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| 1 | Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis显示文摘Lipid-based boundary layers formed on liposome-containing hydrogels can facilitate lubrication.However,these boundary layers can be damaged by shear,resulting in decreased lubrication.Here,a shear-responsive boundary-lubricated drug-loaded hydrogel is created by incorporating celecoxib(CLX)-loaded liposomes within dynamic covalent bond-based hyaluronic acid(HA)hydrogels(CLX@Lipo@HA-gel).The dynamic cross-linked network enables the hydrogel to get restructured in response to shear,and the HA matrix allows the accumulation of internal liposome microreservoirs on the sliding surfaces,which results in the formation of boundary layers to provide stable lubrication.Moreover,hydration shells formed surrounding the hydrogel can retard the degradation process,thus helping in sustaining lubrication.Furthermore,in vitro and in vivo experiments found that CLX@Lipo@HA-gels can maintain anabolic-catabolic balance,alleviate cartilage wear,and attenuate osteoarthritis progression by delivering CLX and shear-responsive boundary lubrication.Overall,CLX@Lipo@HA-gels can serve as shear-responsive boundary lubricants and drug-delivery vehicles to alleviate friction-related diseases like osteoarthritis. | Yiting Lei Xingkuan Wang Junyi Liao Jieliang Shen Yuling Li Zhengwei Cai Ning Hu Xiaoji Luo Wenguo Cui Wei Huang | 2022 | Bioactive Materials2022，7，10： | 4 |
| 2 | Exhausted local lactate accumulation via injectable nanozyme-functionalized hydrogel microsphere for inflammation relief and tissue regeneration显示文摘Local lactate accumulation greatly hinders tissue repair and regeneration under ischemic condition.Herein,an injectable microsphere(MS@MCL)for local lactate exhaustion was constructed by grafting manganese dioxide(MnO_(2))-lactate oxidase(LOX)composite nanozyme on microfluidic hyaluronic acid methacrylate(HAMA)microspheres via chemical bonds,achieving a long-term oxygen-promoted lactate exhaustion effect and a long half-life in vivo.The uniform and porous microspheres synthesized by microfluidic technology is beneficial to in situ injection therapy and improving encapsulation efficiency.Furthermore,chemical grafting into HAMA microspheres through amide reactions promoted local enzymatic concentration and activity enhancement.It was showed that the MS@MCL eliminated oxidative and inflammatory stress and promoted extracellular matrix metabolism and cell survival when co-cultured with nucleus pulposus cells(NPCs)in vitro.In the rat degenerative intervertebral disc model caused by lactate injection,MS@MCL showed a long-term therapeutic effect in reducing intervertebral height narrowing and preventing extracellular matrix(ECM)degradation as well as inflammatory damage in vivo.Altogether,this study confirms that this nanozyme-functionalized injectable MS@MCL effectively improves the regenerative and reparative effect in ischemic tissues by disposing of enriched lactate in local microenvironment. | Jieliang Shen Ao Chen Zhengwei Cai Zhijie Chen Ruichao Cao Zongchao Liu Yuling Li Jie Hao | 2022 | Bioactive Materials2022，7，6： | 2 |
| 3 | RNA modifications:importance in immune cell biology and related diseases显示文摘RNA modifications have become hot topics recently.By influencing RNA processes,including generation,transportation,function,and metabolization,they act as critical regulators of cell biology.The immune cell abnormality in human diseases is also a research focus and progressing rapidly these years.Studies have demonstrated that RNA modifications participate in the multiple biological processes of immune cells,including development,differentiation,activation,migration,and polarization,thereby modulating the immune responses and are involved in some