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| 1 | Energy balance closure at ChinaFLUX sites显示文摘Network of eddy covariance observation is measuring long-term carbon and water fluxes in contrasting ecosystems and climates. As one important reference of independently evaluating scalar flux estimates from eddy covariance, energy balance closure is used widely in study of carbon and water fluxes. Energy balance closure in ChinaFLUX was evaluated by statistical regression of turbulent energy fluxes (sensible and latent heat) against available energy (net radiation, soil heat flux, canopy heat storage) and the energy balance ratio (EBR) and the frequency distribution of relative errors of energy balance (δ). The trends of diurnal and seasonal variation of energy balance in ChinaFLUX were analyzed. The results indicated that the imbalance was prevalent in all observation sites, but there were little differences among sites because of the properties variation of sites. The imbalance was greater during nocturnal periods than daytime and closure was improved with friction velocity intensifying. Generally the results suggested that estimates of the scalar turbulent fluxes of sensible and latent heat were underestimated and/or that available energy was overestimated. Finally, we discussed certain factors that are contributed to the imbalance of energy, such as systematic errors associated with the sampling mismatch, systematic instrument bias, neglected energy sinks, low and high frequency loss of turbulent fluxes and advection of heat and water vapor. | LI Zhengquan, YU Guirui, WEN Xuefa, ZHANG Leiming, REN Chuanyou & FU Yuling Chinese Ecosystem Research Network Synthesis Research Center, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China Graduate School of the Chinese Academy of Sciences, Beijing 100039, China | 2005 | Science China Earth Sciences2005，48，z1： | 50 |
| 2 | The bHLH Transcription Factor MYC3 Interacts with the Jasmonate ZIM-Domain Proteins to Mediate Jasmonate Response in Arabidopsis显示文摘Arabidopsis Jasmonate ZIM 域蛋白质(JAZ ) 充当复杂的 SCFCOI1 的底层镇压他们的下游地指向,它为调整 JA 的植物开发和防卫是必要的。bHLH 抄写因素 MYC2 被发现 JA 回答包括与 JAZ 交往并且调停 JA 禁止的根生长。这里,我们识别了直接由它的 N 终端区域的优点与 JAZ 交往了调整 JA 回答的另一 bHLH 抄写因素 MYC3。有 MYC3 的 overexpression 的转基因的植物在 JA 禁止的根延伸和幼苗开发展出了超敏性。交往 JAZ 模式和 MYC3 的导致 JA 的表示模式从 MYC2 的那些是可区分的。我们推测那 MYC3, MYC2 可以在 JA 回答的规定有冗余而且可区分的功能。 | Zhiwei Cheng Li Sun Tiancong Qi Bosen Zhang Wen Peng Yule Liu Daoxin Xie | 2011 | Molecular Plant2011，4，2： | 35 |
| 3 | Molecular Mechanisms of Leaf Morphogenesis显示文摘工厂维持能力作为茎的主要侧面的附器在整个他们的生命周期和形式叶子形成侧面的附器。叶子在射击的外部地区开始顶端的分裂组织然后发展成弄平的结构。在大多数植物,叶作为一块太阳的面板工作,在光合作用把二氧化碳和水变换成糖类和氧的地方。为了生产结构,那能最佳地完成这功能,植物精确控制叶子的开始,形状,和极性。而且,叶开发是高度灵活的 ? 但是与保存规章的机制跟随普通主题。叶子可能从被变换成确定的、弄平的结构的侧面的分支演变。许多另外的植物部分例如花的器官,被认为专业化叶子,并且因此,叶开发位于他们的形态发生下面。这里,我们在三维的叶形式怎么被建立的理解考察最近的进展。我们集中基因,植物激素,和机械性质怎么调制叶开发,并且讨论 ? 在叶开始,极性建立和维护,变平的叶,和闰的生长的上下文的这些因素。 | Fei Du Chunmei Guan Yuling Jiao | 2018 | Molecular Plant2018，11，9： | 25 |
| 4 | L_-glutamine provides acid resistance for Escherichia coil through enzymatic release of ammonia显示文摘 | Peilon Lu | 2013 | Cell Research2013，23，5： | 23 |
| 5 | Variation of head and facial morphological characteristics with increased age of Han in Southern China显示文摘We investigated 13940 (6735 male, 7250 female) adult head and facial physical attributes from 19 different Han ethnic groups in 10 southern-China provinces, and calculated 12 head and facial indexes. Indexes were used to analyze the variation of head and facial morphological characteristics with increased age. Results showed that as age increases: (1) Head breadth, minimum frontal breadth, face breadth, interocular breadth, external biocular breadth, lip height, lip thickness, head circumference, auricular height, length-breadth head index, length-height head index, and lip-index values decline significantly in a linear fashion. (2) Nose breadth, mouth breadth, morphological facial height, upper-lip height, physiognomic ear length, physiognomic ear breadth, visor skin-fold, and vertical head-facial index values significantly increase in a linear fashion. | LI YongLan ZHENG LianBin YU KeLi LU ShunHua ZHANG XingHua LI YuLing WANG Yang XUE Hong DENG Wei | 2013 | Chinese Science Bulletin2013，58，4： | 20 |
