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| 1 | Clinical Observation of Transepithelial Corneal Collagen Cross-linking by Iontophoresis of Riboflavin in Treatment of Keratoconus显示文摘Purpose: To evaluate the efficacy and safety of transepithelial collagen cross-linking by iontophoretic delivery of riboflavin in treatment of progressive keratoconus.Methods:.Eleven patients(15 eyes) with progressive keratoconus were enrolled. After 0.1% riboflavin-distilled water solution was deliveried via transepithelial iontophpresis for 5 min with 1 m A current, and ultraviolet radiation(370 nm,.3 m W /cm2) was performed at a 1.5 cm distance for 30 min. The follow up were 6 months in all eyes. The uncorrected visual acuity, corrected visual acuity,endothelial cell counting, corneal thickness,.intraocular pressure, corneal curvature, corneal topography,.OCT and corneal opacity before and 6-month after surgery were analyzed.Results: At 6 month postoperatively, mean uncorrected visual acuity and corrected visual acuity changed from 0.36 to 0.30 and from 0.42 to 0.57 without statistical significance..The mean value of each index of corneal curvature declined without statistical significance.Kmax value dereased from 60.91 to59.91, and the astigmatism declined from 3.86 to 3.19. Central corneal thickness decreased from 460.93 μm to 455.40μm,.and thinnest corneal thickness declined from 450.87 μm to 440.60 μm with no statistical significance..Intraocular pressure was significantly elevated from 10.85 mm Hg to 12.62 mm Hg. Endothelial cell count did not change significantly. No corneal haze occurred. Mean depth of corneal demarcation line was 288.46 μm at 1 month postoperatively..Conclusion:.Transepithelial corneal collagen cross-linking by iontophoresis is effective and safe in the treatment of progressive keratoconus, and yields stable clinical outcomes during 6-month follow up..However,.long-term follow up is urgently required. | Na Li Zhengjun Fan Xiujun Peng Xu Pang Chunyu Tian | 2014 | Eye Science2014，29，3： | 15 |
| 2 | Preparation of carbon-coated iron oxide nanoparticles dispersed on graphene sheets and applications as advanced anode materials for lithium-ion batteries显示文摘 | Huilong Fei Zhiwei Peng Lei Li Yang Yang Wei Lu Errol L. G. Samuel Xiujun Fan James M. Tour | 2014 | Nano Research2014，7，4： | 10 |
| 3 | Iontophoretic Delivery of Riboflavin into the Rabbit Cornea:a Primary Study显示文摘Purpose: To determine the penetrability of riboflavin into the corneal stroma by iontophoresis and to compare the permeability effects of different solvents.Methods: Twenty rabbits were randomly divided into four groups: a group that received 0.1% riboflavin-balanced salt solution(BSS) by iontophoresis, a group that received 0.1%riboflavin-saline solution by iontophoresis, a group that received 0.1% riboflavin-distilled water solution by iontophoresis, and a control group that received classical riboflavin instillation after corneal de-epithelialization. The degree of yellowing of the de-epithelialized corneal stromal button from each rabbit was compared.Results: The yellow color scores for the corneal stromal buttons in the three iontophoresis groups were compared with those of control group. Iontophoretic delivery of a 0.1% riboflavin-distilled water solution yielded similar yellow changes in the corneal stromal button when compared with classical riboflavin instillation after de-epithelialization. However, the other two solvents did not sufficiently enhance the permeability of riboflavin.Conclusion: Riboflavin can effectively penetrate into the corneal stroma to saturation levels by iontophoresis. Using distilled water as the solvent can promote penetrability. | Na Li Xiujun Peng Zhengjun Fan Yu Xia | 2014 | Eye Science2014，29，1： | 9 |
| 4 | High thermal conductivity of suspended few-layer hexagonal boron nitride sheets显示文摘推迟的很少层的热传导六角形的硼氮化物(h-BN ) 表试验性地用一个 noncontact micro-Raman 光谱学方法被调查。为单层(1L ) 的一阶的温度系数, bilayer (2L ) 并且九层(9L ) h-BN 表被测量是(当时, electrospinning 准备的 3.41 xide nanofibers 被期望减少了热电导率与体积样品相比。自从它包含复杂样品准备方法,热电导率正在质问的 nanofibers 的大小。在这个工作,我们在场对单个 nanofiber 的热电导率的大小合适的一个新奇方法。一 microelectro 机械(MEMS ) 设备被设计了并且制作了在单个 nanofiber 上执行热传导性大小。一个特殊 Si 模板被设计收集并且转单个 nanofibers 到 MEMS 设备名上吗? | Haiqing Zhou Jixin Zhu Zheng Liu Zheng Yan Xiujun Fan Jian Lin Gunuk Wang Qingyu Yan Ting Yu Pulickel M. Ajayan James M. Tour | 2014 | Nano Research2014，7，8： | 9 |
