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| 1 | Entropy analysis in electrical magnetohydrodynamic(MHD) flow of nanofluid with effects of thermal radiation,viscous dissipation,and chemical reaction显示文摘The unsteady mixed convection flow of electrical conducting nanofluid and heat transfer due to a permeable linear stretching sheet with the combined effects of an electric field, magnetic field, thermal radiation, viscous dissipation, and chemical reaction have been investigated. A similarity transformation is used to transform the constitutive equations into a system of nonlinear ordinary differential equations.The resultant system of equations is then solved numerically using implicit finite difference method.The velocity, temperature, concentration, entropy generation, and Bejan number are obtained with the dependence of different emerging parameters examined. It is noticed that the velocity is more sensible with high values of electric field and diminished with a magnetic field. The radiative heat transfer and viscous dissipation enhance the heat conduction in the system. Moreover, the impact of mixed convection parameter and Buoyancy ratio parameter on Bejan number profile has reverse effects. A chemical reaction reduced the nanoparticle concentration for higher values. | Yahaya Shagaiya Daniel Zainal Abdul Aziz Zuhaila Ismail Faisal Salah | 2017 | Theoretical & Applied Mechanics Letters2017，7，4： | 5 |
| 2 | In Silico Prediction and Validation of Gfap as an miR-3099 Target in Mouse Brain显示文摘MicroRNAs are small non-coding RNAs that play crucial roles in the regulation of gene expression and protein synthesis during brain development. MiR-3099 is highly expressed throughout embryogenesis, especially in the developing central nervous system. Moreover, miR-3099 is also expressed at a higher level in differentiating neurons in vitro, suggesting that it is a potential regulator during neuronal cell development. This study aimed to predict the target genes of miR-3099 via in-silico analysis using four independent prediction algorithms(miRDB,miRanda, Target Scan, and DIANA-micro-T-CDS) with emphasis on target genes related to brain development and function. Based on the analysis, a total of 3,174 miR-3099 target genes were predicted. Those predicted by at least three algorithms(324 genes) were subjected to DAVID bioinformatics analysis to understand their overallfunctional themes and representation. The analysis revealed that nearly 70% of the target genes were expressed in the nervous system and a significant proportion were associated with transcriptional regulation and protein ubiquitination mechanisms. Comparison of in situ hybridization(ISH) expression patterns of miR-3099 in both published and in-house-generated ISH sections with the ISH sections of target genes from the Allen Brain Atlas identified 7 target genes(Dnmt3a, Gabpa, Gfap, Itga4,Lxn, Smad7, and Tbx18) having expression patterns complementary to miR-3099 in the developing and adult mouse brain samples. Of these, we validated Gfap as a direct downstream target of miR-3099 using the luciferase reporter gene system. In conclusion, we report the successful prediction and validation of Gfap as an miR-3099 target gene using a combination of bioinformatics resources with enrichment of annotations based on functional ontologies and a spatio-temporal expression dataset. | Shahidee Zainal Abidin Jia-Wen Leong Marzieh Mahmoudi Norshariza Nordin Syahril Abdullah Pike-See Cheah King-Hwa Ling | 2017 | Neuroscience Bulletin2017，33，4： | 3 |
