capacity and operable fleet size constraints. Since the research problem is a combinatorial optimization problem, a genetic algorithm is developed to search for the optimal result in a large solution space. The model was successfully implemented on a bus transit route in the City of Chengdu, China, and the optimal solution was proved to be better than the original operation in terms of total cost. The sensitivity of model parameters to some key attributes/variables is analyzed and discussed to explore further the potential of accruing additional benefits or avoiding some of the drawbacks of stop-skipping services. | 瞿何舟 CHIEN Steven I-Jy 刘晓波 张培桐 BLADIKAS Athanassios | 2016 | Journal of Central South University2016，23，7： | 3 |
| 7 | SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress显示文摘 | Hyun-Seok Kim Krish Patel Kristi Muldoon-Jacobs Kheem S. Bisht Nukhet Aykin-Burns J. Daniel Pennington Riet van der Meer Phuongmai Nguyen Jason Savage Kjerstin M. Owens Athanassios Vassilopoulos Ozkan Ozden Seong-Hoon Park Keshav K. Singh Sarki A. Abdulka | 2010 | Cancer Cell2010，，1： | 3 |
| 8 | Upgraded role of autophagy in colorectal carcinomas显示文摘Autophagy is a basic catabolic process closely asso-ciated with degradation of cellular components. The role of autophagy in colorectal cancer(CRC) remains controversial. The mechanism of autophagy has been identified as protecting mechanism against tumorige-nesis by isolation of damaged organelles or as cytopro-tective provides energy in hypoxic regions of CRC tumors. Mutations in proto-oncogenes, such as RAS and BRAF, have been associated with autophagy initiation through signaling pathways of BRAF/MEK/ERK and PI3 K/AKT/m TOR. A combination therapy of chemotherapeutic agents and autophagy inhibitors such as hydroxychloroquine or immunotherapy might represent a major step that could be evaluated as a putative novel therapeutic strategy in CRC patients. | Evangelos Koustas Panagiotis Sarantis Athanassios G Papavassiliou Michalis V Karamouzis | 2018 | World Journal of Gastrointestinal Oncology2018，10，11： | 3 |
| 9 | Effect of early propranolol administration on portal hypertensive gastropathy in cirrhotic rats显示文摘AIM:To investigate any protective effect of early propranolol administration in the development of portal hypertensive gastropathy in cirrhotic rats. METHODS:For the development of liver cirrhosis and portal hypertensive gastropathy,60 rats underwent ligation of the left adrenal vein and complete devascularization of the left renal vein,followed by phenobarbital and carbon tetrachloride(CCl4) administration.After two weeks of CCl4 administration, the rats were randomly separated into two groups.In group A,propranolol was continuously administered intragastrically throughout the study,whereas in group B normal saline(placebo)was administered instead. Hemodynamic studies and vascular morphometric analysis of gastric sections were performed after complete induction of cirrhosis. RESULTS:Vascular morphometric studies showed higher numbers of vessels in all mucosal layers in the control group.Statistical analysis revealed a significantly higher total vascular surface in the control group compared to the propranolol group,but with no statistically significant difference between the mean vascular surfaces between the groups.Our study clearly shows that the increased mucosal blood flow is manifested by a marked increase of vessel count. CONCLUSION:Early propranolol's administration in portal hypertensive cirrhotic rats seems to prevent intense gastric vascular congestion that characterizes portal hypertensive gastropathy. | Savas Rafailidis Charalampos Demertzidis Konstantinos Ballas Michail Alatsakis Nikolaos Symeonidis Theodoros Pavlidis Kyriakos Psarras Valentini Tzioufa-Asimakopoulou Athanassios Sakadamis | 2009 | World Journal of Gastroenterology2009，15，34： | 3 |
| 10 | Review of state-of-the-art decision support systems (DSSs) for prevention and suppression of forest fires显示文摘Forest ecosystems are our priceless natural resource and are a key component of the global carbon budget. Forest fires can be a hazard to the viability and sustainable management of forests with consequences for natural and cultural environments, economies, and the life quality of local and regional populations. Thus, the selection of strategies to manage forest fires, while considering both functional and economic efficiency, is of primary importance. The use of decision support systems(DSSs) by managers of forest fires has rapidly increased. This has strengthened capacity to prevent and suppress forest fires while protecting human lives and property. DSSs are a tool that can benefit incident management and decision making and policy, especially for emergencies such as natural disasters. In this study we reviewed state-of-the-art DSSs that use: database management systems and mathematical/economic algorithms for spatial optimization of firefighting forces; forest fire simulators and satellite technology for immediate detection and prediction of evolution of forest fires; GIS platforms that incorporate several tools to manipulate, process and analyze geographic data and develop strategic and operational plans. | Stavros Sakellariou Stergios Tampekis Fani Samara Athanassios Sfougaris Olga Christopoulou | 2017 | Journal of Forestry Research2017，28，6： | 3 |
