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| 1 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 2 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 3 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 4 | 3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia显示文摘3-N-butylphthalide is an effective drug for acute ischemic stroke. However, its effects on chronic cerebral ischemia-induced neuronal injury remain poorly understood. Therefore, this study ligated bilateral carotid arteries in 15-month-old rats to simulate chronic cerebral ischemia in aged humans. Aged rats were then intragastrically administered 3-n-butylphthalide. 3-N-butylphthalide administration improved the neuronal morphology in the cerebral cortex and hippocampus of rats with chronic cerebral ischemia, increased choline acetyltransferase activity, and decreased malondialdehyde and amyloid beta levels, and greatly improved cognitive function. These findings suggest that 3-n-butylphthalide alleviates oxidative stress caused by chronic cerebral ischemia, improves cholinergic function, and inhibits amyloid beta accumulation, thereby improving cerebral neuronal injury and cognitive deficits. | Wanhong Zhao Chao Luo Jue Wang Jian Gong Bin Li Yingxia Gong Jun Wang Hanqin Wang | 2014 | Neural Regeneration Research2014，9，7： | 43 |
| 5 | Correlation analysis between vegetation coverage and climate drought conditions in North China during 2001–2013显示文摘Climate change is one of the most important factors that affect vegetation distribution in North China. Among all climatic factors, drought is considered to have the most significant effect on the environment. Based on previous studies, the climate drought index can be used to assess the evolutionary trend of the ecological environment under various arid climatic conditions. It is necessary for us to further explore the relationship between vegetation coverage(index) and climate drought conditions. Therefore, in this study, based on MODIS-NDVI products and meteorological observation data, the Palmer Drought Severity Index(PDSI) and vegetation coverage in North China were first calculated. Then, the interannual variations of PDSI and vegetation coverage during 2001–2013 were analyzed using a Theil-Sen slope estimator. Finally, an ecoregion perspective of the correlation between them was discussed. The experimental results demonstrated that the PDSI index and vegetation coverage value varied over different ecoregions. During the period 2001–2013, vegetation coverage increased in the southern and northern mountains of North China, while it showed a decreasing trend in the Beijing-Tianjin-Tangshan City Circle area and suburban agricultural zone located in Hebei Province and Henan Province). Over 13 years, the climate of the northeastern part of North China became more humid, while in the southern part of North China, it tended to be dry. According to the correlation analysis results, 73.37% of North China showed a positive correlation between the vegetation coverage and climate drought index. A negative correlation was observed mainly in urban and suburban areas of Beijing, Tianjin, Hebei Province, and Henan Province. In most parts of North China, drought conditions in summer and autumn had a strong influence on vegetation coverage. | GONG Zhaoning ZHAO Shuyi GU Jinzhi | 2017 | Journal of Geographical Sciences2017，27，2： | 38 |
