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| 1 | Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis显示文摘Lipid-based boundary layers formed on liposome-containing hydrogels can facilitate lubrication.However,these boundary layers can be damaged by shear,resulting in decreased lubrication.Here,a shear-responsive boundary-lubricated drug-loaded hydrogel is created by incorporating celecoxib(CLX)-loaded liposomes within dynamic covalent bond-based hyaluronic acid(HA)hydrogels(CLX@Lipo@HA-gel).The dynamic cross-linked network enables the hydrogel to get restructured in response to shear,and the HA matrix allows the accumulation of internal liposome microreservoirs on the sliding surfaces,which results in the formation of boundary layers to provide stable lubrication.Moreover,hydration shells formed surrounding the hydrogel can retard the degradation process,thus helping in sustaining lubrication.Furthermore,in vitro and in vivo experiments found that CLX@Lipo@HA-gels can maintain anabolic-catabolic balance,alleviate cartilage wear,and attenuate osteoarthritis progression by delivering CLX and shear-responsive boundary lubrication.Overall,CLX@Lipo@HA-gels can serve as shear-responsive boundary lubricants and drug-delivery vehicles to alleviate friction-related diseases like osteoarthritis. | Yiting Lei Xingkuan Wang Junyi Liao Jieliang Shen Yuling Li Zhengwei Cai Ning Hu Xiaoji Luo Wenguo Cui Wei Huang | 2022 | Bioactive Materials2022，7，10： | 4 |
| 2 | Experimental investigations on the fluid flow mechanism in porous media of enhanced oil recovery by alkli/surfactant/polymer flooding显示文摘The fluid flow mechanism in porous media of enhanced oil recovery by Alkli/ Surfactant/ Polymer (ASP) flooding is investigated by measuring production performance, pressure distribution and saturation distribution through installing differential pressure transducers and saturation measuring probes in a physical model of vertical heterogeneous reservoir. The fluid flow variation in porous media is the main reason of enhanced oil recovery of ASP flooding. The pressure field and saturation field are nonlinearly coupled together and the interaction between them results in the fluid flow variation in the reservoir. In a vertical heterogeneous reservoir, the ASP agents initially flow in the high permeability layer, and fluid changes the flow direction toward the low and the middle permeability layers because the resistance in the high permeability layer is increased under the physical and chemical action of adsorption, retention and emulsion. ASP flooding displaces out not only the residual oil in the high permeability layer, but also the remaining oil in the low and the middle permeability layers by increasing swept volume and displacing efficiency. | WANG Jialu SHEN Pingping CHEN Yongzhong ZHANG Zubo JIA Xu TIAN Yuling | 2005 | Science China(Technological Sciences)2005，48，4： | 3 |
| 3 | Plant multiscale networks:charting plant connectivity by multi-level analysis and imaging techniques显示文摘In multicellular and even single-celled organisms,individual components are interconnected at multiscale levels to produce enormously complex biological networks that help these systems maintain homeostasis for development and environmental adaptation.Systems biology studies initially adopted network analysis to explore how relationships between individual components give rise to complex biological processes.Network analysis has been applied to dissect the complex connectivity of mammalian brains across different scales in time and space in The Human Brain Project.In plant science,network analysis has similarly been applied to study the connectivity of plant components at the molecular,subcellular,cellular,organic,and organism levels.Analysis of these multiscale networks contributes to our understanding of how genotype determines phenotype.In this review,we summarized the theoretical framework of plant multiscale networks and introduced studies investigating plant networks by various experimental and computational modalities.We next discussed the currently available analytic methodologies and multi-level imaging techniques used to map multiscale networks in plants.Finally,we highlighted some of the technical challenges and key questions remaining to be addressed in this emerging field. | Xi Zhang Yi Man Xiaohong Zhuang Jinbo Shen Yi Zhang Yaning Cui Meng Yu Jingjing Xing Guangchao Wang Na Lian Zijian Hu Lingyu Ma Weiwei Shen Shunyao Yang Huimin Xu Jiahui Bian Yanping Jing Xiaojuan Li Ruili Li Tonglin Mao Yuling Jiao Sodmergen Haiyun Ren Jinxing Lin | 2021 | Science China(Life Sciences)2021，64，9： | 3 |
