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| 1 | HDACs,histone deacetylation and gene transcription: from molecular biology to cancer therapeutics显示文摘组蛋白 deacetylases (HDAC ) 并且嘘一乙酰转移 ases (帽子) 是其酶的活动控制蛋白质离氨酸残余的乙酰化状态的二抵抗酶家庭,尤其是在核心 histones.Acetylation 的 N 终端扩展包含的那些嘘通过它对染色质符合构造的影响影响基因表示。Inaddition,几 non-histone 蛋白质由特定的离氨酸残余的乙酰化状态在他们的稳定性或生物功能被调整。HDAC 在大量的生物学过程干涉并且是部分一多每个成员在有它的专业化功能的蛋白质家庭。另外, HDAC 活动紧通过指向的招募, protein-proteininteractions 和 translational 以后修正被控制。房间周期前进,房间幸存和区别的控制在这些酶的最重要的角色之中。因为这些过程被恶意的转变影响, HDAC 禁止者作为反被开发在癌症病人的肿瘤的药和 ares howing 鼓励功效。 | PaolaGallinari StefaniaDiMarco PhillipJones MichelePallaoro ChristianSteinkühler | 2007 | Cell Research2007，17，3： | 33 |
| 2 | Epidural anesthesia improves pancreatic perfusion and decreases the severity of acute pancreatitis显示文摘AIM: To study the safety of epidural anesthesia(EA),its effect on pancreatic perfusion and the outcome of patients with acute pancreatitis(AP).METHODS: From 2005 to August 2010,patients with predicted severe AP [Ranson score ≥ 2,C-reactive protein > 100 or necrosis on computed tomography(CT)] were prospectively randomized to either a group receiving EA or a control group treated by patientcontrolled intravenous analgesia. Pain management was evaluated in the two groups every eight hours using the visual analog pain scale(VAS). Parameters for clinical severity such as length of hospital stay,use of antibiotics,admission to the intensive care unit,radiological/clinical complications and the need for surgical necrosectomy including biochemical data were recorded. A CT scan using a perfusion protocol was performed on admission and at 72 h to evaluate pancreatic blood flow. A significant variation in blood flow was defined as a 20% difference in pancreatic perfusion between admission and 72 h and was measured in the head,body and tail of the pancreas.RESULTS: We enrolled 35 patients. Thirteen were randomized to the EA group and 22 to the control group. There were no differences in demographic characteristics between the two groups. The Balthazar radiological severity score on admission was higher in the EA group than in the control group(mean score 4.15 ± 2.54 vs 3.38 ± 1.75,respectively,P = 0.347) and the median Ranson scores were 3.4 and 2.7 respectively(P = NS). The median duration of EA was 5.7 d,and no complications of the epidural procedure were reported. An improvement in perfusion of the pancreas was observed in 13/30(43%) of measurements in the EA group vs 2/27(7%) in the control group(P = 0.0025). Necrosectomy was performed in 1/13 patients in the EA group vs 4/22 patients in the control group(P = 0.63). The VAS improved during the first ten days in the EA group compared to the control group(0.2 vs 2.33,P = 0.034 at 10 d). Length of stay and mortality were not statistically different between the 2 groups(26 d vs 30 d,P = 0.65,and 0% for both respectively).CONCLUSION: Our study demonstrates that EA increases arterial perfusion of the pancreas and improves the clinical outcome of patients with AP. | Samira M Sadowski Axel Andres Philippe Morel Eduardo Schiffer Jean-Louis Frossard Alexandra Platon Pierre-Alexandre Poletti Leo Bühler | 2015 | World Journal of Gastroenterology2015，21，43： | 21 |
| 3 | Clinical outcome and predictors of survival after TIPS insertion in patients with liver cirrhosis显示文摘AIM:To determine the clinical outcome and predictors of survival after transjugular intrahepatic portosystemic stent shunt (TIPS) implantation in cirrhotic patients. METHODS:Eighty-one patients with liver cirrhosis and consequential portal hypertension had TIPS implantation (bare metal) for either refractory ascites (RA) (n= 27) or variceal bleeding (VB) (n = 54). Endpoints for the study were:technical success, stent occlusion and stent stenosis, rebleeding, RA and mortality. Clinical records of patients were collected and analysed. Baseline characteristics [e.g., age, sex, CHILD score and the model for end-stage liver disease score (MELD score), underlying disease] were retrieved. The Kaplan-Meier method was employed to calculate survival from the time of TIPS implantation and comparisons were made by log rank test. A multivariate analysis of factors influencing survival was carried out using the Cox proportional hazards regression model. Results were expressed as medians and ranges. Comparisons between groups were performed by using the Mann-Whitney Utest and the χ 2 test as appropriate. RESULTS:No difference could be seen in terms of age, sex, underlying disease or degree of portal pressure gradient (PPG) reduction between the ascites and the bleeding group. The PPG significantly decreased from 23.4 ± 5.3 mmHg (VB) vs 22.1 ± 5.5 mmHg (RA) before TIPS to 11.8 ± 4.0 vs 11.7 ± 4.2 after TIPS implantation (P = 0.001 within each group). There was a tendency towards more patients with stage CHILD A in the bleeding group compared to the ascites group (24 vs 6, P = 0.052). The median survival for the ascites group was 29 mo compared to > 60 mo for the bleeding group (P = 0.009). The number of radiological controls for stent patency was 6.3 for bleeders and 3.8 for ascites patients (P = 0.029). Kaplan-Meier calculation indicated that stent occlusion at first control (P = 0.027), ascites prior to TIPS implantation (P = 0.009), CHILD stage (P = 0.013), MELD score (P = 0.001) and those patients not having undergone liver transplantation (P = 0.024) were significant predictors of survival. In the Cox regression model, stent occlusion (P = 0.022), RA (P = 0.043), CHILD stage (P = 0.015) and MELD score (P = 0.004) turned out to be independent prognostic factors of survival. The anticoagulation management (P = 0.097), the porto-systemic pressure gradient (P= 0.460) and rebleeding episodes (P = 0.765) had no significant effect on the overall survival. CONCLUSION:RA, stent occlusion, initial CHILD stage and MELD score are independent predictors of survival in patients with TIPS, speaking for a close follow-up in these circumstances. | Hauke S Heinzow Philipp Lenz Michael Khler Frank Reinecke Hansjrg Ullerich Wolfram Domschke Dirk Domagk Tobias Meister | 2012 | World Journal of Gastroenterology2012，18，37： | 17 |
| 4 | Epidural anaesthesia restores pancreatic microcirculation and decreases the severity of acute pancreatitis显示文摘瞄准:在尖锐胰腺炎(AP ) 期间在胰腺的微循环上调查硬膜上的麻醉(EA ) 的效果。方法:AP 被牛磺胆酸钠的注射导致进 Sprague-Dawley 老鼠的胰腺的管。认识到 EA,一根导管被介绍进在 T7 和 T9 之间的硬膜外腔, bupivacaine 被注射。Microcirculatory 流动被激光 Doppler flowmetry 测量。动脉的血气体分析被执行。在实验(<or=5 h ) 的结束,胰为组织学被移开。动物被划分成三个组:组织 1 (n=9 ) ,没有 EA 的 AP;组织 2 (n=4 ) ,没有 AP 的 EA;并且组织 3 (n=6 ) , AP 由 EA 对待。结果:在组 1,在 AP 以前的胰腺的微循环流动是 141+/- 39 个灌注单位(PU ) 。在 AP 以后,微循环流动显然减少了到 9+/- 6 PU (P<0.05 ) 。与基础过量开发的新陈代谢的酸中毒()-14+/-3 mmol/L。组织学揭示了广泛的浮肿和织物坏死。在组 2, EA 显著地没修改微循环流动。被仍然是未改变、组织学的分析显示出正常胰腺的织物。在组 3, AP 开始从 155+/-25 在微循环流动引起了重要减少到 11+/-7 PU (P<0.05 ) 。在 EA 的开始以后,微循环流动显然再增加了到 81+/-31 PU (P<0.05 ) 。是 -6+/-4 mmol/L,它与组 1 相比是显著地不同的(P<0.05 ) 。而且,组织学在组 1 在比那的组 3 在胰腺的组织揭示了不太广泛的浮肿和坏死。结论:AP 在胰以内引起了戏剧的微循环变化,与新陈代谢的酸中毒和织物坏死的开发。EA 允许微循环流动的部分恢复并且阻止了织物坏死和全身的复杂并发症的开发。因此, EA 应该被看作治疗学的选择阻止进化水肿到坏死的 AP。 | AlpDemirag CatherineMPastor PhilippeMorel NilgunGüvener GangMai ThierryBerney LeoHBühler CopinJean-Christophe Jean-LouisFrossard Andreas W.Sielenk mper Gang Mai | 2006 | World Journal of Gastroenterology2006，12，6： | 14 |
| 5 | 快硬地面自流平砂浆的早期收缩与膨胀机理 | E.Bühler R.Zurbriggen 张量 | 2007 | 膨胀剂与膨胀混凝土2007，，2： | 13 |
| 6 | 霉菌毒素及脱毒方法概述显示文摘 | Dirk Hhler 马玺 赵玉华 | 2000 | 国外畜牧科技2000，27，4： | 5 |
| 7 | 厚壁奥氏体焊缝超声波检测之探究(英文)显示文摘由于奥氏体焊缝中材料性能的各向异性和微观组织结构的不同,奥氏体焊缝的超声波检测是非常困难的。超声波在奥氏体焊缝中会沿金属结晶方向发生偏转,并在焊缝边界上发生散射。过去十年来,人们开发了多种模拟各向异性材料中声波传播的仿真工具。本文则以常规超声波检测方法为基础,将声线跟踪法和弹性动力学有限积分技术(EFIT)相结合,应用于含晶间应力腐蚀裂纹的厚壁奥氏体焊缝中,其结果显示声线跟踪法和弹性动力学有限积分技术(EFIT)结合应用,有助于超声波检测参数的选取。 | Han T Y Khler B Schmitz V Zimmer A Langenberg K J | 2009 | 无损检测2009，31，11： | 3 |
