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| 1 | Silencing NOA1 Elevates Herbivory-Induced Jasmonic Acid Accumulation and Compromises Most of the Carbon-Based Defense Metabolites in Nicotiana attenuata显示文摘Nitric oxide-associated protein 1 (NOA1) is involved in various abiotic stress responses and is required for plant resistance to pathogen infections. However, the role of NOA1 in plant-herbivore interactions has not been explored. We created NOA1-silenced Nicotiana attenuata plants (irNaNOA1). Compared with wild-type (WT) plants, irNaNOA1 plants had highly decreased photosynthesis rates. We further examined various traits important for plant defense against its specialist herbivore Manduca sexta by treating WT and irNaNOA1 plants with mechanical wounding and M. sexta oral secretions (OS). NOA1-silenced plants showed elevated levels of herbivory-induced jasmonic acid (JA), but decreased JA-isoleucine conjugate (JA-Ile) levels. The decreased JA-Ile levels did not result from compromised JAR (jasmonic acid resistant) activity in irNOA1 plants. Moreover, nitrogen-rich defensive compounds, nicotine and trypsin proteinase inhibitors, did not differ between WT and irNaNOA1 plants. In contrast, concentrations of most carbon-based defensive compounds were lower in these plants than in WT plants, although the levels of chlorogenic acid were not changed. Therefore, silencing NOA1 alters the allocation of carbon resources within the phenylpropanoid pathway. These data suggest the involvement of NOA1 in N. attenuata's defense against M. sexta attack, and highlight its role in photosynthesis, and biosynthesis of jasmonates and secondary metabolites. | Hendrik Wünsche Ian T. Baldwin | 2011 | Journal of Integrative Plant Biology2011，53，8： | 6 |
| 2 | Multidisciplinary management of nonfunctional neuroendocrine tumor of the pancreas显示文摘Pancreatic neuroendocrine tumors(PNETs) are a rare and diverse group of tumors; nonfunctional(NF) PNETs account for the majority of cases. Most patients with NF-PNETs have metastatic disease at the time of presentation. A variety of treatment modalities exist, including medical, liver directed, and surgical treatments. Aggressive surgical management is associated with prolonged survival, however available data are limited by selection bias and the frequent combination of PNETs with carcinoid tumors. Although few patients with metastatic disease will be cured, application of currently available therapies in a multidisciplinary setting can lead to excellent outcomes with prolonged patient survival. | Ian W Folkert Paul Hernandez Robert E Roses | 2016 | World Journal of Gastroenterology2016，22，11： | 6 |
| 3 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 4 | Factor analysis identifies subgroups of constipation显示文摘AIM:To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic dysfunction.METHODS:One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item,wide-ranging selfreport questionnaire.One hundred of these patients had colonic transit measured scintigraphically.Factor analysis determined whether constipation-related symptoms grouped into distinct aspects of symptomatology.Cluster analysis was used to determine whether indi-vidual patients naturally group into distinct subtypes.RESULTS:Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main descriptors.Amongst all clusters there was a considerable proportion of patients with demonstrable delayed colon transit,irritable bowel syndrome positive criteria and regular stool frequency.The majority of patients with these characteristics also reported regular laxative use.CONCLUSION:Factor analysis identified four constipation subgroups,based on severity and laxative unresponsiveness,in a constipated population.However,clear stratification into clinically identifiable groups remains imprecise. | Philip G Dinning Mike Jones Linda Hunt Sergio E Fuentealba Jamshid Kalanter Denis W King David Z Lubowski Nicholas J Talley Ian J Cook | 2011 | World Journal of Gastroenterology2011，17，11： | 3 |
| 5 | Holocene moisture evolution in arid central Asia and its out-of-phase relationship with Asian monsoon history显示文摘 | Fahu Chen Zicheng Yu Meilin Yang Emi Ito Sumin Wang David B. Madsen Xiaozhong Huang Yan Zhao Tomonori Sato H. John B. Birks Ian Boomer Jianhui Chen Chengbang An Bernd Wünnemann | 2007 | Quaternary Science Reviews2007，，3： | 2 |