| 5 | Corneal refractive surgery and phakic intraocular lens for treatment of amblyopia caused by high myopia or anisometropia in children显示文摘 | Tian Chunyu Peng Xiujun Fan Zhengjun Yin Zhengqin | 2014 | Chinese Medical Journal2014，，11： | 6 |
| 6 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 7 | Clinical Evaluation of Pranoprofen Combined with Fluorometholone Eye Drops on Postoperative Reaction of Corneal Cross-linking显示文摘Purpose:To evaluate the efficacy and safety of pranoprofen eye drops for reducing postoperative ocular pain and inflammation after corneal cross-linking (CXL). Methods:Twenty-seven patients (38 eyes) with keratoconus undergoing CXL were examined and randomly divided into control (12 cases; 18 eyes) and experimental groups (15 cases;20 eyes).The patients in the control group were given fluorometholone eye drops,and those in the experimental group were administered with fluorometholone combined with pranoprofen eye drops.Corneal irritation and haze were compared between the two groups at 1 month postoperatively. Results:At 1 to 3 days after surgery,the corneal irritation in the experimental group was significantly reduced compared with that in the control group (P<0.05), but there was no significant difference on 5 to 7 days postoperatively (P>0.05). The average degree of haze in the experimental group was significantly lower than that in the control group 1 month after surgery (P<0.05), but there was no significant difference in the best-corrected vision acuity and intraocular pressure between the two groups. There were 2 cases with >20 mmHg intraocular pressure in the control group. Conclusion:The combined use of fluorometholone and pranoprofen can significantly reduce inflammatory response,alleviate corneal irritation at early stage after CXL,effectively prevent and control the average of haze,and reduce the incidence of steroid-induced ocular hypertension after surgery. | Xu Pang Zhengjun Fan Xiujun Peng Hongzhen Jia Tengfei Wu | 2012 | Eye Science2012，27，4： | 4 |
| 8 | 2020 Roadmap on two-dimensional nanomaterials for environmental catalysis显示文摘Environmental catalysis has drawn a great deal ofattention due to its clean ways to produce useful chemicals or carry out some chemical processes.Photocatalysis and electrocatalysis play important roles in these fields.They can decompose and remove organic pollutants from the aqueous environment,and prepare some fine chemicals.Moreover,they also can carry out some important reactions,such as 02 reduction reaction(ORR),O2 evolution reaction(OER),H2 evolution reaction(HER),CO2 reduction reaction(C02 RR),and N2 fixation(NRR).For catalytic reactions,it is the key to develop high-performance catalysts to meet the demand fortargeted reactions.In recentyears,two-dimensional(2 D) materials have attracted great interest in environmental catalysis due to their unique layered structures,which offer us to make use of their electronic and structural characteristics.Great progress has been made so far,including graphene,black phosphorus,oxides,layered double hydroxides(LDHs),chalcogenides,bismuth-based layered compounds,MXenes,metal organic frameworks(MOFs),covalent organic frameworks(COFs),and others.This content drives us to invite many famous groups in these fields to write the roadmap on two-dimensional nanomaterials for environmental catalysis.We hope that this roadmap can give the useful guidance to researchers in future researches,and provide the research directions. | Yulu Yang Mingguang Wu Xingwang Zhu Hui Xu Si Ma Yongfeng Zhi Hong Xia Xiaoming Liu Jun Pan Jie-Yinn Tang Siang-Piao Chai Leonardo Palmisano Francesco Parrino Junli Liu Jianzhong Ma Ze-Lin Wang Ling Tan Yu-Fei Zhao Yu-Fei Song Pardeep Singh Pankaj Raizada Deli Jiang Di Li R.A.Geioushy Jizhen Ma Jintao Zhang Song Hu Rongjuan Feng Gang Liu Minghua Liu Zhenhua Li Mingfei Shao Neng Li Jiahe Peng Wee-Jun Ong Nikolay Kornienko Zhenyu Xing Xiujun Fan Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 2 |
