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| 1 | 增压直喷汽油机热平衡和平衡试验对比显示文摘为提高内燃机能量利用效率,针对增压直喷汽油机联合开展了万有特性下热平衡和平衡试验.基于热力学第一定律和第二定律,建立内燃机热力学分析模型,结合试验数据得出该机的热平衡图和平衡图,在此基础上分析了内燃机工作参数对各种形式能量流和流的分布影响,并对热平衡和平衡进行了对比分析.结果表明:从热平衡分析来看,燃料能量主要损失在废热中,各种形式能量流分数大小呈明显的波动变化;从平衡分析来看,不可逆损所占比例最大,是限制内燃机效率的主要因素;热效率和排气能量分数分别与效率和排气流分数的等值线形态相似;排气分数峰值出现在高速高负荷区,传热分数峰值出现在低速低负荷区.针对分析结果,提出了几点改善汽油机能量利用效率的建议. | 刘敬平 付建勤 任承钦 朱国辉 邓帮林 KESHAV Varde | 2013 | 内燃机学报2013，31，1： | 8 |
| 2 | Nocardiopsistins A-C:New angucyclines with anti-MRSA activity isolated from a marine sponge-derived Nocardiopsis sp.HB-J378显示文摘Marine natural products have become an increasingly important source of new drug leads during recent years.In an attempt to identify novel anti-microbial natural products by bioprospecting deep-sea Actinobacteria,three new angucyclines,nocardiopsistins A-C,were isolated from Nocardiopsis sp.strain HB-J378.Notably,the supplementation of the rare earth salt Lanthanum chloride(LaCl3)during fermentation of HB-J378 significantly increased the yield of these angucyclines.The structures of nocardiopsistins A-C were identified by 1D and 2D NMR and HR-MS data.Nocardiopsistins A-C have activity against MRSA(methicillin-resistant Staphylococcus aureus)with MICs of 3.12–12.5μg/mL;the potency of nocardiopsistin B is similar to that of the positive control,chloramphenicol.Bioinformatic analysis of the draft genome of HB-J378 identified a set of three core genes in a biosynthetic gene cluster that encode a typical aromatic or type II polyketide synthase(PKS)system,including ketoacyl:ACP synthaseα-subunit(KSα),β-subunit(KSβ)and acyl carrier protein(ACP).The production of nocardiopsistins A-C was abolished when the three genes were knocked out,indicating their indispensable role in the production of nocardiopsistins. | Dongbo Xu Keshav K.Nepal Jing Chen Dedra Harmody Haining Zhu Peter J.McCarthy Amy E.Wright Guojun Wang | 2018 | Synthetic and Systems Biotechnology2018，3，4： | 3 |
| 3 | SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress显示文摘 | Hyun-Seok Kim Krish Patel Kristi Muldoon-Jacobs Kheem S. Bisht Nukhet Aykin-Burns J. Daniel Pennington Riet van der Meer Phuongmai Nguyen Jason Savage Kjerstin M. Owens Athanassios Vassilopoulos Ozkan Ozden Seong-Hoon Park Keshav K. Singh Sarki A. Abdulka | 2010 | Cancer Cell2010，，1： | 3 |
| 4 | Addition of senna improves quality of colonoscopy preparation with magnesium citrate显示文摘AIM: To prospectively investigate the effectiveness and patient’s tolerance of two low-cost bowel cleansing preparation protocols based on magnesium citrate only or the combination of magnesium citrate and senna. METHODS: A total of 342 patients who were referred for colonoscopy underwent a colon cleansing protocol with magnesium citrate alone (n = 160) or magnesium citrate and senna granules (n = 182). The colonoscopist rated the overall efficacy of colon cleansing using an established score on a 4-point scale. Patients were questioned before undergoing colonoscopy for side effects and symptoms during bowel preparation. RESULTS: The percentage of procedures rescheduled because ofinsufficient colon cleansing was 7% in the magnesium citrate group and 4% in the magnesium citrate/senna group (P = 0.44). Adequate visualization of the colonic mucosa was rated superior under the citramag/senna regimen (P = 0.004). Both regimens were well tolerated, and did not significantly differ in the occurrence of nausea, bloating or headache.However, abdominal cramps were observed more often under the senna protocol (29.2%) compared to the magnesium citrate only protocol (9.9%, P < 0.0003). CONCLUSION: The addition of senna to the bowel preparation protocol with magnesium citrate significantly improves the cleansing outcome. | Stergios Vradelis Evangelos Kalaitzakis Yalda Sharifi Otto Buchel Satish Keshav Roger W Chapman Barbara Braden | 2009 | World Journal of Gastroenterology2009，15，14： | 3 |