| 11 | Decoding altitude-activated regulatory mechanisms occurring during apple peel ripening显示文摘Apple(Malus domestica Borkh)is an important fruit crop cultivated in a broad range of environmental conditions.Apple fruit ripening is a physiological process,whose molecular regulatory network response to different environments is still not sufficiently investigated and this is particularly true of the peel tissue.In this study,the influence of environmental conditions associated with low(20 m)and high(750 m)altitude on peel tissue ripening was assessed by physiological measurements combined with metabolomic and proteomic analyses during apple fruit development and ripening.Although apple fruit ripening was itself not affected by the different environmental conditions,several key color parameters,such as redness and color index,were notably induced by high altitude.Consistent with this observation,increased levels of anthocyanin and other phenolic compounds,including cyanidin-3-O-galactoside,quercetin-3-O-rhamnoside,quercetin-3-O-rutinoside,and chlorogenic acid were identified in the peel of apple grown at high altitude.Moreover,the high-altitude environment was characterized by elevated abundance of various carbohydrates(e.g.,arabinose,xylose,and sucrose)but decreased levels of glutamic acid and several related proteins,such as glycine hydroxymethyltransferase and glutamate–glyoxylate aminotransferase.Other processes affected by high altitude were the TCA cycle,the synthesis of oxidative/defense enzymes,and the accumulation of photosynthetic proteins.From the obtained data we were able to construct a metabolite-protein network depicting the impact of altitude on peel ripening.The combined analyses presented here provide new insights into physiological processes linking apple peel ripening with the prevailing environmental conditions. | Evangelos Karagiannis Michail Michailidis Georgia Tanou Federico Scossa Eirini Sarrou George Stamatakis Martina Samiotaki Stefan Martens Alisdair R.Fernie Athanassios Molassiotis | 2020 | Horticulture Research2020，7，1： | 3 |
| 12 | E2F transcription factors and digestive system malignancies:How much do we know?显示文摘The E2F proteins comprise a family of 8 members that function as transcription factors.They are key targets of the retinoblastoma protein(RB)and were initially divided into groups of activators and repressors.Accumulating data suggest that there is no specific role for each individual E2F member.Instead,each E2F can exert a variety of cellular effects,some of which represent opposing ones.For instance,specific E2Fs can activate transcription and repression,promote or hamper cell proliferation,augment or inhibit apoptosis,all being dependent on the cellular context.This complexity reflects the importance that these transcription factors have on a cell’s fate.Thus,delineating the specific role for each E2F member in specific malignancies,although not easy,is a challenging and continuously pursued task,especially in view of potential E2F targeted therapies.Therefore,several reviews are continuously trying to evaluate available data on E2F status in various malignancies.Such reviews have attempted to reach a consensus,often in the simplistic form of oncogenes or tumor suppressor genes for the E2Fs.However they frequently miss spatial and temporal alterations of these factors during tumor development,which should also be considered in conjunction with the status of the regulatory networks that these factors participate in.In the current‘‘Letter to the Editor’’,we comment on the flaws,misinterpretations and omissions in one such review article published recently in the World Journal of Gastroenterology regarding the role of E2Fs in digestive system malignancies. | Konstantinos Evangelou Sophia Havaki Athanassios Kotsinas | 2014 | World Journal of Gastroenterology2014，20，29： | 2 |
