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| 1 | 西班牙医学肿瘤学会(SEOM)实体肿瘤骨转移临床指南(2016)显示文摘恶性肿瘤骨转移常见于许多进展性实体肿瘤,尤其以乳腺、前列腺、甲状腺、肺、肾等部位发生的恶性肿瘤最为多见。骨转移将导致骨相关事件(SREs),即发生病理性骨折、脊髓受压、需行骨放疗或骨科手术、伴发高钙血症等情况,患者出现疼痛和功能障碍,生活质量受到负面影响。临床上需要通过几种影像学技术来明确骨转移诊断。骨靶向治疗包括强效双磷酸盐制剂——唑来膦酸和抗核因子κB受体激动剂配体(RANKL)单克隆抗体药物——狄诺塞麦(denosumab),二者均可降低多种类型肿瘤发生SREs的风险或延迟其进展;镭223是一种α粒子发射源,能够提高激素抵抗性前列腺癌骨转移患者的总存活率;必要时需采取包括骨科手术及放射治疗在内的多科协同疗法。西班牙医学肿瘤学会(Sociedad Espa?ola de Oncología Médica,SEOM)发表的这一指南对骨转移的发病机理、临床表现、实验室检查、影像学诊断与疗效评估、骨靶向制剂以及放疗、手术等局部治疗进行综述,在此基础上为骨转移患者的治疗提供推荐性意见。 | Grávalos C Rodríguez C Sabino A 白朝晖 陈旭琼 | 2017 | 中国骨科临床与基础研究杂志2017，9，1： | 10 |
| 2 | Accuracy of Magnetic Resonance Enterography in Assessing Response to Therapy and Mucosal Healing in Patients With Crohn’s Disease显示文摘 | Ingrid Ordás Jordi Rimola Sonia Rodríguez José M. Paredes María J. Martínez-Pérez Esther Blanc Juan A. Arévalo Marta Aduna Montserrat Andreu Alexander Radosevic Anna M. Ramírez-Morros Susana Pinó Marta Gallego Aranzazu Jauregui-Amezaga Elena Ricart Julián | 2013 | Gastroenterology2013，，： | 3 |
| 3 | First-line single-agent cetuximab in elderly patients with metastatic colorectal cancer. A phase II clinical and molecular study of the Spanish group for digestive tumor therapy (TTD)显示文摘 | J. Sastre E. Aranda C. Grávalos B. Massutí M. Varella-Garcia F. Rivera G. Soler A. Carrato J.L. Manzano E. Díaz-Rubio M. Hidalgo | 2009 | Critical Reviews in Oncology and Hematology2009，，1： | 2 |
| 4 | Proinflammatory Cytokines and Early Neurological Worsening in Ischemic Stroke显示文摘 | Nicolás Vila José Castillo Antonio Dávalos ángel Chamorro | 2000 | Stroke: Journal of the American Heart Association2000，，10： | 2 |
| 5 | IL-6 and IGF-1 are Independent Prognostic Factors of Liver Steatosis and Non-Alcoholic Steatohepatitis in Morbidly Obese Patients显示文摘 | David García-Galiano Miguel A. Sánchez-Garrido Isabel Espejo José Luis Montero Guadalupe Costán Trinidad Marchal Antonio Membrives José M. Gallardo-Valverde Juan R. Mu?oz-Casta?eda Eugenio Arévalo Manuel Mata Jordi Muntané | 2007 | Obesity Surgery2007，，： | 2 |
| 6 | Deposition of litter and nutrients in leaves and twigs in different plant communities of northeastern Mexico显示文摘Studies on litterfall and decomposition provide estimations of decomposition rates of different ecosystems.This is key information to understanding ecosystem dynamics and changes in a scenario of global warming.The objective of this research was to assess litterfall production,the potential deposition of macro and micronutrients through leaf and twig fall as well as macronutrient—use efficiency in three forest ecosystems at different altitudes: a pine forest mixed with deciduous species(S1); a Quercus spp.forest(S2); and,a Tamaulipan thornscrub forest(S3).Total annual litterfall deposition was 594,742 and 533 g m^(-2) for S1,S2 and S3.Leaf litter was higher (68%) than twigs(18%),reproductive structures(8%) or miscellaneous material(6%).Micronutrient leaf deposition was higher for Fe followed by Mn,Zn and Cu.Macronutrient leaf deposition was higher for Ca followed by K,Mg and P.Even though P deposition in leaves and twigs was lower than other macronutrients,its nutrient use efficiency was higher than Ca,Mg or K.Altitude and species composition determine litter and nutrient deposition,with higher values at mid-altitudes(550 m).Altitude is an important factor to consider when analyzing litter production as well as nutrient deposition as shown in this study.Litter production and nutrient deposition are expected to change in a scenario of global warming. | Humberto González-Rodríguez Roque Gonzalo Ramírez-Lozano Israel Cantú-Silva Marco Vinicio Gómez-Meza Eduardo Estrada-Castillón José Ramón Arévalo | 2018 | Journal of Forestry Research2018，29，5： | 2 |
