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| 1 | Recurrence of choledocholithiasis following endoscopic bile duct clearance: Long term results and factors associated with recurrent bile duct stones显示文摘AIM To evaluate the rate of recurrence of symptomatic chol-edocholithiasis and identify factors associated with the recurrence of bile duct stones in patients who underwent endoscopic retrograde cholangiopancreatography(ERCP) and endoscopic sphincterotomy(EST) for bile duct stone disease.METHODS All patients who underwent ERCP and EST for bile duct stone disease and had their bile duct cleared from 1/1/2005 until 31/12/2008 was enrolled. All symptomatic recurrences during the study period(until 31/12/2015) were recorded. Clinical and laboratory data potentially associated with common bile duct(CBD) stone recurrence were retrospectively retrieved from patients' files.RESULTS A total of 495 patients were included. Sixty seven(67) out of 495 patients(13.5%) presented with recurrent symptomatic choledocholithiasis after 35.28 ± 16.9 mo while twenty two(22) of these patients(32.8%) experienced a second recurrence after 35.19 ± 23.2 mo. Factors associated with recurrence were size(diameter) of the largest CBD stone found at first presentation(10.2 ± 6.9 mm vs 7.2 ± 4.1 mm, P = 0.024), diameter of the CBD at the first examination(15.5 ± 6.3 mm vs 12.0 ± 4.6 mm, P = 0.005), use of mechanical lithotripsy(ML)(P = 0.04) and presence of difficult lithiasis(P = 0.04). Periampullary diverticula showed a trend towards significance(P = 0.066). On the contrary, number of stones, angulation of the CBD, number of ERCP sessions required to clear the CBD at first presentation, more than one ERCP session needed to clear the bile duct initially and a gallbladder in situ did not influence recurrence. CONCLUSION Bile duct stone recurrence is a possible late complication following endoscopic stone extraction and CBD clearance. It appears to be associated with anatomical parameters(CBD diameter) and stone characteristics(stone size, use of ML, difficult lithiasis) at first presentation. | Christos Konstantakis Christos Triantos Vasileios Theopistos Georgios Theocharis Ioannis Maroulis Georgia Diamantopoulou Konstantinos Thomopoulos | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，1： | 46 |
| 2 | Comparative clinical study of ultrasound-guided A1 pulley release vs open surgical intervention in the treatment of trigger finger显示文摘AIM To investigate the effectiveness of ultrasound-guided release of the first annular pulley and compare results with the conventional open operative technique.METHODS In this prospective randomized, single-center, clinical study, 32 patients with trigger finger or trigger thumb, grade Ⅱ-Ⅳ according to Green classification system, were recruited. Two groups were formed; Group A(16 patients) was treated with an ultrasound-guided percutaneous release of the affected A1 pulley under local anesthesia. Group B(16 patients) underwent an open surgical release of the A1 pul ey, through a 10-15 mm incision. Patients were assessed pre- and postoperatively(follow-up:2,4 and 12 wk) by physicians blinded to the procedures. Treatment of triggering(primary variable of interest) was expressed as the 'success rate' per digit. The time for taking postoperative pain killers, range of motion recovery, QuickD ASH test scores(Greek version), return to normal activities(including work), complications and cosmetic results were assessed.RESULTS The success rate in group A was 93.75%(15/16) and in group B 100%(16/16). Mean times in group A patients were 3.5 d for taking pain killers, 4.1 d for returning to normal activities, and 7.2 and 3.9 d for complete extension and flexion recovery, respectively. Mean Quick DASH scores in group A were 45.5 preoperatively and, 7.5, 0.5 and 0 after 2, 4, and 12 wk postoperatively. Mean times in group B patients were 2.9 d for taking pain killers, 17.8 d for returning to normal activities, and 5.6 and 3 d for complete extension and flexion recovery. Mean QuickD ASH scores in group B were 43.2 preoperatively and, 8.2, 1.3 and 0 after 2, 4, and 12 wk postoperatively. The cosmetic results found excellent or good in 87.5%(14/16) of group A patients, while in 56.25%(9/16) of group B patients were evaluated as fair or poor.CONCLUSION Treatment of the trigger finger using ultrasonography resulted in fewer absence of work days, and better cosmetic results, in comparison with the open surgery technique. It is a promising method that represents excellent results without major complications, so that it could be possibly be established as a first-line treatment in the trigger finger's disease. | Vasileios S Nikolaou Michael-Alexander Malahias Maria-Kyriaki Kaseta Ioannis Sourlas George C Babis | 2017 | World Journal of Orthopedics2017，8，2： | 14 |