| 3 | Effect of SrCO_3 addition on the dynamic compressive strength of ZTA显示文摘Ceramic parts usually experience dynamic load in armor applications. Therefore, studying the dynamic behaviors of ceramics is important. Limited data are available on the dynamic behaviors of ceramics; thus, it is helpful to predict the dynamic strength of ceramics on the basis of their mechanical properties. In this paper, the addition of SrCO_3 into zirconia-toughened alumina(ZTA) was demonstrated to improve the fracture toughness of ZTA due to the formation of the SrAl_(12)O_(19)(SA6) phase. The porosity of ZTA was found to be increased by the addition of SrCO_3. These newly formed pores served as the nucleation sites of cracks under dynamic load; these cracks eventually coalesced to form damaged zones in the samples. Although the KIC values of the samples were improved, the dynamic strength was not enhanced because of the increase in porosity; in fact, the dynamic strength of ZTA ceramics decreased with the addition of SrCO_3. | Ali Arab Roslan Ahmad Zainal Arifin Ahmad | 2016 | International Journal of Minerals,Metallurgy and Materials2016，23，4： | 3 |
| 4 | Effects of palbociclib on oral squamous cell carcinoma and the role of PIK3CA in conferring resistance显示文摘Objective: Lack of effective therapies remains a problem in the treatment of oral squamous cell carcinoma(OSCC), especially in patients with advanced tumors. OSCC development is driven by multiple aberrancies within the cell cycle pathway, including amplification of cyclin D1 and loss of p16. Hence, cell cycle inhibitors of the CDK4/6-cyclin D axis are appealing targets for OSCC treatment. Here, we determined the potency of palbociclib and identified genetic features that are associated with the response of palbociclib in OSCC.Methods: The effect of palbociclib was evaluated in a panel of well-characterized OSCC cell lines by cell proliferation assays and further confirmed by in vivo evaluation in xenograft models. PIK3CA-mutant isogenic cell lines were used to investigate the effect of PIK3CA mutation towards palbociclib response.Results: We demonstrated that 80% of OSCC cell lines are sensitive to palbociclib at sub-micromolar concentrations.Consistently, palbociclib was effective in controlling tumor growth in mice. We identified that palbociclib-resistant cells harbored mutations in PIK3CA. Using isogenic cell lines, we showed that PIK3CA mutant cells are less responsive to palbociclib as compared to wild-type cells with concurrent upregulation of CDK2 and cyclin E1 protein levels. We further demonstrated that the combination of a PI3 K/mTOR inhibitor(PF-04691502) and palbociclib completely controlled tumor growth in mice.Conclusions: This study demonstrated the potency of palbociclib in OSCC models and provides a rationale for the inclusion of PIK3CA testing in the clinical evaluation of CDK4/6 inhibitors and suggests combination approaches for further clinical studies. | Nur Syafinaz Zainal Bernard Kok Bang Lee Zheng Wei Wong Iuan Sheau Chin Pei San Yee Chai Phei Gan Kein Seong Mun Zainal Ariff Abdul Rahman J. Silvio Gutkind Vyomesh Patel Sok Ching Cheong | 2019 | Cancer Biology & Medicine2019，16，2： | 3 |
| 5 | Batch adsorption of basic dye using acid treated kenaf fibre char: Equilibrium, kinetic and thermodynamic studies显示文摘 | Dalia Khalid Mahmoud Mohamad Amran Mohd Salleh Wan Azlina Wan Abdul Karim Azni Idris Zurina Zainal Abidin | 2011 | Chemical Engineering Journal2011，，： | 2 |
| 6 | Cathodic electrodeposition of SnS in the presence of EDTA in aqueous media显示文摘 | Ghazali A Zainal Z Hussein M Z | 1998 | Solar Energy Materials & Solar Cells1998，55，： | 2 |
| 7 | Land use change in highland area and its impact on river water quality:a review of case studies in Malaysia显示文摘The policy of encouraging agriculture and development for mass tourism has led to environmental problems in Cameron Highlands,Malaysia.Rampant development and land clearing have significantly altered the land cover of Cameron Highlands for the past 30 years.Sensitive highlands areas are prone to landslides and soil erosion which then contributed to the main water pollution issues in the network of river system,sedimentation and siltation.The continuous trend of river water quality deterioration in Cameron Highlands has raised the issues for discussion in this review article.The purpose of this review is to briefly summarize the land use change,agriculture practices,agro-tourism,and agriculture policy and management toward water quality of the river system network in Cameron Highlands specifically in the downtown where