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| 1 | Advances and challenges in laparoscopic surgery in the management of hepatocellular carcinoma显示文摘Hepatocellular carcinoma is the fifth most common malignancy and the third most common cause of cancer-related mortality worldwide. From the wide variety of treatment options, surgical resection and liver transplantation are the only therapeutic ones. However, due to shortage of liver grafts, surgical resection is the most common therapeutic modality implemented. Owing to rapid technological development, minimally invasive approaches have been incorporated in liver surgery. Liver laparoscopic resection has been evaluated in comparison to the open technique and has been shown to be superior because of the reported decrease in surgical incision length and trauma, blood loss, operating theatre time, postsurgical pain and complications, R0 resection, length of stay, time to recovery and oral intake. It has been reported that laparoscopic excision is a safe and feasible approach with near zero mortality and oncologic outcomes similar to open resection. Nevertheless, current indications include solid tumors in the periphery < 5 cm, especially in segments Ⅱ through Ⅵ, while according to the consensus laparoscopic major hepatectomy should only be performed by surgeons with high expertise in laparoscopic and hepatobiliary surgery in tertiary centers. It is necessary for a surgeon to surpass the 60-cases learning curve observed in order to accomplish the desirable outcomes and preserve patient safety. In this review, our aim is to thoroughly describe the general principles and current status of laparoscopic liver resection for hepatocellular carcinoma, as well as future prospects. | Ioannis A Ziogas Georgios Tsoulfas | 2017 | World Journal of Gastrointestinal Surgery2017，9，12： | 10 |
| 2 | Evolving role of Sorafenib in the management of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the most common malignant diseases worldwide and comes third in cancer-related mortality.Although there is a broad spectrum of treatment options to choose from,only a few patients are eligible candidates to receive a curative therapy according to their stage of disease,and thus palliative treatment is implemented in the majority of the patients suffering from liver cancer.Sorafenib,a multikinase inhibitor,is the only currently approved agent for systemic therapy in patients with advanced stage HCC and early stage liver disease.It has been shown to improve the overall survival,but with various side effects,while its cost is not negligible.Sorafenib has been in the market for a decade and has set the stage for personalized targeted therapy.Its role during this time has ranged from monotherapy to neoadjuvant and adjuvant treatment with surgical resection,liver transplantation and chemoembolization or even in combination with other chemotherapeutic agents.In this review our aim is to highlight in depth the current position of Sorafenib in the armamentarium against HCC and how that has evolved over time in its use either as a single agent or in combination with other therapies. | Ioannis A Ziogas Georgios Tsoulfas | 2017 | World Journal of Clinical Oncology2017，8，3： | 4 |
| 3 | Circulating autoantibodies to endogenous erythropoietin are associated with chronic hepatitis C virus infection-related anemia显示文摘BACKGROUND: Chronic hepatitis C virus(HCV) infection is associated with autoimmune phenomena and is often complicated by anemia. Circulating autoantibodies to endogenous erythropoietin(anti-EPO) have been detected in patients with chronic viral infections and were correlated to anemia. The present study aimed to determine anti-EPO prevalence in patients with chronic HCV infection and investigate its possible association with anemia.METHODS: Ninety-three consecutive patients(62 males and 31 females) with chronic HCV infection, who had never received antiviral therapy or recombinant EPO, were enrolled in the study. Circulating anti-EPO were detected in the serum by using an ELISA assay. Quantitative determination of serum EPO levels was done by radioimmunoassay. HCV RNA viral load measurement and genotype sequencing were also performed.RESULTS: Circulating anti-EPO were detected in 10.8% of HCV-infected patients and the prevalence of anti-EPO was significantly higher in patients with