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| 1 | LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration显示文摘新兴的研究在少些在染色质水平,但是相对调整基因表示记录长非编码的 RNA (LncRNAs ) 的角色被知道他们怎么调整 DNA methylation。这里,我们识别 lncRNA, Dum (发展联系 pluripotency 2 (Dppa2 ) 在上游的有约束力的肌肉 lncRNA ) 在骨胳的 myoblast 房间。Dum 的表示动态地在 vitro 并且在 vivo 在 myogenesis 期间被调整。它被在 myoblast 区别之上有约束力的 MyoD transcriptionally 也导致。功能的分析证明它支持 myoblast 区别和导致损坏的肌肉新生。机械学地, Dum 被发现它的附近的基因到沉默, Dppa2,在通过招募的 cis Dnmt1, Dnmt3a 和 Dnmt3b。而且, intrachromosomal 在 Dum 地点和 Dppa2 倡导者之间循环为 Dum/Dppa2 相互作用是必要的。一起,我们识别了与 Dnmts 交往调整 myogenesis 的新奇 lncRNA。 | Lijun Wang Yu Zhao Xichen Bao Xihua Zhu Yvonne Ka-yin Kwok Kun Sun Xiaona Chen Yongheng Huang Ralf Jauch Miguel A Esteban Hao Sun Huating Wang | 2015 | Cell Research2015，25，3： | 34 |
| 2 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 3 | Identification of mecciRNAs and their roles in the mitochondrial entry of proteins显示文摘Mammalian mitochondria have small genomes encoding very limited numbers of proteins.Over one thousand proteins and noncoding RNAs encoded by the nuclear genome must be imported from the cytosol into the mitochondria.Here,we report the identification of hundreds of circular RNAs(mecciRNAs)encoded by the mitochondrial genome.We provide both in vitro and in vivo evidence to show that mecciRNAs facilitate the mitochondrial entry of nuclear-encoded proteins by serving as molecular chaperones in the folding of imported proteins.Known components involved in mitochondrial protein and RNA importation,such as TOM40 and PNPASE,interact with mecciRNAs and regulate protein entry.The expression of mecciRNAs is regulated,and these transcripts are critical for the adaption of mitochondria to physiological conditions and diseases such as stresses and cancers by modulating mitochondrial protein importation.mecciRNAs and their associated physiological roles add categories and functions to the known eukaryotic circular RNAs and shed novel light on the communication between mitochondria and the nucleus. | Xu Liu Xiaolin Wang Jingxin Li Shanshan Hu Yuqi Deng Hao Yin Xichen Bao Qiangfeng Cliff Zhang Geng Wang Baolong Wang Qinghua Shi Ge Shan | 2020 | Science China(Life Sciences)2020，63，10： | 15 |
| 4 | The adult human testis transcriptional cell atlas显示文摘Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and differentiation,alongside complex germ cell-niche interactions,to ensure long-term fertility and faithful genome propagation. Here,we performed single-cell RNA sequencing of -6500 testicular cells from young adults. We found five niche/somatic cell types (Leydig,myoid,Sertoli,endothelial,macrophage),and observed germline-niche interactions and key human-mouse differences. Spermatogenesis,including meiosis,was reconstructed computationally,revealing sequential coding,non-coding,and repeat-element transcriptional signatures. Interestingly,we identified five discrete transcriptional/developmental spermatogonial states,including a novel early SSC state,termed State 0. Epigenetic features and nascent transcription analyses suggested developmental plasticity within spermatogonial States. To understand the or丨gin of State 0,we profiled testicular cells from infants,and identified distinct similarities between adult State 0 and infant SSCs. Overall,our datasets describe key transcriptional and epigenetic signatures of the normal adult human testis,and provide new insights into germ cell developmental transitions and plasticity. | Jingtao Guo Edward J. Grow Hana Mlcochova Geoffrey J. Maher Cecilia Lindskog Xichen Nie Yixuan Guo Yodai Takei Jina Yun Long Cai Robin Kim Douglas T. Carrell Anne Goriely James M. Hotaling Bradley R. Cairns | 2018 | Cell Research2018，28，12： | 12 |
