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| 1 | High-energy Metal Fuels for Rocket Propulsion: Characterization and Performance显示文摘A joint international effort to improve solid propellant performance within the framework of a FP7European Project was described.Several metallized solid rocket propellants,of the broad family AP/HTPB/Metal in the ratio 68/14/18,were experimentally analyzed seeking to optimize the delivered specific impulse by identifying the most suitable high-energy fuel.Keeping the same nominal composition,different metallic fuels(including micrometric and nanometric Al,AlH3,and a variety of dual metal compositions)were characterized,tested,and contrasted to a conventional micrometric aluminum(30μm average grain size)certified for space flights.In order to overcome the intrinsic performance limitations of the matrix AP/HTPB,a new matrix consisting of ADN/GAP satisfying also the need for environmentally benign propellant formulation was considered as well.A comparative analysis between the two solid propellant systems in terms of ideal thermochemistry and experimental combustion properties reveals advantages and disadvantages of both.Overall,it is judged worthwhile to develop ADN/GAP propellants,with or without metallic fuels,to enhance the current status of solid rocket propulsion.Controlling morphology and mechanical properties of ADN/GAP compositions and understanding their flame structure and aggregation/agglomeration properties are the main issues still challenging industrial users. | Luigi T. DELUCA Filippo MAGGI Stefano DOSSI Volker WEISER Andrea FRANZIN Volker GETTWERT Thomas HEINTZ | 2013 | 火炸药学报2013，36，6： | 11 |
| 2 | Role of MGMT as biomarker in colorectal cancer显示文摘O6-methylguanine DNA methyltransferase(MGMT) gene promoter methylation plays an important role in colorectal carcinogenesis, occurring in about 30%-40% of metastatic colorectal cancer. Its prognostic role has not been defined yet, but loss of expression of MGMT, which is secondary to gene promoter methylation, results in an interesting high response to alkylating agents such as dacarbazine and temozolomide. In a phase 2 study on heavily pre-treated patients with MGMT methylated metastatic colorectal cancer, temozolomide achieved about 30% of disease control rate. Activating mutations of RAS or BRAF genes as well as mismatch repair deficiency may represent mechanisms of resistance to alkylating agents, but a dose-dense schedule of temozolomide may potentially restore sensitivity in RAS-mutant patients. Further development of temozolomide in MGMT methylated colorectal cancer includes investigation of synergic combinations with other agents such as fluoropyrimidines and research for additional biomarkers, in order to better define the role of temozolomide in the treatment of individual patients. | Alessandro Inno Giuseppe Fanetti Maria Di Bartolomeo Stefania Gori Claudia Maggi Massimo Cirillo Roberto Iacovelli Federico Nichetti Antonia Martinetti Filippo de Braud Ilaria Bossi Filippo Pietrantonio | 2014 | World Journal of Clinical Cases2014，2，12： | 10 |
| 3 | Innovative Metallized Formulations for Solid Rocket Propulsion显示文摘Several metallized solid rocket propellants,AP/Metal/HTPB in the ratio 68/18/14,were experimentally analyzed at the Space Propulsion Laboratory of Politecnico di Milano.Effects of the metals(micrometric and nanometric Al,B,Mg,and a variety of dual metals) on the performance of the propellant were studied and contrasted to a conventional micrometric aluminum(30 μm average grain size) taken as reference.It is shown that the propellant microstructure plays a fundamental role in controlling the critical aggregation/agglomeration phenomena occurring below and near the burning surface.Two specific effects of microstructure in terms of steady burning rate and average agglomerate size are illustrated. | Luigi T DeLUCA Luciano GALFETTI Filippo MAGGI Giovanni COLOMBO Alice REINA Stefano DOSSI Daniele CONSONNI Melissa BRAMBILLA | 2012 | 含能材料2012，20，4： | 3 |
| 4 | Effects of treatment with St. John’s Wort on blood glucose levels and pain perceptions of streptozotocin-diabetic rats显示文摘 | ?zgür Devrim Can Yusuf ?ztürk Nilgün ?ztürk Gianni Sagratini Massimo Ricciutelli Sauro Vittori Filippo Maggi | 2011 | Fitoterapia2011，，4： | 1 |
| 5 | Theoretical analysis of hydrides in solid and hybrid rocketpropulsion显示文摘 | Filippo Maggi Gabriela Gariani Luciano GaKetti | 2012 | International Journal of Hydrogen Energy2012，37，： | 1 |
| 6 | Essential‐Oil Polymorphism in the ‘Resurrection Plant’ Myrothamnus moschatus and Associated Ethnobotanical Knowledge显示文摘 | Emmanuel Randrianarivo Philippe Rasoanaivo Marcello Nicoletti Solofoniaina Razafimahefa Manon Lefebvre Fabrizio Papa Sauro Vittori Filippo Maggi | 2013 | Chemistry & Biodiversity2013，，11： | 1 |
