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| 1 | 颅内出血患者抗栓药逆转指南美国神经重症监护学会和美国重症医学会对医疗卫生专业人员的声明显示文摘背景抗栓药的使用,包括抗凝药、抗血小板药和溶栓药,在过去10年中日益增多并且预计将继续上升。虽然抗栓药相关性颅内出血可能是灾难性的,但快速逆转凝血功能障碍可能有助于限制血肿增大和改善转归。方法美国神经重症监护学会联合美国重症医学会组建了一个国际性多机构委员会,涉及的专业领域包括神经重症监护、神经内科、神经外科、卒中、血液学、血液病理学、急诊医学、药学、护理和指南制定,目的是进行文献评价并制定一份循证实践指南。该委员会进行了正式的文献检索,并对符合标准的研究进行了评价。结果利用GRADE方法学,委员会提出了在颅内出血情况下逆转维生素K拮抗药、直接Xa因子拮抗药、直接凝血酶抑制药、普通肝素、低分子肝素、类肝素、戊多糖、溶栓药和抗血小板药的推荐意见。结论该指南提供了及时和循证的抗栓药逆转策略以协助临床医生治疗抗栓药相关性颅内出血。 | Jennifer A. Frontera John J. Lewin Ⅲ Alejandro A. Rabinstein Imo P. Aisiku Anne W. Alexandrov Aaron M. Cook Gregory J. del Zoppo Monisha A. Kumar Ellinor I. B. Peerschke Michael F. Stiefel Jeanne S Teitelbaum Katja E. Wartenberg Cindy L. Zerfoss 杨一萍 谢丽丽 宁小金 季宇腾 柯开富 | 2016 | 国际脑血管病杂志2016，24，11： | 24 |
| 2 | Heteromeric and Homomeric Geranyl Diphosphate Synthases from Catharanthus roseus and Their Role in Monoterpene Indole Alkaloid Biosynthesis显示文摘Catharanthus roseus 是二很重要的 monoterpene 吲哚碱(MIA ) 的唯一的来源反癌症代理人:vinblastine 和长春新碱。MIA 拥有萜烯和分别地从 terpenoid 和 shikimate 小径导出的吲哚一半。Geranyl diphosphate (GPP ) ,入口点到萜烯一半的形成,由 GPP synthase (GPPS ) 是 isopentenyl diphosphate (IPP ) 和 dimethylallyl diphosphate (DMAPP ) 的冷凝作用的一个产品。这里,我们报导与顺序类似编码蛋白质到大子单元(CrGPPS.LSU ) 和 heteromeric GPPS,和 homomeric 的小子单元(CrGPPS.SSU ) 的三基因 GPPS。CrGPPS.LSU 是生产 GPP 和 geranyl geranyl diphosphate (GGPP ) 的 bifunctional 酶, CrGPPS.SSU 是不活跃的,而 CrGPPS 是形成 GPP 的 homomeric 酶。在 Escherichia coli 的两个子单元的合作表示与生产仅仅 GPP 的提高的活动导致了 heteromeric 酶。当 CrGPPS.LSU 和 CrGPPS 在更旧、更年轻的叶子显示出更高的表示时,分别地, CrGPPS.SSU 显示出一个增加的趋势并且逐渐地减少了。叶子的甲基 jasmonate (MeJA ) 处理显著地导致了仅仅 CrGPPS.SSU 的表示。而 CrGPPS 是 mitochondrial, GFP 本地化显示 CrGPPS.SSU 是 plastidial。在 C 的 AmGPPS.SSU 的短暂 overexpression。roseus 叶子导致了增加的 vindoline, vinblastine 和长春新碱的立即的 monomeric 先锋。尽管 C。roseus 有 heteromeric 和 homomeric GPPS 酶,我们的结果含有有为 MIA 生合成调整 GPP 流动的 CrGPPS.SSU 的仅仅 heteromeric GPPS 的参与。 | Avanish Rai Shachi S. Smita Anup Kumar Singh Karuna Shanker Dinesh A. Nagegowda | 2013 | Molecular Plant2013，6，5： | 20 |
| 3 | 18F-FDGPET/CT对局部进展性乳腺癌病人新辅助化疗早期反应的评价作用显示文摘我们评估^18F—FDG PET/CT对于乳腺癌病人新辅助化疗(NACT)2个周期后反应的评价作用。23例女性局部进展性乳腺癌病人纳入本研究。NACT2个周期后,根据临床检查、CT和^18F—FDG PET/CT评价早期反应。以NACT6个周期后手术病理结果作为参照。治疗前PET/CT显示23例病人共有26个病灶。原发性肿瘤大小为1.90~11.60cm,FDG最大标准摄取值(SUVmax)为3.6~38.6(平均11.7)。NACT2个周期后行PET/CT检查,原发性肿瘤大小为0.0—7.6cm, | A. Kumar R. Kumar V. Seenu S.D. Gupta M. Chawla A. Malhotra 范璐(译) 刘筠(校) | 2009 | 国际医学放射学杂志2009，32，4： | 18 |
| 4 | Recovery of metals and other beneficial products from coal fly ash: a sustainable approach for fly ash management显示文摘 | Prafulla Kumar Sahoo Kangjoo Kim M. A. Powell Sk Md Equeenuddin | 2016 | International Journal of Coal Science & Technology2016，3，3： | 8 |
