|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 腹壁疝补片修补相关感染:病理学、治疗和结局显示文摘目的分析应用合成补片行疝修补后出现需要去除补片的手术部位感染并发症病人的临床及人口统计学特点,补片植入手术的细节以及感染发生后的治疗和结局。方法从病人资料表中获得病人的感染相关因素(人口统计学参数、疝修补术特点和使用的网片)。收集32例连续病例的标本(补片和组织),行细菌培养和显微镜检查。前瞻性评估补片取出后的结局。结果 22例接受了切口疝修补术,10例接受了腹股沟疝修补术,大部分病人手术时间较长,28例出现过早期伤口并发症(浆液肿或血肿)。在'补片植入-取出'间期,部分病人进行了保守治疗,例如局麻下引流或者窦道切除。22例的网片被完全取出(其中9例是补片部分取出后),其余10例部分取出补片治疗有效。大部分补片(24例)是多纤丝聚丙烯网片,补片周围组织的显微镜观察发现有白细胞浸润、巨细胞反应、胶原纤维无序排列以及脓肿形成。32例共进行了51例次手术治疗,补片取出后,有6例复发和2例肠瘘。平均随访时间为40(30~97)个月。结论大多数需要去除补片的感染病例前次疝修补术时间较长,并且有未经治疗的术后早期伤口并发症。补片部分取出通常不会成功,而且会带来并发症。取出全部补片的外科探查手术应该在全麻下进行。 | Tolino MJ Tripoloni DE Ratto R Garcia MI | 2010 | 中国实用外科杂志2010，30，12： | 20 |
| 2 | Current view of the immunopathogenesis in inflammatory bowel disease and its implications for therapy显示文摘Although the aetiology of inflammatory bowel disease (IBD) remains unknown, the pathogenesis is gradually being unravelled, seeming to be the result of a combination of environmental, genetic, and immunological factors in which an uncontrolled immune response within the intestinal lumen leads to inflammation in genetically predisposed individuals. Multifactorial evidence suggests that a defect of innate immune response to microbial agents is involved in IBD. This editorial outlines the immunopathogenesis of IBD and their current and future therapy. We present IBD as a result of dysregulated mucosal response in the intestinal wall facilitated by defects in epithelial barrier function and the mucosal immune system with excessive production of cytokines growth factors, adhesion molecules, and reactive oxygen metabolites, resulting in tissue injury. Established and evolving therapies are discussed in the second part of this editorial and at the end of this section we review new therapies to modulate the immune system in patients with IBD. | MI Torres A Ríos | 2008 | World Journal of Gastroenterology2008，14，13： | 18 |
| 3 | New aspects in celiac disease显示文摘Celiac disease (CD) is a common autoimmune disorder characterized by an immune response to ingested gluten and has a strong HLA association with HLA- DQ2 and HLA-DQ8 molecules, but human HLA-DQ risk factors do not explain the entire genetic susceptibility to gluten intolerance. CD is caused by the lack of immune tolerance (oral tolerance) to wheat gluten. In this sense, the expression of soluble HLA-G in CD is of special interest because the molecule plays an important role in the induction of immune tolerance. The enhanced expression of soluble HLA-G found in CD may be part of a mechanism to restore the gluten intolerance. In this editorial, we review recent progress in understanding CD in relation to its prevalence, diagnosis and possible mechanisms of pathogenesis. | MI Torres MA López Casado A Ríos | 2007 | World Journal of Gastroenterology2007，13，8： | 10 |
| 4 | Understanding important features of deep learning models for segmentation of high-resolution transmission electron microscopy images显示文摘Cutting edge deep learning techniques allow for image segmentation with great speed and accuracy.However,application to problems in materials science is often difficult since these complex models may have difficultly learning meaningful image features that would enable extension to new datasets.In situ electron microscopy provides a clear platform for utilizing automated image analysis.In this work,we consider the case of studying coarsening dynamics in supported nanoparticles,which is important for understanding,for example,the degradation of industrial catalysts.By systematically studying dataset preparation,neural network architecture,and accuracy evaluation,we describe important considerations in applying deep learning to physical applications,where generalizable and convincing models are required.With a focus on unique challenges that arise in high-resolution images,we propose methods for optimizing performance of image segmentation using convolutional neural networks,critically examining the application of complex deep learning models in favor of motivating intentional process design. | James P.Horwath Dmitri N.Zakharov Rémi Mégret Eric A.Stach | 2020 | npj Computational Materials2020，，1： | 8 |