| 9 | Characteristics of Channeling Flow in Cultivated Horizon of Saline Rice Soil显示文摘By applying bromide ion as tracer,the channeling flow has been quantitatively described in saline rice soil and alkaline soil of Da,an City,Jilin Province of China.Breakthrough curves of bromide ion in the saline rice soils after 1-year cultivation and 5-year cultivation and alkaline soil have been attained.Results show that the rice cultivation practice can improve the alkaline soil structure,however,it can accelerate the development of channeling flow pathway.Therefore,the channeling flow pathway has been developed widely in saline rice soil,but rarely in the alkaline soil.Three models of convection-dispersion equation(CDE),transfer functional model(TFM) and Back-Progation Network(BP Network) were used to simulate the transportation process of bromide ion.The peaks of probability density function of saline rice soil are higher with left skewed feature compared with that of the alkaline soil.It shows that the TFM and CDE can simulate the transportation process of the bromide ion in saline rice soil after 5-year cultivation,however,some deviation exists when it was used to simulate transportation process of bromide ion in saline rice soil after 1-year cul-tivation and alkaline soil;BP network can effectively simulate transportation process of bromide ion in both saline rice soil and alkaline soil. | LUO Jinming DENG Wei ZHANG Xiaoping YANG Fan LI Xiujun | 2006 | Chinese Geographical Science2006，16，4： | 1 |
| 10 | Research Progress in Corneal Cross-linking Agents显示文摘Corneal collagen cross-linking with UVA-riboflavin is currently the only method for preventing the progression of keratoconus from the pathological perspective. Topical application of a direct cross-linking agent is now attracting widespread attention in clinical settings..This article reviews the research progress in the application of indirect or direct cross-linking agents(e.g., riboflavin, glucose, ribose, glutaraldehyde,formaldehyde,.glyceraldehyde,.short chain aliphatic β-nitro alcohol, and genipin) in the treatment of corneal diseases and analyzes the cross-linking efficacy,.toxicity,.and merits and disadvantages of each cross-linking agent,.providing clinical information for further studies. | Na Li Xiujun Peng Zhengjun Fan | 2014 | Eye Science2014，29，2： | 1 |
| 11 | New techniques to improve classical corneal collagen cross-linking treatment显示文摘 | Li Na Peng Xiujun Fan Zhengjun Xia Yu Wu Tengfei | 2014 | Chinese Medical Journal2014，，8： | 1 |
| 12 | Decreased CDld level is associated with CD86 over-expression in B cells from systemic lupus erythematosus显示文摘 | Fei Liu Jianjian Ji Xiujun Li Xiaojing Li Jingjing Xu Huimin Yue Shuli Zhao Hongye Fan Yayi Hog | 2017 | Acta Biochimica et Biophysica Sinica2017，49，4： | 1 |
| 13 | Identification of Avian-Derived Ingredients in Livestock and Poultry Meat by PCR Technology显示文摘In order to establish a quick and specific method which could identify the avian-derived ingredients,this study used 16 S rRNA gene sequence as target site,and designed the specific primers of chicken,pigeon meat and quail meat. The DNA of common livestock and poultry meat( including mutton,beef,pork,rabbit meat,pigeon meat,quail meat,chicken,duck and goose) was used as template. Though PCR amplification and specific detection,a quick determination method was established to identify the avian-derived ingredients. The results showed that the selected primers could identify the ingredients of animal origin effectively and quickly. The method was convenient and concise,and could detect the chicken-derived,pigeon-derived,quail-derived ingredients in livestock and poultry food quickly and accurately. | Jingxin ZHANG Yushi GAO Xiujun TANG Yanfeng FAN Mengjun TANG Dawei CHEN Qinglian GE Rong GU | 2016 | Asian Agricultural Research2016，8，12： | 0 |