immune related diseases.In this review,we present existing knowledge of the biological functions and underlying mechanisms of RNA modifications,including N6-methyladenosine(m^(6)A),5-methylcytosine(m^(5)C),N1-methyladenosine(m1 A),N7-methylguanosine(m^(7)G),N4-acetylcytosine(ac^(4)C),pseudouridine(Ψ),uridylation,and adenosine-to-inosine(A-to-I)RNA editing,and summarize their critical roles in immune cell biology.Via regulating the biological processes of immune cells,RNA modifications can participate in the pathogenesis of immune related diseases,such as cancers,infection,inflammatory and autoimmune diseases.We further highlight the challenges and future directions based on the existing knowledge.All in all,this review will provide helpful knowledge as well as novel ideas for the researchers in this area. | Lian Cui Rui Ma Jiangluyi Cai Chunyuan Guo Zeyu Chen Lingling Yao Yuanyuan Wang Rui Fan Xin Wang Yuling Shi | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 2 |
| 4 | Effect of humic acid and metal ions on the debromination of BDE209 by nZVM prepared from steel pickling waste liquor显示文摘作为一在 situ 补习技术答应, nanoscale zero-valent 铁(nZVI ) 能有效地移开象 decabromodiphenyl 醚(BDE209 ) 那样的 polybrominated diphenyl 醚,然而,它的使用被它的高生产费用限制。用是的钢 pickling 浪费白酒,准备 nanoscale zero-valent 金属(nZVM ) 的原料能克服这缺乏。腐殖的酸和金属离子在补习上有最大的影响,这被显示出。结果证明 nZVM 和 nZVI 能有效地两个都在他们的移动效率与小差别移开 BDE209,并且腐殖的酸禁止了移动效率,而金属离子支持了它。支持的效果跟随了顺序 Ni 2+> Cu 2+> 公司 2+ 和二个因素的累积效果是支持和禁止的单个效果的联合。当 nZVM 的是水晶时, nZVM 和 nZVI 之间的主要差别躺在他们的水晶形式,当 nZVI 被发现非结晶。然而, nZVM 和 nZVI 与类似的移动效率移开 BDE209,这被发现。效果和 nZVM 和 nZVI 上的腐殖的酸和金属离子的累积效果以 BDE209 移动的效率是很类似的。 | Yuling CAI | 2015 | Frontiers of Environmental Science & Engineering2015，9，5： | 1 |
| 5 | Chinese tomato yelIow Ieaf curl virus— a new species of geminivirus显示文摘 | Yule Liu Jianhe Cai Dongling Li Bixia Qin Bo Tian | 1998 | Science in China Series C: Life Sciences1998，，4： | 1 |
| 6 | Normalized decoupling control for high-dimensional MIMO processes for application in room temperature control HVAC systems 显示文摘 | Shen Yuling Cai Weniian Li Shaoyuan | 2010 | Control EnKineering Practice2010，18，： | 1 |
| 7 | Chinese tomato yelIow Ieaf curl virus— a new species of geminivirus显示文摘 | Yule Liu Jianhe Cai Dongling Li Bixia Qin Bo Tian | 1998 | Science in China Series C: Life Sciences1998，，4： | 1 |
| 8 | MICROSTRUCTURAL STUDIES OF ULTRAFINE IRON PARTICLES显示文摘The constitution,structure and surface state of the ultrafine iron particles prepared by gasevaporation technique have been investigated by means of X-ray analysis,high-reasolutionelectron microscopy(HREM)and electron spectroscopy for chemical analysis(ESCA).Theresults showed that the fine particles are spherical ones of~20 nm in diameter with α-Fecores and covered by Fe3O4 fine crystalline layers of~4 nm thickness. | WANG Shuhe CAI Yuling AN Gang WEN Lishi ZHUANG Yuzhi Institute of Metal Research,Academia Sinica,Shenyang,China WANG Shuhe,Associate Professor,Institute of Metal Research,Academia Sinica,Shenyang 110015,China | 1990 | Acta Metallurgica Sinica(English Letters)1990，3，8： | 1 |
| 9 | Improving the accuracy of genomic prediction for meat quality traits using whole genome sequence data in pigs显示文摘Background Pork quality can directly affect customer purchase tendency and meat quality traits have become valu-able in modern pork production.However,genetic improvement has been slow due to high phenotyping costs.In this study,whole genome sequence(WGS)data was used to evaluate the prediction accuracy of genomic best linear unbiased prediction(GBLUP)for meat quality in large-scale crossbred commercial pigs.Results We produced WGS data(18,695,907 SNPs and 2,106,902 INDELs exceed quality control)from 1,469 sequenced Duroc×(Landrace×Yorkshire)pigs and developed a reference panel for meat quality including meat color