| 3 | Vanishing bone disease(Gorham-Stout syndrome): A review of a rare entity显示文摘Vanishing bone disease(Gorham-Stout syndrome) is a rare entity of unknown etiology, characterized by de struction of osseous matrix and proliferation of vascula structures, resulting in destruction and absorption o bone. Despite the extensive investigation of the patho genetic mechanisms of the disease, its etiology hasn'been clarified and several theories exist. The syndrome can affect one or multiple bones of the patient, includ ing the skull, the upper and lower extremities, the spine and pelvis. The clinical presentation of a patient suffer ing from vanishing bone disease includes, pain, func tional impairment and swelling of the affected region although asymptomatic cases have been reported, as well as cases in which the diagnosis was made after a pathologic fracture. In this short review we summarize the theories regarding the etiology as well as the clini cal presentation, the diagnostic approach and treat ment options of this rare disease. | Vasileios S Nikolaou Dimitrios Chytas Demitrios Korres Nicolas Efstathopoulos | 2014 | World Journal of Orthopedics2014，5，5： | 13 |
| 4 | Common controversies in total knee replacement surgery: Current evidence显示文摘Total knee replacement(TKR) is a widely used operation that has radically improved the quality of life of millions of people during the last few decades. However, some technical details, concerning the surgical procedure and the rehabilitation following total knee arthroplasty, are still a matter of a strong debate. In this review of the literature, we have included the best evidence available of the last decade, in an effort to shed light on some of the most controversial subjects related to TKR surgery. Posterior-stabilized or cruciate-retaining prosthesis? To use a tourniquet during operation or not? Do patients need continuous passive motion for their post-surgery rehabilitation? To resurface patella or not? These are some of the most controversial topics that until now have been persistent dilemmas for the orthopedic surgeon. Results of this systematic review of the literature are highly controversial. These conflicting results are an indication that larger and more well conducted high quality trials are needed in order to gain more secure answers. At the same time, it is becoming apparent that a meticulous operative technique, respecting the soft tissue envelope and knowing the principles of alignment and soft tissue balancing, aresome of the parameters that might contribute more to achieving the optimal results for the patients. | Vasileios S Nikolaou Dimitrios Chytas George C Babis | 2014 | World Journal of Orthopedics2014，5，4： | 9 |
| 5 | A Technological Overview of Biogas Production from Biowaste显示文摘当今时代,人类对化石燃料的不合理利用和温室气体对环境的影响,使研究者关注有机资源和垃圾的可持续能源转化。全球的能源需求非常大,主要能源来自化石能源。目前的研究认为厌氧消化是一种高效的可替代技术,其既能产生生物燃料,又能可持续地处理垃圾。在沼气工业,为了促进沼气的生成和提高质量,有几种不同的技术趋势。然而,投资厌氧消化的成功取决于原料成本低和沼气使用范围广(热能、电能和燃料)。在欧洲能源市场,沼气的生产一直在增长,为生物能源的发展提供了一条经济的替代选择。本文的目的是对由木质纤维素类的生物垃圾生产沼气进行综述,为沼气经济提供重要信息。 | Spyridon Achinas Vasileios Achinas Gerrit Jan Willem Euverink | 2017 | Engineering2017，3，3： | 8 |
| 6 | Role of genetics in the diagnosis and prognosis of Crohn's disease显示文摘Considering the epidemiological, genetic and immunological data, we can conclude that the inflammatory bowel diseases are heterogeneous disorders of multifactorial etiology in which hereditability and environment interact to produce the disease. It is probable that patients have a genetic predisposition for the development of the disease coupled with disturbances in immunoregulation. Several genes have so far been related to the diagnosis of Crohn's disease. These genes are related to innate pattern recognition receptors, to epithelial barrier homeostasis and maintenance of epithelial barrier integrity, to autophagy and to lymphocyte