most of the development and agriculture activities are concentrated.A rigorous review has been done on the existing literature to determine the relationship between land use change and agriculture practices toward river water quality in Cameron Highlands from 2001 to 2017.The total number of reviewed papers was 68.The outcomes established from previous researchers have highlighted factors such as soil erosion,landslides,agriculture activities,urbanization,and unplanned development associated with land use change have significantly influenced the river water quality in the highland areas.Continuous land use changes without proper development plan and law enforcement may critically threaten the sustainability of river network in the highlands area. | Azlini Razali Sharifah Norkhadijah Syed Ismail Suriyani Awang Sarva Mangala Praveena Emilia Zainal Abidin | 2018 | Ecological Processes2018，7，1： | 2 |
| 8 | Assessing the kinetic model of hydro-distillation and chemical composition ofAquilaria malaccensis leaves essential oil显示文摘This study aimed to model the kinetic of hydro-distillation of Aquilaria malaccensis leaves oil in order to understand and optimize the extraction process. In addition, this study, for the first time, aimed to identify the chemical compositions of the A. malaccensis leave-oil. By assessing both first-order kinetic model and the model of simultaneous washing and diffusion, the result indicated that the model of simultaneous washing and diffusion better describes the hydro-distillation mechanism of the essential oil from A. malaccensis leaves.The optimum time, solid to liquid ratio, and the heating power for extracting the highest amount of essential oil were found to be around 3 h, 1:10(g·ml-1), and 300 W respectively. Yellow essential oil with a strong smell and a yield of 0.05 v/w was extracted by hydro-distillation Clevenger apparatus. Chemical compounds of the essential oil were analyzed using gas chromatography–mass spectroscopy(GC/MS), which resulted in identification of 42 compounds that constitute 93% of essential oil. Among the identified components,Pentadecanal(32.082%), 9-Octadecenal,(Z)(15.894%), and Tetradecanal(6.927%) were the major compounds.Considering the fact that all the identified major components possess pesticidal properties, A. malaccensis leaves can be regarded as a promising natural source for producing pesticides. | Mahtab Samadi Zurina Zainal Abidin Robiah Yunus Dayang Radiah Awang Biak Hiroyuki Yoshida Eng Hai Lok | 2017 | Chinese Journal of Chemical Engineering2017，25，2： | 2 |
| 9 | Impact of interdependence between supply chain partners on strategic alliance outcomes: Role of relational capital as a mediating construct显示文摘 | Murali Sambasivan Loke Siew-Phaik Zainal Abidin Mohamed Yee Choy Leong | 2011 | Management Decision2011，，4： | 2 |
| 10 | Acaricidal activity of Cymbopogon citratus and Azadirachta indica against house dust mites显示文摘Objective:To examine the acaricidal effects of the essential oil of Cymbopogon citratits leaf extract(lemongrass)and ethanolic Azadirachta indica leaf extract(neem)against house dust mites Dermatophagoides farinae(D.farinae)and Dermalophagoides pteronyssinus(D.pteronyssinus).Methods:Twenty-five adults mites were placed onto treated filter paper that is soaked with plant extract and been tested at different concentrations(50.00%,25.00%,12.50%,6.25%and 3.13%)and exposure times(24hrs,48hrs,72hrs and 96 hrs).All treatments were replicated 7 times,and the experiment repeated once.The topical and contact activities of the two herbs were investigated.Results:Mortalities from lemongrass extract were higher than neem for both topical and contact activities.At 50%concentration,both 24 hrs topical and contact exposures to lemongrass resulted in more than 91%mortalities for both species of inites.At the same concentration and exposure time,neem resulted in topical mortalities of 40.3%and 15.7%against D.pteronyssinus and D.farinae respectively;contact mortalities were 8.0%and 8.9%against the 2 mites,respectively.There was no difference in topical mortalities of D.pteronyssinus from exposure to concentrations oflemongrass and neem up to 12.50%;lemongrass was more effective than neem at the higher concentrations.Conclusions:Generally,topical mortalities of D.farinae due to lemongrass are higher than that due to neem.Contact mortalities of lemongrass are always higher that neem against both species of mites. | Azima Laili Hanifah Siti Hazar Awang Ho Tze Ming Suhaili Zainal Abidin Maizatul Hashima Omar | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，5： | 2 |
