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| 1 | Molecular pathogenesis of lymphomas of mucosa-associated lymphoid tissue-from(auto)antigen driven selection to the activation of NF-_(k)B signaling显示文摘Lymphomas of mucosa-associated lymphoid tissue(MALT) are typically present at sites such as the stomach, lung or urinary tract, where lymphoid tissues scatter in mucosa lamina propria, intra- or sub-epithelial cells. The infection of certain pathogens, such as Helicobacter pylori, Chlamydophila psittaci, Borrelia burgdorferi, hepatitis C virus, or certain autoantigens cause these sites to generate a germinal center called the 'acquired lymphoid tissue'. The molecular pathogenesis of MALT lymphoma is a multi-step process. Receptor signaling, such as the contact stimulation of B cell receptors and CD4 positive T cells mediated by CD40/CD40-ligand and T helper cell type 2 cytokines like interleukin-4, contributes to tumor cell proliferation. A number of genetic alterations have been identified in MALT lymphoma, and among them are important translocations, such as t(11;18)(q21;q21), t(1;14)(p22;q32), t(14;18)(q32;q21) and t(3;14)(p13;q32). Fusion proteins generated by these translocations share the same NF-?B signaling pathway, which is activated by the caspase activation and recruitment domain containing molecules of the membrane associated guanylate kinase family, B cell lymphoma-10 and MALT1(CBM) protein complex. They act downstream of cell surface receptors, such as B cell receptors, T cell receptors, B cell activating factors and Toll-like receptors, and participate in the biological process of MALT lymphoma. The discovery of therapeutic drugs that exclusively inhibit the antigen receptor signaling pathway will be beneficial for the treatment of B cell lymphomas in the future. | ZHANG YiAn WEI Zheng LI Jing LIU Peng | 2015 | Science China(Life Sciences)2015，58，12： | 4 |
| 2 | A glimpse of life science research at Tsinghua显示文摘Life Science at Tsinghua University has a long and eventful history.The Biology Department,founded in 1926,was among the oldest and most prestigious in China.In 1952,the Biology Department,together with other natural science departments,were eliminated from the University by order of the central government.In 1984,the Department of Biological Science and Biotechnology was re-established,with Professor Poo Mu-ming being the founding Director.In the ensuing 25 years,the Department went through rapid transformations and gained national and international recognition.In September 2009,the Department of Biological Science and Biotechnology was replaced by the School of Life Sciences. | SHI YiGong | 2014 | Science China(Life Sciences)2014，57，1： | 0 |
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