differentiation. So far, the strongest and most replicated associations with Crohn's disease have been demonstrated with NOD2 , IL23R and ATG16L1 genes. Many genes have so far been implicated in the prognosis of Crohn's disease and many attempts have been made for classification of genetic profiles in Crohn's disease.CARD15 seems to be not only a susceptibility gene, but also a disease-modifier gene for Crohn's disease. Enriching our understanding of Crohn's disease genetics is of value, but when combining genetic data with functional data the outcome could be of major importance to clinicians. | Epameinondas V Tsianos Konstantinos H Katantions Vasileios E Tsianos | 2011 | World Journal of Gastroenterology2011，17，48： | 8 |
| 7 | IGCT——更高功率处理能力的正确选择显示文摘IGCT被视为大功率应用的理想开关器件,其主要优势不仅体现在高可靠性上,同时,其低损耗使得系统损耗较低。在三电平拓扑中,IGCT与目前最高水平的IGBT在器件损耗方面的对比结果为IGCT的较低。由于IGCT器件是基于晶闸管特性,系统中独立的箝位电路设计是必须的,以实现其与续流二极管配合工作时的高可靠性。文中不仅提到了对故障现象的特别考虑,重点介绍了外围电路设计和故障电流保护策略,而且介绍了IGCT目前最新的研发成果。在朝更大功率容量方向发展方面,IGCT器件具有很大的潜力。 | Thomas Stiasny Vasileios Kappatos Thomas Setz Sven Klaka Makan Chen Madhan Mohan | 2015 | 大功率变流技术2015，0，6： | 8 |
| 8 | Implant retention after acute and hematogenous periprosthetic hip and knee infections: Whom, when and how?显示文摘Periprosthetic joint infections(PJI) of the hip and the knee are grossly classified as early post-operative, acute hematogenous and late chronic infections. Whereas two-stage exchange arthroplasty is the standard of care in North America for treating chronic infections, irrigation and debridement(I and D) with retention of implants has been used in an attempt to treat the other two types of PJIs. The rationale of this approach is that a PJI may be eradicated without the need of explanting the prostheses, as long as it has not transitioned into a chronic state. With the present paper, we review current evidence regarding the role of I and D with implant retention for treating PJIs of the hip and the knee. While a very wide range of success rates is reported in different studies, a short period of time between initiation of symptoms and intervention seems to play a prominent role with regards to a successful outcome. Moreover, pathogens of higher virulence and resistance to antibiotics are associated with a poorer result. Specific comorbidities have been also correlated with a less favorable outcome. Finally, one should proceed with serial I and Ds only under the condition that a predefined,aggressive protocol is applied. In conclusion,when treating a PJI of the hip or the knee, all the above factors should be considered in order to decide whether the patient is likely to benefit from this approach. | Georgios K Triantafyllopoulos Vasileios Soranoglou Stavros G Memtsoudis Lazaros A Poultsides | 2016 | World Journal of Orthopedics2016，7，9： | 7 |
| 9 | Potential of hybrid adaptive filtering in inflammatory lesion detection from capsule endoscopy images显示文摘A new feature extraction technique for the detection of lesions created from mucosal inflammations in Crohn's disease, based on wireless capsule endoscopy(WCE) images processing is presented here. More specifically, a novel filtering process, namely Hybrid Adaptive Filtering(HAF), was developed for efficient extraction of lesion-related structural/textural characteristics from WCE images, by employing Genetic Algorithms to the Curvelet-based representation of images. Additionally, Differential Lacunarity(DLac) analysis was applied for feature extraction from the HAF-filtered images. The resulted scheme, namely HAF-DLac, incorporates support vector machines for robust lesion recognition performance. For the training and testing of HAFDLac, an 800-image database was used, acquired from 13 patients who undertook WCE examinations, where the abnormal cases were grouped into mild and severe, according to the severity of the depicted lesion, for a more extensive evaluation of the performance. Experimental results, along with comparison with other related efforts, have shown that the HAF-DLac approach evidently outperforms them in the field of WCE image analysis for automated lesion detection, providing higher classification results, up to 93.8%(accuracy), 95.2%(sensitivity), 92.4%(specificity) and 92.6%(precision). The promising performance of HAF-DLac paves the way for a complete computer-aided diagnosis system that could support physicians' clinical practice. | Vasileios S Charisis Leontios J Hadjileontiadis | 2016 | World Journal of Gastroenterology2016，22，39： | 6 |
