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| 1 | A deep learning-enabled portable imaging flow cytometer for cost-effective, highthroughput, and label-free analysis of natural water samples显示文摘We report a deep learning-enabled field-portable and cost-effective imaging flow cytometer that automatically captures phase-contrast color images of the contents of a continuously flowing water sample at a throughput of 100 mL/h.The device is based on partially coherent lens-free holographic microscopy and acquires the diffraction patterns of flowing micro-objects inside a microfluidic channel.These holographic diffraction patterns are reconstructed in real time using a deep learning-based phase-recovery and image-reconstruction method to produce a color image of each micro-object without the use of external labeling.Motion blur is eliminated by simultaneously illuminating the sample with red,green,and blue light-emitting diodes that are pulsed.Operated by a laptop computer,this portable device measures 15.5 cm×15 cm×12.5 cm,weighs 1 kg,and compared to standard imaging flow cytometers,it provides extreme reductions of cost,size and weight while also providing a high volumetric throughput over a large object size range.We demonstrated the capabilities of this device by measuring ocean samples at the Los Angeles coastline and obtaining images of its micro-and nanoplankton composition.Furthermore,we measured the concentration of a potentially toxic alga(Pseudo-nitzschia)in six public beaches in Los Angeles and achieved good agreement with measurements conducted by the California Department of Public Health.The cost-effectiveness,compactness,and simplicity of this computational platform might lead to the creation of a network of imaging flow cytometers for largescale and continuous monitoring of the ocean microbiome,including its plankton composition. | Zoltán Gӧrӧcs Miu Tamamitsu Vittorio Bianco Patrick Wolf Shounak Roy Koyoshi Shindo Kyrollos Yanny Yichen Wu Hatice Ceylan Koydemir Yair Rivenson Aydogan Ozcan | 2018 | Light(Science & Applications)2018，7，1： | 14 |
| 2 | Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial显示文摘 | Stephen B Hanauer Brian G Feagan Gary R Lichtenstein Lloyd F Mayer S Schreiber Jean Frederic Colombel Daniel Rachmilewitz Douglas C Wolf Allan Olson Weihang Bao Paul Rutgeerts | 2002 | The Lancet2002，，9317： | 6 |
| 3 | The Protective role of sparse vegetation in wind erosion 显示文摘 | Stephen A Wolfe William G Niekling | 1993 | Progress in Physical Geography1993，17，1： | 2 |
| 4 | A Novel Line Immunoassay Based on Recombinant Virulence Factors Enables Highly Specific and Sensitive Serologic Diagnosis of Helicobacter pylori Infection显示文摘 | Luca Formichella Laura Romberg Christian Bolz Michael Vieth Michael Geppert Gereon G?ttner Christina N?lting Dirk Walter Wolfgang Schepp Arne Schneider Kurt Ulm Petra Wolf Dirk H. Busch Erwin Soutschek Markus Gerhard | 2013 | Clinical and Vaccine Immunology2013，，11： | 2 |
| 5 | Molecular mechanism of diabetic renal hypertrophy显示文摘 | Wolf G Ziyadeh FN | 1999 | Kidney Int1999，56，2： | 2 |
| 6 | Antecedents of organizational slack 显示文摘 | Sharman M P Wolf G Chase R B | 1988 | Academy of Management Review1988，13，4： | 1 |
| 7 | Erkl,2 Phosphorylates p27 (Kipl): functional evidence for a role in high glucose-induced hypertrophy of mesangial cells显示文摘 | Wolf G Reinking R Zahner G | 2003 | Diabetologia2003，46，： | 1 |
| 8 | Anomalous behavior of spectra near phase singularities of focused wave 显示文摘 | Gbur G Visser T D Wolf E | 2002 | Phys Rev Lett2002，88，5： | 1 |
| 9 | Digital Image Fusion of Early and Delayed CT Scans:How to Achieve Optimal Opacification of Vessels and Squamous Cell Carcinomas of the Head and Neck显示文摘 | Groell R Wiltgen M Wolf G | 2002 | AJR2002，178，1： | 1 |
| 10 | Ribosomal protein Lll negatively regulates oncoprotein MDM2 and mediates a p53- dependent ribosomal-stress checkpoint pathway 显示文摘 | Zhang Y 'Wolf G W Bhat K | 2003 | Mol Cell Biol2003，23，23： | 1 |
| 11 | Mdecular mechanisms of diabetic renal hyperophy显示文摘 | Wolf G Ziyadeh FN | 1999 | Kidney Int1999，56，： | 1 |
| 12 | Growth factors and the development of diabetic nephropathy显示文摘 | Wolf G | 2003 | Curr Diab Rep2003，3，6： | 1 |
| 13 | Asymmetrical (ADMA) and symmetrical dimethylarginine (SDMA) as potential risk factors for cardiovascular and renal outcome in chronic kidney disease-possible candidates for paradoxical epidemiology?显示文摘 | Busch M Fleck C Wolf G | 2006 | Amino Acids2006，30，3： | 1 |
| 14 | Bortezmnib therapy alone and in combination with dexamethasone for p reviously untreated symptom-atic multiple myeloma显示文摘 | JAGANNATH S DURIE B G WOLF J | 2005 | Br J Haematol2005，129，6： | 1 |
| 15 | Skin island flaps sup- plied by the vascular axis of the sensitive superficial nerves anatomic study and clinical experience in the leg 显示文摘 | Masquelet AC Romana MC Wolf G | 1992 | Plast Recon Surg1992，89，6： | 1 |
| 16 | Angiotensin Ⅱ stimulates expression of transforming growth factor beta receptor type Ⅱ in cultured mouse proximal tubular cells显示文摘 | Wolf G Ziyadeh FN Stah1 RA | 1999 | J Molmed1999，77，5： | 1 |
| 17 | Leptin stimulates proliferation and TGF β expression in renal glomerular endothelial cells: Potential role in glomeruloselerosis 显示文摘 | Wolf G Hamann A Han D C | 1999 | Kidney Int1999，56，： | 1 |
| 18 | Skin island flaps supplied by the vascular axis of the sensitive superficial nerves:anatomic study and clinical experience in the leg显示文摘 | Masquelet AC Romana MC Wolf G | 1992 | Plast Reconstr Surg1992，89，6： | 1 |
| 19 | Angiotensin Ⅱ is involved in progression of disease importance of non-hemodynamicic mechanisms 显示文摘 | Wolf G | 1998 | Nephrology1998，19，7： | 1 |
| 20 | Three dimensional partial zona dissection for preimplantation genetic diagnosis and assisted hatching 显示文摘 | Cieslak J Ivakhnenko V Wolf G | 1999 | Fertil Steril1999，71，： | 1 |
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