| 5 | Myosin XI Is Required for Actin-Associated Movement of Plastid Stromules显示文摘Stromules 是从质体和偶尔相连的单个质体的表面延长的高度有活力的充满基质的小管,允许在互连的质体之间的复杂生物分子的运动。有细胞骨架汇编的禁止者的实验在 stromule 运动显示了一个基于肌动朊的系统的参与。然而,与系统联系的马达蛋白质没被识别。这里,我们肌浆球蛋白 XI 在烟草涉及 stromules 的形成和运动的现在的直接证据离开。2,3-butanedione 2-monoxime 的申请,肌浆球蛋白 ATPase 活动的一个禁止者,从烟草叶导致了 stromules 的损失表皮的细胞。在 Nicotiana benthamiana 的叶子的肌浆球蛋白 XI 的短暂 RNA 干扰也从表皮的房间导致了 stromules 的损失,没有为肌动朊或肌浆球蛋白 VIII 的抄本上的任何效果。在烟草叶的一个标注 GFP 的肌浆球蛋白 XI 尾巴领域的短暂表示表皮的房间证明对叶绿体,以及到线粒体和其它局部性的熔化蛋白质包细胞器。我们的调查结果作为涉及 stromules 的形成和运动的关键蛋白质识别肌浆球蛋白 XI。 | Senthil Kumar A. Natesan James A. Sullivan John C. Gray | 2009 | Molecular Plant2009，2，6： | 6 |
| 6 | Flavonoids and ROS Play Opposing Roles in Mediating Pollination in Ornamental Kale (Brassica oleracea var. acephala)显示文摘 | Xingguo Lan Jia Yang Kumar Abhinandan Yuzhe Nie Xiaoyu Li Yuhua Li Marcus A. Samuel | 2017 | Molecular Plant2017，10，10： | 5 |
| 7 | Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)显示文摘 | Shiv Kumar Sarin Ashish Kumar John A. Almeida Yogesh Kumar Chawla Sheung Tat Fan Hitendra Garg H. Janaka Silva Saeed Sadiq Hamid Rajiv Jalan Piyawat Komolmit George K. Lau Qing Liu Kaushal Madan Rosmawati Mohamed Qin Ning Salimur Rahman Archana Rastogi St | 2009 | Hepatology International2009，，1： | 4 |
| 8 | Optimization of fused deposition modeling process parameters using a fuzzy inference system coupled with Taguchi philosophy显示文摘 | Saroj Kumar Padhi Ranjeet Kumar Sahu S. S. Mahapatra Harish Chandra Das Anoop Kumar Sood Brundaban Patro A. K. Mondal | 2017 | Advances in Manufacturing2017，5，3： | 4 |
| 9 | A Versatile Phenotyping System and Analytics Platform Reveals Diverse Temporal Responses to Water Availability in Setaria显示文摘Phenotyping 在使用大规模 genomic 数据理解并且改善农业庄稼成为了限制率的步。这里,为控制环境植物生长的系铃羊 Phenotyping 站台和 automatedmultimodal phenotyping 被描述。系统为 1140 植物有能力,它每天通过车站过去记录荧光,在红外线附近、可见的图象。植物计算机视觉(PlantCV ) 作为公开源码被开发,硬件为量的图象分析的与平台无关的软件。在一个 4 星期的实验,野 Setaria viridisand 驯养了 Setaria italica 有根本上不同的时间的回答浇可获得性。当两根线在有限的水条件下面生产了生物资源的类似的层次时, Setaria viridis 在水下面维持了一样的水使用效率饱满条件,当 Setaria italica 变了到不太有效的生长时。总的来说,系铃羊 Phenotyping 平台和 PlantCV 软件在高度,生物资源,水使用效率,颜色,植物建筑学,和织物水上检测了 genotypeand 环境的重要效果地位特点。在实验的功课期间获得的所有 ∼79000 图象是公开可得到的。 | Noah Fahlgren Maximilian Feldman Malia A. Gehan Melinda S. Wilson Christine Shyu Douglas W. Bryant Steven T. Hill Colton J. McEntee ankalpi N. Warnasooriya Indrajit Kumar Tracy Ficor Stephanie Turnipseed Kerrigan B. Gilbert Thomas P. Brutnell James C. Carrington Todd C. Mockler Ivan Baxter | 2015 | Molecular Plant2015，8，10： | 4 |
| 10 | )plication of geo-microbial prospecting method for finding oil and gas reservoirs显示文摘 | M. A. Rasheed Syed Zaheer Hasan P. L. Srinivasa Rao Annapurna Boruah V.Sudarshan B. Kumar T. Harinarayana | 2015 | Frontiers of Earth Science2015，9，1： | 3 |