| 8 | Disagreement between symptom-reflux association analysis parameters in pediatric gastroesophageal reflux disease investigation显示文摘AIM: To assess the agreement within 3 commonly used symptom-reflux association analysis (SAA) parameters investigating gastroesophageal reflux disease (GERD) in infants. METHODS: Twenty three infants with suspected GERD were included in this study. Symptom index (SI), Symptom sensitivity index (SSI) and symptom association probability (SAP) related to cough and irritability were calculated after 24 h combined pH/multiple intraluminal impedance (MII) monitoring. Through defined cutoff values, SI, SSI and SAP values are differentiated in normal and abnormal, whereas abnormal values point towards gastroesophageal reflux (GER) as the origin of symptoms. We analyzed the correlation and the concordance of the diagnostic classification of these 3 SAA parameters.RESULTS: Evaluating the GER-irritability association, SI, SSI and SAP showed non-identical classification of normal and abnormal cases in 39.2% of the infants. When irritability was taken as a symptom, there was only a poor inter-parameter association between SI and SSI, and between SI and SAP (Kendall’s tau b = 0.37, P < 0.05; Kendall’s tau b = 0.36, P < 0.05, respectively). Evaluating the GER-cough association, SI, SSI and SAP showed non-identical classification of normal and abnormal cases in 52.2% of the patients. When cough was taken as a symptom, only SI and SSI showed a poor inter-parameter association (Kendall’s tau b = 0.33, P < 0.05). CONCLUSION: In infants investigated for suspected GERD with pH/MII-monitoring, SI, SSI and SAP showed a poor inter-parameter association and important dis-agreements in diagnostic classification. These limitations must be taken into consideration when interpreting the results of SAA in infants. | Samuel C Lüthold Mascha K Rochat Peter Bhler | 2010 | World Journal of Gastroenterology2010，16，19： | 3 |
| 9 | Dietary copper triggers onset of fulminant hepatitis in the Long-Evans cinnamon rat model显示文摘AIM:To investigate the impact of dietary copper given at different time points on the onset of fulminant hepatitis. METHODS:The Long-Evans cinnamon (LEC) rat model of Wilson's disease (WD) was used to study the impact of high dietary copper (hCu) on the induction of fulminant hepatitis at early or late time points of life. High Cu diet was started in rat pups or in adults (month 5) for three months. Animals that received reduced dietary copper (rCu) throughout their lifetime served as a control. Hepatitis-associated serum markers (alanine aminotransferase, aspartate transaminase, bilirubin) were analyzed in animal groups receiving hCu or rCu. Liver copper content and liver histology were revealed at sacrifice. A set of 5 marker genes previously found to be affected in injured liver and which are related to angiogenesis (Vegfa), fat metabolism (Srebf1), ex-tracellular matrix (Timp1), oxidative stress (Hmox1), and the cell cycle (Cdkn1a) were analyzed by real-time polymerase chain reaction. RESULTS:Regardless of the time point when hCu was started, LEC rats (35/36) developed fulminant hepatitis and died. Animals receiving rCu (36/36) remained healthy, did not develop hepatitis, and survived long term without symptoms of overt disease, although liver copper accumulated in adult animals (477 ± 75 μg/g). With regard to start of hCu, onset of fulminant hepatitis was significantly (P < 0.001) earlier in adults (35 ± 9 d) that showed pre-accumulation of liver copper as compared to the pup group (77 ± 15 d). Hepatitis-associated serum markers, liver copper and liver histology, as well as gene expression, were affected in LEC rats receiving hCu. However, except for early and rapid onset of hepatitis, biochemical and molecular markers were similar at the early and late time points of disease. CONCLUSION:Rapid onset of fulminant hepatitis in asymptomatic LEC rats with elevated liver copper suggests that there is a critical threshold of liver copper which is important to trigger the course of WD. | Ramsi Siaj Vanessa Sauer Sandra Stppeler Hans-Ullrich Spiegel Gabriele Khler Andree Zibert Hartmut HJ Schmidt | 2012 | World Journal of Gastroenterology2012，18，39： | 3 |