anemia(19.4% vs 5.3%, P=0.040) compared to that in those without anemia. Compared to anti-EPO negative cases, anti-EPO positive patients had higher frequency of anemia(70.0% vs 34.9%, P=0.030), lower EPO concentrations(median 16.35 vs 30.65 m U/m L, P=0.005), and higher HCV RNA viral load(median 891.5×103 vs 367.5×103 IU/m L, P=0.016). In multivariate regression analysis the presence of anti-EPO remained an independent predictor of anemia(adjusted OR: 14.303, 95% CI: 1.417-36.580, P=0.024). EPO response to anemia was less prominent among anti-EPO positive patients(P=0.001).CONCLUSIONS: Circulating anti-EPO are detected in a significant proportion of treatment-na?ve HCV-infected patients and are independently associated with anemia, suggesting a further implication of autoimmunity in the pathophysiology of HCV-related anemia. | Aristotelis Tsiakalos Theoharis Voumvas Alexandros Psarris Christina K Oikonomou Dimitrios C Ziogas Ioannis Ketikoglou Grigorios Hatzis Nikolaos V Sipsas | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，3： | 4 |
| 4 | Mortality risk after preoperative versus postoperative chemotherapy and radiotherapy in lymph node-positive rectal cancer显示文摘 | Seery T E Ziogas A Lin B S | 2013 | Journal of Gastrointestinal Surgery2013，17，2： | 1 |
| 5 | Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival显示文摘 | Zell J A Ziogas A Ignatenko N | 2009 | Clin Cancer Res2009，15，19： | 1 |
| 6 | A TwoSwitch high-performance Current Regulated DC/AC Converter Module显示文摘 | Phoivos D Ziogas Geza Joos | 1995 | IEEE Trans on Industry Applications1995，31，3： | 1 |
| 7 | The effectiveness of plant essential oils on the growth of Botrytis cinerea, Fusarium sp and Clavibacter michiganensis subsp michiganensis 显示文摘 | Daferera DJ Ziogas BN Polissiou MG | 2003 | Crop Prote2003，22，1： | 1 |
| 8 | EGFR as a prognostic marker for gastric cancer显示文摘 | Liakakos T Xeropotamos N Ziogas D | 2008 | World J Surg2008，32，6： | 1 |
| 9 | A novel approach for minimizing high-frequency transformer copper losses显示文摘 | Jean-pierre Vandelac Phoivos D Ziogas | 1988 | IEEE transactions on power electronics1988，，3： | 1 |
| 10 | Prognostic factors for survival in ex?tensive stage small cell lung cancer (ED-SCLC) : the importance of smoking history, socioeconomic and marital statuses, and eth?nicity显示文摘 | Ou SH Ziogas A Zell lA | 2009 | J Thorac Oncol2009，4，1： | 1 |
| 11 | Analysis and design of forced commutated cycloconverter structures with improved transfer characteristics显示文摘 | Ziogas P D Khan S I Rashid M H | 1986 | IEEE Trans on Industrial Electronics1986，33，3： | 1 |
| 12 | Programmed PWM techniques to eliminate harmonics:a critical evaluation显示文摘 | Prasad N Enjeti Phoivos D Ziogas James F Lindsay | 1990 | IEEE Transactions on Industry Applications1990，26，2： | 1 |
| 13 | Some improved forced commutated cycloconverter structures显示文摘 | Ziogas P D Khan S I Rashid M H | 1985 | IEEE Trans on IAS1985，21，5： | 1 |
| 14 | Circular isthmic-cervical sutures can be an alternative method to control peripartum haemorrhage during caesarean section for placenta praevia accreta显示文摘 | Dedes I Ziogas V | | 0，，06： | 1 |
| 15 | Neuronal NO mediates cerebral vasodilator responses to K+ in hypertensive rats显示文摘 | Chrissobolis S Ziogas J Anderson C R | 2002 | Am J Physiol Heart Circ Physiol2002，282，5： | 1 |
| 16 | Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer显示文摘 | Crawford NP Ziogas A Peel DJ | 2006 | Breast Cancer Res2006，8，2： | 1 |
| 17 | Performance analysis of a PWM inverter VAR compensator显示文摘 | JOOS G MORAN L ZIOGAS P | 1991 | IEEE Transac-tions on Power Electronics1991，6，3： | 1 |
| 18 | Polyamines reprogram oxidative and nitrosative status and the proteome of citrus plants exposed to salinity stress显示文摘 | GEORGIA TANOU VASILEIOS ZIOGAS MAYA BELGHAZI ANASTASIS CHRISTOU PANAGIOTA FILIPPOU DOMINIQUE JOB VASILEIOS FOTOPOULOS ATHANASSIOS MOLASSIOTIS | 2014 | Plant Cell Environ2014，，4： | 1 |
| 19 | Molecular characterization of benzimidazole-resistant B. cinerea field isolates with reduced or enhanced sensitivity to zoxamide and diethofencarb显示文摘 | A. Malandrakis A. Markoglou B. Ziogas | 2010 | Pesticide Biochemistry and Physiology2010，，1： | 1 |
| 20 | Annlysis of a static power converter under unbance: a novel approach 显示文摘 | ENJTI P A ZIOGAS P D | 1990 | IEEE Trans Ind Electr1990，37，1： | 1 |
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