| 5 | Diminution of toxic copper accumulation in toxic milk mice modeling Wilson disease by embryonic hepatocyte intrasplenic transplantation显示文摘AIM: To observe the therapeutic effect of intrasplenic transplantation with embryonic hepatocytes on amelioration of hereditary copper accumulation in toxic milk (TX) mouse modeling Wilson disease. METHODS: Donor hepatocytes were harvested from 14-d fetal liver of a pregnant homogeneous DL mouse. These cells were successively cultured, labeled with fluorescein dye Hoechst 33342 for 24 h, and sequentially infused into the spleen parenchyma of the recipient TX mice. No host immunosuppression measures were taken. Two and four weeks after transplantation, the recipients were killed for routine histologic investigation and immunohistochemistry study up to 4 wk after transplantation. The serum copper and ceruloplasmin concentrations of the recipient mice were determined by graphite furnace atomic absorption spectroscopy.RESULTS: In the following 2nd and 4th wk after transplantation, the donor hepatocytes could be visualized in the livers of 47.3% recipients. The serum ceruloplasmin and copper concentrations increased by 1.6-fold after 2 wk and 2.0-fold times after 4 wk respectively, which ultimately rose from about 30% of the normal level to nearly 60%(P<0.01). The hepatic copper concentration decreased 7.2%, 4 wk after transplantation. Pathologic examination showed that there were many actively proliferative hepatocyte precursor cells with specific embryonic hepatocyte marker AFP migrated into hepatic sinusoidsof the recipients. A large number of cells carrying hepatocytes marker and albumin were observed in the recipient spleen tissues.CONCLUSION: Embryonic hepatocytes are capable of differentiating into mature hepatocytes in vivo. After transplantation, the hereditary abnormalities of copper metabolism in TX mice could be corrected partially by intrasplenic transplantation of homogeneous embryonic hepatocytes. | ZhuShi Xiu-LingLiang Bing-XunLu Su-YuePan XiChen Qi-QiangTang YingWang FanHuang | 2005 | World Journal of Gastroenterology2005，11，24： | 8 |
| 6 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
| 7 | The transcription factor OpWRKY2 positively regulates the biosynthesis of the anticancer drug camptothecin in Ophiorrhiza pumila显示文摘The limited bioavailability of plant-derived natural products with anticancer activity poses major challenges to the pharmaceutical industry.An example of this is camptothecin,a monoterpene indole alkaloid with potent anticancer activity that is extracted at very low concentrations from woody plants.Recently,camptothecin biosynthesis has been shown to become biotechnologically amenable in hairy-root systems of the natural producer Ophiorrhiza pumila.Here,time-course expression and metabolite analyses were performed to identify novel transcriptional regulators of camptothecin biosynthesis in O.pumila.It is shown here that camptothecin production increased over cultivation time and that the expression pattern of the WRKY transcription factor encoding gene OpWRKY2 is closely correlated with camptothecin accumulation.Overexpression of OpWRKY2 led to a more than three-fold increase in camptothecin levels.Accordingly,silencing of OpWRKY2 correlated with decreased camptothecin levels in the plant.Further detailed molecular characterization by electrophoretic mobility shift,yeast one-hybrid and dual-luciferase assays showed that OpWRKY2 directly binds and activates the central camptothecin pathway gene OpTDC.Taken together,the results of this study demonstrate that OpWRKY2 acts as a direct positive regulator of camptothecin biosynthesis.As such,a feasible strategy for the over-accumulation of camptothecin in a biotechnologically amenable system is presented. | Xiaolong Hao Chenhong Xie Qingyan Ruan Xichen Zhang Chao Wu Bing Han Jun Qian Wei Zhou Hans-Wilhelm Nutzmann Guoyin Kai | 2021 | Horticulture Research2021，8，1： | 7 |
