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| 1 | Lateral lymph node dissection for low rectal cancer: Is it necessary?显示文摘Rectal cancer constitutes a major public health issue.Total mesorectal excision has remained the gold standard treatment for mid and low rectal tumors since its introduction in the late 1980s.Removal of all lymph nodes located in the mesorectum has indeed improved pathological and oncological outcomes.However,when cancer spreads to the lateral lymph nodes(located along the iliac and obturator arteries)Western and Japanese practices differ.Where the Western guidelines consider this condition as an advanced form of the disease and use neoadjuvant radiochemotherapy liberally,the Japanese guidelines define it as a local disease and proceed to lateral lymph node dissection with or without neoadjuvant treatment.Herein,we review the current literature regarding both therapeutic strategies,with the aim of contributing to potential improvements in treatment and outcome for patients with low and mid rectal cancer. | Niki Christou Jeremy Meyer Christian Toso Frédéric Ris Nicolas Christian Buchs | 2019 | World Journal of Gastroenterology2019，25，31： | 11 |
| 2 | Hallmarks in colorectal cancer:Angiogenesis and cancer stem-like cells显示文摘Carcinogenesis is a multistep process that requires the accumulation of various genetic and epigenetic aberrations to drive the progressive malignant transformation of normal human cells.Two major hallmarks of carcinogenesis that have been described are angiogenesis and the stem cell characteristic of limitless replicative potential.These properties have been targeted over the past decade in the development of therapeutic treatments for colorectal cancer(CRC),one of the most commonly diagnosed and lethal cancers worldwide.The treatment of solid tumor cancers such as CRC has been challenging due to the heterogeneity of the tumor itself and the chemoresistance of the malignant cells.Furthermore,the same microenvironment that maintains the pool of intestinal stem cells that contribute to the continuous renewal of the intestinal epithelia also provides the necessary conditions for proliferative growth of cancer stem-like cells.These cancer stem-like cells are responsible for the resistance to therapy and cancer recurrence,though they represent less than 2.5%of the tumor mass.The stromal environment surrounding the tumor cells,referred to as the tumor niche,also supports angiogenesis,which supplies the oxygen and nutrients needed for tumor development.Anti-angiogenic therapy,such as with bevacizumab,a monoclonal antibody against vascular-endothelial growth factor,significantly prolongs the survival of metastatic CRC patients.However,such treatments are not completely curative,and a large proportion of patient tumors retain chemoresistance or show recurrence.This article reviews the current knowledge regarding the molecular phenotype of CRC cancer cells,as well as discusses the mechanisms contributing to their maintenance.Future personalized therapeutic approaches that are based on the interaction of the carcinogenic hallmarks,namely angiogenic and proliferative attributes,could improve survival and decrease adverse effects induced by unnecessary chemotherapy. | Muriel Mathonnet Aurelie Perraud Niki Christou Hussein Akil Carole Melin Serge Battu Marie-Odile Jauberteau Yves Denizot | 2014 | World Journal of Gastroenterology2014，20，15： | 5 |
| 3 | Challenges and opportunities in the application of artificial intelligence in gastroenterology and hepatology显示文摘Artificial intelligence(AI)is an umbrella term used to describe a cluster of interrelated fields.Machine learning(ML)refers to a model that learns from past data to predict future data.Medicine and particularly gastroenterology and hepatology,are data-rich fields with extensive data repositories,and therefore fruitful ground for AI/ML-based software applications.In this study,we comprehensively review the current applications of AI/ML-based models in these fields and the opportunities that arise from their application.Specifically,we refer to the applications of AI/ML-based models in prevention,diagnosis,management,and prognosis of gastrointestinal bleeding,inflammatory bowel diseases,gastrointestinal