score,marbling score,L*(lightness),a*(redness),and b*(yellowness)of genomic prediction.The prediction accuracy was defined as the Pearson correlation coefficient between adjusted phenotypes and genomic estimated breeding values in the validation population.Using different marker density panels derived from WGS data,accuracy differed substantially among meat quality traits,varied from 0.08 to 0.47.Results showed that MultiBLUP outperform GBLUP and yielded accuracy increases ranging from 17.39%to 75%.We optimized the marker density and found medium-and high-density marker panels are beneficial for the estimation of heritability for meat quality.Moreover,we conducted genotype imputation from 50K chip to WGS level in the same population and found average concord-ance rate to exceed 95%and r^(2)=0.81.Conclusions Overall,estimation of heritability for meat quality traits can benefit from the use of WGS data.This study showed the superiority of using WGS data to genetically improve pork quality in genomic prediction. | Zhanwei Zhuang Jie Wu Yibin Qiu Donglin Ruan Rongrong Ding Cineng Xu Shenping Zhou Yuling Zhang Yiyi Liu Fucai Ma Jifei Yang Ying Sun Enqin Zheng Ming Yang Gengyuan Cai Jie Yang Zhenfang Wu | 2023 | Journal of Animal Science and Biotechnology2023，14，5： | 1 |
| 10 | Chinese tomato yelIow Ieaf curl virus— a new species of geminivirus显示文摘 | Yule Liu Jianhe Cai Dongling Li Bixia Qin Bo Tian | 1998 | Science in China Series C: Life Sciences1998，，4： | 1 |
| 11 | Chinese tomato yelIow Ieaf curl virus— a new species of geminivirus显示文摘 | Yule Liu Jianhe Cai Dongling Li Bixia Qin Bo Tian | 1998 | Science in China Series C: Life Sciences1998，，4： | 1 |
| 12 | cRGD-functionalized, DOX-conjugated, and 64 Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging显示文摘 | Xiaoqiang Yang Hao Hong Jamison J. Grailer Ian J. Rowland Alireza Javadi Samuel A. Hurley Yuling Xiao Yunan Yang Yin Zhang Robert J. Nickles Weibo Cai Douglas A. Steeber Shaoqin Gong | 2011 | Biomaterials2011，，17： | 1 |
| 13 | Photophysical and photochemical processes of riboflavin (vitamin B2) by means of the transient absorption spectra in aqueous solution显示文摘 | Changyuan Lu Zhenhui Han Guanshu Liu Xichen Cai Yuling Chen Side Yao | 2001 | Science in China Series B: Chemistry2001，，1： | 1 |
| 14 | Chinese tomato yelIow Ieaf curl virus— a new species of geminivirus显示文摘 | Yule Liu Jianhe Cai Dongling Li Bixia Qin Bo Tian | 1998 | Science in China Series C: Life Sciences1998，，4： | 1 |
| 15 | RBM46 is essential for gametogenesis and functions in post-transcriptional roles affecting meiotic cohesin subunits显示文摘RBM46 is a germ cell-specific RNA-binding protein required for gametogenesis,but the targets and molecular functions of RBM46 remain unknown.Here,we demonstrate that RBM46 binds at specific motifs in the 3'UTRs of mRNAs encoding multiple meiotic cohesin subunits and show that RBM46 is required for normal synaptonemal complex formation during meiosis initiation.Using a recently reported,high-resolution technique known as LACE-seq and working with low-input cells,we profiled the targets of RBM46 at single-nucleotide resolution in leptotene and zygotene stage gametes.We found that RBM46 preferentially binds target mRNAs containing GCCUAU/GUUCGA motifs in their 3'UTRs regions.In Rbm46 knockout mice,the RBM46-target cohesin subunits displayed unaltered mRNA levels but had reduced translation,resulting in the failed assembly of axial elements,synapsis disruption,and meiotic arrest.Our study thus provides mechanistic insights into the molecular functions of RBM46 in gametogenesis and illustrates the power of LACE-seq for investigations of RNA-binding protein functions when working with low-abundance input materials. | Yue Lv Gang Lu Yuling Cai Ruibao Su Liang Liang Xin Wang Wenyu Mu Xiuqing He Tao Huang Jinlong Ma Yueran Zhao Zi-Jiang Chen Yuanchao Xue Hongbin Liu Wai-Yee Chan | 2023 | Protein & Cell2023，14，1： | 0 |