| 8 | Experimental study on the mechanical properties and consolidation mechanism of microbial grouted backfill显示文摘Backfill mining technology is the practice of returning waste materials underground for both disposal and geotechnical stability,however,a challenge with current technologies is that they commonly require cement-based binders which have a relatively high environmental impact.Finding alternatives to cement-based binders can improve environmental performance and this paper proposes microbial grouted backfill(MGB)as a potential solution.In this paper,the effects of the cementation solution concentration(CSC),volume ratio of bacterial solution to cementation solution(VRBC),particle sizes of the aggregates,and the number of grouting batches on the mechanical properties of MGB are studied.The experimental results show that MGB strength increased,up to a peak value,as CSC was increased,before decreasing as CSC was increased further.The results also show that MGB strength increased,up to a peak value,as VRBC decreased,before decreasing as the VRBC was decreased further.The peak strength was achieved at a CSC of 2 mol/L and a VRBC of 1:9.The strength of the MGB also increased as the number of grouting batches increased.Graded MGB samples showed the highest UCS,25.12 MPa,at particle sizes of 0.2 to 0.8 mm,while full(non-graded)MGB samples displayed mean UCS values ranging from1.56 MPa when the maximum particle size was 0.2 mm,up to 13 MPa when the maximum particle size was 1.2 mm.MGB samples are consolidated by the calcium carbonate that is precipitated during microbial metabolism,and the strength of MGB increases linearly as calcium carbonate content increases.The calcium carbonate minerals produced in MGB materials are primarily calcite,with secondary amounts of vaterite. | Xuejie Deng Yu Li Fei Wang Xiaoming Shi Yinchao Yang Xichen Xu Yanli Huang Benjamin de Wit | 2022 | International Journal of Mining Science and Technology2022，32，2： | 7 |
| 9 | dentification and characterization of GRA6/ SRA7 of Neospora caninum in MDBK cells显示文摘 | Jingquan Dong Jianhua Li Jinpeng Wang Fei Li Ju Yang Pengtao Gong He Li Xichen Zhang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，4： | 5 |
| 10 | Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease显示文摘Accumulating evidence suggests that C-type lectin-like receptor-2(CLEC-2)plays an important role in atherothrombosis.In this case-control study,we investigated the association between CLEC-2 and incidence of coronary artery disease(CAD).A total of 216 patients,including 14 cases of stable angina pectoris(SAP,non-ACS)and 202 cases of acute coronary syndrome(ACS),and 89 non-CAD control subjects were enrolled.Plasma levels of soluble CLEC-2(sCLEC-2)were measured using the enzyme-linked immunosorbent assay(ELISA).Compared with the control group(65.69(55.36–143.22)pg/mL),the plasma levels of sCLEC-2 were significantly increased in patients with CAD(133.67(88.76–220.09)pg/mL)and ACS(134.16(88.88–225.81)pg/mL).The multivariate adjusted odds ratios(95%confidence interval)of CAD reached 2.01(1.52–2.66)(Ptrend<0.001)for each 1-quartile increase in sCLEC-2.Restricted cubic splines showed a positive dose-response association between sCLEC2 and CAD incidence(Plinearity<0.001).The addition of sCLEC-2 to conventional risk factors improved the C statistic(0.821 vs.0.761,P=0.004)and reclassification ability(net reclassification improvement:57.45%,P<0.001;integrated discrimination improvement:8.27%,P<0.001)for CAD.In conclusion,high plasma sCLEC-2 is independently associated with CAD risk,and the prognostic value of sCLEC-2 may be evaluated in future prospective studies. | Min Fei Li Xiang Xichen Chai Jingchun Jin Tao You Yiming Zhao Changgeng Ruan Yiwen Hao Li Zhu | 2020 | Frontiers of Medicine2020，14，1： | 5 |
| 11 | Foraging strategies in the greater horseshoe bat(Rhinolophus ferrumequinum)on Lepidoptera in summer显示文摘The diet of the bat Rhinolophus ferrumequinum was studied at the Zhi’an Village of Ji’an City in China, from June to August 2004. The bats were trained in a laboratory (volume: 9×4×4 m3). Foraging strategies of the bat were ob- served at night and prey remains were collected and identi- fied. The results showed that the diet consisted mainly of Lepidoptera in summer, including 11 families, more than 30 species of moths, such as Noctuidae (36.6% by number), Sphingidae (24.1%), Geometridae (13.4%) and Limacodidae (9.5%). The length of culled wings ranged from 10―40 mm (97.7%). Pearson correlation analysis showed that the bat R. ferrumequinum foraged their prey selectively, but not op- portunistically. From field studies, two ways were observed in which the bats retrieved their prey including aerial hawk- ing during peak active period of the insects and flycatching during the insects’ non-peak activity period. The bats never gleaned prey from the ground, though they appeared to be well able to detect fluttering moths on the ground. | JIN Longru FENG Jiang SUN Keping LIU Ying WU Lei LI Zhenxin ZHANG Xichen | 2005 | Chinese Science Bulletin2005，50，14： | 5 |