| 6 | Ginsenoside Rgl protects against ischemic/reperfusioninduced neuronal injury through miR-144/Nrf2/ARE pathway显示文摘Ginsenoside Rg1 (Rg1),a saponin extracted from Panax ginseng,has been well documented to be effective against ischemic/ reperfusion (I/R)neuronal injury.However,the underlying mechanisms remain obscure.In the present study,we investigated the roles of Nrf2 and miR-144 in the protective effects of Rgl against I/R-induced neuronal injury.In OGD/R-treated PC12 cells,Rgl (0.01-1 μmol/L)dose-dependently attenuated the cell injury accompanied by prolonging nuclear accumulation of Nrf2,enhancing the transcriptional activity of Nrf2,as well as promoting the expression of ARE-target genes.The activation of the Nrf2/ARE pathway by Rgl was independent of disassociation with Keapl,but resulted from post-translational regulations.Knockdown of Nrf2 abolished all the protective changes of Rgl in OG-D/R-treated PC12 cells.Furthermore,Rgl treatment significantly decreased the expression of miR-144,which downregulated Nrf2 production by targeting its 3'-untranlated region after OGD/R.Knockdown of Nrf2 had no effect on the expression of miR-144,suggesting that miR-144 was an upstream regulator of Nrf2.We revealed that there was a direct binding between Nrf2 and miR-144 in PC12 cells.Application of anti-miR-144 occluded the activation of the Nrf2/ ARE pathway by Rgl in OGD/R-treated PC12 cells.In tMCAO rats,administration of Rgl (20 mg/kg).significantly alleviated ischemic injury,and activated Nff2/ARE pathway.The protective effects of Rgl were abolished by injecting of AAV-HIF-miR-144-shRNA into the predicted ischemic penumbra.In conclusion,our results demonstrate that Rgl alleviates oxidative,stress after I/R through inhibiting miR-144 activity and subsequently promoting the Nrf2/ARE pathway at the post-translational-level. | Shi-feng Chu Zhao Zhang Xin Zhou Wen-bin He Chen Chen Piao Luo Dan-dan Liu Qi-di Ai Hai-fan Gong Zhen-zhen Wang Hong-shuo Sun Zhong-ping Feng Nai-hong Chen | 2019 | Acta Pharmacologica Sinica2019，40，1： | 30 |
| 7 | China's wetland change (1990-2000) determined by remote sensing显示文摘Two wetland maps for the entire China have been produced based on Landsat data acquired around 1990 and 2000. Wetlands in China have been divided into 3 broad categories with 15 sub-categories except rice fields. In 1990, the total wetland area in China was 355208 km2 whereas in 2000 it dropped to 304849 km2 with a net loss of 50360 km2. During an approximate 10-year period, inland wetland reduced from 318326 to 257922 km2, coastal wetland dropped from 14335 to 12015 km2, while artificial wetland increased from 22546 to 34911 km2. The greatest natural wetland loss occurred in Heilongjiang, Inner Mon- golia, and Jilin with a total loss of over 57000 km2 of wetland. In western China, over 13000 km2 of wetlands were newly formed in Xinjiang, Tibet, and Qinghai. About 12000 km2 of artificial wetlands were also added for fish farm and reservoir constructions. The newly formed wetlands in western China were caused primarily by climate warming over that region whereas the newly created artificial wetlands were caused by economic developments. China’s wetland loss is caused mainly by human activities. | Peng Gong ZhenGuo Niu Xiao Cheng KuiYi Zhao DeMin Zhou JianHong Guo Lu Liang XiaoFeng Wang DanDan Li HuaBing Huang et al. | 2010 | Science China Earth Sciences2010，53，7： | 28 |