premalignant and malignant lesions,other nonmalignant gastrointestinal lesions and diseases,hepatitis B and C infection,chronic liver diseases,hepatocellular carcinoma,cholangiocarcinoma,and primary sclerosing cholangitis.At the same time,we identify the major challenges that restrain the widespread use of these models in healthcare in an effort to explore ways to overcome them.Notably,we elaborate on the concerns regarding intrinsic biases,data protection,cybersecurity,intellectual property,liability,ethical challenges,and transparency.Even at a slower pace than anticipated,AI is infiltrating the healthcare industry.AI in healthcare will become a reality,and every physician will have to engage with it by necessity. | Chrysanthos D Christou Georgios Tsoulfas | 2021 | World Journal of Gastroenterology2021，27，37： | 5 |
| 4 | Atypical anastomotic malignancies of small bowel after subtotal gastrectomy with BillorthⅡgastroenterostomy for peptic ulcer:Report of three cases and review of the literature显示文摘AIM To present patients who developed small-bowel malignancy at the level of the gastrointestinal anastomosis decades after a subtotal gastrectomy for ulcer,to review relevant literature,and to attempt to interpret the reasons those cancers developed to these postsurgical non-gastric sights.METHODS For the current retrospective study and review of literature,the surgical and histopathological records dated from January 1,1993 to December 31,2017 of our department were examined,searching for patients who have undergone surgical treatment of small-bowel malignancy to identify those who have undergone subtotal gastrectomy for benign peptic ulcer.A systematic literature search was also conducted using Pub Med,EMBASE,and Cochrane Library to identify similar cases.RESULTS We identified three patients who had developed smallintestine malignancy at the level of the gastrointestinal anastomosis decades after a subtotal gastrectomy with Billroth Ⅱ gastroenterostomy for benign peptic ulcertwo patients with adenocarcinoma originated in the Braun anastomosis and one patient with lymphoma of the efferent loop.All three patients were submitted to surgical resection of the tumor with Roux-en-Y reconstruction of the digestive tract.In the literature review,we only found one case of primary small-intestinal cancer that originated in the efferent loop after Billroth Ⅱ gastrectomy because of duodenal ulcer but none reporting Braun anastomosis adenocarcinoma following partial gastrectomy for benign disease.We also did not find any case of efferent loop lymphoma following gastrectomy.CONCLUSION Anastomotic gastric cancer following distal gastrectomy for peptic ulcer is a well-established clinical entity.However,malignancies of the afferent or efferent loop of the gastrointestinal anastomosis are extremely uncommon.The substantial diversion of the potent carcinogenic pancreaticobiliary secretions through the Braun anastomosis and the stomach hypochlorhydria,allowing the formation of carcinogenic factors from food,are the two most prominent pathogenetic mechanisms for those tumors. | Efstathios Kotidis Orestis Ioannidis Manousos George Pramateftakis Konstantinos Christou Ioannis Kanellos Konstantinos Tsalis | 2018 | World Journal of Gastrointestinal Oncology2018，10，7： | 4 |
| 5 | The new global map of human brucellosis显示文摘 | Georgios Pappas Photini Papadimitriou Nikolaos Akritidis Leonidas Christou Epameinondas V Tsianos | 2006 | The Lancet Infectious Diseases2006，，2： | 3 |
| 6 | Association of liver cirrhosis related IgA nephropathy with portal hypertension显示文摘A high incidence of IgA nephropathy has been reported in patients with liver cirrhosis, though, clinically evident nephrotic syndrome is very uncommon. Impaired hepatic clearance of circulating IgA immune complexes and subsequent deposition in renal glomeruli has been considered principally in the pathogenesis of liver cirrhosis associated IgA nephropathy. Here we report on a patient with cryptogenic liver cirrhosis and splenic vein thrombosis, who presented with nephrotic syndrome. Renal biopsy showed findings consistent with IgA nephropathy. Lower endoscopy showed features of portal hypertensive colopathy. Following initiation of propranolol and anticoagulant treatment to reduce portal pressure, a gradual decrease of proteinuria and hematuria to normal range was noted. The potential pathogenetic role of portal hypertension in the development of IgA nephropathy in cirrhotic patients is discussed. | Georgios Kalambokis Leonidas Christou Dimitrios Stefanou Evdokia Arkoumani Epameinondas V Tsianos | 2007 | World Journal of Gastroenterology2007，13，43： | 3 |