| 10 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 2 |
| 11 | Self‐Healing Polymers via Supramolecular Forces显示文摘 | Florian Herbst Diana D?hler Philipp Michael Wolfgang H. Binder | 2013 | Macromol Rapid Commun2013，，3： | 2 |
| 12 | Hepatic resection for colorectal metastases: Can preoperative scoring predict patient outcome?显示文摘 | Tom Mala M.D. Geir B?hler M.D. ?ystein Mathisen M.D. Ph.D. Anstein Bergan M.D. Ph.D. Odd S?reide M.D. Ph.D | 2002 | World Journal of Surgery2002，，11： | 2 |
| 13 | Addressing concerns about cisplatin application during pregnancy显示文摘 | Malgorzata Lanowska Christhardt K?hler Peter Oppelt Alexander Schmittel Elisabeth Gottschalk Kati Hasenbein Achim Schneider Simone Marnitz | 2011 | Journal of Perinatal Medicine2011，，3： | 2 |
| 14 | ELECTROSTATICALLY SUPPORTED MIXING OF FINE GRAINED PARTICLES显示文摘The processing of fine-grained particles with diameters between 1 and 10 microns is difficult due to strong van-der-Waals attraction forces. In order to improve the handling properties, the fine-grained particles, i.e. host-particles,are coated with various nanoparticles, i.e. guest-particles. The mixing of fine-grained powders is influenced by particle-particle interactions. If these forces are distinctively used, both interactive and ordered mixtu.res can be produced.These particle mixtures consist of composite-particles that have new physical properties. These modified properties depend strongly on the coating process, the diameter- and mass-relationship of the guest- and the host-particles. The properties of the composite-particles can systematically be adjusted to the requirements of industrial applications. For example, a laboratory bubbling fluidized bed can be used to describe the conveying behavior of the functionalized host-particles. Applications for the functionalized particles are in the pharmaceutical and the powder coating industries,e.g. enhanced dry powder inhalers and thin lacquer films. The present research compares three different mixing/coating processes. The composite-particles are characterized by TEM, SEM and with their fluidization characteristics. The coating process itself is monitored by the electrostatic charge of the particles. | K.-E. Wirth M. Linsenbühler | 2005 | China Particuology2005，3，1： | 2 |
| 15 | Detection of disseminated tumor cells in patients with cervical cancer显示文摘 | Scheungraber C Müller B K?hler C | | 0，，06： | 1 |
| 16 | S3 Guideline: Sedation for gastrointestinal endoscopy 2008显示文摘 | A. Riphaus T. Wehrmann B. Weber J. Arnold U. Beilenhoff H. Bitter S. von Delius D. Domagk A. Ehlers S. Faiss D. Hartmann W. Heinrichs M.-L. Hermans C. Hofmann S. In der Smitten M. Jung G. K?hler M. Kraus J. Martin A. Meining J. Radke T. R?sch H. Seifert A | 2009 | Endoscopy2009，，09： | 1 |
| 17 | Fish oil supplementation in the parenteral nutrition of critically ill medical patients:a randomised controlled trial显示文摘 | Friesecke S Lotze C Ko hler J | 2008 | Intensive Care Med2008，34，8： | 1 |
| 18 | Biomaterial-induced sar-coma:a novel model to study preneoplastic change显示文摘 | Kirkpatrick C J Alves A Khler H | 2000 | Am JPathol2000，156，4： | 1 |
| 19 | Discovery and analysis of inflammatory disease- related genes using cDNA microarrays显示文摘 | Hler R A Schena M Chai A | 1997 | Proc Natl Acad Sci USA1997，94，6： | 1 |
| 20 | Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation显示文摘 | Wagner AH Khler T Rückschloss U | 2000 | Arterioscler Thromb Vasc Biol2000，20，1： | 1 |
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