| 5 | Phytochemical profile and biological activity of Juglans regia显示文摘Juglans regia Linn.(Juglandaceae), popularly known as English or Persian walnut, is a valuable medicinal plant with a potency to cure various diseases in traditional medicine. Since ancient time, different local ethnic groups have used various part of J.regia for a wide array of ailments including helminthiasis, diarrhea, sinusitis, stomach ache, arthritis, asthma, eczema, scrofula, skin disorders, diabetes mellitus, anorexia, thyroid dysfunction, cancer and infectious diseases. Biological activities of J.regia have been reported in several peer review journals and scientific attention is increasing. The present review attempts to provide comprehensive information on plant description, ethnobotanical use, toxicity, phytochemical profile, pharmacology, clinical studies and current research prospective of the J.regia. Currently, there is an immense interest on isolation/identification of active constituents from walnut and screening those active compounds for pharmacological activities. In addition, researchers are performing clinical trials as well as screening various solvent extracts or fractions of J.regia in several animal diseases models to identify promising therapeutic benefits. In the present work, we review the latest information based on published scientific investigations of J.regia. | Nisha Panth Keshav Raj Paudel Rajendra Karki | 2016 | Journal of Integrative Medicine2016，14，5： | 2 |
| 6 | 新型冠状病毒主要蛋白酶6YNQ黄酮类化合物抑制剂的鉴定:一项分子对接研究显示文摘目的新型冠状病毒肺炎(COVID-19)的病原体新型冠状病毒(SARS-CoV-2)是导致最近疫情全球大流行的原因,由于目前尚无针对SARS-CoV-2的有效药物或疫苗,我们研究了黄酮类化合物对抗SARS-CoV-2主要蛋白酶6YNQ的潜力。方法对SARS-CoV-2的主要蛋白酶6YNQ进行计算机模拟研究。结果所选的21种黄酮类化合物中,芦丁结合能(−8.7 kcal/mol)最高,与催化位点结合良好。结论黄酮类化合物对SARS-CoV-2主要蛋白酶6YNQ有抑制作用,这些计算模拟研究支持了黄酮类化合物可能有助于COVID-19治疗的假设。 | SUMIT Arora GOVIND Lohiya KESHAV Moharir SAPAN Shah SUBHASH Yende | 2020 | Digital Chinese Medicine2020，3，4： | 2 |
| 7 | Carbon nanomaterials for cardiovascular theranostics:Promises and challenges显示文摘Cardiovascular diseases(CVDs)are the leading cause of death worldwide.Heart attack and stroke cause irreversible tissue damage.The currently available treatment options are limited to“damage-control”rather than tissue repair.The recent advances in nanomaterials have offered novel approaches to restore tissue function after injury.In particular,carbon nanomaterials(CNMs)have shown significant promise to bridge the gap in clinical translation of biomaterial based therapies.This family of carbon allotropes(including graphenes,carbon nanotubes and fullerenes)have unique physiochemical properties,including exceptional mechanical strength,electrical conductivity,chemical behaviour,thermal stability and optical properties.These intrinsic properties make CNMs ideal materials for use in cardiovascular theranostics.This review is focused on recent efforts in the diagnosis and treatment of heart diseases using graphenes and carbon nanotubes.The first section introduces currently available derivatives of graphenes and carbon nanotubes and discusses some of the key characteristics of these materials.The second section covers their application in drug delivery,biosensors,tissue engineering and immunomodulation with a focus on cardiovascular applications.The final section discusses current shortcomings and limitations of CNMs in cardiovascular applications and reviews ongoing efforts to address these concerns and to bring CNMs from bench to bedside. | Keshav Narayan Alagarsamy Sajitha Mathan Weiang Yan Alireza Rafieerad Saravanan Sekaran Hanna Manego Sanjiv Dhingra | 2021 | Bioactive Materials2021，6，8： | 2 |