| 8 | A multi-resolution global land cover dataset through multisource data aggregation显示文摘Recent developments of 30 m global land characterization datasets(e.g., land cover, vegetation continues field) represent the finest spatial resolution inputs for global scale studies. Here, we present results from further improvement to land cover mapping and impact analysis of spatial resolution on area estimation for different land cover types. We proposed a set of methods to aggregate two existing 30 m resolution circa 2010 global land cover maps, namely FROM-GLC(Finer Resolution Observation and Monitoring-Global Land Cover) and FROM-GLC-seg(Segmentation), with two coarser resolution global maps on development, i.e., Nighttime Light Impervious Surface Area(NL-ISA) and MODIS urban extent(MODIS-urban), to produce an improved 30 m global land cover map—FROM-GLC-agg(Aggregation). It was post-processed using additional coarse resolution datasets(i.e., MCD12Q1, GlobCover2009, MOD44 W etc.) to reduce land cover type confusion. Around 98.9% pixels remain 30 m resolution after some post-processing to this dataset. Based on this map, majority aggregation and proportion aggregation approaches were employed to create a multi-resolution hierarchy(i.e., 250 m, 500 m, 1 km, 5 km, 10 km, 25 km, 50 km, 100 km) of land cover maps to meet requirements for different resolutions from different applications. Through accuracy assessment, we found that the best overall accuracies for the post-processed base map(at 30 m) and the three maps subsequently aggregated at 250 m, 500 m, 1 km resolutions are 69.50%, 76.65%, 74.65%, and 73.47%, respectively. Our analysis of area-estimation biases for different land cover types at different resolutions suggests that maps at coarser than 5 km resolution contain at least 5% area estimation error for most land cover types. Proportion layers, which contain precise information on land cover percentage, are suggested for use when coarser resolution land cover data are required. | YU Le WANG Jie LI XueCao LI CongCong ZHAO YuanYuan GONG Peng | 2014 | Science China Earth Sciences2014，57，10： | 24 |
| 9 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 10 | Cardiotoxicity of 5-fluorouracil and capecitabine in Chinese patients: a prospective study显示文摘Background:5-Fluorouracil(5-FU)and capecitabine-associated cardiotoxicity ranging from asymptomatic electro-cardiography(ECG)abnormalities to severe myocardial infarction has been reported in a number of studies,but such cardiotoxicity in Chinese patients with malignant diseases has not been investigated to date.In the present study,we aimed to prospectively evaluate the incidence rates and clinical manifestations of 5-FU-and capecitabine-associated cardiotoxicity in cancer patients recruited from multiple centers in China.Methods:Among the 527 patients who completed the study,196 received 5-FU-based chemotherapy and 331 received capecitabine-based chemotherapy as either first-line or adjuvant therapy.Adverse events were reported during the treatment and up to 28 days of follow-up.Outcome measures included ECG,myocardial enzymes,cardiac troponin,brain natriuretic peptide and echocardiography.Univariate analysis and logistic regression were performed for subgroup analysis and identification of significant independent variables that are associated with cardiotoxicity of both agents.Results:In total,161 of 527 patients(30.6%)experienced cardiotoxicity.The incidence rate of cardiotoxicity was 33.8%(112/331)in the capecitabine group,which was significantly higher than the rate of 25%(49/196)in the 5-FU group(P=0.0042).110/527 patients(20.9%)suffered arrhythmia,105/527(19.9%)developed