| 11 | Soil Aggregates, Organic Matter, and Labile C and N Fractions after 37 Years of N, P and K Applications to an Irrigated Subtropical Soil under Maize-Wheat Rotation显示文摘 | S. Kumar M. S. Aulakh A. K. Garg | 2011 | Journal of Agricultural Science and Technology(A)2011，1，2X： | 3 |
| 12 | Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL)显示文摘 | Gamal Shiha Shiv Kumar Sarin Alaa Eldin Ibrahim Masao Omata Ashish Kumar Laurentius A. Lesmana Nancy Leung Nurdan Tozun Saeed Hamid Wasim Jafri Hitoshi Maruyama Pierre Bedossa Massimo Pinzani Yogesh Chawla Gamal Esmat Wahed Doss Taher Elzanaty Puja Sakhuj | 2009 | Hepatology International2009，，2： | 2 |
| 13 | Management of Newly Diagnosed Symptomatic Multiple Myeloma: Updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines 2013显示文摘 | Joseph R. Mikhael David Dingli Vivek Roy Craig B. Reeder Francis K. Buadi Suzanne R. Hayman Angela Dispenzieri Rafael Fonseca Taimur Sher Robert A. Kyle Yi Lin Stephen J. Russell Shaji Kumar P. Leif Bergsagel Steven R. Zeldenrust Nelson Leung Matthew T. D | 2013 | Mayo Clinic Proceedings2013，，4： | 2 |
| 14 | Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper显示文摘 | Matthias G. Friedrich Udo Sechtem Jeanette Schulz-Menger Godtfred Holmvang Pauline Alakija Leslie T. Cooper James A. White Hassan Abdel-Aty Matthias Gutberlet Sanjay Prasad Anthony Aletras Jean-Pierre Laissy Ian Paterson Neil G. Filipchuk Andreas Kumar Ma | 2009 | Journal of the American College of Cardiology2009，，17： | 2 |
| 15 | Thermal Degradation and Decomposition Kinetics of Freeze Dried Cow and Camel Milk as well as Their Constituents显示文摘 | K. V. Sunooj J. George V. A. Sajeev Kumar K. Radhakrishna A. S. Bawa | 2011 | Journal of Food Science and Engineering2011，1，2： | 2 |
| 16 | Modeling the effect of time delay in budget allocation to control an epidemic through awareness显示文摘 | A. K. Misra Rajanish Kumar Rai Yasuhiro Takeuchi | 2018 | International Journal of Biomathematics2018，11，2： | 2 |
| 17 | Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)显示文摘 | Shiv Kumar Sarin Ashish Kumar John A. Almeida Yogesh Kumar Chawla Sheung Tat Fan Hitendra Garg H. Janaka Silva Saeed Sadiq Hamid Rajiv Jalan Piyawat Komolmit George K. Lau Qing Liu Kaushal Madan Rosmawati Mohamed Qin Ning Salimur Rahman Archana Rastogi St | 2009 | Hepatology International2009，，1： | 2 |
| 18 | Effects of N on Plant Response to Heat-wave:A Field Study with Prairie Vegetation显示文摘More intense,more frequent,and longer heat-waves are expected in the future due to global warming,which could have dramatic ecological impacts.Increasing nitrogen (N) availability and its dynamics will likely impact plant responses to heat stress and carbon (C) sequestration in terrestrial ecosystems.This field study examined the effects of N availability on plant response to heat-stress (HS) treatment in naturally-occurring vegetation.HS (5 d at ambient or 40.5 ?C) and N treatments (±N) were applied