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| 1 | Biliary strictures complicating living donor liver transplantation:Problems,novel insights and solutions显示文摘Biliary stricture complicating living donor liver transplantation(LDLT) is a relatively common complication, occurring in most transplant centres across the world. Cases of biliary strictures are more common in LDLT than in deceased donor liver transplantation. Endoscopic management is the mainstay for biliary strictures complicating LDLT and includes endoscopic retrograde cholangiography, sphincterotomy and stent placement(with or without balloon dilatation). The efficacy and safety profiles as well as outcomes of endoscopic management of biliary strictures complicating LDLT is an area that needs to be viewed in isolation, owing to its unique set of problems and attending complications; as such, it merits a tailored approach, which is yet to be well established. The diagnostic criteria applied to these strictures are not uniform and are over-reliant on imaging studies showing an anastomotic narrowing. It has to be kept in mind that in the setting of LDLT, a subjective anastomotic narrowing is present in most cases due to a mismatch in ductal diameters. However, whether this narrowing results in a functionally significant narrowing is a question that needs further study. In addition, wide variation in the endotherapy protocols practised in most centres makes it difficult to interpret the results and hampers our understanding of this topic. The outcome definition for endotherapy is also heterogenous and needs to be standardised to allow for comparison of data in this regard and establish a clinical practice guideline. There have been multiple studies in this area in the last 2 years, with novel findings that have provided solutions to some of these issues. This review endeavours to incorporate these new findings into the wider understanding of endotherapy for biliary strictures complicating LDLT, with specific emphasis on diagnosis of strictures in the LDLT setting, endotherapy protocols and outcome definitions. An attempt is made to present the best management options currently available as well as directions for future research in the area. | Harshavardhan B Rao Arjun Prakash Surendran Sudhindran Rama P Venu | 2018 | World Journal of Gastroenterology2018，24，19： | 14 |
| 2 | Coronary artery anomalies overview: The normal and the abnormal显示文摘The aim of this review is to give a comprehensive and concise overview of coronary embryology and normal coronary anatomy, describe common variants of normal and summarize typical patterns of anomalous coronary artery anatomy. Extensive iconography supports the text, with particular attention to images obtained in vivo using non-invasive imaging. We have divided this article into three groups, according to their frequency in the general population: Normal, normal variant and anomaly. Although congenital coronary artery anomalies are relatively uncommon, they are the second most common cause of sudden cardiac death among young athletes and therefore warrant detailed review. Based on the functional relevance of each abnormality, coronary artery anomalies can be classified as anomalies with obligatory ischemia, without ischemia or with exceptional ischemia. The clinical symptoms may include chest pain, dyspnea, palpitations, syncope, cardiomyopathy, arrhythmia, myocardial infarction and sudden cardiac death. Moreover, it is important to also identify variants and anomalies without clinical relevance in their own right as complications during surgery or angioplasty can occur. | Adriana DM Villa Eva Sammut Arjun Nair Ronak Rajani Rodolfo Bonamini Amedeo Chiribiri | 2016 | World Journal of Radiology2016，8，6： | 14 |
| 3 | Thermal decomposition and kinetics of plastic bonded explosives based on mixture of HMX and TATB with polymer matrices显示文摘This work describes thermal decomposition behaviour of plastic bonded explosives(PBXs) based on mixture of 1,3,5,7-tetranitro-1,3,5,7-tetrazocane(HMX) and 2,4,6-triamino-1,3,5-trinitrobenzene(TATB)with Viton A as polymer binder. Thermal decomposition of PBXs was undertaken by applying simultaneous thermal analysis(STA) and differential scanning calorimetry(DSC) to investigate influence of the HMX amount on thermal behavior and its kinetics. Thermogravimetric analysis(TGA) indicated that the thermal decomposition of PBXs based on mixture of HMX and TATB was occurred in a three-steps. The first step was mainly due to decomposition of HMX. The second step was ascribed due to decomposition