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| 1 | Liver stiffness in the hepatitis B virus carrier:A non-invasive marker of liver disease influenced by the pattern of transaminases显示文摘AIM: To investigate the usefulness of transient elastography by Fibroscan (FS),a rapid non-invasive technique to evaluate liver fibrosis,in the management of chronic hepatitis B virus (HBV) carriers.METHODS: In 297 consecutive HBV carriers,we studied the correlation between liver stiffness (LS),stage of liver disease and other factors potentially influencing FS measurements.In 87 chronic hepatitis B (CHB) patients,we monitored the FS variations according to the spontaneous or treatment-induced variations of biochemical activity during follow-up.RESULTS: FS values were 12.3 ± 3.3 kPa in acute hepatitis,10.3 ± 8.8 kPa in chronic hepatitis,4.3 ± 1.0 kPa in inactive carriers and 4.6 ± 1.2 kPa in blood donors.We identified the cut-offs of 7.5 and 11.8 kPa for the diagnosis of fibrosis ≥ S3 and cirrhosis respectively,showing 93.9% and 86.5% sensitivity,88.5% and 96.3% specificity,76.7% and 86.7% positive predictive value (PPV),97.3% and 96.3% negative predictive value (NPV) and 90.1% and 94.2% diagnostic accuracy.At multivariate analysis in 171 untreated carriers,fibrosis stage (t = 13.187,P < 0.001),active vs inactive HBV infection (t = 6.437,P < 0.001),alanine aminotransferase (ALT) (t = 4.740,P < 0.001) and HBV-DNA levels (t = -2.046,P = 0.042) were independently associated with FS.Necroinflammation score (t = 2.158,> 10/18 vs ≤ 10/18,P = 0.035) and ALT levels (t = 3.566,P = 0.001) were independently associated with LS in 83 untreated patients without cirrhosis and long-term biochemical remission (t = 4.662,P < 0.001) in 80 treated patients.During FS monitoring (mean follow-up 19.9 ± 7.1 mo) FS values paralleled those of ALT in patients with hepatitis exacerbation (with 1.2 to 4.4-fold increases in CHB patients) and showed a progressive decrease during antiviral therapy.CONCLUSION: FS is a non-invasive tool to monitor liver disease in chronic HBV carriers,provided that the pattern of biochemical activity is taken into account.In the inactive carrier,it identifies non-HBV-related causes of liver damage and transient reactivations.In CHB patients,it may warrant a more appropriate timing of control liver biopsies. | Filippo Oliveri Barbara Coco Pietro Ciccorossi Piero Colombatto Veronica Romagnoli Beatrice Cherubini Ferruccio Bonino Maurizia Rossana Brunetto | 2008 | World Journal of Gastroenterology2008，14，40： | 43 |
| 2 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 3 | Anti-TNF alpha in the treatment of ulcerative colitis:A valid approach for organ-sparing or an expensive option to delay surgery?显示文摘Ulcerative colitis(UC)is an inflammatory bowel disease affecting large bowel with variable clinical course.The history of disease has been modified by the introduction of biologic therapy,in particular Infliximab(IFX),that has demonstrated efficacy in inducing fast symptoms remission,promoting mucosal healing and maintaining long-term remission.However,surgery is still needed for UC patients:in case of failure of medical therapy and if acute complications or a malignancy occurred.Surgical treatment is associated with a short-term postoperative mortality and morbidity respectively of 0%-4%and 30%.In this study we systematically analyzed:the role of IFX in reducing the colectomy rate,the risk of post-operative morbidity in pre-operatively IFX-treated patients and the cost-effectiveness of IFX therapy.Four of 5 analyzed randomized controlled trials demonstrated that therapy with IFX significantly reduces the colectomy rate.Moreover,pre-operative treatment with IFX doesn’t seem to increase post-operative infectious complications.By an economic point of view,the cost-effectiveness of IFX-therapy was demonstrated for UC patients suffering from moderate to severe UC in a study based on a cost estimation of the National Health Service of England and Wales.However,the argument is debated. | Gianluca Rizzo Daniela Pugliese Alessandro Armuzzi Claudio Coco | 2014 | World Journal of Gastroenterology2014，20，17： | 5 |
| 4 | Complete decoding of TAL effectors for DNA recognition显示文摘 | Ju n jiao Yang Yuan Zhang Pengfei Yuan Yuexin Zhou Changzu Cai Qingpeng Ren Dingqiao Wen Coco Chu Hai Qi Wensheng Wei | 2014 | Cell Research2014，24，5： | 3 |
| 5 | Retinoic acid receptors and cancer: from molecular mechanisms to therapy显示文摘 | Alessandra di Masi Loris Leboffe Elisabetta De Marinis Francesca Pagano Laura Cicconi Cécile Rochette-Egly Francesco Lo Coco Paolo Ascenzi Clara Nervi | 2014 | Molecular Aspects of Medicine2014，，： | 2 |