| 16 | Expression and role of PTV1 lncRNA in glioma cells progression显示文摘Objective The aim of this study was to investigate the expression of PTV1 lncRNA in gliomas and themechanism of its interaction with miR-203a.Methods U87 and U251 cells were cultured stably and transfected with sh-PTV1 or ov-PTV1, respectively.The proliferative activity of U87 and U251 cells was detected and the transplanted tumor model nude micewere divided into U87 and U251 groups. U87-sh and u251-ov cells were injected into the armpit, thenmiR-203a mic and miR-203a inhibitors were administered to detect the changes in the expression of tumorrelatedproteins.Results The relative expression of PTV1 in gliomas was significantly higher than that in normal braintissues, while in GBM it was significantly higher than that in low-grade gliomas. Knockdown of PTV1significantly inhibited the proliferation of U87 cells, resulting in fewer cell clones;overexpression of rPTV1significantly promoted the proliferation of U251 cells, resulting in more cell colonies. The dual LuciferaseReporter assay showed that SP2 was a potential target of miR-203a. When U87 cells were treated with amiR-203a mimic, the expression of SP2 decreased;and when U251 cells were treated with a miR-203ainhibitor, the expression of SP2 increased significantly. SP2 was overexpressed in u87-sh cells and theproliferation, migration, and invasion of u87-sh cells were significantly enhanced. U251-ov cells showedthe opposite trend. Compared with the control group mice, the tumor volume in u87-sh group mice wassignificantly smaller and the positive rate of SP2 in tumor tissue was significantly lower. After administrationof the miR-203a inhibitor, the tumor volume increased gradually and the positive rate of SP2 increasedsignificantly, while u251-ov mice showed the opposite trend.Conclusion lncRNA PTV1 can be used as a molecule to interfere with miR-203a expression in order todownregulate SP2 and to promote the proliferation and invasion of glioma cells. lncRNA PTV1 may be anew biomarker and therapeutic target for glioma. | Yue Li Yuling Bai Yan Qi Chang Cai Ying Liao Xiuzhu Liu Pengchen He | 2021 | Oncology and Translational Medicine2021，7，2： | 0 |
| 17 | There is the second virus that causes tobacco leaf curl disease (not TbLCV-CHI) in the field显示文摘Sequence analysis of virus isolation DNA of tobacco leaf curl disease shows that there is the second geminivirus (not Chinese Tobacco Leaf Curl Virus, TbLCV-CHI) that causes tobacco leaf curl disease in the field in the Guangxi Zhuang Autonomous Region, China. This virus DNA-A contains 2 734 nt. Large intergenic region (LIR) contains 269 nt, the virus sense strand contains 2 open reading frames (ORFs): AV1 (115 aa) and AV2 (coat protein gene, CP, 256 aa), and the complementary sense strand contains 4 ORFs: AC1 (replicase gene, 361 aa), AC2 (transactivator, 134 aa), ACS (134 aa) and AC4 (97 aa). The virus belongs to one kind of subgroup III gemini- viruses from old world, and could be the Chinese tomato yellow leaf curl virus (TYLCV-CHI). | GONG Qianhong LIU Yule HONG Yiguo WANG Huanyu CHEN Gang CAI Jianhe | 2000 | Chinese Science Bulletin2000，45，12： | 0 |
| 18 | Weakened humoral immune responses of inactivated SARS-CoV-2 vaccines in patients with solid tumors显示文摘Dear Editor Coronavirus disease 19(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),remains a pandemic.Cancer patients have a higher risk of poor outcomes for SARS-CoV-2 infection than the general population[1].Vaccines were shown to effectively prevent SARS-CoV-2 infection,severe disease progression,and mortality.Inactivated SARS-CoV-2 vaccines(BBIBPCorV and CoronaVac)have been approved and widely used in China,with the former shown to be more effective than the latter[2].Hence,there is an urgent need to investigate the safety and humoral immune responses of inactivated vaccines in cancer patients. | Zhiwei Chen Peng Zhu Zuojin Liu Bin Zhu Guobing Yin Jia Ming Rui Song Qingbo Pan Tong Li Xingwei Jiang Bing Wang Shuaibin Liu Hongxing Cai Jingjie Wang Yuling Han Zijing Lin Yang Hong Min Chen Mingli Peng Lina Hu Dachuan Cai Hong Ren | 2023 | Cancer Communications2023，43，2： | 0 |
