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| 1 | Application of a biochemical and clinical model to predict individual survival in patients with end-stage liver disease显示文摘AIM:To investigate the capability of a biochemical and clinical model,BioCliM,in predicting the survival of cirrhotic patients.METHODS:We prospectively evaluated the survival of 172 cirrhotic patients.The model was constructed using clinical(ascites,encephalopathy and variceal bleeding) and biochemical(serum creatinine and serum total bilirubin) variables that were selected from a Cox proportional hazards model.It was applied to estimate 12-,52-and 104-wk survival.The model's calibration using the Hosmer-Lemeshow statistic was computed at 104 wk in a validation dataset.Finally,the model's validity was tested among an independent set of 85 patients who were stratified into 2 risk groups(low risk≤8 and high risk>8).RESULTS:In the validation cohort,all measures of fi t,discrimination and calibration were improved when the biochemical and clinical model was used.The proposed model had better predictive values(c-statistic:0.90,0.91,0.91) than the Model for End-stage Liver Disease(MELD) and Child-Pugh(CP) scores for 12-,52-and 104-wk mortality,respectively.In addition,the Hosmer-Lemeshow(H-L) statistic revealed that the biochemical and clinical model(H-L,4.69) is better calibrated than MELD(H-L,17.06) and CP(H-L,14.23).There were no significant differences between the observed and expected survival curves in the stratified risk groups(low risk,P=0.61;high risk,P=0.77).CONCLUSION:Our data suggest that the proposed model is able to accurately predict survival in cirrhotic patients. | Eduardo Vilar Gomez Luis Calzadilla Bertot Bienvenido Gra Oramas Enrique Arus Soler Raimundo Llanio Navarro Javier Diaz Elias Oscar Villa Jiménez Maria del Rosario Abreu Vazquez | 2009 | World Journal of Gastroenterology2009，15，22： | 6 |
| 2 | Ge-on-Si modulators operating at mid-infrared wavelengths up to 8 μm显示文摘We report mid-infrared Ge-on-Si waveguide-based PIN diode modulators operating at wavelengths of 3.8 and8 μm. Fabricated 1-mm-long electro-absorption devices exhibit a modulation depth of >35 dB with a 7 V forward bias at 3.8 μm, and a similar 1-mm-long Mach–Zehnder modulator has a Vπ· L of 0.47 V · cm. Driven by a 2.5 Vpp RF signal, 60 MHz on-off keying modulation was demonstrated. Electro-absorption modulation at 8 μm was demonstrated preliminarily, with the device performance limited by large contact separation and high contact resistance. | TIANTIAN LI MILOS NEDELJKOVIC NANNICHA HATTASAN WEI CAO ZHIBO QU CALLUM GLITTLEJOHNS JORDI SOLER PENADES LORENZO MASTRONARDI VINITA MITTAL DANIEL BENEDIKOVIC DAVID JTHOMSON FREDERIC YGARDES HEQUAN WU ZHIPING ZHOU GORAN ZMASHANOVICH | 2019 | Photonics Research2019，7，8： | 5 |
| 3 | Protein phosphatase PP1γ2 in sperm morphogenesis and epididymal initiation of sperm motility显示文摘serine/threonine 磷酸酶(PP1 ) 对碘氧基苯甲醚 PP1 γ 2,主要在睾丸表示了,是在精子的关键酶。高 PP1 γ 2 在在不成熟的精子的支票的催化活动抓住活动性。在在鞭毛的不成熟的精子和活动性刺激和变化的 PP1 γ 2 原因活动性开始的抑制在成熟精子打败了参数。PP1 γ 2 对碘氧基苯甲醚在学习的所有哺乳动物的精子是在场的:老鼠,老鼠,仓鼠,牛的、非人类的首领和人。我们现在识别了在精子以内调整 PP1 γ 2 的不同水池的至少四它的规章的蛋白质。我们的研究提供新卓见进位于精子活动性的开发和规定下面的生物化学的机制。我们假设那由于磷酸化在精子 PP1 γ 2 活动变化,到催化子单元的规章的蛋白质的可逆绑定在活动性和精子的能力的开发和规定是批评的使肥沃卵。Ppp1cc 基因的指向的混乱,编码 PP1 γ 1 或 PP1 γ 2 isoforms,由于损害精子形式在老鼠引起男不孕。我们的观察建议除了活动性,蛋白质 phosphatasePP1 γ 2 可能在哺乳动物的精子的专业化 flagellarstructures 的发展玩 isoform 特定的功能。 | Rumela Chakrabarti Lina Cheng Pawan Purl David Soler Srinivasan Vijayaraghavan | 2007 | Asian Journal of Andrology2007，9，4： | 5 |