| 6 | Viral effector protein manipulates host hormone signaling to attract insect vectors显示文摘 | Dewei Wu Tiancong Qi Wan-Xiang Li Haixia Tian Hua Gao Jiaojiao Wang Jin Ge Ruifeng Yao Chunmei Ren Xian-Bing Wang Yule Liu Le Kang Shou-Wei Ding Daoxin Xie | 2017 | Cell Research2017，27，3： | 20 |
| 7 | Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy显示文摘The phosphatidylinositol 3-kinase(PI3K) pathway is frequently activated in human cancers.Class I PI3 Ks are lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate(PIP2) at the 3-OH of the inositol ring to generate phosphatidylinositol 3,4,5-trisphosphate(PIP3), which in turn activates Akt and the downstream effectors like mammalian target of rapamycin(m TOR) to play key roles in carcinogenesis. Therefore, PI3 K has become an important anticancer drug target, and currently there is very high interest in the pharmaceutical development of PI3 K inhibitors. Idelalisib has been approved in USA and Europe as the first-in-class PI3 K inhibitor for cancer therapy. Dozens of other PI3 K inhibitors including BKM120 and ZSTK474 are being evaluated in clinical trials. Multifaceted studies on these PI3 K inhibitors are being performed, such as single and combinational efficacy, resistance, biomarkers,etc. This review provides an introduction to PI3 K and summarizes key advances in the development of PI3 K inhibitors. | Wennan Zhao Yuling Qiu Dexin Kong | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 19 |
| 8 | A Deep Adaptive Learning Method for Rolling Bearing Fault Diagnosis Using Immunity显示文摘The extraction of rolling bearing fault features using traditional diagnostic methods is not sufficiently comprehensive and the features are often chosen subjectively and depend on human experience. In this paper, an improved deep convolutional process is used to extract a set of features adaptively. The hidden multi-layer feature of deep convolutional neural networks is also exploited to improve the extraction features. A deterministic detection of low-confidence samples is performed to ensure the reliability of the recognition results and to decrease the rate of false positives by evaluating the diagnosis of the deep convolutional neural network. To improve the efficiency of the continuous learning elements of the rolling bearing fault diagnosis, a clone learning strategy based on cloning and mutation operations is proposed. The experimental results show that the proposed deep convolutional neural network model can extract multiple rolling bearing fault features, improve classification and detection accuracy by reducing the false positive rate when diagnosing rolling bearing faults, and accelerate learning efficiency when using low-confidence rolling bearing fault samples. | Yuling Tian Xiangyu Liu | 2019 | Tsinghua Science and Technology2019，24，6： | 18 |
| 9 | Advances in carbon flux observation and research in Asia显示文摘As an important component of FLUXNET, Asia is increasingly becoming the hotspot in global carbon research for its vast territory, complex climate type and vegetation diversity. The present three regional flux observation networks in Asia (i.e. AsiaFlux, KoFlux and ChinaFLUX)have 54 flux observation sites altogether, covering tropic rainforest, evergreen broad-leaved forest, broad-leaved and coniferous mixed forest, shrubland, grassland, alpine meadow and cropland ecosystems with a latitudinal distribution from 2°N to 63°N. Long-term and continuous fluxes of carbon dioxide, water vapor and energy between the biosphere and atmosphere are mainly measured with eddy covariance technique to (1) quantify and compare the carbon, water and energy budgets across diverse ecosystems; (2) quantify the environmental and biotic controlling mechanism on ecosystem carbon, water and energy fluxes; (3) validate the