| 7 | Reducing anastomotic leak in colorectal surgery: The old dogmas and the new challenges显示文摘Anastomotic leak(AL)constitutes a significant issue in colorectal surgery,and its incidence has remained stable over the last years.The use of intra-abdominal drain or the use of mechanical bowel preparation alone have been proven to be useless in preventing AL and should be abandoned.The role or oral antibiotics preparation regimens should be clarified and compared to other routes of administration,such as the intravenous route or enema.In parallel,preoperative antibiotherapy should aim at targeting collagenase-inducing pathogens,as identified by the microbiome analysis.AL can be further reduced by fluorescence angiography,which leads to significant intraoperative changes in surgical strategies.Implementation of fluorescence angiography should be encouraged.Progress made in AL comprehension and prevention might probably allow reducing the rate of diverting stoma and conduct to a revision of its indications. | Jeremy Meyer Surennaidoo Naiken Niki Christou Emilie Liot Christian Toso Nicolas Christian Buchs Frédéric Ris | 2019 | World Journal of Gastroenterology2019，25，34： | 3 |
| 8 | Heterogeneous integration of contact-printed semiconductor nanowires for high-performance devices on large areas显示文摘In this work,we have developed a contact-printing system to efficiently transfer the bottom-up and top-down semiconductor nanowires(NWs),preserving their as-grown features with a good control over their electronic properties.In the close-loop configuration,the printing system is controlled with parameters such as contact pressure and sliding speed/stroke.Combined with the dry pre-treatment of the receiver substrate,the system prints electronic layers with high NW density(7 NWs/μm for bottom-up ZnO and 3 NWs/μm for top-down Si NWs),NW transfer yield and reproducibility.We observed compactly packed(~115 nm average diameters of NWs,with NW-to-NW spacing~165 nm)and well-aligned NWs(90%with respect to the printing direction).We have theoretically and experimentally analysed the role of contact force on NW print dynamics to investigate the heterogeneous integration of ZnO and Si NWs over pre-selected areas.Moreover,the contact-printing system was used to fabricate ZnO and Si NW-based ultraviolet(UV)photodetectors(PDs)with Wheatstone bridge(WB)configuration on rigid and flexible substrates.The UV PDs based on the printed ensemble of NWs demonstrate high efficiency,a high photocurrent to dark current ratio(>10^(4))and reduced thermal variations as a result of inherent self-compensation of WB arrangement.Due to statistically lesser dimensional variations in the ensemble of NWs,the UV PDs made from them have exhibited uniform response. | Carlos García Núñez Fengyuan Liu William Taube Navaraj Adamos Christou Dhayalan Shakthivel Ravinder Dahiya | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 9 | Role of three-dimensional printing and artificial intelligence in the management of hepatocellular carcinoma:Challenges and opportunities显示文摘Hepatocellular carcinoma(HCC)constitutes the fifth most frequent malignancy worldwide and the third most frequent cause of cancer-related deaths.Currently,treatment selection is based on the stage of the disease.Emerging fields such as three-dimensional(3D)printing,3D bioprinting,artificial intelligence(AI),and machine learning(ML)could lead to evidence-based,individualized management of HCC.In this review,we comprehensively report the current applications of 3D printing,3D bioprinting,and AI/ML-based models in HCC management;we outline the significant challenges to the broad use of these novel technologies in the clinical setting with the goal of identifying means to overcome them,and finally,we discuss the opportunities that arise from these applications.Notably,regarding 3D printing and bioprinting-related