| 13 | Stimulation of oval cell and hepatocyte proliferation by exogenous bombesin and neurotensin in partially hepatectomized rats显示文摘AIM:To investigate the effect of the neuropeptides bombesin(BBS)and neurotensin(NT)on oval cell proliferation in partially hepatectomized rats not pretreated with a known hepatocyte inhibitor.METHODS:Seventy male Wistar rats were randomly divided into five groups:Ⅰ=controls,Ⅱ=sham operated,Ⅲ=partial hepatectomy 70%(PHx),Ⅳ=PHx+ BBS(30μg/kg per day),Ⅴ=PHx+NT(300μg/kg per day).Forty eight hours after liver resection,portal en-dotoxin levels and hepatic glutathione redox state were determined.α-fetoprotein(AFP)mRNA(in situ hybridisation),cytokeratin-19 and Ki67 antigen expression (immunohistochemistry)and apoptosis(TUNEL)were evaluated on liver tissue samples.Cells with morphological features of oval cells that were cytokeratin-19 (+)and AFP mRNA(+)were scored in morphometric analysis and their proliferation was recorded.In addition,the proliferation and apoptotic rates of hepatocytes were determined.RESULTS:In the control and sham operated groups,oval cells were significantly less compared to groups Ⅲ,ⅣandⅤ(P<0.001).The neuropeptides BBS and NT significantly increased the proliferation of oval cells compared to groupⅢ(P<0.001).In addition,BBS and NT induced a significant increase of hepatocyte proliferation(P<0.001),whereas it decreased their apoptotic activity(P<0.001)compared to groupⅢ.BBS and NT significantly decreased portal endotoxemia (P<0.001)and increased the hepatic GSH:GSSG ratio (P<0.05 and P<0.001,respectively)compared to groupⅢ.CONCLUSION:BBS and NT stimulated oval cell proliferation in a model of liver regeneration,without use of concomitant suppression of hepatocyte proliferation as oval cell activation stimuli,and improved the hepatocyte regenerative response.This peptides-induced combined stimulation of oval cell and hepatocyte proliferation might serve as a possible treatment modality for several liver diseases. | Stelios F Assimakopoulos Athanassios C Tsamandas Ilias H Alexandris Christos Georgiou Constantine E Vagianos Chrisoula D Scopa | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 2 |
| 14 | Stable Isotope Signatures and Moisture Transport of a Typical Heavy Precipitation Case in the Southern Tianshan Mountains显示文摘Stable oxygen isotopes in precipitation contain meaningful environmental information on a synoptic scale and can be applied to diagnose hydrometeorological processes.A series of rainstorms occurred at the southern Tianshan Mountains during the period from May to June 2013,and the event-based precipitation was sampled along the mountain range from west to east.Based on δ18 O values in precipitation samples as well as the corresponding meteorological parameters,the moisture transport paths during the sampling period were identified.In late-May(stage 1),isotopes in precipitation collected generally showed a depleting trend.In mid-June(stage 2),there was no coherent trend of isotopes in precipitation for these stations,and only isotope values in Aksu showed a continually depleting trend.Checking other meteorological proxies during the sampling period,the event-based precipitation isotopes sensitively reflected the moisture process.In central Asia,both the westerly and monsoon moisture can be delivered to cause extreme precipitation events,and the isotopic information provides an alternative tool to investigate the atmospheric processes. | WANG Liwei ZHANG Mingjun WANG Shengjie Athanassios AARGIRIOU WANG Gaofei Vasileios SALAMALIKIS SHI Mengyu JIAO Rong | 2020 | Chinese Geographical Science2020，30，1： | 2 |
| 15 | Ruptured ectopic pregnancy: risk factors for a life-threatening condition显示文摘 | Michael Sindos Athanasia Togia Theodoros N. Sergentanis Apostolos Kabagiannis Fotodotis Malamas Athanassios Farfaras Ioannis N. Sergentanis Vassiliki Bassiotou Stefanos Antoniou | 2009 | Archives of Gynecology and Obstetrics2009，，5： | 2 |
| 16 | Classification of non-well-founded sets and an ap- plication显示文摘 | Takashi Nitta Tomoko Okada and Athanassios Tzouvaras | 2003 | Mathematical Logic Quarterly2003，，49： | 1 |
| 17 | Combined analysis of molecular and clinical predictors of Gefitinib activity in advanced non - small cell lung cancer: Epidermal growth factor receptor mutations do not tell the whole story显示文摘 | Athanassios Argiris | 2006 | J Thorac Oncol2006，1，： | 1 |
| 18 | Persistence of rRNA operon mutated copies and rapid reemergenee of linezolid resistance in Staphylococcus aureus 显示文摘 | Athanassios T Pillai Satish K Gold Howard S | 2007 | J Antimicrob Chemother2007，60，3： | 1 |
| 19 | Off-line diagnosis of deterministic faults in continuous dynamic multivariable processes usingspeech recognition methods显示文摘 | ATHANASSIOS Kassidas PAUL A Taylor JOHN F MacGregor | 1998 | J Proc Cont1998，8，56： | 1 |
| 20 | Polyamines reprogram oxidative and nitrosative status and the proteome of citrus plants exposed to salinity stress显示文摘 | GEORGIA TANOU VASILEIOS ZIOGAS MAYA BELGHAZI ANASTASIS CHRISTOU PANAGIOTA FILIPPOU DOMINIQUE JOB VASILEIOS FOTOPOULOS ATHANASSIOS MOLASSIOTIS | 2014 | Plant Cell Environ2014，，4： | 1 |
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