| 12 | Specific Relationship between the Surface Air Temperature and the Area of the Terra Nova Bay Polynya,Antarctica显示文摘Antarctic polynyas play an important role in regional atmosphere?ice?ocean interactions and are considered to help generate the global deep ocean conveyer belt.Polynyas therefore have a potential impact on the Earth’s climate in terms of the production of sea ice and high-salinity shelf water.In this study,we investigated the relationship between the area of the Terra Nova Bay polynya and the air temperature as well as the eastward and northward wind based on the ERA5 and ERAInterim reanalysis datasets and observations from automatic weather stations during the polar night.We examined the correlation between each factor and the polynya area under different temperature conditions.Previous studies have focused more on the effect of winds on the polynya,but the relationship between air temperature and the polynya area has not been fully investigated.Our study shows,eliminating the influence of winds,lower air temperature has a stronger positive correlation with the polynya area.The results show that the relationship between the polynya area and air temperature is more likely to be interactively influenced.As temperature drops,the relationship of the polynya area with air temperature becomes closer with increasing correlation coefficients.In the low temperature conditions,the correlation coefficients of the polynya area with air temperature are above 0.5,larger than that with the wind speed. | Yifan DING Xiao CHENG Xichen LI Mohammed SHOKR Jiawei YUAN Qinghua YANG Fengming HUI | 2020 | Advances in Atmospheric Sciences2020，37，5： | 3 |
| 13 | Experimental study of single-row chevron-jet impingement heat transfer on concave surfaces with different curvatures显示文摘To address the curvature effect on single-row chevron-nozzle jet impingement heat transfer on concave surface,a series of experiments are conducted in the present investigation.Four concave surfaces including one semi-cylindrical concave surface and three parabolic concave surfaces with different width-to-depth ratios are tested under three typical Reynolds numbers(Re=5000,10000 and 15000)and several dimensionless nozzle-to-surface distances ranging from 1 to 8.The results show that the concave curvature has a clear impact on chevron-nozzle jet impingement heat transfer,tightly dependent on jet Reynolds number and impinging distance.In general,the semicylindrical concave surface produces the highest longitudinally-averaged Nusselt number at the leading line of concave surface.Under a low jet Reynolds number,the parabolic concave surface with a highly curved curvature produces higher longitudinally-averaged Nusselt number at the leading line and more uniform longitudinally-averaged Nusselt number distribution along the curvilinear direction.However,the longitudinally-averaged Nusselt number at the leading line of concave surface is the lowest for the highly curved surface under a high jet Reynolds number and large impinging distance.In comparison with the round-nozzle,chevron nozzle plays a more significant role on improving jet impingement heat transfer at small impinging distances. | Yuanwei LYU Jingzhou ZHANG Xichen LIU Yong SHAN | 2019 | Chinese Journal of Aeronautics2019，32，10： | 3 |