challenges,we elaborate on cost and cost-effectiveness,cell sourcing,cell viability,safety,accessibility,regulation,and legal and ethical concerns.Similarly,regarding AI/ML-related challenges,we elaborate on intellectual property,liability,intrinsic biases,data protection,cybersecurity,ethical challenges,and transparency.Our findings show that AI and 3D printing applications in HCC management and healthcare,in general,are steadily expanding;thus,these technologies will be integrated into the clinical setting sooner or later.Therefore,we believe that physicians need to become familiar with these technologies and prepare to engage with them constructively. | Chrysanthos D Christou Georgios Tsoulfas | 2022 | World Journal of Gastrointestinal Oncology2022，14，4： | 2 |
| 10 | Transgenic and genome-edited fruits: background, constraints, benefits, and commercial opportunities显示文摘Breeding has been used successfully for many years in the fruit industry,giving rise to most of today’s commercial fruit cultivars.More recently,new molecular breeding techniques have addressed some of the constraints of conventional breeding.However,the development and commercial introduction of such novel fruits has been slow and limited with only five genetically engineered fruits currently produced as commercial varieties—virus-resistant papaya and squash were commercialized 25 years ago,whereas insect-resistant eggplant,non-browning apple,and pink-fleshed pineapple have been approved for commercialization within the last 6 years and production continues to increase every year.Advances in molecular genetics,particularly the new wave of genome editing technologies,provide opportunities to develop new fruit cultivars more rapidly.Our review,emphasizes the socioeconomic impact of current commercial fruit cultivars developed by genetic engineering and the potential impact of genome editing on the development of improved cultivars at an accelerated rate. | Maria Lobato-Gomez Seanna Hewitt Teresa Capell Paul Christou Amit Dhingra Patricia Sarai Giron-Calva | 2021 | Horticulture Research2021，8，1： | 2 |
| 11 | Multiple organ dysfunction score:a reliable descriptor of a complex clinical outcome显示文摘 | Marshall J C Cook D J Christou N V | 1995 | Crit Care Med1995，23，： | 2 |
| 12 | Risk assessment in support to land-use planning in Europe: Towards more consistent decisions?显示文摘 | Michalis Christou Zsuzsanna Gyenes Michael Struckl | 2010 | Journal of Loss Prevention in the Process Industries2010，，3： | 2 |
| 13 | Soluble L-selectin at levels present in septic patients diminishes leukocyte-endothelial cell interactions in mice in vivo:A mechanism for decreased leukocyte delivery to remote septic sites in sepsis显示文摘 | Ferri LE Swartz D Christou NV | 2001 | Crit Care Med2001，29，： | 2 |
| 14 | The development and current status of perennial rhizomatous grasses as energy crops in the US and Europe显示文摘 | Iris Lewandowski Jonathan M.O. Scurlock Eva Lindvall Myrsini Christou | 2003 | Biomass and Bioenergy2003，，4： | 2 |
| 15 | Accuracy and criteria for localizing arterial occlusion with transcranial Doppler 显示文摘 | Demchuk AM Christou L Wein TH | 2000 | Neuroimaging2000，10，1： | 1 |
| 16 | Leptin in relation to growth and developmental processes in the fetus显示文摘 | Christou H Serdy S Mantzoros CS | 2002 | Sesmin Reprod Med2002，20，2： | 1 |
| 17 | Multiple organ dysfunction score:a reliable description of a complex clinical outcome显示文摘 | Marshall J C Cook D J Christou N V | 1995 | Crit Care Med1995，23，10： | 1 |
| 18 | Meta-analysis of frac- tional flow reserve versus quantitative coronary angiography and noninva- sire imaging for evaluation of myocardial ischemia 显示文摘 | Christou MA Siontis GC Katritsis DG | 2007 | Am J Cardiol2007，99，4： | 1 |
| 19 | Prevention of hypoxia - induced pulmonary hypertension by enhancement of endogenous heme oxygenase- 1 in the rat显示文摘 | Christou H Movita T Hsieh CM | 2000 | Circ Res2000，86，： | 1 |
| 20 | Thrombolysis in brain ischemia (TIBI) transcranial Doppler flow grades predict clinical severity, early recovery, and mortality in patients treated with intravenous tissue plasminogen activator 显示文摘 | Demchuk AM Burgin WS Christou I | 2001 | Stroke2001，32，： | 1 |
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