to 16 1 m2 plots in restored prairie vegetation dominated by Andropogon gerardii (warm-season C4 grass) and Solidago canadensis (warm-season C3 forb).Before,during,and after HS,air,canopy,and soil temperature were monitored; net CO2 assimilation (Pn),quantum yield of photosystem II (PSII),stomatal conductance (gs),and leaf water potential (w) of the dominant species and soil respiration (Rsoil) of each plot were measured daily during HS.One week after HS,plots were harvested,and C% and N% were determined for rhizosphere and bulk soil,and above-ground tissue (green/senescent leaf,stem,and flower).Photosynthetic N-use efficiency (PNUE) and N resorption rate (NRR) were calculated.HS decreased Pn,gs,w,and PNUE for both species,and +N treatment generally increased these variables (±HS),but often slowed their post-HS recovery.Aboveground biomass tended to decrease with HS in both species (and for green leaf mass in S.canadensis),but decrease with +N for A.gerardii and increase with +N for S.canadensis.For A.gerardii,HS tended to decrease N% in green tissues with +N,whereas in S.canadensis,HS increased N% in green leaves.Added N decreased NRR for A.gerardii and HS increased NRR for S.canadensis.These results suggest that heat waves,though transient,could have significant effects on plants,communities,and ecosystem N cycling,and N can influence the effect of heat waves. | Dan Wang Scott A. Heckathorn Kumar Mainali E. William Hamilton | 2008 | Journal of Integrative Plant Biology2008，50，11： | 2 |
| 19 | Development and evaluation of a cloud-gap-filled MODIS daily snow-cover product显示文摘 | Dorothy K. Hall George A. Riggs James L. Foster Sujay V. Kumar | 2009 | Remote Sensing of Environment2009，，3： | 2 |
| 20 | MSH1 Is a Plant Organellar DNA Binding and Thylakoid Protein under Precise Spatial Regulation to Alter Development显示文摘作为新陈代谢的中心,植物细胞器参予维护,防卫,并且发信号。MSH1 是在线粒体和质体涉及 organellar 染色体稳定性的植物特定的蛋白质。MSH1 的质体弄空在开发和 DNA methylation 引起可继承的、非基因的变化。我们从抑制衬里到亚 compartmentalize MSH1 效果的 RNAi 用半互补异种和 transgene 空的 segregants 调查了 msh1 显型。我们证明那 MSH1 表情空间地被调整,明确地在外皮和脉管的实质以内本地化到质体。蛋白质绑 DNA 并且本地化 nucleoids,而是分别和蛋白质蛋白质相互作用数据到质体和 mitochondrial 显示 MSH1 也与 thylakoid 膜联系。在上色,不能生活的压力忍耐,可变生长率,和推迟的成熟的质体 MSH1 弄空结果。从在植物的 7%-10% 的线粒体结果的弄空在叶形态学,热忍耐,和 mitochondrial 染色体稳定性改变了。MSH1 不直接在原子核以内本地化,但是质体弄空在是 MSH1 的可继承的独立人士的 flowering 时间,成熟,和生长率生产非基因的变化。MSH1 弄空在质体和 mitochondrially 改变的线的一个子集改变非光敏的氧化还原作用行为。宫外的表示生产有害效果,加重它的严格的表达式控制。解开 MSH1 效果的复杂性提供卓见进扳机植物特定, transgenerational 改编行为。 | Kamaldeep S. Virdi Yashitola Wamboldt Hardik Kundariya John D. Laurie Ido Keren K.R. Sunil Kumar Anna Block Gilles Basset Steve Luebker Christian Elowsky Philip M. Day Johnna L. Roose Terry M. Bricker Thomas Elthon Sally A. Mackenzie | 2016 | Molecular Plant2016，9，2： | 2 |
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