| 14 | Identification of ten serum microRNAs from a genome‐wide serum microRNA expression profile as novel noninvasive biomarkers for nonsmall cell lung cancer diagnosis显示文摘 | XiChen ZhibinHu WenjingWang YiBa LijiaMa ChunniZhang ChengWang ZhijiRen YangZhao SijiaWu RuiZhuang YixinZhang HengHu ChazhenLiu LinXu JunWang HongbingShen JunfengZhang KeZen Chen‐YuZhang | 2012 | Int J Cancer2012，，7： | 3 |
| 15 | Deducing Complete Selection Rule Set for Driver Nodes to Guarantee Network’s Structural Controllability显示文摘Structural controllability is critical for operating and controlling large-scale complex networks. In real applications, for a given network, it is always desirable to have more selections for driver nodes which make the network structurally controllable. Different from the works in complex network field where structural controllability is often used to explore the emergence properties of complex networks at a macro level,in this paper, we investigate it for control design purpose at the application level and focus on describing and obtaining the solution space for all selections of driver nodes to guarantee structural controllability. In accord with practical applications,we define the complete selection rule set as the solution space which is composed of a series of selection rules expressed by intuitive algebraic forms. It explicitly indicates which nodes must be controlled and how many nodes need to be controlled in a node set and thus is particularly helpful for freely selecting driver nodes. Based on two algebraic criteria of structural controllability, we separately develop an input-connectivity algorithm and a relevancy algorithm to deduce selection rules for driver nodes. In order to reduce the computational complexity,we propose a pretreatment algorithm to reduce the scale of network's structural matrix efficiently, and a rearrangement algorithm to partition the matrix into several smaller ones. A general procedure is proposed to get the complete selection rule set for driver nodes which guarantee network's structural controllability. Simulation tests with efficiency analysis of the proposed algorithms are given and the result of applying the proposed procedure to some real networks is also shown, and these all indicate the validity of the proposed procedure. | Xichen Wang Yugeng Xi Wenzhen Huang Shuai Jia | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，5： | 2 |
| 16 | The structural change of Cu-Sn melt显示文摘With the high-temperature viscometer and magnetic susceptibility measurement device designed by our group,the viscosity and the magnetic susceptibility of the Cu65Sn35 melt were measured during the cooling process.An anomalous change can be found in the curves of viscosity and magnetic susceptibility at a certain temperature.The structure of the melt was studied by the high-temperature X-ray diffractometer.The anomalous change also can be found in the pair distribution function,correlation radius,and coordination number at the approximate tem-perature,which shows the microstructural change of the Cu65Sn35 melt.From the results,it was confirmed that the Cu6Sn5 compound occurs in the melt,which leads to the structural change of the melt. | HOU JiXin SUN JianJun ZHAN ChengWei TIAN XueLei CHEN XiChen | 2007 | Science China(Physics,Mechanics & Astronomy)2007，50，4： | 2 |
| 17 | The impact of mean dynamic topography on a sea-level anomaly assimilation in the South China Sea based on an eddy-resolving model显示文摘The sea-level anomaly (SLA) from a satellite altimeter has a high accuracy and can be used to improve ocean state estimation by assimilation techniques. However, the lack of an accurate mean dynamic topography (MDT) is still a bothersome issue in an ocean data assimilation. The previous studies showed that the errors in MDT have significant impacts on assimilation results, especially on the time-mean components of ocean states and on the time variant parts of states via nonlinear ocean dynamics. The temporal-spatial differences of three MDTs and their impacts on the SLA analysis are focused on in the South China Sea (SCS). The theoretical analysis shows that even for linear models, the errors in MDT have impacts on the SLA analysis using a sequential data assimilation