of TATB, while the third step was occurred due to decomposition of the polymer matrices. The thermal decomposition % was increased with increasing HMX amount. The kinetics related to thermal decomposition were investigated under non-isothermal for a single heating rate measurement. The variation in the activation energy of PBXs based on mixture of HMX and TATB was observed with varying the HMX amount. The kinetics from the results of TGA data at various heating rates under non-isothermal conditions were also calculated by Flynn—Wall—Ozawa(FWO) and Kissinger-Akahira-Sunose(KAS)methods. The activation energies calculated by employing FWO method were very close to those obtained by KAS method. The mean activation energy calculated by FWO and KAS methods was also a good agreement with the activation energy obtained from single heating rate measurement in the first step decomposition. | Arjun Singh Tirupati C.Sharma Mahesh Kumar Jaspreet Kaur Narang Prateek Kishore Alok Srivastava | 2017 | Defence Technology(防务技术)2017，13，1： | 8 |
| 4 | Evaluation of phenolic composition, antioxidant, anti-inflammatory and anticancer activities of Polygonatum verticillatum(L.)显示文摘Objective: Polygonatum verticillatum(L.) All.(Ruscaceae), one of the Ashtawarga plants, is widely used for treatment of various ailments. The present study was undertaken to determine the phenolic composition,antioxidant, anti-inflammatory and anticancer activities of several extracts(petroleum ether, dichloromethane, chloroform, ethanol, and aqueous) from the rhizomes of the plant.Methods: Coarsely powdered dry rhizome was successively extracted with different solvents of increasing polarity(petroleum ether, dichloromethane, chloroform, ethanol and water). The phenolic compositions, in terms of total phenolic content(TPC), total flavonoid content(TFC) and total condensed tannin content(TTC), were evaluated with the Folin–Ciocalteu assay, aluminum chloride colorimetric assay and vanillin spectrophotometric assay, respectively. Total antioxidant capacity, 1,1-diphenyl-2-picrylhydrazyl and 2,20-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) assays were used to assess the antioxidant potential of each extract. A protein denaturation model and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay were used to evaluate in vitro anti-inflammatory and anticancer activities, respectively. Gas chromatography–mass spectrometry(GC/MS) analysis was carried out to demonstrate various phytoconstituents in each extract. Correlation studies were also performed between phenolic composition(TPC, TFC and TTC) and different biological activities.Results: Ethanol extract showed maximum TPC(0.126 mg/g, gallic acid equivalent in dry sample), TFC(0.094 mg/g, rutin equivalent in dry sample) and TTC(29.32 mg/g, catechin equivalent in dry sample),as well as antioxidant and anti-inflammatory properties. Chloroform extract exhibited the strongest cytotoxicity against the human breast cancer cell line, MCF-7. GC/MS analysis revealed the presence of 90 different phytoconstituents among the extracts. Antioxidant and anti-inflammatory activities had a positive correlation with TPC, TFC and TTC. However, the anticancer activity showed a negative correlation with TPC, TFC and TTC.Conclusion: From the present study, it can be concluded that P. verticillatum possessed remarkable antioxidant, anti-inflammatory, and anticancer activities, which could be due to different secondary metabolites of the plant. Phenolic compounds are likely responsible for antioxidant and antiinflammatory activities. However, flavonoids and other compounds might contribute to the anticancer potential of the plant. | SANDeep Kumar Singh Arjun Patra | 2018 | Journal of Integrative Medicine2018，16，4： | 7 |
| 5 | Endovascular treatment of pulmonary embolism: Selective review of available techniques显示文摘Acute pulmonary embolism(PE) is the third most common cause of death in hospitalized patients. The development of sophisticated diagnostic and therapeutic modalities for PE, including endovascular therapy, affords a certain level of complexity to the treatment of patients with this important clinical entity. Furthermore, the lack of level I evidence for the safety and effectiveness of catheter directed therapy brings controversy to a promising treatment approach. In this review paper, we discuss the pathophysiology and clinical presentation of PE, review the medical and surgical treatment of the condition, and describe in detail the tools that are available for the endovascular therapy of PE, including mechanical thrombectomy, suction thrombectomy, and fibrinolytic therapy. We also review the literature available to date on these methods, and describe the function of the Pulmonary Embolism Response Team. | John L Nosher Arjun Patel Sugeet Jagpal Christopher Gribbin Vyacheslav Gendel | 2017 | World Journal of Radiology2017，9，12： | 6 |