| 14 | Complete Sequence Determination and Origin of Mitochondrial DNA Control Region in Dehua Black Chicken显示文摘Primers were designed according to the genomic DNA of red jungle fowl,and the complete sequence of mt DNA D-loop region in Dehua black chicken was obtained.Combined with the D-loop region complete sequence of red jungle fowl in Gen Bank,the maternal origin of Dehua black chicken was explored.The results showed that the complete sequence of mt DNA D-loop region in Dehua black chicken was 1 231 bp,and the average contents of T,C,A and G were33.5%,26.5%,26.7% and 13.3%,respectively.Phylogenetic analysis showed that Dehua black chicken clustered with red jungle fowl (Gallus gallus spadiceus),suggesting Dehua black chicken probably originated from G.g.spadiceus in Yunnan Province or nearby areas. | Lu Junxian Jia Xiaoxu Tang Xiujun Fan Yanfeng Gu Rong Ge Qinglian Gao Yushi | 2016 | Animal Husbandry and Feed Science2016，8，5： | 0 |
| 15 | Targeting LncRNA LLNLR-299G3.1 with antisense oligonucleotide inhibits malignancy of esophageal squamous cell carcinoma cells in vitro and in vivo显示文摘Accumulating evidence has indicated that long non-coding RNAs(lncRNAs)play critical roles in the development and progression of cancers,including esophageal squamous cell carcinoma(ESCC).However,the mechanisms of lncRNAs in ESCC are still incompletely understood and therapeutic attempts for in vivo targeting cancer-associated lncRNA remain a challenge.By RNA-sequencing analysis,we identified that LLNLR-299G3.1 was a novel ESCC-associated lncRNA.LLNLR-299G3.1 was up-regulated in ESCC tissues and cells and promoted ESCC cell proliferation and invasion.Silencing of LLNLR-299G3.1 with ASO(antisense oligonucleotide)resulted in opposite effects.Mechanistically,LLNLR-299G3.1 bound to cancerassociated RNA binding proteins and regulated the expression of cancer-related genes,including OSM,TNFRSF4,HRH3,and SSTR3.ChIRP-seq(chromatin isolation by RNA purification and sequencing)revealed that these genes contained enriched chromatin binding sites for LLNLR-299G3.1.Rescue experiments confirmed that the effects of LLNLR-299G3.1 on ESCC cell proliferation were dependent on interaction with HRH3 and TNFRSF4.Therapeutically,intravenous delivery of placental chondroitin sulfate A binding peptide-coated nanoparticles containing antisense oligonucleotide(pICSA-BP-ANPs)strongly inhibited ESCC tumor growth and significantly improved animal survival in vivo.Overall,our results suggest that LLNLR-299G3.1 promotes ESCC malignancy through regulating gene-chromatin interactions and targeting ESCC by pICSA-BP-ANPs may be an effective strategy for the treatment of lncRNA-associated ESCC. | LI TIAN YONGYI HUANG BAOZHEN ZHANG YI SONG LIN YANG QIANQIAN CHEN ZHENG WANG YILING WANG QIHAN HE WENHAN YANG SHUYONG YU TIANYU LU ZICHEN LIU KAIPING GAO XIUJUN FAN JIAN SONG RIHONG ZHAI | 2023 | Oncology Research2023，31，4： | 0 |
| 16 | Variation in Central Corneal Thickness during Open- or Closed-Eye Riboflavin Instillation for Corneal Collagen Cross-linking显示文摘Purpose:To assess the effect of having an open or closed eye on the variation in central corneal thickness during riboflavin instillation for corneal collagen cross-linking (CXL).Methods:.Thirty eyes of 15 New Zealand White rabbits underwent an in vivo anterior segment optical coherence tomography (OCT) examination at 0,10,20,and 30 min after riboflavin instillation on the de-epithelialized corneal surface.Each eye of every rabbit was randomly placed into one of two different treatment groups(open-eye or closed-eye)during the instillation;.the examinations were performed one after the other.After instillation for 30 min,the changes in the corneal stroma and anterior chamber were observed by slit lamp.Results:.A significant decrease in the central corneal thickness(CCT).was demonstrated during riboflavin instillation;.the variations were smaller in the measurements performed with the eye closed than with the eye open.(81.36±15.13μm and129.20±12.05μm respectively)..Both methods turned the corneal stroma and anterior chamber yellow.Conclusion:Keeping the eye closed during riboflavin instillation reduced the decrease in the CCT..The same yellow change in the corneal stroma and anterior chamber occurred,but the exposure time of the ocular surface was shorter.Therefore,.keeping the eye closed was a more effective and safer method than keeping the eye open. | Na Li Xiujun Peng Zhengjun Fan Xu Pang Yu Xia | 2013 | Eye Science2013，28，4： | 0 |