| 4 | Spermiogram and sperm head morphometry assessed by multivariate cluster analysis results during adolescence (12-18 years) and the effect of varicocele显示文摘这个工作从精索静脉曲张的 12 ~ 18 岁,和效果在青少年评估精子头 morphometric 特征。在年龄的 150 和 224 个月之间的志愿者(平均数 191, n = 87 ) ,在 12 岁到达了 oigarche,在 Barranquilla 的区域被招募,哥伦比亚。精子头的 Morphometric 分析与主要部件(PC ) 和判别式分析被执行。联合精液和精子参数提供了五 PC:二与精子 morphometry 有关,到精子活动性,并且二到精液部件。精索静脉曲张和 nonvaricocele 组的 morphometric 结果上的判别式分析没提供一个有用分类矩阵。精液相关的 PC,最解释(40%) 与精子活动性有关。包括精子头延伸和尺寸,二 PC 是足够的评估精子 morphometric 特征。大多数 morphometric 变量与年龄被相关,随尺寸的增加和在精子头的延伸的减少。为头尺寸,全部精子人口能被划分成二 morphometric subpopulations, SP1 和 SP2,它没在青春期期间变化。为精索静脉曲张个人,一般来说,更大的有的 SP1 和更多的伸长的精子比 SP2 出发,它有更小并且更多的伸长的头比在 nonvaricocele 人。在摘要, CASA-Morph 和 multivariate 簇分析估计的精子头 morphometry 提供精液结构并且可能的更好的理解精子功能。Morphometric 分析比从常规精液分析获得的数据提供更多信息。 | Fernando Vasquez Caries Soler Patricia Camps Anthony Valverde Almudena Garcia-Molina | 2016 | Asian Journal of Andrology2016，18，6： | 5 |
| 5 | Dimensions of human ejaculated spermatozoa in Papanicolaou- stained seminal and swim-up smears obtained from the Integrated Semen Analysis System (ISAS)显示文摘客观大小为分析(CASMA ) 用机器制造把正常与反常精子头区分开来的电脑辅助的精子 morphometric 被要求。在精液并且从在游泳起来以后的 72 件另外的精液样品的精子的 72 件样品的精子的 morphometric 特征被自动化半的综合精子分析系统( ISAS )确定电脑辅助的系统,测量了精子头参数长度(L),宽度(W),区域(A),周界(P), acrosomal 区域(交流),和导出的价值 L/W 和 P/A 。为每个人,分布的一张同类的人口描绘了精液的精子(7 942 个房间:中部的价值 L 4.4 渭 m, W 2.8 渭 m, 9.8 渭 m 2, P 12.5 渭 m,交流 47.5% , L/W 1.57, P/A 1.27 ) ,并且在在内单个、在单个之中的变化没有重要差别。不同的人能有显著地不同的尺寸的精子。领导尺寸因为从不同的人(4 812 个房间) 的游泳起来精子类似于在精液的那些,仅仅由 2% 鈥 ?% 不同。L, W 和 L/W 的价值在世界健康组织给的限制以内掉落了() 。尽管这些样品不是生物学上匹配的、线性混合效果,统计分析允许这些组的有效比较。 404 精子的 subpopulation 考虑了适合从精液和游泳起来的“正常”的精液的精子被中部的价值描绘的紧标准(并且95%信心间隔) L , 4.3 渭m ( 3.8 鈥? .9 ), W , 2.9 渭m ( 2.6 鈥? .3 ),一, 10.2 渭m 2 ( 8.5 鈥? 2.2 ), P , 12.4 渭m ( 11.3 鈥? 3.9 ),交流,49%( 36 鈥? 0 ), L/W , 1.49 ( 1.32 鈥? .67 )并且 P/A , 1.22 ( 1.11 鈥? .35 )。在谁给的第 95 变数区间的百分之一信心限制以内的这些中部的价值秋天,而是为 L 和 W 的信心间隔更大。尽管在在人之中并且在游泳起来以后的头尺寸的这些差别能被 CASMA 检测,小差别使,技术员将能区分他们,不大可能。价值能为这里使用的 CASMA 机器被用作缺省精子头价值。 | Giuseppe Bellastella Trevor G. Cooper MarinaBattaglia Anda Strose Inma Torres Barbara Hellenkemper Caries Soler Antonio A. Sinisi | 2010 | Asian Journal of Andrology2010，12，6： | 4 |
| 6 | 全科医学科研的范畴、研究需求和适用方法——《欧洲全科医学/家庭医学和基本医疗保健科研纲要》中文摘译显示文摘本文对《欧洲全科医学/家庭医学和基本医疗保健科研纲要》的中文译稿进行了重点摘登。该文件由欧洲全科医学科研网络制订,包括7部分内容:序言、导言、方法、结果、独立章节,讨论和启示。作为在欧洲发展全科医学科研的核心指南,该文件对欧洲的全科医学学科和科研发展产生了深远的影响。欧洲的全科医学体系和以此为基础而构建的学科理论共识与我国全科医学当前的实际情况可能更为接近。因篇幅所限,本文刊登了其中最重要,对中国研究者也最实用的5部分内容,包括:(1)导言——全科医学的核心能力/特征以及全科医学科研的意义;(2)结果——全科医学的6个核心领域(基本保健管理、'以人为本'的照护、解决具体问题的技能、综合的方法、以社区为导向、整体的方法)的科研范畴,研究需求和适用方法;(3)独立章节——如何发展基本的科研能力和避免常见的科研失误;(4)讨论——未来的全科医学科研重点;(5)启示——科学协会、研究机构、患者参与、科研工作、期刊、科研政策在发展学科方面应注重的问题。因欧洲的全科医学体制和我国较为相似,且存在一定的科研发展代差,该文件在当前阶段也可为我国全科医学研究者所用,基于全科医学学科的视角,从概念、分类学、范围和科研方法等方面,为我国全科医学科研的发展提供参照。 | Eva Hummers-Pradier Martin Beyer Patrick Chevallier Sophia Eilat-Tsanani Christos Lionis Lieve Peremans Davorina Petek Imre Rurik Jean Karl Soler Henri E.J.H.Stoffers Pinar Topsever Mehmet Ungan Paul van Royen Hanny Prick 无 | 2022 | 中国全科医学2022，25，9： | 4 |
| 7 | The influence of canopy-layer composition on understory plant diversity in southern temperate forests显示文摘Background: Understory plants represents the largest component of biodiversity in most forest ecosystems and plays a key role in forest functioning.Despite their importance, the influence of overstory-layer composition on understory plant diversity is relatively poorly understood within deciduous-evergreen broadleaved mixed forests.The aim of this work was to evaluate how tree overstory-layer composition influences on understory-layer diversity in three forest types(monospecific deciduous Nothofagus pumilio(Np), monospecific evergreen Nothofagus betuloides(Nb), and mixed N.pumilio-N.betuloides(M) forests), comparing also between