| 19 | 拟南芥ARGNAUTE 1在植物响应激素和胁迫过程中结合染色质并促进基因表达显示文摘文章简介经典的RNA干扰是指真核生物中由小RNA诱发的基因沉默。小RNA由Dicer(一种核糖核酸内切酶)从双链或具茎环结构的前体RNA加工而来,随后被RNA干扰的核心效应蛋白ARGONAUTE(AGO)家族蛋白所结合。通过小RNA与靶序列的碱基互补配对. | 刘畅 辛颖 徐乐 Zhaokui Cai Yuanchao Xue Yong Liu Daoxin Xie Yule Liu 戚益军 | 2019 | 科学新闻2019，0，2： | 0 |
| 20 | Geology,Geochemistry,and Genesis of the Tongcun Reduced Porphyry Mo(Cu) Deposit,NW Zhejiang Province,China显示文摘The Tongcun Mo(Cu) deposit in Kaihua city of Zhejiang Province,eastern China,occurs in and adjacent to the Songjiazhuang granodiorite porphyry and is a medium-sized and important porphyry type ore deposit.Two irregular Mo(Cu) orebodies consist of various types of hydrothermal veinlets.Intensive hydrothermal alteration contains skarnization,chloritization,carbonatization,silicification and sericitization.Based on mineral assemblages and crosscutting relationships,the oreforming processes are divided into five stages,i.e.,the early stage of garnet + epidote ± chlorite associated with skarnization and K-feldspar + quartz ± molybdenite veins associated with potassicsilicic alteration,the quartz-sulfides stage of quartz + molybdenite ± chalcopyrite ± pyrite veins,the carbonatization stage of calcite veinlets or stockworks,the sericite + chalcopyrite ± pyrite stage,and the late calcite + quartz stage.Only the quartz-bearing samples in the early stage and in the quartzsulfides stage are suitable for fluid inclusions(FIs) study.Four types of FIs were observed,including1) CO_2-CH_4 single phase FIs,2) CO_2-bearing two- or three-phase FIs,3) Aqueous two-phase FIs,and4) Aqueous single phase FIs.FIs of the early stages are predominantly CO_2- and CH_4-rich FIs of the CO_2-CH4-H_2O-NaCl system,whereas minerals in the quartz-sulfides stage contain CO_2-rich FIs of the CO_2-H_2O-NaCl system and liquid-rich FIs of the H_2O-NaCl system.For the CO_2-CH_4 single phase FIs of the early mineralization stage,the homogenization temperatures of the CO_2 phase range from 15.4 ℃ to 25.3 ℃(to liquid),and the fluid density varies from 0.7 g/cm^3 to 0.8 g/cm^3;for two- or three-phase FIs of the CO_2-CH_4-H_2O-NaCl system,the homogenization temperatures,salinities and densities range from 312℃ to 412℃,7.7 wt%NaCl eqv.to 10.9 wt%NaCl eqv.,and 0.9 g/cm^3 to 1.0 g/cm^3,respectively.For CO_2-H_2O-NaCI two- or threephase FIs of the quartz-sulfides stage,the homogenization temperatures and salinities range from255℃ to 418℃,4.8 wt%NaCl eqv.to 12.4 wt%NaCl eqv.,respectively;for H_2O-NaCl two-phase FIs,the homogenization temperatures range from 230 ℃ to 368 ℃,salinities from 11.7 wt%NaCl eqv.to16.9 wt%NaCl eqv.,and densities from 0.7 g/cm^3 to 1.0 g/cm^3.Microthermometric measurements and Laser Raman spectroscopy analyses indicate that CO_2 and CH_4 contents and reducibility(indicated by the presence of CH_4) of the fluid inclusions trapped in quartz-sulfides stage minerals are lower than those in the early stage.Twelve molybdenite separates yield a Re-Os isochron age of 163 ± 2.4 Ma,which is consistent with the emplacement age of the Tongcun,Songjiazhuang,Dayutang and Huangbaikeng granodiorite porphyries.The | TANG Yanwen LI Xiaofeng XIE Yuling HUANG Cheng WEI Hao CAI Jiali YIN Yifan QIN Chaojian LIU Rong | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 0 |
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