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| 1 | Obstructive jaundice due to hepatobiliary cystadenoma or cystadenocarcinoma显示文摘Hepatobiliary cystadenomas (HBC) and cystadenocarci- nomas are rare cystic lesions. Most patients with these lesions are asymptomatic, but presentation with ob- structive jaundice may occur. The first patient presented with intermittent colicky pain and recurrent obstructive jaundice. Imaging studies revealed a polypoid lesion in the left hepatic duct. The second patient had recurrent jaundice and cholangitis. Endoscopic retrograde cholan- giopancreatography (ERCP) showed a cystic lesion at the confluence of the hepatic duct. In the third patient with intermittent jaundice and cholangitis, cholangioscopy re- vealed a papillomatous structure protruding into the left bile duct system. In the fourth patient with obstructive jaundice, CT-scan showed slight dilatation of the intrahe- patic bile ducts and dilatation of the common bile duct of 3 cm. ERCP showed filling of a cystic lesion. All patients underwent partial liver resection, revealing HBC in the specimen. In the fifth patient presenting with obstructive jaundice, ultrasound examination showed a hyperecho- genic cystic lesion centrally in the liver. The resection specimen revealed a hepatobiliary cystadenocarcinoma. HBC and cystadenocarcinoma may give rise to obstruc- tive jaundice. Evaluation with cross-sectional imaging techniques is useful. ERCP is a useful tool to differentiate extraductal from intraductal obstruction. | Deha Erdogan Olivier RC Busch Erik AJ Rauws Otto M van Delden Dirk J Gouma Thomas M van Gulik | 2006 | World Journal of Gastroenterology2006，12，35： | 26 |
| 2 | Results of percutaneous sclerotherapy and surgical treatment in patients with symptomatic simple liver cysts and polycystic liver disease显示文摘AIM: To evaluate the results of the treatment of simple liver cysts (solitary and multiple) and polycystic liver disease (PLD) using percutaneous sclerotherapy and/or surgical procedures in a single tertiary referral centre. METHODS: Retrospective analysis of 54 patients referred for evaluation and possible treatment of simple liver cysts (solitary and multiple) and PLD, from January 1997 to July 2006. RESULTS: Simple liver cysts were treated in 41 pts (76/) with a mean size of 12.6 cm. The most common reason for referral was abdominal pain or discomfort (85/). Percutaneous sclerotherapy was performed as initial treatment in 30 pts, showing cyst recurrence in 6 pts (20/). Surgical treatment was initially performed in 11 pts with cyst recurrence in 3 pts (27/). PLD was treated in 13 pts (24/) with a mean size of the dominant cyst of 13 cm. Percutaneous sclerotherapy for PLD was performed in 9 pts with recurrence in 7 pts (77.8/). Surgical treatment for PLD was undertaken in 4 pts (30.8/) with recurrence in all. Eventually, 2 pts with PLD in the presence of polycystic kidney disease underwent liver-and kidney transplantation because of deterioration of liver and kidney function. CONCLUSION: The majority of patients with simple liver cysts and PLD are referred for progressive abdominal pain. As initial treatment, percutaneous sclerotherapy is appropriate. Surgical deroofing is indicated in caseof cyst recurrence after percutaneous sclerotherapy. However, the results of percutaneous sclerotherapy and surgical treatment for PLD are disappointing. Partial liver resection is indicated when there is suspicion of a pre-malignant lesion. | Deha Erdogan Otto M van Delden Erik AJ Rauws Olivier RC Busch Johan S Lameris Dirk J Gouma Thomas M van Gulik | 2007 | World Journal of Gastroenterology2007，13，22： | 15 |