| 4 | Exhausted local lactate accumulation via injectable nanozyme-functionalized hydrogel microsphere for inflammation relief and tissue regeneration显示文摘Local lactate accumulation greatly hinders tissue repair and regeneration under ischemic condition.Herein,an injectable microsphere(MS@MCL)for local lactate exhaustion was constructed by grafting manganese dioxide(MnO_(2))-lactate oxidase(LOX)composite nanozyme on microfluidic hyaluronic acid methacrylate(HAMA)microspheres via chemical bonds,achieving a long-term oxygen-promoted lactate exhaustion effect and a long half-life in vivo.The uniform and porous microspheres synthesized by microfluidic technology is beneficial to in situ injection therapy and improving encapsulation efficiency.Furthermore,chemical grafting into HAMA microspheres through amide reactions promoted local enzymatic concentration and activity enhancement.It was showed that the MS@MCL eliminated oxidative and inflammatory stress and promoted extracellular matrix metabolism and cell survival when co-cultured with nucleus pulposus cells(NPCs)in vitro.In the rat degenerative intervertebral disc model caused by lactate injection,MS@MCL showed a long-term therapeutic effect in reducing intervertebral height narrowing and preventing extracellular matrix(ECM)degradation as well as inflammatory damage in vivo.Altogether,this study confirms that this nanozyme-functionalized injectable MS@MCL effectively improves the regenerative and reparative effect in ischemic tissues by disposing of enriched lactate in local microenvironment. | Jieliang Shen Ao Chen Zhengwei Cai Zhijie Chen Ruichao Cao Zongchao Liu Yuling Li Jie Hao | 2022 | Bioactive Materials2022，7，6： | 2 |
| 5 | Normalized decoupling control for high-dimensional MIMO processes for application in room temperature control HVAC systems 显示文摘 | Shen Yuling Cai Weniian Li Shaoyuan | 2010 | Control EnKineering Practice2010，18，： | 1 |
| 6 | The effect of different intensities of treadmill exercise on cognitive function deficit following a severe controlled cortical impact in rats 显示文摘 | Xiafeng Shen Aiping Li Yuling Zhang | 2013 | Int J Mol Sci2013，14，21： | 1 |
| 7 | Polymorphisms involved in the miR-218 - LAMB3 pathway and susceptibility of cervical cancer, a case–control study in Chinese women显示文摘 | Xiaoyi Zhou Xiaojun Chen Lingmin Hu Suping Han Fulin Qiang Yuling Wu Li Pan Hongbing Shen Ying Li Zhibin Hu | 2010 | Gynecologic Oncology2010，，2： | 1 |
| 8 | Polymorphisms involved in the miR-218 - LAMB3 pathway and susceptibility of cervical cancer, a case–control study in Chinese women显示文摘 | Xiaoyi Zhou Xiaojun Chen Lingmin Hu Suping Han Fulin Qiang Yuling Wu Li Pan Hongbing Shen Ying Li Zhibin Hu | 2010 | Gynecologic Oncology2010，，2： | 1 |
| 9 | Common genetic heterogeneity of human interleukin-37 leads to functional variance显示文摘Interleukin-37(IL-37)is an inhibitory member of the IL-1 family of cytokines.We previously found that balanced selection maintains common variations of the human IL37 gene.However,the functional consequences of this selection have yet to be validated.Here,using cells expressing exogenous IL-37 variants,including IL-37 Ref and IL-37 Var1 and Var2,we found that the three variants of IL-37 exhibited different immunoregulatory potencies in response to immune stimulation.The protein level of IL-37 Var2 was found to be significantly less than that of IL-37 Ref or Var1,despite the comparable mRNA levels of all three variants.Further study showed that IL-37 Var2 was rapidly degraded by a proteasome-dependent mechanism mediated by enhanced polyubiquitination,leading to a transient upregulation of IL-37 Var2 after immune stimulation.Finally,when ectopically expressed in cells,human IL-37 Var2 exerted less inhibition on proinflammatory cytokine production than did other IL-37 variants.Conversely,purified extracellular IL-37 variant proteins demonstrated comparable inhibitory abilities in vitro.In conclusion,our study reveals that common genetic variants of IL37 lead to different immune-inhibitory potencies,primarily as a result of differences in IL-37 protein stability,suggesting the possible involvement of these variants in various human diseases. | Jingjing Yan Yuling Zhang Shimeng Cheng Bin Kang Jinbiao Peng Xiaodan Zhang Meichun Yuan Wenqi Chu Wen Zhang Jiayin Shen Shuye Zhang | 2017 | Cellular & Molecular Immunology2017，14，9： | 1 |