soil-vegetation-atmosphere model; and (4) serve the integrated study of terrestrial ecosystem carbon and water cycle. Over the last decades, great advancements have been made in the theory and technology of flux measurement, ecosystem flux patterns, simulation and scale conversion by Asian flux community. The establishment of ChinaFLUX has greatly filled the gap of flux observation and research in Eurasia. To further promote the flux measurement and research,accelerate data sharing and improve the data quality, it is necessary to present a methodological system of flux estimation and evaluation over complex terrain and to develop the integrated research that combines the flux measurement, stable isotope measurement, remote sensing observation and GIS technique. It also requires the establishment of the Joint Committee of Asian Flux Network in the Asia-Pacific region in order to promote the cooperation and communication of ideas and data by supporting project scientists, workshops and visiting scientists. | YU Guirui, ZHANG Leiming, SUN Xiaomin, FU Yuling & LI Zhengquan Synthesis Center of Chinese Ecosystem Research Network (CERN), Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China Graduate School of the Chinese Academy of Sciences, Beijing 100039, China | 2005 | Science China Earth Sciences2005，48，z1： | 16 |
| 10 | Role of plant autophagy in stress response显示文摘Autophagy is a conserved pathway for the bulk degradation of cytoplasmic components in all eukaryotes.This process plays a critical role in the adaptation of plants to drastic changing environmental stresses such as starvation,oxidative stress,drought,salt,and pathogen invasion.This paper summarizes the current knowledge about the mechanism and roles of plant autophagy in various plant stress responses. | Shaojie Han Bingjie Yu Yan Wang Yule Liu | 2011 | Protein & Cell2011，2，10： | 15 |
| 11 | Traditional Chinese medicine in COVID-19显示文摘COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2(SARSCo V-2)has spread across the globe,posing an enormous threat to public health and safety.Traditional Chinese medicine(TCM),in combination with Western medicine(WM),has made important and lasting contributions in the battle against COVID-19.In this review,updated clinical effects and potential mechanisms of TCM,presented in newly recognized three distinct phases of the disease,are summarized and discussed.By integrating the available clinical and preclinical evidence,the efficacies and underlying mechanisms of TCM on COVID-19,including the highly recommended three Chinese patent medicines and three Chinese medicine formulas,are described in a panorama.We hope that this comprehensive review not only provides a reference for health care professionals and the public to recognize the significant contributions of TCM for COVID-19,but also serves as an evidence-based in-depth summary and analysis to facilitate understanding the true scientific value of TCM. | Ming Lyu Guanwei Fan Guangxu Xiao Taiyi Wang Dong Xu Jie Gao Shaoqin Ge Qingling Li Yuling Ma Han Zhang Jigang Wang Yuanlu Cui Junhua Zhang Yan Zhu Boli Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 14 |
| 12 | An eco-environmental friendly operation: An effective method to mitigate the harmful blooms in the tributary bays of Three Gorges Reservoir显示文摘Harmful algal blooms, which frequently occur in different tributaries, have become a serious water quality problem of the Three Gorges Reservoir (TGR) since its initial filling. A three-year monitoring campaign from 2008 to 2010 was conducted to identify the controlling factors of algal blooms and effective preventive measures. The following results were obtained: 1) Layered and bidirectional currents, called intrusive density currents, dominate the tributary bays of the TGR year round; 2) continuously increasing water level can make the intruding density current shift from the middle to the surface, and surface intrusive water can reduce the surface water temperature and break the stable stratification of the tributary; 