| 6 | A review on dump slope stabilization by revegetation with reference to indigenous plant显示文摘The waste,subgrade ROM and fine dumps of iron ore mines are characterized by high rock fragment contents,low moisture retention capacity,higher bulk density,low nutrients,lower pH and elevated metal concentrations.Use of suitable revegetation programme,that require the selection of right type of plants to be used vis-à-vis the site condition and characteristics,can enhance the long-term stability,both mechanical and ecological,of dumps(waste,subgrade ROM and fines)through providing vegetative cover to control soil erosion and gully formation,consolidation of dump top and side surfaces,binding the loose particles through intricate roof system,etc.This paper overviews the roles of revegetation programme that can be used where vegetation is considered to be the long-term answer to slope protection and erosion control.Various revegetation processes like Coir matting,lemon grass,vetiver grass and indigenous plant may find a wide range of usage in iron ore mines for dump stabilization.The Miyawaki method of plantation is more effective than the conventional method of plantation.This will lead to co-existence of plants,and as a matter of fact each plant draws from the other vital nutrients and they grow to become strong and healthy.The Miyawaki plantation technique aims at“survival of the fittest”,and the area which undergone such plantation has an ecology of their own.The indigenous plant has good binding capacity and helps to control soil erosion as well as improve the dump stability.These indigenous plant species include Shorea robusta(Sal),Dalbergia sisoo(Shisham),Karanj and Azadirachta(Neem).The growth of indigenous plants is dependent upon the soil quality as well as the organic matter of the dump material.The leaf debris plays an important role for improving the organic matter of the dump material to successfully implement the revegetation programme. | Vibhash Ranjan Phalguni Sen Dheeraj Kumar Arjun Sarsawat | 2015 | Ecological Processes2015，4，1： | 5 |
| 7 | 基于MEPDG的温拌发泡沥青混合料性能研究显示文摘为探究泡沫沥青温拌技术对沥青混合料性能及沥青路面设计厚度的影响,通过力学-经验路面设计指南(MEPDG)软件对温拌发泡沥青混合料(WMA Foam)路面和热拌沥青混合料(HMA)路面在相同设计条件下的车辙、疲劳开裂以及国际平整度指标(IRI)等进行预测比较,并根据MEPDG路面设计方法分别得出了温拌发泡沥青混合料和热拌沥青混合料在相同情况下的路面设计厚度。结果表明:采用石灰岩碎石作集料时,WMA Foam与HMA表现出相近的性能。而对以天然砾石为集料的PG 64-22原样沥青混合料,发泡沥青温拌技术的采用使得混合料的车辙深度和国际平整度指数(IRI)相比HMA混合料有显著增加。此外,采用天然砾石和PG 64-22原样沥青的温拌发泡沥青路面设计厚度远大于对应热拌沥青路面的设计厚度。 | 周维祥 Munir Nazzal Ala R.Abbas Ayman W.Ali Arjun Roy | 2016 | 中外公路2016，36，4： | 4 |
| 8 | 新冠疫情期间留学生局部解剖学线上教学的策略与实践显示文摘新冠疫情背景下,留学生线上教学面临着比中国学生更多的挑战。在充分考虑疫情期间留学生局部解剖学线上教学诸多困难的基础上,精心设计线上教学策略并采取多种举措保障实施。 | 阚氏海 李京敏 孙毅 赵冬梅 Sinkemani Arjun 李琳 | 2021 | 卫生职业教育2021，39，14： | 4 |
| 9 | Anti–IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis显示文摘 | Iris M. Otani Arjun A. Anilkumar Robert O. Newbury Monica Bhagat Lisa Y. Beppu Ranjan Dohil David H. Broide Seema S. Aceves | 2013 | The Journal of Allergy and Clinical Immunology2013，，6： | 3 |
| 10 | Outcomes After Minimally Invasive Esophagectomy: Review of Over 1000 Patients显示文摘 | James D. Luketich Arjun Pennathur Omar Awais Ryan M. Levy Samuel Keeley Manisha Shende Neil A. Christie Benny Weksler Rodney J. Landreneau Ghulam Abbas Matthew J. Schuchert Katie S. Nason | 2012 | Annals of Surgery2012，，1： | 3 |
| 11 | Is laser photocoagulation still effective in diabetic macular edema? Assessment with optical coherence tomography in Nepal显示文摘AIM: To find out the outcome of laser photocoagulation in clinically significant macular edema (CSME) by optical coherence tomography (OCT). · METHODS: It was a prospective, non-controlled, case series study enrolling 81 eyes of 64 patients with CSME between August 2008 and January 2010. All patients received modified grid photocoagulation with frequency doubled Nd: YAG laser. Each patient was evaluated in terms of best-corrected visual acuity (BCVA) and regression or progression of maculopathy after laser therapy at 1, 3 and 6 months. Spearman's correlation test was used to show the correlation between BCVA and total macular volume (TMV). Analysis of variance (ANOVA) was used to compare among groups and independent t-test was used to compare in each group. · RESULTS: There is high correlation between BCVA and TMV (P ≤0.001). BCVA improved in 50.6%, remained static in 39.5 % and deteriorated in 9.9% patients after 6 month of treatment. The Baseline TMV (mean and SD) were 9.26±1.83, 10.4±2.38, 11.5±3.05, 8.89±0.75 and 9.47±1.98 mm3 for different OCT patterns, ST (sponge like thickening), CMO (cystoid macular edema), SFD (subfoveal detachment), VMIA (Vitreo macular interface abnormality) and average TMV respectively (P =0.04). After 6 months of laser treatment, the mean TMV decreased from 9.47±1.98mm3 to 8.77±1.31mm3(P =0.01). In ST there was significant decrease in TMV, P =0.01, Further within these groups at 6 months, they were significantly different, P =0.01. · CONCLUSION: OCT showed the different morphological variant of CSME while the response of treatment is different. TMV decreased the most and hence showed the improvement in vision after 6 months of laser treatment. In the era of Anti vascular endothelial growth factors (VEGFs), efficacy of laser seems to be in shadow but it is still first line of treatment in developing nation like Nepal where antiVEGFs may not be easily available and affordable. | Arjun Shrestha Deepak Khadka Angira Karmacharya Nhukesh Maharjan Anand Shrestha Raba Thapa Govinda Poudyal | 2012 | International Journal of Ophthalmology(English edition)2012，5，2： | 3 |
| 12 | Innovative approaches to genome editing in avian species显示文摘The tools available for genome engineering have significantly improved over the last 5 years, allowing scientist to make precise edits to the genome. Along with the development of these new genome editing tools has come advancements in technologies used to deliver them. In mammals genome engineering tools are typically delivered into in vitro fertilized single cell embryos which are subsequently cultured and then implanted into a recipient animal.In avian species this is not possible, so other methods have been developed for genome engineering in birds. The most common involves in vitro culturing of primordial germ cells(PGCs), which are cells that migrate through the embryonic circulatory system to the developing gonad and colonize the gonad, eventually differentiating into the gonadocytes which produce either sperm or ova. While in culture the PGCs can be modified to carry novel transgenes or gene edits, the population can be screened and enriched, and then transferred into a recipient embryo. The largest drawback of PGC culture is that culture methods do not transfer well across avian species, thus there are reliable culture methods for only a few species including the chicken. Two newer technologies that appear to be more easily adapted in a wider range of avian species are direct injection and sperm transfection assisted gene editing(STAGE).The direct injection method involves injecting genome engineering tools into the circulatory system of the developing embryo just prior to the developmental time point when the PGCs are migrating to the gonads. The genome engineering tools are complexed with transfection reagents, allowing for in vivo transfection of the PGCs. STAGE utilizes sperm transfection to deliver genome engineering tools directly to the newly fertilized embryo. Preliminary evidence indicates that both methodologies have the potential to be adapted for use in birds species other than the chicken, however further work is needed in this area. | Caitlin A.Cooper Timothy J.Doran Arjun Challagulla Mark L.V.Tizard Kristie A.Jenkins | 2018 | Journal of Animal Science and Biotechnology2018，9，2： | 2 |
| 13 | Systematic review of outcomes for endoscopic sinus surgery and subsequent aspirin desensitization in aspirin-exacerbated respiratory disease显示文摘Objective:To review and evaluate outcomes of patients with aspirin-exacerbated respiratory disease(AERD)following endoscopic sinus surgery and subsequent aspirin desensitization.Methods:Electronic searches of OVID MEDLINE(1948 to September 10,2019),EMBASE(1980 to September 10,2019),and PubMed were performed on September 10,2019.A systematic review of the literature was performed using the 2009 PRISMA guidelines.Studies with both preoperative and postoperative data for patients with AERD who underwent sinus surgery and aspirin desensitization were considered appropriate for inclusion.Publications were written in English and included patients aged 18 years or older.Results:Six studies met inclusion criteria for this systematic review.The primary outcome measure was change in symptom profile measured by patient-reported quality of life scores.The results demonstrate statistically significant improvement in symptoms following