| 10 | Fracturing process and effect of fracturing degree onwave velocity of a crystalline rock显示文摘The present paper investigates the effect of fracturing degree on P-and S-wave velocities in rock.The deformation of intact brittle rocks under loading conditions is characterized by a microcracking procedure,which occurs due to flaws in their microscopic structure and propagates through the intact rock,leading to shear fracture.This fracturing process is of fundamental significance as it affects the mechanical properties of the rock and hence the wave velocities.In order to determine the fracture mechanism and the effect of fracturing degree,samples were loaded at certain percentages of peak strength and ultrasonic wave velocity was recorded after every test.The fracturing degree was recorded on the outer surface of the sample and quantified by the use of the indices P_(10)(traces of joints/m),P_(20)(traces of joints/m^2) and P_(21)(length of fractures/m^2).It was concluded that the wave velocity decreases exponentially with increasing fracturing degree.Additionally,the fracturing degree is described adequately with the proposed indices.Finally,other parameters concerning the fracture characteristics,rock type and scale influence were found to contribute to the velocity decay and need to be investigated further. | Charalampos Saroglou Vasileios Kallimogiannis | 2017 | Journal of Rock Mechanics and Geotechnical Engineering2017，9，5： | 6 |
| 11 | Response of colour and hygroscopic properties of Scots pine wood to thermal treatment显示文摘The effect of heat treatment on the surface colour and hygroscopic properties of pine wood were investigated in this study. Boards of Scots pine wood (Pinus sylvestris L.) were subjected to thermal treatment at 200℃, for 4, 6, and 8 h. The change of equilibrium moisture content and density values of the specimens in order to facilitate the understanding of the treated material behavior. The colour parameters L*, a* and b*, used to depict the total colour change (ΔΕ) of wood surface, were shown to change proportionally to the treatment intensity. Moreover, swelling in the tangential and radial directions and absorption of the specimens appeared to be enhanced in great extent by the thermal treatment process. The mean value of swelling percentage in the tangential direction decreased 10.26%, 17.22%, and 19.60% for specimens treated for 4, 6, and 8 h, respectively, referring to the final measurement after 72 h of immersion. In radial direction, mean value of swelling percentage decreased 19.56%, 32.75%, and 34.65% for treated for 4, 6 and 8 h, respectively, after 72 h immersion, which attests the decrease in swelling and improvement in the hygroscopic behavior of Scots pine wood. | Vasiliki Kamperidou Ioannis Barboutis Vasileios Vasileiou | 2013 | Journal of Forestry Research2013，24，3： | 6 |
| 12 | Incidental finding of Zinner syndrome in a Greek military recruit: a case report of a rare clinical entity显示文摘Background: Zinner syndrome represents a rare congenital malformation of the urinary tract. It comprises a constellation of Wolffian duct anomalies and is almost exclusively encountered as a classic triad of seminal vesicle cysts, ejaculatory duct obstruction and renal agenesis. Patients can be either asymptomatic or symptomatic. Recently, minimally invasive surgical techniques have emerged, superseding traditional surgery for select symptomatic cases. Our case highlights the finding of a rare clinical syndrome that was incidentally detected during a routine mass screening of military recruits in the Greek Armed Forces.Case presentation: Herein, we present a case of a 19-year-old male who reported having a solitary right kidney when examined in a military training center of Northern Greece. No additional clinical information was available;thus, referral to a tertiary urology department for further investigation ensued. Imaging studies, namely, computed tomography and magnetic resonance imaging, revealed left renal aplasia, multiple left seminal vesicle cysts, and ejaculatory duct obstruction. Laboratory values and urinalysis were within normal range. Semen analysis was significant for cryptozoospermia. Our patient