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| 1 | 以食物为基础的膳食模式与慢性疾病预防显示文摘Matthias B Schulze及其同事讨论了目前已知的膳食模式与癌症、冠心病、卒中及2型糖尿病的关联,重点在仍不确定的领域和未来的研究方向。 | Matthias B Schulze Miguel A Martínez-González Teresa T Fung Alice H Lichtenstein Nita G Forouhi 陈夏燕(译) 王燕芳(译) 武阳丰(校) | 2021 | 英国医学杂志中文版2021，24，3： | 3 |
| 2 | 新加坡成人慢性呼吸系统疾病患者6分钟步行距离的最小临床重要差异值研究(英文)显示文摘目的:6 min步行距离(6MWD)是临床上常见的功能性运动能力测试,特别是对于慢性呼吸系统疾病患者。一些文献记载了关于白种人的6MWD的最小临床重要差异(MCID),但对亚洲人群的相关信息未见记载。本研究旨在建立亚洲成人慢性呼吸道疾病患者6MWD的最小临床重要差异。方法:采用'锚定'法和'分布'法对新加坡中央医院肺康复计划登记处的资料进行了分析。'锚定'法收集确诊为慢性呼吸道疾病的患者50例,其中男38例,女12例;平均年龄(64.2±12.3)岁,通过电话采访及使用整体变化评估量表(GROC)评价患者肺康复计划后的自觉改善程度,再将患者在肺康复计划中6MWD的改变数值与相对应的患者自觉改善程度进行比较,这种关系用操作特征曲线(ROC)统计表示。通过'分布'法确定6MWD的MCID,从门诊和住院的肺康复计划(PRP)参与者中检索医疗记录136例,其中男103例,女33例;平均年龄(60.1±14.1)岁。结果 :ROC曲线表明6MWD出现临床显著性变化的最佳临界值为17.4 m,其对应的敏感性为79.4%,特异性为81.3%,阳性似然比为4.23。由'分布'法确定6MWD的最小临床重要差异值为18.6 m。结论:18.6 m为新加坡华人6MWD的最小临床重要差异的估计值。 | Meredith T L YEUNG Alan W P WONG Katherine S L HUANG Alice Y M JONES | 2015 | 康复学报2015，25，1： | 3 |
| 3 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 4 | Innovative Metallized Formulations for Solid Rocket Propulsion显示文摘Several metallized solid rocket propellants,AP/Metal/HTPB in the ratio 68/18/14,were experimentally analyzed at the Space Propulsion Laboratory of Politecnico di Milano.Effects of the metals(micrometric and nanometric Al,B,Mg,and a variety of dual metals) on the performance of the propellant were studied and contrasted to a conventional micrometric aluminum(30 μm average grain size) taken as reference.It is shown that the propellant microstructure plays a fundamental role in controlling the critical aggregation/agglomeration phenomena occurring below and near the burning surface.Two specific effects of microstructure in terms of steady burning rate and average agglomerate size are illustrated. | Luigi T DeLUCA Luciano GALFETTI Filippo MAGGI Giovanni COLOMBO Alice REINA Stefano DOSSI Daniele CONSONNI Melissa BRAMBILLA | 2012 | 含能材料2012，20，4： | 3 |
| 5 | Development of a platform tech-nology to generate long-acting protein therapeutics显示文摘 | Heather P Alice T Ian W | 2012 | EndocriAbstr2012，289，2： | 1 |
| 6 | Multicenter random- ized phase lI clinical trial comparing neoadjuvant oxalipla- tin, capecitabine, and preoperative radiotherapy with or without cetuximab followed by total mesorectal excision in patients with high-risk rectal cancer (EXPERT-C)显示文摘 | Alice D David C Josep T | 2012 | J Clin Oncol2012，30，14： | 1 |
| 7 | Changes in soluble nitrogenous compounds, caseins and free amino acids during ripening of artisanal prato cheese: a Brazilian semi-hard cows variety显示文摘 | Gorostiza A Alexandre J C Alice T V | 2004 | Food Chemistry2004，85，3： | 1 |