endoscopic sinus surgery,with sustained improvement following aspirin desensitization.Revision surgery rates were significantly lower in patients maintained on aspirin therapy.Conclusion:This review suggests that surgery followed by aspirin desensitization results in improvement in both subjective and objective outcome measures.The adjunctive use of aspirin desensitization allows for long-term stability in symptom scores.Recurrence of polyps and worsening symptoms requiring revision surgery occurs when aspirin maintenance therapy is inter-rupted. | Lindsey Ryan Daniel Segarra Mark Tabor Arjun Parasher | 2020 | World Journal of Otorhinolaryngology-Head and Neck Surgery2020，6，4： | 2 |
| 14 | Keeping an eye on the diabetic foot: The connection between diabetic eye disease and wound healing in the lower extremity显示文摘Diabetic eye disease is strongly associated with the development of diabetic foot ulcers(DFUs).DFUs are a common and significant complication of diabetes mellitus(DM)that arise from a combination of micro-and macrovascular compromise.Hyperglycemia and associated metabolic dysfunction in DM lead to impaired wound healing,immune dysregulation,peripheral vascular disease,and diabetic neuropathy that predisposes the lower extremities to repetitive injury and progressive tissue damage that may ultimately necessitate amputation.Diabetic retinopathy(DR)is caused by cumulative damage to the retinal microvasculature from hyperglycemia and other diabetes-associated factors.The severity of DR is closely associated with the development of DFUs and the need for lower extremity revascularization procedures and/or amputation.Like the lower extremity,the eye may also suffer end-organ damage from macrovascular compromise in the form of cranial neuropathies that impair its motility,cause optic neuropathy,or result in partial or complete blindness.Additionally,poor perfusion of the eye can cause ischemic retinopathy leading to the development of proliferative diabetic retinopathy or neovascular glaucoma,both serious,visionthreatening conditions.Finally,diabetic corneal ulcers and DFUs share many aspects of impaired wound healing resulting from neurovascular,sensory,and immunologic compromise.Notably,alterations in serum biomarkers,such as hemoglobin A1c,ceruloplasmin,creatinine,low-density lipoprotein,and highdensity lipoprotein,are associated with both DR and DFUs.Monitoring these parameters can aid in prognosticating long-term outcomes and shed light on shared pathogenic mechanisms that lead to end-organ damage.The frequent cooccurrence of diabetic eye and foot problems mandate that patients affected by either condition undergo reciprocal comprehensive eye and foot evaluations in addition to optimizing diabetes management. | David J Ramsey James T Kwan Arjun Sharma | 2022 | World Journal of Diabetes2022，13，12： | 2 |
| 15 | Training and transfer of colonoscopy skills: a multinational, randomized, blinded, controlled trial of simulator versus bedside training显示文摘 | Adam Haycock Arjun D. Koch Pietro Familiari Foke van Delft Evelien Dekker Lucio Petruzziello Jelle Haringsma Siwan Thomas-Gibson | 2010 | Gastrointestinal Endoscopy2010，，2： | 2 |
| 16 | Esophagectomy for T1 Esophageal Cancer: Outcomes in 100 Patients and Implications for Endoscopic Therapy显示文摘 | Arjun Pennathur Andrew Farkas Alyssa M. Krasinskas Peter F. Ferson William E. Gooding Michael K. Gibson Matthew J. Schuchert Rodney J. Landreneau James D. Luketich | 2009 | The Annals of Thoracic Surgery2009，，4： | 2 |
| 17 | MicroRNA expression profiles of esophageal cancer显示文摘 | Andrew Feber Liqiang Xi James D. Luketich Arjun Pennathur Rodney J. Landreneau Maoxin Wu Scott J. Swanson Tony E. Godfrey Virginia R. Litle | 2008 | The Journal of Thoracic and Cardiovascular Surgery2008，，2： | 2 |
| 18 | Elbow dislocation with ipsilateral diaphyseal forearm bone fracture: A rare injury report with literature review显示文摘 | Vijay Goni Prateek Behera Umesh Kumar Meena Nirmal raj Gopinathan Narendranadh Akkina R.H.H. Arjun | 2015 | Chinese Journal of Traumatology2015，18，2： | 2 |
| 19 | Proximal tibial and fibular physeal fracture causing popliteal artery injury and peroneal nerve injury: A case report and review of literature显示文摘 | Uday Guled Nirmal Raj Gopinathan Vijay G. Goni Arjun Rhh Rakesh John Prateek Behera | 2015 | Chinese Journal of Traumatology2015，18，4： | 2 |
| 20 | Resection for Esophageal Cancer: Strategies for Optimal Management显示文摘 | Arjun Pennathur James D. Luketich | 2008 | The Annals of Thoracic Surgery2008，，2： | 2 |
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