two geographical locations(coast and mountain) to estimate differences at landscape level.Results: We recorded 46 plant species: 4 ferns, 12 monocots, and 30 dicots.Canopy-layer composition influences the herb-layer structure and diversity in two different ways: while mixed forests have greater similarity to evergreen forests in the understory structural features, deciduous and mixed were similar in terms of the specific composition of plant assemblage.Deciduous pure stands were the most diverse, meanwhile evergreen stands were least diverse.Lack of exclusive species of mixed forest could represent a transition where evergreen and deciduous communities meet and integrate.Moreover, landscape has a major influence on the structure, diversity and richness of understory vegetation of pure and mixed forests likely associated to the magnitude and frequency of natural disturbances, where mountain forest not only had highest herb-layer diversity but also more exclusive species.Conclusions: Our study suggests that mixed Nothofagus forest supports coexistence of both pure deciduous and pure evergreen understory plant species and different assemblages in coastal and mountain sites.Maintaining the mixture of canopy patch types within mixed stands will be important for conserving the natural patterns of understory plant composition in southern beech mixed forests. | Luciana Mestre Monica Toro-Manriquez Rosina Soler Alejandro Huertas-Herrera Guillermo Martinez-Pastur Maria Vanessa Lencinas | 2017 | Forest Ecosystems2017，4，2： | 3 |
| 8 | First-line single-agent cetuximab in elderly patients with metastatic colorectal cancer. A phase II clinical and molecular study of the Spanish group for digestive tumor therapy (TTD)显示文摘 | J. Sastre E. Aranda C. Grávalos B. Massutí M. Varella-Garcia F. Rivera G. Soler A. Carrato J.L. Manzano E. Díaz-Rubio M. Hidalgo | 2009 | Critical Reviews in Oncology and Hematology2009，，1： | 2 |
| 9 | Euro 4000型机车防寒改造显示文摘由Vossloh Espana(西班牙)公司开发的Euro4000型电传动内燃机车经过成功改造,可适应在斯堪的纳维亚地区寒冷冬季运用,该地区冬季最低气温达到零下40℃。文中介绍了该机车的结构特点和主要技术参数。 | Ricardo Albelda Soler 程永陆 | 2011 | 国外内燃机车2011，，2： | 2 |
| 10 | ddRAD sequencing-based genotyping for population structure analysis in cultivated tomato provides new insights into the genomic diversity of Mediterranean‘da serbo’type long shelf-life germplasm显示文摘Double digest restriction-site associated sequencing(ddRAD-seq)is a flexible and cost-effective strategy for providing in-depth insights into the genetic architecture of germplasm collections.Using this methodology,we investigated the genomic diversity of a panel of 288 diverse tomato(Solanum lycopersicum L.)accessions enriched in‘da serbo’(called‘de penjar’in Spain)long shelf life(LSL)materials(152 accessions)mostly originating from Italy and Spain.The rest of the materials originate from different countries and include landraces for fresh consumption,elite cultivars,heirlooms,and breeding lines.Apart from their LSL trait,‘da serbo’landraces are of remarkable interest for their resilience.We identified 32,799 high-quality SNPs,which were used for model ancestry population structure and non-parametric hierarchical clustering.Six genetic subgroups were revealed,clearly separating most‘da serbo’landraces,but also the Spanish germplasm,suggesting a subdivision of the population based on type and geographical provenance.Linkage disequilibrium(LD)in the collection decayed very rapidly within<5 kb.We then investigated SNPs showing contrasted minor frequency allele(MAF)in‘da serbo’materials,resulting in the identification of high frequencies in this germplasm of several mutations in genes related to stress tolerance and fruit maturation