3) the appearing or fading away of algal blooms is closely associated with fluctuations in the TGR water level. Thus, the water level fluctuation patterns of different 'tide-types' may prevent the occurrence of algal blooms in the spring and summer, and the 'stair-type' tides may control autumn blooms during the impounding period. These methods were feasible and effective throughout the actual TGR's operation in 2009 2011. These patterns formed an eco-environmentally friendly operation (EEFO) to mitigate algal blooms. As an in situ treatment with easier operation and less negative impact and loss, compared with chemical and filter-feeding fish methods, the EEFO is currently considered as the most feasible remedial measure to remit the eco-environmental problems at the Three Gorges Dam (TGD). | YANG ZhengJian LIU DeFu JI DaoBin XIAO ShangBin HUANG YuLing MA Jun | 2013 | Science China(Technological Sciences)2013，56，6： | 14 |
| 13 | Modeling gross primary production of a temperate grassland ecosystem in Inner Mongolia, China, using MODIS imagery and climate data显示文摘Carbon fluxes in temperate grassland ecosystems are characterized by large inter-annual variations due to fluctuations in precipitation and land water availability. Since an eddy flux tower has been in operation in the Xilin Gol grassland, which belongs to typical temperate grassland in North China, in this study, observed eddy covariance flux data were used to critically evaluate the biophysical per- formance of different remote sensing vegetation indices in relation to carbon fluxes. Furthermore, vegetation photosynthesis model (VPM) was introduced to estimate gross primary production (GPP) of the grassland ecosystem for assessing its dependability. As defined by the input variables of VPM, Moderate Resolution Imaging Spectroradimeter (MODIS) and standard data product MOD09A1 were downloaded for calculating enhanced vegetation index (EVI) and land surface water index (LSWI). Measured air temperature (Ta) and photosynthetically active radiation (PAR) data were also included for model simulating. Field CO2 flux data, during the period from May, 2003 to September, 2005, were used to estimate the 'observed' GPP (GPPobs) for validation. The seasonal dynamics of GPP predicted from VPM (GPPVPM) was compared quite well (R2=0.903, N=111, p<0.0001) with the observed GPP. The ag- gregate GPPVPM for the study period was 641.5 g C·m?2, representing a ~6% over-estimation, compared with GPPobs. Additionally, GPP predicted from other two typical production efficiency model (PEM) represents either higher overestimation or lower underestimation to GPPobs. Results of this study demonstrate that VPM has potential for estimating site-level or regional grassland GPP, and might be an effective tool for scaling-up carbon fluxes. | WU WeiXing WANG ShaoQiang XIAO XiangMing YU GuiRui FU YuLing HAO YanBin | 2008 | Science China Earth Sciences2008，51，10： | 13 |
| 14 | Prolonged manganese exposure induces severe deficits in lifespan,development and reproduction possibly by altering oxidative stress response in Caenorhabditis elegans显示文摘We examined the possible multiple defects induced by acute and prolonged exposure to high levels of manganese(Mn) solution by monitoring the endpoints of lifespan,development,reproduction,and stress response.Our data suggest that acute exposure(6 h) to Mn did not cause severe defects of life span,development,and reproduction,similarly,no significant defect could be found in animals exposed to a low concentration of Mn(2.5 μmol/L) for 48 h.In contrast,prolonged exposure(48 h) to high Mn concentrations(75 and 200 μmol/L) resulted in significant defects of life span,development,and reproduction,as well as the increase of the percentage of population with hsp-16.2::gfp expression indicating the obvious induction of stress responses in exposed animals.Moreover,prolonged exposure(48 h) to high concentrations(75 and 200 μmol/L) of Mn decreased the expression levels of antioxidant genes of sod-1,sod-2,sod-3,and sod-4 compared to control.Therefore,prolonged exposure to high concentrations of Mn will induce the severe defects of life span,development,and reproduction in nematodes possibly by affecting the stress response and expression of antioxidant genes in Caenorhabditis elegans. | XIAO Jing | 2009 | Journal of Environmental Sciences2009，21，6： | 13 |