| 7 | Phytochemical investigation of the essential oil from the ‘resurrection plant’ Myrothamnus moschatus (Baillon) Niedenzu endemic to Madagascar显示文摘 | Philippe Rasoanaivo Ermenegilde Ralaibia Filippo Maggi Fabrizio Papa Sauro Vittori Marcello Nicoletti | 2012 | Journal of Essential Oil Research2012，，3： | 1 |
| 8 | Evaluation of the anticonvulsant activity of the essential oil of Myrothamnus moschatus in convulsion induced by pentylenetetrazole and picrotoxin显示文摘Objective: To evaluate the anticonvulsant effect of the essential oil of Myrothamnus moschatus(M. moschatus) in convulsion induced by pentylenetetrazole and picrotoxin in rodent models.Methods: The essential oil of the aerial parts of M. moschatus was extracted by steam distillation. Thereafter, it was injected subcutaneously to rats and mice at escalating doses(0.1–0.8 m L/kg). Ten minutes after drug injection, pentylenetetrazole was injected intraperitoneally to rats and picrotoxin was administered to mice by the same route.Diazepam served as the positive control. Every single animal was placed into transparent cage and observed for convulsive behavior for 30 min by using ordinary security cameras connected to a video recorder. Death occurring for a period of 24 h was also recorded.Results: The essential oil at 0.8 m L/kg completely arrested the pentylenetetrazole-induced convulsion without any sedative effect and delayed its appearance at lower doses, but showed moderate activities on picrotoxin-induced convulsion. For the rats treated with pentylenetetrazole alone, the mortality was 100% within 1 h, but for the rats pre-treated with the essential oil, the mortality was 0%. For the mice treated with picrotoxin, the mortality rate was also 100%, while 20%–100% died in those that had been pre-treated with the oil.Conclusions: The results confirmed at least partly the traditional uses of the smoke of M. moschatus for the management of convulsion, and implied that the essential oil may inhibit the convulsion by GABAergic neuromodulation. | Emmanuel Randrianarivo Filippo Maggi Marcello Nicoletti Philippe Rasoanaivo | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，6： | 0 |
| 9 | Evaluation of the chemical constituents,antioxidant and enzyme inhibitory activities of six Yemeni green coffee beans varieties显示文摘Coffee arabica L.is an economical crop cultivated in many countries including Yemen.The present study evaluated the phytochemical contents of the methanolic extracts,prepared by maceration,of six Yemeni green coffee beans varieties namely Esmaeli,Hamadi,Harazi,Mattari,Odaini and Yafei.Antioxidant(phosphomolybdenum,antiradical,reducing power and ferrous chelating),and enzyme inhibition activity of the extracts against acetylcholinesterase butyrylcholinesterase,tyrosinase,α-glucosidase,andα-amylase were also studied.Quantification of total phenols revealed that all green beans varieties were richer in their total polyphenolic(63.77-110.98 mg gallic acid equivalent per g of extract)content than their flavonoids one(2.86-5.57 mg rutin equivalent per g of extract).HPLC-MS/MS analysis of 30 selected bioactive compounds showed that all varieties had the same types of phytoconstituents with differences in their relative abundance.Caffeine(1613.89-2466.38μg/g)followed by 5-caffeoylquinic acid(1017.63-1313.39μg/g)were the dominant compounds in all varieties with caffeine more abundant in Esmaeli variety while 5-caffeoylquinic acid in Odaini variety.All varieties displayed a pronounced antioxidant property in all the in vitro assays with Odaini variety significantly(p<0.05)exerted the highest anti-DPPH radicals(253.96 mg Trolox equivalent(TE)/g),metal chelating(19.73 mg Disodium edetate equivalents/g),Cu^(2+)(441.11 mg TE/g)and Fe3+(221.04 mg TE/g)reducing activities.Furthermore,the majority of green coffee beans varieties showed comparable enzyme inhibition property with highest activity recorded against tyrosinase(39.35-46.96 mg kojic acid equivalents/g)and acetylcholinesterase(1.80-2.17 mg galanthamine equivalents/g)enzymes.In conclusion,all Yemeni green coffee beans varieties have proven to be rich source of biochemicals with beneficial impact on human health and could be of significant applications in food,pharmaceutical and cosmetics industry. | Ammar Mohammed Ahmed Ali Sakina Yagi Ahmed A.Qahtan Abdurrahman A.Alatar Simone Angeloni Filippo Maggi Giovanni Caprioli Eslam M.Abdel-Salam Kouadio Ibrahime Sinan Gokhan Zengin | 2022 | Food Bioscience2022，46，2： | 0 |
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