| 5 | Accelerating phase-field-based microstructure evolution predictions via surrogate models trained by machine learning methods显示文摘The phase-field method is a powerful and versatile computational approach for modeling the evolution of microstructures and associated properties for a wide variety of physical,chemical,and biological systems.However,existing high-fidelity phase-field models are inherently computa fonally expensive,requiring high-performance computing resources and sophisticated numefical integration schemes to achieve a useful degree of accuracy.In this paper,we present a computationally inexpensive,accurate,data-driven surmogate model that directly learns the microstructural evolution of targeted systems by combining phase-field and history-dependent machine-learning techniques.We integrate a statisti cally representative,low-dimensianal description of the micrastructure,obtained direcdy from phase-field simulations,with either a time-series multivariate adaptive regression splines autoregressive al garithm or a lang short-term memory neural network.The neural-network-trained surrogate model shows the bestperformance and accurately predicts the nanlinear microstructure evolutian of a two-phase mixture during spinodal decomposition in seconds,without the need for'on-the-fly'solutions of the phase-field equations of motion.We also show that the predictions from our machine learned surrogate model can be fed directly as an input into a classical high-fideli ty phase-field model in order to accelerate the high-fidelity phase field simulations by leaping in time.Such machine-learned phase-field framework opens a promising path forward to use accelerated phase field simulations for discovering,understanding,and predicting processing-microstructure-performance relationships. | David Montes de Oca Zapiain James A.Stewart Rémi Dingreville | 2021 | npj Computational Materials2021，，1： | 4 |
| 6 | Frequency and prognostic role of mucosal healing in patients with Crohn's disease and ulcerative colitis after one-year of biological therapy显示文摘AIM:To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn’s disease(CD)and ulcerative colitis(UC).METHODS:The data from 41 patients with CD and 22 patients with UC were assessed.Twenty-four CD patients received infliximab,and 17 received adalimumab.The endoscopic severity of CD was quantified with the simplified endoscopic activity score for Crohn’s disease in CD and with the Mayo endoscopic subscore in UC.RESULTS:Mucosal healing was achieved in 23 CD and7 UC patients.Biological therapy had to be restarted in78%of patients achieving complete mucosal healing with CD and in 100%of patients with UC.Neither clinical remission nor mucosal healing was associated with the time to restarting the biological therapy in either CD or UC.CONCLUSION:Mucosal healing did not predict sustained clinical remission in patients in whom the biological therapies had been stopped. | Klaudia Farkas Péter László Lakatos Mónika Szcs va Pallagi-Kunstár Anita Bálint Ferenc Nagy Zoltán Szepes Noémi Vass Lajos S Kiss Tibor Wittmann Tamás Molnár | 2014 | World Journal of Gastroenterology2014，20，11： | 2 |
| 7 | 定期运动有助于改善高血压患者蛋白质稳态、炎症和血管活性显示文摘体育锻炼是一种公认的非药物控制血压的策略,除了降低血压外,运动还能对高血压患者的炎症特征、自主功能、内皮功能和抗氧化状态产生积极的影响。但其对高血压患者的蛋白质稳态的影响尚不清楚。已有动物研究表明,运动训练干预可以改善蛋白质质量控制机制,但在动物模型中报告的积极作用仍有待于在人类身上得到证实。本研究旨在根据报告的运动习惯,评估患高血压成年人的蛋白质稳态,生活质量以及炎症、氧化应激和血管活性生物标记物状态。 | Teixeira M Gouveia M Duarte A Ferreira M Simões MI Conceição M Silva G Magalhães S Ferreira R Nunes A Vieira SI Ribeiro F 周卫(译) 叶鹏(审校) | 2020 | 中华高血压杂志2020，28，12： | 2 |