ischemic changes,while only 20/527 patients(3.8%)presented heart failure and 6/527 patients(1.1%)had myocardial infarction.Pre-existing cardiac disease,hypertension,capecitabine-based chemotherapy and duration of treatment were identified as sig-nificant risk factors associated with cardiotoxicity.The odds ratio were 15.7(prior history of cardiac disease versus no history),1.86(capecitabine versus 5-FU),1.06(5-8 versus 1-4 chemotherapy cycles)and 1.58(hypertension versus no hypertension),respectively.Conclusions:Cardiotoxicity induced by fluoropyrimidines in the Chinese population may be underestimated in clini-cal practice.Close monitoring of patients is recommended,especially for those patients at high risk for cardiotoxicity.Possible risk factors are duration of treatment,capecitabine-based chemotherapy,pre-existing cardiac diseases and hypertension.Trial registration This study was initiated on January 22,2014 and has been retrospectively registered with the registra-tion number ChiCTR1800015434 . | Jianjun Peng Chao Dong Chang Wang Weihua Li Hao Yu Min Zhang Qun Zhao Bo Zhu Jun Zhang Wenliang Li Fenghua Wang Qiong Wu Wenhao Zhou Ying Yuan Meng Qiu Gong Chen | 2018 | Cancer Communications2018，38，1： | 23 |
| 11 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 12 | Studies on classification,criteria and control of rockbursts显示文摘This paper attempts to present the findings involving rockbursts classification,rockburst failure criteria,and related control measures.Experimental investigations were performed using the strainburst testing machine and impact-induced rockburst testing machine.According to the stress paths and experimental methods,rockbursts were classified into two major groups,i.e.the strainbursts and impact-induced bursts.The mechanisms and criteria of rockburst obtained from experimental investigations were discussed.Then,the developments of constant-resistance and large-deformation bolt(CRLDB),which can adapt itself to the external loading at a constant resistance by elongating continually,were introduced.The deformation energy of country rocks with large deformation can be absorbed by CRLDBs.Finally,the principles and the experimental results for control and prevention of rockburst using the CRLDBs were presented. | Manchao He Hongman Xia Xuena Jia Weili Gong Fei Zhao Kangyuan Liang | 2012 | Journal of Rock Mechanics and Geotechnical Engineering2012，4，2： | 21 |
| 13 | Pre-treatment with IL-1β enhances the efficacy of MSC transplantation in DSS-induced colitis显示文摘间充质的干细胞(MSC ) 试验性地被使用了对待煽动性的混乱,部分由于他们的抑制免疫力的性质。尽管 interleukin-1β(IL-1β) 是最重要的煽动性的调停人之一,成长证据显示那 IL-1β发信号得到 MSC 的抑制免疫力的性质。然而,它仍然保持不清楚怎么 IL-1β发信号完成这项活动。这里,我们集中于 IL-1β 的治疗学的功效;在葡聚糖硫酸盐钠(决策支持系统) 的告知的 MSC 劝诱了大肠炎模型,除了加重的机制。我们首先发现了那 IL-1β没有在 vitro 的任何看得见的显型变化,告知的 MSC 显著地稀释了导致决策支持系统的鼠科的大肠炎的发展。而且, IL-1β告知的 MSC 通过提高 cyclooxygenase-2 (COX-2 ) 在怒气和 mesenteric 淋巴节点(MLN ) 调制了有免疫力的房间的平衡, IL-6 和 IL-8 表示并且影响腹巨噬细胞的极化。重要地, IL-1β告知的 MSC 拥有了一个提高的能力经由 chemokine 受体类型 4 的 upregulation (CXCR4 ) 移居到内脏的煽动性的地点表示。在摘要, IL-1β告知的 MSC 在对待导致决策支持系统的大肠炎改进了功效,它部分至少取决于他们的增加的抑制免疫力的能力和提高的迁居能力。 | Hongye Fan Guangfeng Zhao Liu Liu Fei Liu Wei Gong Xianqin Liu Liu Yang Jianjun Wang Yayi Hou | 2012 | Cellular & Molecular Immunology2012，9，6： | 21 |