such as CTR1 and JAR1.Finally,a mini-core collection of 58 accessions encompassing most of the diversity was selected for further exploitation of key traits.Our findings suggest the presence of a genetic footprint of the‘da serbo’germplasm selected in the Mediterranean basin.Moreover,we provide novel insights on LSL‘da serbo’germplasm as a promising source of alleles for tolerance to stresses. | Salvatore Esposito Teodoro Cardi Gabriele Campanelli Sara Sestili María JoséDíez Salvador Soler Jaime Prohens Pasquale Tripodi | 2020 | Horticulture Research2020，7，1： | 2 |
| 11 | Computerised tomography vs magnetic resonance imaging for modeling of patient-specific instrumentation in total knee arthroplasty显示文摘AIM: To summarise and compare currently available evidence regarding accuracy of pre-operative imaging, which is one of the key choices for surgeons contemplating patient-specific instrumentation(PSI) surgery.METHODS: The MEDLINE and EMBASE medical literature databases were searched, from January 1990 to December 2013, to identify relevant studies. The data from several clinical studies was assimilated to allow appreciation and comparison of the accuracy of each modality. The overall accuracy of each modality was calculated as proportion of outliers > 3% in the coronal plane of both computerised tomography(CT) or magnetic resonance imaging(MRI). RESULTS: Seven clinical studies matched our inclusion criteria for comparison and were included in our study for statistical analysis. Three of these reported series using MRI and four with CT. Overall percentage of outliers > 3% in patients with CT-based PSI systems was 12.5% vs 16.9% for MRI-based systems. These results were not statistically significant. CONCLUSION: Although many studies have been undertaken to determine the ideal pre-operative imaging modality, conclusions remain speculative in the absence of long term data. Ultimately, information regarding accuracy of CT and MRI will be the main determining factor. Increased accuracy of pre-operative imaging could result in longer-term savings, and reduced accumulated dose of radiation by eliminating the need for post-operative imaging and revision surgery. | Paul Stirling Rejith Valsalan Mannambeth Agustin Soler Vineet Batta Rajeev Kumar Malhotra Yegappan Kalairajah | 2015 | World Journal of Orthopedics2015，6，2： | 2 |
| 12 | Antioxidant and immunomodulatory effects of Viusid in patients with chronic hepatitis C显示文摘AIM:To investigate the efficacy of Viusid,a nutritional supplement,as an antioxidant and an immunomodulator in patients with chronic hepatitis C.METHODS:Sixty patients with chronic hepatitis C who were non-responders to standard antiviral treatment were randomly assigned to receive Viusid(3 sachets daily,n=30) or placebo(n=30) for 24 wk.The primary outcome was the change in serum malondialdehyde and 4-hydroxyalkenals(lipid peroxidation products).Secondary outcomes were changes in serum tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ) and interleukin-10(IL-10).RESULTS:Statistically significant reductions in serum 4-hydroxyalkenals and malondialdehyde levels were observed in both groups in comparison with pretreatment values,but the patients who received Viusid showed a more marked reduction as compared with the control group(P=0.001).TNF-α levels significantly increased from 6.9 to 16.2 pg/mL(P< 0.01) in the patients who received placebo in comparison with almost unchanged levels,from 6.6 to 7.1 pg/mL(P=0.26),in the patients treated with Viusid(P=0.001).In addition,IL-10 levels were markedly increased in the patients treated with Viusid(from 2.6 to 8.3 pg/mL,P=0.04) in contrast to the patients