remained asymptomatic during the entire hospitalization. Long-term follow-up was recommended. Nevertheless, he declined further investigation and sought treatment in a private practice setting.Conclusions: This article aims to present the incidental diagnosis of a rare syndrome in a military setting. Population screening conducted in the armed forces permits the identification of undiagnosed diseases that warrant further investigation. To the best of our knowledge, this was the first report of Zinner syndrome in a military recruit and the second case cited of a Greek patient in the published literature. Regular follow-up is the key to timely intervention in conservatively managed cases. | Evangelos NSymeonidis Chrysovalantis Gkekas Ioannis Tsifountoudis Asterios Symeonidis ChristosGeorgiadis Vasileios Kalyvas Apostolos Malioris Michail Papathanasiou | 2019 | Military Medical Research2019，6，3： | 5 |
| 13 | Growth performance, nutrient digestibility, antioxidant capacity,blood biochemical biomarkers and cytokines expression in broiler chickens fed different phytogenic levels显示文摘The effects of inclusion levels of a phytogenic feed additive(PFA), characterized by menthol anethol and eugenol, on broiler growth performance, nutrient digestibility, biochemical biomarkers and total antioxidant capacity(TAC) of plasma and meat, as well as on the relative expression of selected cytokines,were studied in a 42-d experiment. A total of 225 one-day-old male Cobb broiler chickens were assigned into 3 treatments, with 5 replicates of 15 chickens each. Chickens were fed maize-soybean meal basal diets following a 3 phase(i.e., starter, grower and finisher) feeding program. Depending on PFA inclusion level, treatments were: no PFA(PFA-0), PFA at 100 mg/kg(PFA-100) and PFA at 150 mg/kg(PFA-150).Feed and water were available ad libitum. Feed conversion ratio(FCR) during finisher phase was improved quadratically(P < 0.05) with increasing PFA level. Overall, increasing PFA level increased body weight gain(BWG) in a linear(P < 0.05) and quadratic(P < 0.05) manner with treatments PFA-100 and PFA-150 being greater(P < 0.05) compared with PFA-0. Total tract apparent digestibility of dry matter increased linearly(P < 0.05) and quadratically(P < 0.05) with increasing PFA level. The apparent metabolizable energy corrected for nitrogen(AMEn) also increased linearly(P < 0.05). Increasing PFA level resulted in a linear(P < 0.05) increase in blood plasma TAC. Expression of pro-inflammatory cytokine interleukin-18(IL-18) was reduced linearly(P < 0.05) in spleen with increasing PFA level. In conclusion, PFA inclusion at 100 mg/kg diet positively influenced performance, whereas PFA inclusion at150 mg/kg resulted in a stronger improvement in AMEn and plasma TAC. Finally, PFA inclusion resulted in a pattern of reduced pro-inflammatory biomarker IL-18 at spleen. Overall, this study provides evidence for the beneficial role of PFA as a natural growth and health promoter in broiler chickens that needs to be further confirmed in field studies. | Vasileios Paraskeuas Konstantinos Fegeros Irida Palamidi Christine Hunger Konstantinos C.Mountzouris | 2017 | Animal Nutrition2017，，2： | 5 |
| 14 | Catheter ablation of atrial fibrillation in the elderly显示文摘BackgroundAtrial 纤维性颤动(AF ) 导管脱离为 AF 作为有希望的治疗策略出现了,但是广泛地没在老人口被采用。试图在老 population.Methods 和 ResultsThe 学习人口决定 AF 导管脱离的安全和功效的现在的学习与发作性的 AF 由 316 个病人组成了经历了左 atrial 脱离。95 个病人是 ≥65 年(48 男性,意味着年龄 68.9 ±3.0 岁) 并且 221 个病人是 <65 岁(130 男性,意味着年龄 52.5 ±10.4 岁) 。在 34.0 ± 的一个吝啬的后续时期以后;15.1 个月, 55 (57.9%) 在老组的病人与 149 相比从心律不齐复发是自由的(67.4%) 在更年轻的组的病人(P = 0.169 ) 。程序的复杂并发症在两个学习组是不平常的。在逻辑回归分析,离开了 atrial 直径( P = 0.003 ),高血压( P = 0.001 ), dyslipidemia ( P = 0.039 ),并且冠的动脉疾病( P = 0.018 )在 AF 的老 population.ConclusionsCatheter 脱离的 AF 复发的独立预言者在更老的病人安全、有效。侵略策略应该与 AF 在征兆的老病人被看作一种其他的选择。 | Louiza Lioni Konstantinos P. Letsas Michael Efremidis Konstantinos Vlachos Georgios Giannopoulos Vasileios Kareliotis Spyridon Deftereos Antonios Sideris | 2014 | Journal of Geriatric Cardiology2014，11，4： | 5 |