| 7 | Blood Pressure Decrease During the Acute Phase of Ischemic Stroke Is Associated With Brain Injury and Poor Stroke Outcome显示文摘 | José Castillo Rogelio Leira María M. García Joaquín Serena Miguel Blanco Antoni Dávalos | 2004 | Stroke: Journal of the American Heart Association2004，，2： | 2 |
| 8 | Neuroprotective effect of aspirin by inhibition of glutamate release after permanent focal cerebral ischemia in rats 显示文摘 | de Cristobal J Moro MA Dávalos A | 2001 | J Neurochemistry2001，79，2： | 2 |
| 9 | Plasma Metalloproteinase-9 Concentration Predicts Hemorrhagic Transformation in Acute Ischemic Stroke显示文摘 | Mar Castellanos Rogelio Leira Joaquín Serena José M. Pumar Ignacio Lizasoain José Castillo Antoni Dávalos | 2003 | Stroke: Journal of the American Heart Association2003，，1： | 2 |
| 10 | Amyloid beta peptide-induced cholinergic fibres loss in the cerebral cortex of the rat is modified by diet high in lipids and by age显示文摘 | Gonzalo-Ruiz A Sanz J M Arévalo J | 2005 | J Chem Neuroanat2005，29，1： | 1 |
| 11 | Neurotoxic effects of thimerosal at vaccines doses on the encephalon and development in 7 days-old hamsters显示文摘 | Laurente J Remuzgo F ávalos B | | 0，，03： | 1 |
| 12 | Neuroprotective effect of aspirin by inhibition of glutamate release after permanent focal cerebral ischemia in rats显示文摘 | De Cristóbal J Moro AM Dávalos A | | 0，，02： | 1 |
| 13 | Iatrogenic ureteral lesions and repair: A review forgynecologists 显示文摘 | DE CICCO C RET DA VALOS M L VAN CLEYNENBREUGEL B | 2007 | J Minim Invasive Gynecol2007，14，4： | 1 |
| 14 | Diagnosis of the follicular variant of papillary thyroid carcinoma显示文摘 | Guyetant S Michalak S Valo I | 2003 | Significance of immunohistochemistry2003，23，1： | 1 |
| 15 | Proinflam- matory cytokines and early neurological worsening in is- chemic stroke 显示文摘 | VILA N CASTILLO J D~VALOS A | 2000 | Stroke2000，31，10： | 1 |
| 16 | Levels of anti-Inflammatory cytokines and neurological worsening in acute ischemic stroke显示文摘 | Nicolás Vila José Castillo Antonio Dávalos | 2003 | Stroke2003，34，3： | 1 |
| 17 | Factors Controlling the Abundance and Size Distribution of the Phototrophic Ciliate Myrionecta rubra in Open Waters of the North Atlantic显示文摘 | DAVID J. S.MONTAGNES JOHNALLEN LOUISEBROWN CELIABULIT RUSSELLDAVIDSON CARLOSDíAZ‐áVALOS SOPHIEFIELDING MIKEHEATH NAOMI P.HOLLIDAY JENSRASMUSSEN RICHARDSANDERS JOANNA J.WANIEK DAVIDWILSON | 2008 | Journal of Eukaryotic Microbiology2008，，5： | 1 |
| 18 | Windstorm damage and forest recovery: accelerated succession, stand structure, and spatial pattern over 25 years in two Minnesota forests 显示文摘 | Allen MS Thapa V Arévalo JR Palmer MW | 2012 | Plant Ecol2012，213，11： | 1 |
| 19 | miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling显示文摘 | Dávalos A Goedekea L Smibert P | | 0，，： | 1 |
| 20 | Modeling teletraffic arrivals by a Poisson cluster process显示文摘 | Gilles Fa? Bárbara González-Arévalo Thomas Mikosch Gennady Samorodnitsky | 2006 | Queueing Systems2006，，2： | 1 |
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