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| 1 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Current trends of liver cirrhosis in Mexico: Similitudes and differences with other world regions显示文摘AIM To investigate the main current etiologies of cirrhosis in Mexico.METHODS We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-December 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in Mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in Mexico. | Nahum Méndez-Sánchez Felipe Zamarripa-Dorsey Arturo Panduro Emma Purón-González Edgar Ulises Coronado-Alejandro Carlos Alejandro Cortez-Hernández Fátima Higuera de la Tijera José Luis Pérez-Hernández Eira Cerda-Reyes Heriberto Rodríguez-Hernández Vania César Cruz-Ramón Oscar Lenin Ramírez-Pérez Nancy Edith Aguilar-Olivos Olga Fabiola Rodríguez-Martínez Samantha Cabrera-Palma Guillermo Cabrera-álvarez | 2018 | World Journal of Clinical Cases2018，6，15： | 2 |
| 4 | Social interactivity in pigeon courtship behavior显示文摘A closed-loop teleprompter system was used to isolate and manipulate social interactivity in thenatural courtship interactions of pigeons Columbia livia. In Experiment 1, a live face-to-face real-time interaction between 2 courting pigeons (Live) was compared to a played back version of thevideo stimulus recorded during the pairs Live interaction. We found that pigeons were behavinginteractively; their behavior depended on the relationships between their own signals and those oftheir partner. In Experiment 2, we tested whether social interactivity relies on spatial cues presentin the facing direction of a partner's display. By moving the teleprompter camera 90~ away from itsoriginal location, the partner's display was manipulated to appear as if it is directed 90~ away fromthe subject. We found no effect of spatial offset on the pigeon's behavioral response. In Experiment3, 3 time delays, 1 s, 3s, and 9s, a Live condition, and a playback condition were chosen to investi-gate the importance of temporal contiguity in social interactivity. Furthermore, both opposite-sex(courtship) and same-sex (rivalry) pairs were studied to investigate whether social-context affectssocial interactivity sensitivity. Our results showed that pigeon courtship behavior is sensitive totemporal contiguity. Behavior declined in the 9 s and Playback conditions as compared to Live con-dition and the shorter time delays. For males only, courtship behavior also increased in the 3-sdelay condition. The effect of social interactivity and time delay was not observed in rivalry inter-actions, suggesting that social interactivity may be specific to courtship. | Emma L.R. WARE Daniel R. SAUNDERS Nikolaus F, TROJE | 2017 | Current Zoology2017，63，1： | 2 |
| 5 | Collapsing glomerulopathy associ ated with inherited mitochondriai injury显示文摘 | Barisoni L Diomedi-Camassei F Santorelli F M Caridi G Thomas D B Emma F | 2008 | Kidney Int2008，74，： | 1 |
| 6 | COCA: A Novel 3-D FE Simulator for the Design of TWTs Multistage Collectors显示文摘 | Coco S Emma F Laudani A | 2001 | IEEE Trans Electron Devices2001，48，1： | 1 |
| 7 | Cellular and molecular physiology of volume-sensitive anion channels显示文摘 | Strange K Emma F Jackson P S | 1996 | Am J Physiol1996，270，： | 1 |
| 8 | Phenotypic and genetic heterogeneity in Dent's disease-the results of an Italian collaborative study显示文摘 | Tosetto E Ghiggeri GM Emma F | 2006 | Nephrol Dial Transplant2006，21，9： | 1 |
| 9 | Clinicians' Attitudes to Clinical Practice Guidelines: a systematic review显示文摘 | Emma W K Jean R S | 2002 | MJA2002，177，9： | 1 |
| 10 | The negativeeffects of bile acids and tumor necrosis factor-αon the tran-scription of cholesterol 7α-hydroxylase gene(CYP7A1)con-verge to hepatic nuclear factor-4显示文摘 | Emma De F Nico M Ana Cecilia A | 2001 | J Biol Chem2001，276，30： | 1 |
| 11 | A case of mesenteric inflammatory veno-occlusive disease mimicking new onset inflammatory bowel disease in a healthy 71-year-old man显示文摘 | Therese B Jesse G Emma F | 2014 | Inflammatory Bowel Diseases2014，20，1： | 1 |
| 12 | Sensitivity analysis of TWT's small signal gain based on the effect of rod shape and dimensions显示文摘 | Emma F Paoloni C | 2000 | IEEE Trans on Electron Devices2000，47，7： | 1 |
| 13 | Accurate analysis of helix slow-wave structures显示文摘 | Emma F Paoloni C | 1998 | IEEE Trans on Electron Devices1998，45，7： | 1 |
| 14 | Inflammatory response to cardiac bypass in ewe fetuses:effects of steroid administration continuous hemodiafiltration显示文摘 | Carotti A Emma F Picca S | 2003 | J Thorac Cardiovase Surg2003，126，6： | 1 |
| 15 | Intracellular electrolytes regulate the volume set point of the organic osmolytel anion channel(VSOACs)显示文摘 | Emma F Mcmanns M Strange K | 1997 | Am J Physiol1997，272，： | 1 |
| 16 | What Parents Say about Disclosing the End of Their Pregnancy Due to Fetal Abnormality显示文摘 | Emma F Kate H Su Z | 2013 | Midwifery2013，29，1： | 1 |
| 17 | Ligation of TLR9 induced on human IL-10-secreting Tregs by 1[alpha],25-dihydroxyvitamin D3 abrogates regulatory function显示文摘 | Urry Zo? Xystrakis Emmanuel Richards David F McDonald Joanne Sattar Zahid Cousins David J Corrigan Christopher J Hickman Emma Brown Zarin Hawrylowicz Catherine M | 2009 | Journal of Clinical Investigation2009，，2： | 1 |
| 18 | Compositional features of polysaccharides from Aloe Vem(Aloe barbadensis Miller) plant tissues显示文摘 | Antoni F Emma S Sanchez SS | 1999 | Carbohydrate Polymers1999，39，2： | 1 |
| 19 | Eculizumab for the treatment of dense-deposit disease显示文摘 | Vivarelli M Pasini A Emma F | 2012 | N Engl J Med2012，366，12： | 1 |
| 20 | Treatment of C3 glomerulopathy with com-plement blockers显示文摘 | Vivarelli M Emma F | 2014 | Semin Thromb Hemost2014，40，4： | 1 |
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