| 14 | Energy-Efficient Computation Offloading and Resource Allocation in Fog Computing for Internet of Everything显示文摘With the dawning of the Internet of Everything(IoE) era, more and more novel applications are being deployed. However, resource constrained devices cannot fulfill the resource-requirements of these applications. This paper investigates the computation offloading problem of the coexistence and synergy between fog computing and cloud computing in IoE by jointly optimizing the offloading decisions, the allocation of computation resource and transmit power. Specifically, we propose an energy-efficient computation offloading and resource allocation(ECORA) scheme to minimize the system cost. The simulation results verify the proposed scheme can effectively decrease the system cost by up to 50% compared with the existing schemes, especially for the scenario that the computation resource of fog computing is relatively small or the number of devices increases. | Qiuping Li Junhui Zhao Yi Gong Qingmiao Zhang | 2019 | China Communications2019，16，3： | 19 |
| 15 | Comparison of glycemic variability and glycated hemoglobin as risk factors of coronary artery disease in patients with undiagnosed diabetes显示文摘背景一个冠的动脉疾病( CAD )风险因素是著名的长期的多糖症的角色,并且 glycemic 可变性仍然是这研究的 debate.The 目的一件事是调查承认 glycemic 的协会有在有 undiagnosed 糖尿病 mellitus ( DM )的病人的 CAD 的存在和严厉的旅行和血红素 A1c ( HbA1c )我们学习了的 .Methods 286 最新诊断了 DM 没有优先的 revascularization 的病人为怀疑的 ischaemic ch 经历冠的 | MI Shu-hua SU Gong LI Zhao YANG Hong-xia ZHENG Hong TAO Hong ZHOU Yun TIAN Lei | 2012 | Chinese Medical Journal2012，，1： | 18 |
| 16 | Association between Ambient Air Pollution and Hospital Emergency Admissions for Respiratory and Cardiovascular Diseases in Beijing: a Time Series Study显示文摘Objective To investigate the association between ambient air pollution and hospital emergency admissions in Beijing. Methods In this study, a semi-parametric generalized additive model(GAM) was used to evaluate the specific influences of air pollutants(PM10, SO2, and NO2) on hospital emergency admissions with different lag structures from 2009 to 2011, the sex and age specific influences of air pollution and the modifying effect of seasons on air pollution to analyze the possible interaction. Results It was found that a 10 μg/m3 increase in concentration of PM10 at lag 03 day, SO2 and NO2 at lag 0 day were associated with an increase of 0.88%, 0.76%, and 1.82% respectively in overall emergency admissions. A 10 μg/m3 increase in concentration of PM10, SO2 and NO2 at lag 5 day were associated with an increase of 1.39%, 1.56%, and 1.18% respectively in cardiovascular disease emergency admissions. For lag 02, a 10 μg/m3 increase in concentration of PM10, SO2 and NO2 were associated with 1.72%, 1.34%, and 2.57% increases respectively in respiratory disease emergency admissions. Conclusion This study further confirmed that short-term exposure to ambient air pollution was associated with increased risk of hospital emergency admissions in Beijing. | ZHANG Ying WANG Shi Gong MA Yu Xia SHANG Ke Zheng CHENG Yi Fan LI Xu NING Gui Cai ZHAO Wen Jing LI Nai Rong | 2015 | Biomedical and Environmental Sciences2015，28，5： | 18 |
| 17 | Efficacy and safety of sunitinib in the treatment of metastatic renal cell carcinoma显示文摘背景酷氨酸 kinase 禁止者(TKI ) sunitinib,为变形肾的房间癌(RCC ) 的第一线治疗的首先指向的代理人,指向脉管的 endothelial 生长因素(VEGF ) 小径。如果高血压是有效预兆的 factor.Methods,这研究的目的是在对待变形清楚房间的 RCC 调查 sunitinib 的功效和安全并且证实有变形 RCC 的 36 个病人的一个总数在 2008 年 6 月和 2010 年 12 月之间被注册。在他们之中, 29 个案例是第一线治疗, 7 个案例在首要的 cytokine 或 sorafinib 治疗上的前进。所有病人的病理被证实在清楚的房间类型占优势。Sunitinib 单音治疗在每日的口头的治疗的重复 6 星期的周期被管理 4 个星期,到 2 个星期列在后面离开在 34 个病人;并且 3 个病人连续地与 37.5 mg/d 被管理直到疾病前进或不能接受的毒性发生了。全面反应率和安全被评估。我们根据中部的后续是的血压 level.Results 把病人划分了成组 A 和组 B 15 个月(10 个周期,范围 1.5-30.0 月(1-20 周期)) 。