| 6 | Identification of a new isoform of the murine Sh2d1a gene and its functional implications显示文摘Signaling lymphocytic activation molecule(SLAM)-associated protein(SAP)is a Src homology(SH)domain 2-containing intracellular adaptor protein that is predominantly expressed in the hematopoietic system by T lymphocytes and NK cells.SAP protein is encoded by the SH2D1A gene located on the X chromosome.Loss-of-function mutations in SAP cause the X-linked lymphoproliferative disease(XLP),a severe immunodeficiency characterized by heightened susceptibility to Epstein-Barr virus and impaired humoral immunity.Normal individuals express several functional and non-functional isoforms of SAP as a result of alternative splicing.In this study,we identify a cryptic exon in the murine Sh2d1a gene.At the mRNA level,the new isoform of SAP(SAP-2)that includes this new exon is widely expressed in lymphoid tissues by C57BL/6 and 129 strains of inbred mice.SAP-2 accounts for approximately 1%3%of total SAP transcripts,and it is dynamically regulated during lymphocyte activation.At the protein level,the SAP-2 isoform is a 144 amino-acid protein.Compared to the dominant 126 amino-acid SAP-1 isoform,the additional 18 amino acids are inserted into a structural region that is critical for phosphotyrosine binding.Our functional analysis in vitro indicates that SAP-2 is a non-functional isoform due to decreased protein stability.Thus,both human and mouse have multiple SAP splice isoforms that may or may not function.Modulation of relative proportions of these isoforms is potentially a mechanism whereby cells can regulate SAP-mediated biological activities. | WU LongYan LU PeiWen MA WeiWei CHU CoCo XU HePing QI Hai | 2014 | Science China(Life Sciences)2014，57，1： | 2 |
| 7 | Neurotrophins and electrical stimulation for protection and repair of spiral ganglion neurons following sensorineural hearing loss显示文摘 | Shepherd RK Coco A Epp SB | 2008 | Hear Res2008，242，： | 1 |
| 8 | Defini-tion of relapse risk and role of nonanthracycline drugsfor consolidation in patients with acute promyelocyticleukemia: A joint study of the PETHEMA andG1MEMA cooperative groups 显示文摘 | SANZ M A LO COCO F MARTIN G | 2000 | Blood2000，96，： | 1 |
| 9 | Randomized, multi- center, phase II b study of preoperative chemoradiotherapy in T3 mid-distal rectal cancer: raltitrexed + oxaliplatin + radiotherapy versus cisplatin+ 5-fluorouracil+radiotherapy 显示文摘 | Valentini V Coco C Minsky BD | 2008 | Int J Radiat On-col Biol Phys2008，70，2： | 1 |
| 10 | GPS Satellites of Opportunity for Ionospheric Monitoring显示文摘 | COCO D | 1991 | Innovation1991，，10： | 1 |
| 11 | Treatment of acute respiratory failure secondaryto pulmonary edema with bilevel positive airway pressure by nasal mask 显示文摘 | Lo Coco A Vitale G Marchese S | 2001 | Monaldi Arch Chest Dia2001，63，： | 1 |
| 12 | Efficacy of caspofungin alone and in combination with voriconazole in guinea pig model of invasive aspergillosis显示文摘 | Kirkpatrick W R Perea S Coco B J | 2002 | Antimicrob Agents Chemother2002，46，： | 1 |
| 13 | Hsp90 (heat shock protein 90) inhibitor occupancy is a direct determinant of client protein degradation and tumor growth arrest in vivo 显示文摘 | TiUotson B Slocum K Coco J | 2010 | J Biol Chem2010，285，39： | 1 |
| 14 | An empirical approach for ranking environmental and energy saving measures in the hotel sector 显示文摘 | Beccali M La Gennusa M Lo Coco L | 2009 | Renewable Energy2009，34，1： | 1 |
| 15 | Measuring technological capabilitiesat the country level: a survey and a menu for choice显示文摘 | ARCHIBUGI D COCO A | 2005 | Research Policy2005，34，2： | 1 |
| 16 | Fractal behaviour in nearshore processes 显示文摘 | Coco G Huntley D A O'Hare T | 2000 | American Society of Civil Engineers2000，，276： | 1 |
| 17 | Preoperative chemoradiation with cisplatin and 5-fiuorouracil for extraperitoneal T3 rectal cancer:Acute toxicity,tumor response,sphincter preservation显示文摘 | Vanlentini V Coco C Cellini N | 1999 | Int J Radiat Oncol Biol Phys1999，45，12： | 1 |
| 18 | COCA: A Novel 3-D FE Simulator for the Design of TWTs Multistage Collectors显示文摘 | Coco S Emma F Laudani A | 2001 | IEEE Trans Electron Devices2001，48，1： | 1 |
| 19 | A multilayer perceptron neural model for the differentiation of laplacian 3-D finite-element solutions 显示文摘 | Capizzi G Coco S Laudani A | 2003 | IEEE Transactions on Magnetics2003，39，3： | 1 |
| 20 | Hepatitis B surface antigen serum levels help to distinguish active from inactive hepatitis B virus genotype D carriers 显示文摘 | Brunetto MR Oliveri F Colombatto P Moriconi F Ciccorossi P Coco B Romagnoli V Cherubini B Moscato G Maina AM Cavallone D Bonino F | 2010 | Gastroenterology2010，139，2： | 1 |
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