| 15 | Management bone loss of the proximal femur in revision hip arthroplasty: Update on reconstructive options显示文摘The number of revision total hip arthroplasties is expected to rise as the indications for arthroplasty will expand due to the aging population. The prevalence of extensive proximal femoral bone loss is expected to increase subsequently. The etiology of bone loss from the proximal femur after total hip arthroplasty is multifactorial. Stress shielding, massive osteolysis, extensive loosening and history of multiple surgeries consist the most common etiologies. Reconstruction of extensive bone loss of the proximal femur during a revision hip arthroplasty is a major challenge for even the most experienced orthopaedic surgeon. The amount of femoral bone loss and the bone quality of the remaining metaphyseal and diaphyseal bone dictate the selection of appropriate reconstructive option. These include the use of impaction allografting, distal press-fit fixation, allograft-prosthesis composites and tumor megaprostheses. This review article is a concise review of the current literature and provides an algorithmic approachfor reconstruction of different types of proximal femoral bone defects. | Vasileios I Sakellariou George C Babis | 2014 | World Journal of Orthopedics2014，5，5： | 5 |
| 16 | Single injection of platelet-rich plasma as a novel treatment of carpal tunnel syndrome显示文摘Both in vitro and in vivo experiments have confirmed that platelet-rich plasma has therapeutic effects on many neuropathies, but its effects on carpal tunnel syndrome remain poorly understood. We aimed to investigate whether single injection of platelet-rich plasma can improve the clinical symptoms of carpal tunnel syndrome. Fourteen patients presenting with median nerve injury who had suffered from mild carpal tunnel syndrome for over 3 months were included in this study. Under ultrasound guidance, 1–2 m L of platelet-rich plasma was injected into the region around the median nerve at the proximal edge of the carpal tunnel. At 1 month after single injection of platelet-rich plasma, Visual Analogue Scale results showed that pain almost disappeared in eight patients and it was obviously alleviated in three patients. Simultaneously, the disabilities of the arm, shoulder and hand questionnaire showed that upper limb function was obviously improved. In addition, no ultrasonographic manifestation of the carpal tunnel syndrome was found in five patients during ultrasonographic measurement of the width of the median nerve. During 3-month follow-up, the pain was not greatly alleviated in three patients. These findings show very encouraging mid-term outcomes regarding use of platelet-rich plasma for the treatment of carpal tunnel syndrome. | Michael Alexander Malahias Elizabeth O.Johnson George C.Babis Vasileios S.Nikolaou | 2015 | Neural Regeneration Research2015，10，11： | 4 |
| 17 | Management and control applications in Agriculture domain via a Future Internet Businessto- Business platform显示文摘The Agriculture business domain,as a vital part of the overall supply chain,is expected to highly evolve in the upcoming years via the developments,which are taking place on the side of the Future Internet.This paper presents a novel Business-to-Business collaboration platform from the agri-food sector perspective,which aims to facilitate the collaboration of numerous stakeholders belonging to associated business domains,in an effective and flexible manner.The contemporary B2B collaboration schemes already place the requirements for swift deployment of cloud applications,capable of both integrating diverse legacy systems,as well as developing in a rapid way new services and systems,which will be able to instantly communicate and provide complete,'farm-to-fork'solutions for farmers,agrifood and logistics service providers,ICT companies,end-product producers,etc.To this end,this conceptual paper describes how these requirements are addressed via the FIspace B2B platform,focusing on the Greenhouse Management&Control scenarios. | Sokratis Barmpounakis Alexandros Kaloxylos Aggelos Groumas Lampros Katsikas Vasileios Sarris Konstantina Dimtsa Fabiana Fournier Eleni Antoniou Nancy Alonistioti Sjaak Wolfert | 2015 | Information Processing in Agriculture2015，2，1： | 4 |