| 17 | Petrogenesis Significance of Chromian Spinels from Northeastern Jiangxi Province Ophiolite(NEJXO), China: Paleogeodynamic Implications显示文摘1 Introduction The northeastern Jiangxi Province ophiolite is located in the SE margin of the Yangtze Block,along the Zhangshudun(Yiyang)-Xingangshan(Dexing),ophiolite belt extending northeast for about 100km(Zhou,1989;Li et al.,1997).The original sequence of the NE Jiangxi ophiolite suite has been structurally disrupted | GUO Guolin FAN Xiujun YANG Jingsui LIU Xiaodong ZHANG Yong ZHOU Wenting | 2015 | Acta Geologica Sinica(English Edition)2015，89，A02： | 0 |
| 18 | Comparison of Central Corneal Thickness using Ultrasound Pachymetry during Corneal Collagen Cross-linking显示文摘Purpose:To study variation in central corneal thickness (CCT) during corneal collagen cross-linking(CXL) using ultrasound pachymetry. Methods:Twenty patients (26 eyes) with progressing keratoconus undergoing riboflavin-UVA-induced CXL were involved in this study. Intraoperative CCT measurement using ultrasonic pachymetry was performed during the procedure.Measurements were obtained before operation, after epithelial removal, after riboflavin drop instillation, and after UVA irradiation. Results:Mean CCT was 495±56 and 450±52 μm before and after epithelial removal, respectively. Mean CCT was 443±42 and 411±39 μm after riboflavin drop instillation and after UVA irradiation, respectively. Statistically significant decreases in CCT occurred between the preoperative period and after epithelial removal, after riboflavin drop instillation and after UVA irradiation. Twenty-six eyes from 20 patients undergoing CXL were divided into 2 groups (I with CCT≥400 μm after UVA irradiation and II with CCT<400 μm after UVA irradiation). No statistically significant difference was noted between I and II in preoperative endothelial cell count, but a statistically greater postoperative endothelial cell count was noted in I compared to II. A statistically significant difference was evident between preoperative and postoperative endothelial cell counts in Group II (P<0.05). Conclusion:Performing CXL with the use of riboflavin and UVA irradiation resulted in a statistically significant decrease in CCT, to a level where the corneal endothelium may be damaged.(Eye Science 2013; 28:15-19) | Xu Pang Xiujun Peng Zhengjun Fan Hongzhen Jia Tengfei Wu | 2013 | Eye Science2013，28，1： | 0 |
| 19 | A histological examination of corneal epithelium after iontophoresis with different riboflavin solutions显示文摘To the Editor:Currently,from a pathological point of view,corneal collagen crosslinking(CXL)with riboflavin is the only new therapy for controlling keratoconus progression.Riboflavin,as a photosensitizer,can be activated after the ultraviolet radiation in the cornea and prevent it from damaging intraocular organizations.Therefore,the concentration of riboflavin in the corneal stroma must be maintained at a sufficient level during the treatment.[1]Riboflavin,a type of water-soluble macromolecule,is resistant to permeating the corneal epithelial barrier.Thus,de-epithelial eye-dripping was adopted conventionally with complications such as inevitable pain,long recovery time,potential risk of infection,and so on;transepithelial corneal CXL is increasingly becoming a research hotspot.It is thus critically important to improve the transepithelial penetration of riboflavin.Although iontophoresis was reported,it had a slightly higher effect with no clear mechanism analysis.[2,3,4]Corneal epithelium is lipophilic and hydrophobic,and hydrophilic drugs enter corneal stroma via intercellular pathways.In this study,permeability effects of riboflavin in different solvents into the cornea via iontophoresis were compared,and the changes of corneal epithelial cell layer organizations were analyzed to examine the solvent components that are most beneficial to iontophoresis and investigate the underlying mechanism of the penetration effect. | Na Li Zhengjun Fan Xiujun Peng | 2022 | Chinese Medical Journal2022，，6： | 0 |
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