| 10 | The relative importance of soil moisture in predicting bacterial wilt disease occurrence显示文摘Soil-borne plant diseases cause major economic losses globally.This is partly because their epidemiology is difficult to predict in agricultural fields,where multiple environmental factors could determine disease outcomes.Here we used a combination of field sampling and direct experimentation to identify key abiotic and biotic soil properties that can predict the occurrence of bacterial wilt caused by pathogenic Ralstonia solanacearum.By analyzing 139 tomato rhizosphere soils samples isolated from six provinces in China,we first show a clear link between soil properties,pathogen density and plant health.Specifically,disease outcomes were positively associated with soil moisture,bacterial abundance and bacterial community composition.Based on soil properties alone,random forest machine learning algorithm could predict disease outcomes correctly in 75%of cases with soil moisture being the most significant predictor.The importance of soil moisture was validated causally in a controlled greenhouse experiment,where the highest disease incidence was observed at 60%of maximum water holding capacity.Together,our results show that local soil properties can predict disease occurrence across a wider agricultural landscape,and that management of soil moisture could potentially offer a straightforward method for reducing crop losses to R.solanacearum. | Gaofei Jiang Ningqi Wang Yaoyu Zhang Zhen Wang Yuling Zhang Jiabao Yu Yong Zhang Zhong Wei Yangchun Xu Stefan Geisen Ville-Petri Friman Qirong Shen | 2021 | Soil Ecology Letters2021，3，4： | 1 |
| 11 | Flexible asymmetric supercapacitor based on MnO_2 honeycomb structure显示文摘A flexible asymmetric supercapacitor with high energy density was constructed by using a flexible substrate of carbonized silk-fabrics decorated with carbon nanotube, electroplating MnO_2 nanosheets and dip-coating activated carbon powders as the positive and the negative electrodes, respectively. By controlling the electroplating time, the MnO_2 nanosheets can be self-assembled to honeycomb structure and showed excellent electrochemical performance in 1 mol/L Na_2SO_4 electrolyte with SC950-EP30 performing the best. It exhibited a high specific capacitance(1110.85 F/g at a current density of 1 A/g based on the mass of MnO_2) and superior rate capability(77.44% capacity retention from 1 A/g to 10 A/g).Thus, the optimal asymmetric device assembled with this material as positive electrode can deliver a maximum energy density of 43.84 Wh/kg and a maximum power density of 6.62 kW/kg. | Yuling Chen Chao Chen Ruitao Lv Wanci Shen Feiyu Kang Nyanhwa Tai Zhenghong Huang | 2018 | Chinese Chemical Letters2018，29，4： | 0 |
| 12 | Genetic Architecture of Childhood Kidney and Urological Diseases in China显示文摘Kidney disease is manifested in a wide variety of phenotypes,many of which have an important hereditary component.To delineate the genotypic and phenotypic spectrum of pediatric nephropathy,a multicenter registration system is being imple-mented based on the Chinese Children Genetic Kidney Disease Database(CCGKDD).In this study,all the patients with kidney and urological diseases were recruited from 2014 to 2020.Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features.The genetic diagnosis was confirmed in 883 of 2256(39.1%)patients from 23 provinces in China.Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome(SRNS,23.5%),glomerulonephritis(GN,32.2%),congenital anomalies of the kidney and urinary tract(CAKUT,21.2%),cystic renal disease(3.9%),renal calcinosis/stone(3.6%),tubulopathy(9.7%),and chronic kidney disease of unknown etiology(CKDu,5.8%).The pathogenic variants of 105 monogenetic disorders were identified.Ten distinct genomic disorders were identified as pathogenic copy number variants(CNVs)in 11 patients.The diagnostic yield differed by subgroups,and was highest in those with cystic renal disease(66.3%),followed by tubulopathy(58.4%),GN(57.7%),CKDu(43.5%),SRNS(29.2%),renal calcinosis/stone(29.3%)and CAKUT(8.6%).Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions.We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed.Our data demonstrate the utility of family-based exome sequencing,and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease. | Ye Fang Hua Shi Tianchao Xiang Jiaojiao Liu Jialu Liu Xiaoshan Tang Xiaoyan Fang Jing Chen Yihui Zhai Qian Shen Guomin Li Li Sun Yunli Bi Xiang Wang Yanyan Qian Bingbing Wu Huijun Wang Wenhao Zhou Duan Ma Jianhua Mao Xiaoyun Jiang Shuzhen Sun Ying Shen Xiaorong Liu Aihua Zhang Xiaowen Wang Wenyan Huang Qiu Li Mo Wang Xiaojie Gao Yubin Wu Fang Deng Ruifeng Zhang Cuihua Liu Li Yu Jieqiu Zhuang Qing Sun Xiqiang Dang Haitao Bai Ying Zhu Siguang Lu Bili Zhang Xiaoshan Shao Xuemei Liu Mei Han Lijun Zhao Yuling Liu Jian Gao Ying Bao Dongfeng Zhang Qingshan Ma Liping Zhao Zhengkun Xia Biao Lu Yulong Wang Mengzhun Zhao Jianjiang Zhang Shan Jian Guohua He Huifeng Zhang Bo Zhao Xiaohua LI Feiyan Wang Yufeng Li Hongtao Zhu Xinhui Luo Jinghai Li Jia Rao Hong Xu | 2021 | Phenomics2021，1，3： | 0 |
| 13 | Electrochemically-induced highly reactive PdO^(*) interface on modulated mesoporous MOF-derived Co_(3)O_(4) support for selective ethanol electro-oxidation显示文摘Herein,Pd nanoparticles loaded Co_(3)O_(4)catalysts(Pd@Co_(3)O_(4))are constructed from zeolitic imidazolate framework-67(ZIF-67)for the ethanol oxidation reaction(EOR).It is demonstrated for the first time that the electrochemical conversion of Co_(3)O_(4)support would result in the charge distribution alignment at the Pd/Co_(3)O_(4)interface and induce the formation of highly reactive Pd-O species(PdO^(*)),which can further catalyze the consequent reactions of the intermediates of the ethanol oxidation.The catalyst,Pd@Co_(3)O_(4)-450,obtained under the optimized conditions exhibits excellent EOR performance with a high mass activity of 590 mA mg-1,prominent operational stability,and extraordinary capability for the electro-oxidation of acetaldehyde intermediates.Importantly,the detailed mechanism investigation reveals that Pd@Co_(3)O_(4)-450 could be benefit to the C-C bond cleavage to promote the desirable C1 pathway for the ethanol oxidation reaction.The present strategy based on the metal-support interaction of the catalyst might provide valuable inspiration for the design of high-performing catalysts for the ethanol oxidation reaction. | Yuling Chen Yali Wen Qun Zhou Lina Shen Fanghui Du Pai Peng Yu Chen Junwei Zheng | 2023 | Journal of Energy Chemistry2023，，11： | 0 |
| 14 | Changing Patterns in Digestive Diseases Mortality in Urban and Rural Areas—China,1987-2021显示文摘What is already known about this topic?Digestive diseases(DDs)are a global health concern with a substantial epidemiological and economic impact,given their high prevalence.What is added by this report?This study investigated the trends in mortality related to DDs in China from 1987 to 2021,focusing on the urban-rural divide.Additionally,it aimed to determine the specific impacts of age,period,and cohort on DDs mortality.What are the implications for public health practice?There is a need to prioritize and allocate more resources toward the future management of DDs in order to effectively address the challenges posed by urbanization and aging populations. | Xinran Shen Feng Wang Yuling Li Binbin Su Zhiqiang Song Bin Cong | 2023 | China CDC weekly2023，5，50： | 0 |
| 15 | Prevalence of hepatic steatosis and metabolic associated fatty liver disease among female breast cancer survivors显示文摘To the Editor:Non-alcoholic fatty liver disease(NAFLD)comes to prevail in Asia and,the prevalence in China is reported tobe24%to36%.lilThe prevalence ofNAFLD and its associated medical burden might be underestimated.The diagnosis of NAFLD led to the exclusion of other chronic liver diseases including“excess”alcohols,thus the population with alcoholic consumptions or other liver diseases might be neglected.In March 2020,the international expert consensus proposed a new concept,“metabolic associated fatty liver disease(MAFLD),”“and replaced the earlier term” of NAFLD.2As themost prevalent female malignancy,breast cancer(BC)shares similar risk factors to MAFLD.Higher levels of obesity and physical inactivity are closely correlated to BC and are significant drive for the increasing trends in the prevalence of BC.Some BC survivors may receive chemotherapy and endocrine therapy,both of which are reported to increase the risk of hepatic steatosis(HS),which is the fundamental criteria of the diagnosis of MAFLD. | Shen Tian Hao Li Renhua Li Liang Ran Shu Li Juan Wu Zhou Xu Xinyu Liang Yuling Chen Jun Xiao Jiaying Wei Chenyu Ma Jingyu Song Ruiling She Kainan Wu Lingquan Kong | 2022 | Chinese Medical Journal2022，135，19： | 0 |
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