| 8 | Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis显示文摘 | Alice T Shaw Beow Y Yeap Benjamin J Solomon Gregory J Riely Justin Gainor Jeffrey A Engelman Geoffrey I Shapiro Daniel B Costa Sai-Hong I Ou Mohit Butaney Ravi Salgia Robert G Maki Marileila Varella-Garcia Robert C Doebele Yung-Jue Bang Kimary Kulig Pauli | 2011 | Lancet Oncology2011，，11： | 1 |
| 9 | Non-aqueous chromium acetylacetonate electrolyte for redox flow batteries显示文摘 | Liu Qinghua Shinkle Aaron A Li Yongdan Monroe Charles W Thompson Levi T Sleightholme Alice E S | 2010 | Electrochemistry Communications2010，12，11： | 1 |
| 10 | Therapeutic use of interleukin-2 in HIV- infected patients 显示文摘 | Alice K P Jorge A T | 2002 | Current Opinion In Pharmacology2002，2，： | 1 |
| 11 | Non-aqueous manganese acetylacetonate electrolyte for redox flow batteries显示文摘 | Sleightholme Alice E S Shinkle Aaron A Liu Qinghua Li Yongdan Monroe Charles W Thompson Levi T | 2011 | Journal of Power Sources2011，196，13： | 1 |
| 12 | Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis显示文摘 | Alice T Shaw Beow Y Yeap Benjamin J Solomon Gregory J Riely Justin Gainor Jeffrey A Engelman Geoffrey I Shapiro Daniel B Costa Sai-Hong I Ou Mohit Butaney Ravi Salgia Robert G Maki Marileila Varella-Garcia Robert C Doebele Yung-Jue Bang Kimary Kulig Pauli | 2011 | Lancet Oncology2011，，11： | 1 |
| 13 | Recreation carrying capacity estimations to support beach management at Praia de Faro, Portugal 显示文摘 | DANIEL A Z ALLAN T W ALICE N | 2011 | Applied Geography2011，31，3： | 1 |
| 14 | Use of nuclear mutants in the analysis of chloroplast development 显示文摘 | William C T Alice B Robert A M | 1987 | Dev Genet1987，8，： | 1 |
| 15 | Activation of p70S6K induces expression of matrix metalloproteinase 9 associated with hepatocyte growth factor-mediated invasion in Human ovarian cancer cells显示文摘 | Alice S Wong T | 2006 | Endocrinology2006，147，： | 1 |
| 16 | The hyperglycemia and adverse pregnancy outcome study:Associations of GDMand obesity with pregnancy outcomes显示文摘 | Mari S G Casey E H Alice F T | 2012 | Diabetes Care2012，35，4： | 1 |
| 17 | Impact of thrombolysis, intra-aortic balloon pump counterpulsation, and their combination in cardiogenic shock complicating acute myocardial infarction: a report from the SHOCK Trial Registry显示文摘 | Timothy A Sanborn Lynn A Sleeper Eric R Bates Alice K Jacobs Jean Boland John K French Jo Dens Vladimir Dzavik Sebastian T Palmeri John G Webb Mark Goldberger Judith S Hochman | 2000 | Journal of the American College of Cardiology2000，，： | 1 |
| 18 | Use of nuclear mutants in the analysis of chloroplast development显示文摘 | WILLIAM C T ALICE B ROBERT A M | 1987 | Development Genetics1987，8，： | 1 |
| 19 | Development of a platform technologyto generate long-acting protein therapeutics显示文摘 | Heather P Alice T Ian W | 2012 | Endocrine Abstracts2012，28，2： | 1 |
| 20 | Gonadal hormone levels in injection drug users显示文摘 | WAHLSTROM JT ALICE T JOSEPH C | 2000 | Drug and Alcohol Dependence2000，60，： | 1 |
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