| 18 | Role of adipose-derived stromal cells in pedicle skin flap survival in experimental animal models显示文摘The use of skin flaps in reconstructive surgery is the first-line surgical treatment for the reconstruction of skin defects and is essentially considered the starting point of plastic surgery. Despite their excellent usability, their application includes general surgical risks or possible complications, the primary and most common is necrosis of the flap. To improve flap survival, researchers have used different methods, including the use of adiposederived stem cells, with significant positive results. In our research we will report the use of adipose-derived stem cells in pedicle skin flap survival based on current literature on various experimental models in animals. | Pericles Foroglou Vasileios Karathanasis Efterpi Demiri George Koliakos Marios Papadakis | 2016 | World Journal of Stem Cells2016，8，3： | 4 |
| 19 | Diagnosis,treatment and prevention of type 2 diabetes mellitus in children and adolescents显示文摘During the last two decades,there have been several reports of an increasing incidence of type 2 diabetes mellitus(T2 DM) in children and adolescents,especially among those belonging to minority ethnic groups.This trend,which parallels the increases in prevalence and degree of pediatric obesity,has caused great concern,even though T2 DM remains a relatively rare disease in children.Youth T2 DM differs not only from type 1 diabetes in children,from which it is sometimes difficult to differentiate,but also from T2 DM in adults,since it appears to be an aggressive disease with rapidly progressive β-cell decline,high treatment failure rate,and accelerated development of complications.Despite the recent research,many aspects of youth T2 DM still remain unknown,regarding both its pathophysiology and risk factor contribution,and its optimal management and prevention.Current management approaches include lifestyle changes,such as improved diet and increased physical activity,together with pharmacological interventions,including metformin,insulin,and the recently approved glucagonlike peptide-1 analog liraglutide.What is more important for everyone to realize though,from patients,families and physicians to schools,health services and policy-makers alike,is that T2 DM is a largely preventable disease that will be addressed effectively only if its major contributor(i.e.,pediatric obesity) is confronted and prevented at every possible stage of life,from conception until adulthood.Therefore,relevant comprehensive,coordinated,and innovative strategies are urgently needed. | Anastasios Serbis Vasileios Giapros Eleni P Kotanidou Assimina Galli-Tsinopoulou Ekaterini Siomou | 2021 | World Journal of Diabetes2021，12，4： | 4 |
| 20 | Cemented Müller straight stem total hip replacement:18 year survival,clinical and radiological outcomes显示文摘AIM: To present the 18 year survival and the clinical and radiological outcomes of the Müller straight stem, cemented, total hip arthroplasty(THA).METHODS: Between 1989 and 2007, 176 primary total hip arthroplasties in 164 consecutive patients were performed in our institution by the senior author. All patients received a Müller cemented straight stem and a cemented polyethylene liner. The mean age of the patients was 62 years(45-78). The diagnosis was primary osteoarthritis in 151 hips, dysplasia of the hip in 12 and subcapital fracture of the femur in 13. Following discharge, serial follow-up consisted of clinical evaluation based on the Harris Hip Score and radiological assessment. The survival of the prosthesis using revision for any reason as an end-point was calculated by KaplanMeier analysis.RESULTS: Twenty-four(15%) patients died during the follow-up study, 6(4%) patients were lost, while the remaining 134 patients(141 hips) were followedup for a mean of 10 years(3-18 years). HSS score at the latest follow-up revealed that 84 hips(59.5%) had excellent results, 30(22.2%) good, 11(7.8%) fair and 9(6.3%) poor. There were 3 acetabular revisions due to aseptic loosening. Six(4.2%) stems were diagnosed as having radiographic definitive loosening; however, only 1 was revised. 30% of the surviving stems showed no radiological changes of radiolucency, while 70% showed some changes. Survival of the prosthesis for any reason was 96% at 10 years and 81% at 18 years. CONCLUSION: The 18 year survival of the Müller straight stem, cemented THA is comparable to those of other successful cemented systems. | Vasileios S Nikolaou Demetrios Korres Stergios Lallos Andreas Mavrogenis Ioannis Lazarettos Ioannis Sourlas Nicolas Efstathopoulos | 2013 | World Journal of Orthopedics2013，4，4： | 4 |
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