十个病人(29.4 ) 完成了部分回答(PR ) ;23 个病人(67.6 ) 表明了持续 2 个周期的稳定的疾病(SD ) 。十七个病人(50 ) 在后续期间得了进步疾病(PD ) 。中部的没有前进的幸存(PFS ) 是 15 个月(范围 3.0-28.5 ) 月。9 个病人的一个总数死了;全面幸存没被到达;死亡病人的中部的幸存时间是 13 个月(范围 7-24 ) 月。最普通的不利事件是手脚症候群(77.8 ) , thrombocytopenia (75.0 ) ,高血压(61.1 ) 和腹泻(46.0 ) 。最不利的事件由治疗打断是可逆的。22 个病人(61.1 ) 得了高血压;并且高血压与很长时间被联系到疾病前进和长全面的幸存(P=0.004, 0.000,分别地) 这研究的结果表明的 .Conclusions 功效和可管理的不利事件与变形清楚的房间 RCC 为病人在首要或第二线的治疗作为一个单个代理人 sunitinib 介绍。进一步,联系 sunitinib 的高血压可以是为在变形 RCC 的治疗功效的一个强壮的预兆的标记。 | LI Xue-song WU Xiang ZHAO Peng-ju HUANG Li-hua SONG Yi GONG Kan SHEN Cheng YU Wei SONG Gang ZHAO Zheng ZHANG Zheng ZHANG Qian WANG Gang HE Zhi-song ZHOU Li-qun JIN Jie | 2011 | Chinese Medical Journal2011，，18： | 17 |
| 18 | Investigating the dynamics of wetland landscape pattern in Beijing from 1984 to 2008显示文摘北京沼泽地的风景模式由于自然、人工的元素经历了一个重要变化。由遥感和 GIS 技术支持了,用在北京的从 1984~2008 的多时间的 TM 图象,这份报纸包括补丁区域通过选择典型索引分析了沼泽地风景模式的动态特征,补丁一般水准区域,分数维的尺寸索引,差异,优势,传染索引和每种沼泽地类型的空间矩心是计算的。最后,纸探索了进化模式和沼泽地风景模式的开车因素。结果如下被获得:全部的沼泽地区域在时期期间增加了 19841996,然后从 1996 ~ 2004 衰退。在 1994 的沼泽地区域说明了仅仅那中的 47.37% 个在 2004。人工的沼泽地区域的比例比自然沼泽地的大。水库沼泽地的比例是 33.50% ~ 53.73% 并且有最大的平均区域。有最少的平均区域的池溏和稻地沼泽地类型说明了 16.46% ~ 45.09% 全部的沼泽地区域。自然的河沼泽地的驱动力主要是自然元素;它的分数维的尺寸索引比其它大。沼泽地风景的香农差异索引在 2004 在 1992 ~ 1.34 从 1.11 增加了,显示每种沼泽地类型的比例之间的差别减少了,每种沼泽地类型的区域是均匀地分布式的。传染索引从 65.59 ~ 58.41 下沉了,显示连接降级了。Miyun 水库有最大的区域,它的区域变化在矩心的地点上有大影响。沼泽地资源从自然、人工的因素的联合效果逐渐地堕落了。在时期期间 20062008,增加的降水和干旱条件被减轻。政府实现了积极政策的系列节省水资源,并且沼泽地区域增加了。 | ZHANG Yiran GONG Zhaoning GONG Huili ZHAO Wenji | 2011 | Journal of Geographical Sciences2011，21，5： | 16 |
| 19 | SOTER-Based Soil Water Erosion Simulation in Hainan Island显示文摘The actual and potential water erosion rates of soils with different land covers in Hainan Island, China,were estimated based on the universal soil loss equation (USLE) and a 1:200 000 Soils and Terrain Digital Database (SOTER) database, from which soil water erosion factors could be extracted. 92.8% of the whole island had a current erosion rate of lower than 500 t km-2 a-1. Soil erosion risk was considered to be high because of its abundant rainfall. Without vegetation cover, the potential soil erosion rate would be extremely high and 90.8% of the island would have a soil erosion rate higher than 2 500 t km-2 a-1. Relative erosion vulnerability of different soil zones, landform types, and lithological regions of the island was compared by introducing a relative erosion hazard parameter α. Cambosols developed from siltstone and mudstone in low hill regions were pinpointed as soils with the highest erosion risk in the island. | ZHAO YUGUO, ZHANG GANLIN and GONG ZITONGInstitute of Soil Science, the Chinese Academy of Sciences, Nanjing 210008 (China) | 2003 | Pedosphere2003，13，2： | 16 |
| 20 | Synthesis and in vitro-Anti-hepatitis B Virus Activities of Several Ethyl 5-Hydroxy-1H-indole-3-carboxylates显示文摘A series of ethyl 5-hydroxyindole-3-carboxylates 6a—10r was designed and synthesized. The structures of all the compounds were confirmed by IR, 1H NMR, and MS and their anti-hepatitis B virus(HBV) activities were evaluated in 2.2.15 cells. Among them, compound 7g{ethyl 5-hydroxy-2-[(3-methoxyphenylsulfinyl) methyl]-1-methyl-4-[(4-methylpiperazin-1-yl)methyl]-1H-indole-3-carboxylate} displays a significant anti-HBV activity, which is more potent than the positive control lamivudine. | ZHAO Chun-shen ZHAO Yan-fang CHAI Hui-fang GONG Ping | 2006 | Chemical Research in Chinese Universities2006，22，5： | 16 |
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