| 11 | A comprehensive MATLAB Simulink PV system simulator with partial shading capability based on two-diode model显示文摘 | Kashif Ishaque Zainal Salam Syafaruddin | 2011 | Solar Energy2011，，9： | 2 |
| 12 | Cold Plasma:A Potential Alternative for Rice Grain Postharvest Treatment Management in Malaysia显示文摘Use of pesticides,herbicides and fertilizers is among the techniques to control insect pests and fungal pathogens.However,the technique is the major contributor to severe environmental implications in terms of air,water and soil pollution.Besides,variable inconsistency becomes an important issue in the implementation of inclined bed dryers,leading to significant rice grain loss.Cold plasma technology has been widely proposed as a potential alternative for rice grain postharvest treatment management due to the presence of generated ionised gas that eventually produces reactive oxygen species or reactive nitrogen species.These species are used to decontaminate foodborne pathogens,mycotoxins and bacterial diseases.This review explores the current literature regarding cold plasma treatment technology,focusing on its efficiency as the microbial decontamination medium and insect pest mortality medium,and on the enhancement functional,nutritional and cooking properties,especially in rice grains.Previous studies have successfully demonstrated the ability of cold plasma treatment to significantly reduce the microbial count of foodborne pathogens,detoxify mycotoxins,and control seedborne rice seedling bacterial diseases.Previous studies have also proved that the implementation of cold plasma technology in postharvest management should be seriously considered for improving rice grain quantity and quality in Malaysia. | Mohd Fadthul Ikmal MISNAL Norizah REDZUAN Muhamad Nor Firdaus ZAINAL Norhayati AHMAD Raja Kamarulzaman RAJA IBRAHIM Linda AGUN | 2022 | Rice science2022，29，1： | 2 |
| 13 | Characterization of TiO2-Chitosan/Glass photocatalyst for/he removal of a monoazo dye via photodegradation-adsorption proces显示文摘 | Zainal Zulkamain Hui Leekong Hussein Mohdzobir | 2009 | Journal of Hazardous Materials2009，164，1： | 1 |
| 14 | Harmonics Mitigation Using Active Power Filter : A Technological Review显示文摘 | Salam Zainal Cheng Tan Pemg Jusoh Awang | 2006 | Faculty of Electrical Engineering2006，8，2： | 1 |
| 15 | Developmental abnormalities and reduced fruit softening in tomato plants expressing an antisense Rabll GTPase gene显示文摘 | Lu C Zainal Z Tucker G A | 2001 | The Plant Cell Online2001，13，8： | 1 |
| 16 | The stearoyl-acyl-carrier-protein desaturase promoter ( Des ) from oil palm confers fruit-specific GUS expression in transgenic tomato显示文摘 | Rima Saed Taha Ismanizan Ismail Zamri Zainal Siti Nor Akmar Abdullah | 2012 | Journal of Plant Physiology2012，，13： | 1 |
| 17 | Photocatalytic treatment of 4-chlorophenol in aqueous ZnO suspensions:intermediates,influence of dosage and inorganic anions显示文摘 | Gaya U I Abdullah A H Zainal Z | 2009 | Journal of Hazardous Materials2009，168，1： | 1 |
| 18 | Tar reduction in biomass producer gas via mechanical,catalytic and thermal methods:A review显示文摘 | Anis S Zainal ZA | | 0，，： | 1 |
| 19 | Prediction of performance of a downdraft gasifier using equilibrium modeling for different biomass materials 显示文摘 | Zainal Z A Mi R Lean C H | 2001 | Energy Conversion and Management2001，42，12： | 1 |
| 20 | Self-assembled Nanocomposite of Organic-inorganic Hybrid显示文摘 | Hussein M Z B Zainal Z Tat O W S | 2000 | Journal of Chemistry2000，16，2： | 1 |
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