assigned to placebo(from 2.8 to 4.1 pg/mL,P=0.09)(P=0.01).Likewise,the administration of Viusid markedly increased mean IFN-γ levels from 1.92 to 2.89 pg/mL(P< 0.001) in comparison with a reduction in mean levels from 1.80 to 1.68 pg/mL(P=0.70) in the placebo group(P< 0.0001).Viusid administration was well tolerated.CONCLUSION:Our results indicate that treatment with Viusid leads to a notable improvement of oxidative stress and immunological parameters in patients with chronic hepatitis C. | Eduardo Vilar Gomez Yadina Martinez Perez Hector Vega Sanchez Gretel Riveron Forment Enrique Arus Soler Luis Calzadilla Bertot Ali Yasells Garcia Maria del Rosario Abreu Vazquez Licet Gonzalez Fabian | 2010 | World Journal of Gastroenterology2010，16，21： | 2 |
| 13 | Writing titles in science: An exploratory study显示文摘 | Viviana Soler | 2006 | English for Specific Purposes2006，，1： | 2 |
| 14 | 用心脏磁共振成像解释肥厚型心肌病的心电图异常显示文摘Aims: To clarify the mechanisms of electrocardiographic abnormalities in hypertrophic cardiomyopathy, 102 patients were examined with cardiac magnetic resonance. Distribution and magnitude of hypertrophy and late-enhancement were correlated with electrocardiographic abnormalities. Methods and results: Abnormal Q waves were associated with greater upper anterior septal thickness(22±7 mm vs. 18±5 mm, P=0.001) and increased ratios of upper anterior septum to mean inferolateral(P=0.01), anterolateral(P=0.002), apical(P=0.001), and right ventricular(P=0.001) wall thickness. There was no relation between abnormal Q waves and late-enhancement, except for Q waves ≥40 ms(P=0.02). Conduction disturbances and absent septal Q waves were associated with late-enhancement(89 vs. 45%, P=0.01 and 75 vs. 39%, P=0.002, respectively). The depth of negative T waves was related to an increased ratio of the mean thickness between apical and basal level(P=0.01), and to the presence of apical late-enhancement(P=0.03). Conclusion: Abnormal Q waves reflect the interrelation between upper anterior septal thickness and other regions of the left and right ventricles, and wider Q waves are associated with late-enhancement. Conduction disturbances and absent septal Q waves are associated with late-enhancement. The depth of negative T waves is related to craniocaudal asymmetry and apical late-enhancement. | Dumont C.A. Monserrat L. Soler R. 刘少伟 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，，12： | 2 |
| 15 | Betunilic acid derivatives: a new class of human immunodeficiency virus type 1 specific inhibitors with a new mode of action 显示文摘 | Evers M Poujade C Soler F | 1996 | J Med Chem1996，39，5： | 1 |
| 16 | Developmental switches in chemokine response profiles during B cell differentiation and maturation显示文摘 | Campbell JJ Soler D | 2000 | J Exp Med2000，191，8： | 1 |
| 17 | Studies of an enneanuclear manganese single-molecule magnet显示文摘 | Rajaraman G Soler M | 2005 | J Am Chem Soc2005，127，15： | 1 |
| 18 | Intectual functioning and memory deficits in schizophrenia显示文摘 | Juan Carlos Ruiz Mar'a Jose' Soler Irma Fuentes | 2007 | Comprehensive Psychiatry2007，48，： | 1 |
| 19 | Analysis of B and T cell clonality and HLA class Ⅱ alleles in patients with idio- pathic thrombocytopenic purpura: correlation with Helico- bacter pylori infection and response to eradication treatment 显示文摘 | Veneri D De Matteis G Soler P | 2005 | Platelats2005，16，5： | 1 |
| 20 | Can chemical signals, responsible for mutualistic partner encounter, promote the specific exploitation of nursery pollination mutualisms? The case of figs and fig wasps 显示文摘 | Proffit M Chen C Soler C | 2009 | Entomol Exp Appl2009，131，1： | 1 |
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