scheme. Assimilation experiments, based on EnOI scheme and HYCOM, with three MDTs from July 2003 to June 2004 also show that the SLA assimilation is very sensitive to the choice of different MDTs in the SCS with obvious differences between the experimental results and observations in the centre of the SCS and in the vicinity of the Philippine Islands. A new MDT for assimilation of SLA data in the SCS was proposed. The results from the assimilation experiment with this new MDT show a marked reduction (increase) in the RMSEs (correlation coefficient) between the experimental and observed SLA. Furthermore, the subsurface temperature field is also improved with this new MDT in the SCS. | XU Dazhi ZHU Jiang QI Yiquan LI Xichen YAN Youfang | 2012 | Acta Oceanologica Sinica2012，31，5： | 2 |
| 18 | Profiles of muscular amino acids,fatty acids,and metabolites in Shaziling pigs of different ages and relation to meat quality显示文摘Pork meat is closely related to physicochemical alterations during growth and development,resulting in differences in nutritional value and meat flavor.This study aimed to evaluate the composition of amino acids,fatty acids,and metabolic profiles in the longissimus thoracis muscle(LM)of Shaziling pigs aged 30,90,150,210,and 300 days.The results showed that the predominant fatty acids identified in the LM of Shaziling pigs were C16:0,C16:1,C18:0,C18:1n9c,and C18:2n6c.An opposite correlation was observed for C18:2n6c and n6/n3 polyunsaturated fatty acids(P<0.05).Alanine,aspartate,glutamate,Dglutamine,and D-glutamate metabolism were the main metabolic pathways for the Shaziling pig meat flavor(P<0.05).Moreover,the correlation coefficients revealed that the contents of anserine,C16:0,C16:1,and C18:1n9c were positively correlated with intramuscular fat and/or p H24hand were negatively correlated with the values of L^(*)(lightness)and b^(*)(yellowness)(P<0.05).In conclusion,age greatly affected the meat quality of Shaziling pigs,and the contents of muscular anserine,C16:0,C16:1,and C18:1n9c might be promising indicators for better meat quality. | Yehui Duan Changbing Zheng Jie Zheng Lu Ma Xinran Ma Yinzhao Zhong Xichen Zhao Fengna Li Qiuping Guo Yulong Yin | 2023 | Science China(Life Sciences)2023，66，6： | 2 |
| 19 | A novel telomerase-interacting OTU protein of Eimeria tenella and its telomerase-regulating activity显示文摘 | Pu Wang Weirong Wang Ju Yang Yongxing Ai Pengtao Gong Xichen Zhang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 2 |
| 20 | Recent advances in wireless epicortical and intracortical neuronal recording systems显示文摘An implantable brain-computer interface(BCI)has proven to be effective in the field of sensory and motor function restoration and in the treatment of neurological disorders.Using a BCI recording system,we can transform current methods of human interaction with machines and the environment,especially to help those with cognitive and mobility disabilities regain mobility and reintegrate into society.However,most reported work has focused on a simple aspect of the whole system,such as electrodes,circuits,or data transmission,and only a very small percentage of systems are wireless.A miniature,lightweight,wireless,implantable microsystem is key to realizing long-term,real-time,and stable monitoring on freely moving animals or humans in their natural conditions.Here,we summarize typical wireless recording systems,from recording electrodes,processing chips and controllers,wireless data transmission,and power supply to the system-level package for either epicortical electrocorticogram(ECoG)or intracortical local field potentials(LFPs)/spike acquisition,developed in recent years.Finally,we conclude with our vision of challenges in next-generation wireless neuronal recording systems for chronic and safe applications. | Bowen JI Zekai LIANG Xichen YUAN Honglai XU Minghao WANG Erwei YIN Zhejun GUO Longchun WANG Yuhao ZHOU Huicheng FENG Honglong CHANG Jingquan LIU | 2022 | Science China(Information Sciences)2022，65，4： | 2 |
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