| 6 | Holocene moisture evolution in arid central Asia and its out-of-phase relationship with Asian monsoon history显示文摘 | Fahu Chen Zicheng Yu Meilin Yang Emi Ito Sumin Wang David B. Madsen Xiaozhong Huang Yan Zhao Tomonori Sato H. John B. Birks Ian Boomer Jianhui Chen Chengbang An Bernd Wünnemann | 2007 | Quaternary Science Reviews2007，，3： | 2 |
| 7 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 8 | Using on-site liver 3-D reconstruction and volumetric calculations in split liver transplantation显示文摘BACKGROUND: Split liver transplantation increases the number of grafts available for transplantation. Pre-recovery assessment of liver graft volume is essential for selecting suitable recipients. The purpose of this study was to determine the ability and feasibility of constructing a 3-D model to aid in surgical planning and to predict graft weight prior to an in situ division of the donor liver. METHODS: Over 11 months, 3-D volumetric reconstruction of 4 deceased donors was performed using Pathfinder Scout~? liver volumetric software. Demographic, laboratory, operative, perioperative and survival data for these patients along with donor demographic data were collected prospectively and analyzed retrospectively.RESULTS: The average predicted weight of the grafts from the adult donors obtained from an in situ split procedure were 1130 g(930-1458 g) for the extended right lobe donors and 312 g(222-396 g) for left lateral segment grafts. Actual adult graft weight was 92% of the predicted weight for both the extended right grafts and the left lateral segment grafts. The predicted and actual graft weights for the pediatric donors were 176 g and 210 g for the left lateral segment grafts and 308 g and 280 g for the extended right lobe grafts, respectively. All grafts were transplanted except for the right lobe from the pediatric donors due to the small graft weight.CONCLUSIONS: On-site volumetric assessment of donors provides useful information for the planning of an in situ split and for selection of recipients. This information may expand the donor pool to recipients previously felt to be unsuitable due to donor and/or recipient weight. | Trevor W Reichman Brittany Fiorello Ian Carmody Humberto Bohorquez Ari Cohen John Seal David Bruce George E Loss | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，6： | 2 |
| 9 | Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort显示文摘 | Ian Jacobs Aleksandra Gentry-Maharaj Matthew Burnell Ranjit Manchanda Naveena Singh Aarti Sharma Andy Ryan Mourad W Seif Nazar N Amso Gillian Turner Carol Brunell Gwendolen Fletcher Rani Rangar Kathy Ford Keith Godfrey Alberto Lopes David Oram Jonathan He | 2011 | Lancet Oncology2011，，1： | 2 |
| 10 | Novel and established applications of microbial polysaccharides显示文摘 | IAN W | 1998 | Trends Biotechnol1998，16，1： | 1 |
| 11 | Development of a platform tech-nology to generate long-acting protein therapeutics显示文摘 | Heather P Alice T Ian W | 2012 | EndocriAbstr2012，289，2： | 1 |
| 12 | The biofilm matrix-an immobilized but dynamic microbi- al environment 显示文摘 | Ian W | 2001 | Trends Microbiol2001，9，5： | 1 |
| 13 | Cole Novel Approach of Medialization Thyroplasty with Arytenoid Adduction Performed under General Anesthesia with a Laryngeal Mask显示文摘 | Nicholas W Stow Jennifer W.Lee Ian E | | 0，，02： | 1 |
| 14 | Maximum likelihood estimation of K distribution paremeters for SAR data显示文摘 | Ian R J Donald B P Dale P W | 1993 | IEEE Transactions on Geoscience and Remote Sensing1993，31，5： | 1 |
| 15 | Rapid swelling and deswelling of thermo reversible hydrophobieally modified poly(N-isopropylacrylamide) hydrogels prepared by freezing polymerisation 显示文摘 | Xue Wei Ian W Hamley Malcolm B Huglin | 2002 | Polymer2002，43，19： | 1 |
| 16 | The synthesis of bottom-up and top-down approaches to climate policy modeling:electricity power technology details in a social accounting framework显示文摘 | Ian S W | 2008 | Energy Economics2008，，30： | 1 |
| 17 | Innovations in vapor-absorption cycles显示文摘 | Shenyi Wu Eames Ian W | 2000 | Applied Energy2000，，66： | 1 |
| 18 | A practical synthesis of a COX-2 specific inhibitor 显示文摘 | Ian W D Jean-Francois M Edward G | 2000 | J Org Chem2000，65，： | 1 |
| 19 | Fire resistance of composite floors subject to compartment fires显示文摘 | Zhaohui Huang Ian W Burgess Roger J Plank | 2003 | Journal of Constructional Steel Research2003，，2： | 1 |
| 20 | A two-dimensional orthotropic model for simulating wood drying processes显示文摘 | Ian W Turner | 1996 | Applied Mathematical Modelling1996，20，1： | 1 |
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