| 8 | Learning two-phase microstructure evolution using neural operators and autoencoder architectures显示文摘Phase-field modeling is an effective but computationally expensive method for capturing the mesoscale morphological and microstructure evolution in materials.Hence,fast and generalizable surrogate models are needed to alleviate the cost of computationally taxing processes such as in optimization and design of materials.The intrinsic discontinuous nature of the physical phenomena incurred by the presence of sharp phase boundaries makes the training of the surrogate model cumbersome.We develop a framework that integrates a convolutional autoencoder architecture with a deep neural operator(DeepONet)to learn the dynamic evolution of a two-phase mixture and accelerate time-to-solution in predicting the microstructure evolution.We utilize the convolutional autoencoder to provide a compact representation of the microstructure data in a low-dimensional latent space.After DeepONet is trained in the latent space,it can be used to replace the high-fidelity phase-field numerical solver in interpolation tasks or to accelerate the numerical solver in extrapolation tasks. | Vivek Oommen Khemraj Shukla Somdatta Goswami Rémi Dingreville George Em Karniadakis | 2022 | npj Computational Materials2022，，1： | 2 |
| 9 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 10 | In vivo generation of dental pulp-like tissue by using dental pulp stem cells, a collagen scaffold, and dentin matrix protein 1 after subcutaneous transplantation in mice显示文摘 | Prescott RS Alsanea R Fayad MI | 2008 | J Endod2008，34，4： | 1 |
| 11 | New filtration process cuts contaminants from offshore produced water 显示文摘 | Mi S A Henry L R Darlington J W | 1998 | Oil and Gas Journal1998，96，44： | 1 |
| 12 | A reproducible model of middle cerebral artery occlusion in mice : hemodynamic, biochemical, and magnetic resonance imaging显示文摘 | Hata R Mies G Wiessner C | 1998 | J Cereb Blood Flow Metab1998，18，4： | 1 |
| 13 | Basic fibroblast growth factor in the primary olfactory pathway:mitogenic effect on ensheathing cells 显示文摘 | Chuah MI Teague R | 1999 | Neurosci1999，88，4： | 1 |
| 14 | Clinical relevance of anti-HLA antibodies pre and post transplant显示文摘 | Kerman R H Orosz CG Lorber MI | 1997 | Am J Med Sci1997，313，： | 1 |
| 15 | Incorporating a statistically based shape model into a system for computor-assisted anterior cruciate ligament surgery显示文摘 | Markus F St(e)phane L R(e)mi J | 1999 | Medical Image Analysis1999，3，3： | 1 |
| 16 | Adsorption studies on citms reticulate(fruit peel of orange): removaland recovery of Ni( Ⅱ ) from electroplating wastewater 显示文摘 | Ajmal M Mi R A R Ahmad R | 2000 | Journal of hazardous Materials2000，79，12： | 1 |
| 17 | Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells显示文摘 | Mi S Miller R H Tang W | 2009 | Ann Neurol2009，65，3： | 1 |
| 18 | Implicit simplicial models for adaptive curve reconstruction显示文摘 | Taubin Gabriel Ronfard Rémi | 1996 | IEEE Transactions on Pattern Analysis and Machine Intelligence1996，18，3： | 1 |
| 19 | Ultrasound biomicroscopic and conventional ultrasono- graphic study of ocular dimensions in primary angle-closure glaucoma显示文摘 | Marchini G Pagliarasco A Toscano A Tosi R Brunelli C Bono- mi L | 1998 | Ophthalmology1998，105，11： | 1 |
| 20 | Human neural crest stem cells derived from human ESCs and induced pluripotent stem cells: induction, maintenance, and differentiation into functional Schwann cells 显示文摘 | Liu Q Spusta SC Mi R | 2012 | Stem Cells Transl Med2012，1，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员