| 8 | Analysis and simulation of a fair queuing algorithm显示文摘 | Demers A Keshav S Shenker S | | 0，，01： | 1 |
| 9 | How much potassium is in the Earth's core ? New insights from partitioning experiments 显示文摘 | Corgne A Keshav S Fei Y | 2007 | Earth and Planetary Science Letter2007，256，： | 1 |
| 10 | Dynamic culture conditions to generate silk-based tissue-engineered vascular grafts显示文摘 | Zhang X Wang X Keshav V | | 0，，19： | 1 |
| 11 | Analysis and simulation of a fair queuing algorithm显示文摘 | DEMERS A KESHAV S SHENKER S | 1990 | Internetworking: Research and Experience1990，1，1： | 1 |
| 12 | Phytochemical profile and pharmacological activity of Aegle marmelos Linn显示文摘Aegle marmelos Linn.(Rutaceae), commonly known as ‘‘bael' in Nepal and India, is a valuable medicinal plant and is considered sacred by the Hindus. It is used to cure several diseases in the Indian traditional medicine system of Ayurveda and has had similar uses among many ethnic communities residing in Indian subcontinent for over 5000 years. Its leaves, bark, stem, fruits and seeds have been used for various medicinal purposes. Bael fruits are especially effective in the treatment of chronic diarrhea, dysentery and peptic ulcers, while they are also useful as a laxative and cure for respiratory infections. Scientific studies have validated many of the ethnomedicinal uses of A. marmelos, which include antibacterial,antiviral, antidiarrheal, gastroprotective, anti-ulcerative colitis, hepatoprotective, antidiabetic, cardioprotective and radioprotective effects. Recently, this plant has also received attention as an anticancer agent for the treatment of various types of cancers. Thus, this review focuses on scientific evidence verifying the important pharmacological activity such as antioxidant, antidiabetic, antimicrobial, hepatoprotective,cardioprotective and anticancer activity of A. marmelos. | Bikash Manandhar Keshav Raj Paudel Biraj Sharma Rajendra Karki | 2018 | Journal of Integrative Medicine2018，16，3： | 1 |
| 13 | Moisture effect on compaction and permeability in compost 显示文摘 | Keshav Das and Harold M Keener | 1997 | J ofEnvi Eng1997，，： | 1 |
| 14 | Dynamic culture conditions to generate silk-based tissue-engineered vascular grafts 显示文摘 | Zhang Xiaohui Wang Xiuli Keshav V | 2009 | Biomaterials2009，30，19： | 1 |
| 15 | Detection of mRNAs for macrophage products in inflammatory bowel disease by in situ hy- bridisation 显示文摘 | Cappello M Keshav S Prince C | 1992 | Gut1992，33，： | 1 |
| 16 | PAN fibre variants显示文摘 | Keshav V D | 1997 | Synthetic Fibres1997，，10： | 1 |
| 17 | Port System Simulation facility with an optimization capability显示文摘 | Keshav P D Stuart J G Gracme M B | 2003 | International Journal of Computational Intelligence and Applications2003，3，4： | 1 |
| 18 | Expression of proliferating cell nuclear antigen(PCNA)in oral submucous fibrosis : an immunohistochemical study显示文摘 | Keshav R Narayanappa U | 2015 | J Clin Diagn Res2015，9，5： | 1 |
| 19 | PAN fibre variants显示文摘 | Keshav V D | 1997 | Synthetic Fibres1997，，10： | 1 |
| 20 | Spinning of pan-fiber: part III: wet spinning 显示文摘 | Keshav V Datye | 1996 | Synthetic Fibers1996，22，4： | 1 |
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