| 3 | Functional significance of cell volume regulatory mechanisms显示文摘 | Lang F Busch GL Ritter M | 1998 | Physiol Rev1998，78，1： | 3 |
| 4 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 5 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 6 | Oscillometric twenty-four-hour ambulatory blood pressure values in healthy children and adolescents: a multicenter trial including 1141 subjects显示文摘 | Soergel M Kirsehstein M Busch C Danne T Gellermann J Holl R | 1997 | J Pediatr1997，130，2： | 1 |
| 7 | Asymmetrical (ADMA) and symmetrical dimethylarginine (SDMA) as potential risk factors for cardiovascular and renal outcome in chronic kidney disease-possible candidates for paradoxical epidemiology?显示文摘 | Busch M Fleck C Wolf G | 2006 | Amino Acids2006，30，3： | 1 |
| 8 | CO2-expanded solvents:Unique and versatile media for performing homogeneous catalytic oxidations显示文摘 | WEI M MUSIE G T BUSCH D H SUBRAMANIAM B | 2002 | J Am Chem Soc2002，124，11： | 1 |
| 9 | Molecular approaches to diagnosis of pulmonary diseases due to Mycoplasma pneumoniae显示文摘 | Abele-Horn M Busch U Nitschko H | 1998 | J Clin Microbiol1998，36，2： | 1 |
| 10 | Renal retransplantation:a retrospective monocentric study显示文摘 | Ott U Busch M Steiner T | 2008 | Transplant Proc2008，40，5： | 1 |
| 11 | High expression of precursor microRNA-155/BIC RNA in children with Bnrkitt lymphoma显示文摘 | Metzler M Wilda M Busch K | 2004 | Genes Chromosome Cancer2004，39，2： | 1 |
| 12 | Agenetic framework for floral patterning显示文摘 | Parcy F Nilsson O Busch M A Lee I Weigel D | 1998 | Nature1998，395，： | 1 |
| 13 | Establishment of a Cre/loxP recombination system for N-terminal epitope tag- ging of genes in Tetrahymena显示文摘 | Clara J L Busch M Alexander V | 2010 | Microbiol2010，10，46： | 1 |
| 14 | Risk and predictors of early epileptic seizures in acute cerebral venous and sinus thrombosis显示文摘 | Masuhr F Busch M Amberger N | 2006 | Eur J Neurol2006，13，8： | 1 |
| 15 | ApoE-epsi- lon4 is associated with reduced memory in long-standing intractable temporal lobe epilepsy显示文摘 | BUSCH R M LINEWEAVER T T NAUGLE R I | 2007 | Neurology2007，68，6： | 1 |
| 16 | Nucleic Acid amplification testing of blood donors for transfusion-transmitted infections disease: report of the interorganizational task force on nucleic acid amplification testing of blood donors显示文摘 | BUSCH M P KLEINMAN S H | 2000 | Transfusion2000，40，2： | 1 |
| 17 | Pure oxygen as a contrast medium in human brain tumor MR imaging显示文摘 | Losert C Peller M Schneider P Thoma M Busch M Reiser M | 2001 | Proc Intl Soc Mag Reson Med2001，9，： | 1 |
| 18 | Determination of the carbon nanotube concentration and homogeneity in resin films by THz spectroscopy and imaging显示文摘 | Peters O Busch S F Fischer B M | 2012 | Journal of Infrared Millimeter and Terahertz Waves2012，33，12： | 1 |
| 19 | Primary Gastric B-Cell Lymphoma: Results of a Prospective Multicenter Study显示文摘 | Wolfgang Fischbach* Brigitte Dragosics? Maria-Elisabeth Kolve-Goebeler§ Christian Ohmann∥ Axel Greiner? Qin Yang∥ Stephan B?hm? Patrick Verreet∥ Olaf Horstmann# Martin Busch** Eckhart Dühmke** Hans-Konrad Müller-Hermelink? Klaus Wilms§ | 2000 | Gastroenterology2000，，5： | 1 |
| 20 | DNA binding of Jun and Fos bZip domains:homodimers and heterodimers induce a DNA conformational change in solution显示文摘 | John M Leppik R Busch SJ | | 0，，22： | 1 |
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