| 15 | The role of maize root size in phosphorus uptake and productivity of maize/faba bean and maize/wheat intercropping systems显示文摘Interspecific root/rhizosphere interactions affect phosphorus (P) uptake and the productivity of maize/faba bean and maize/wheat intercropping systems. The aim of these experiments was to determine whether manipulation of maize root growth could improve the productivity of the two intercropping systems. Two near isogenic maize hybrids (the larger-rooted T149 and smaller-rooted T222) were intercropped with faba bean and wheat, under conditions of high- and low-P availability. The larger-rooted T149 showed greater competitive ability than the smaller-rooted T222 in both maize/faba bean and maize/wheat intercropping systems. The higher competitive ability of T149 improved the productivity of the maize/faba bean intercropping system in P-sufficient conditions. In maize/wheat intercropping systems, root growth, shoot biomass, and P uptake of maize were inhibited by wheat, regardless of the P-supply. Compared with T222, the larger-rooted T149 suffered less in the intercropping systems. The total biomass of the maize/wheat intercropping system was higher for wheat/T149 than for wheat/T222 under low-P conditions. These data suggested that genetic improvement of maize root size could enhance maize growth and its ability to compete for P resources in maize/faba bean and maize/wheat intercropping systems. In addition, depending on the P availability, larger maize roots could increase the productivity of intercropping systems. | ZHANG YiKai CHEN FanJun LI Long CHEN YanHua LIU BingRan ZHOU YuLing YUAN LiXing ZHANG FuSuo MI GuoHua | 2012 | Science China(Life Sciences)2012，55，11： | 13 |
| 16 | Study on the velocity structure of the crust in Southwest Yunnan of the north-south seismic belt—Results from the Menghai-Gengma-Lushui deep seismic sounding profile显示文摘Southwest Yunnan, located in the southern segment of the north-south seismic belt, is one of the regions with strong tectonic movement and seismic activity in China. Study on the characteristics of tectonic setting and deep geophysical field in the region is an important issue in basic science. In 2013, we conducted a 600-km-long Menghai-Gengma-Lushui profile of deep seismic wide-angle reflection/refraction and high-resolution seismic refraction in Southwest Yunnan. In this paper, we use 6 groups of clear intracrustal P-wave phases picked from the seismic record sections of 11 shots to build a velocity structure model of basement and 2D crustal P-wave of the region by using finite difference inversion and ray travel time forward fitting technology. The results show that, from south to north, the crust gradually thickens along the profile and its basement shows a significant lateral heterogeneity. In the vicinity of the Nanting River fault, the basement structure shows the character of alternate depressions and uplifts, and the shallowest basement is about 1.0 km. In the vicinity of Tengchong and Lancang, the basement is about 5.0 km deep. The velocity of the middle and lower crust in the region generally increases with the increasing of depth. At the block boundary and beneath the fault tectonic belt, the velocity contours show apparent irregularity and the P-wave velocity changes sharply. In this region, the Moho gradually deepens from south to north with relatively large lateral undulations. The shallowest point of the Moho is located near Menghai at a depth of about 32.0 km. The deepest point of the Moho is located near Tengchong at a depth of about 40.5 km. Between Gengma and Yongde, the Moho shows significantly fast uplifting and depressing with an amplitude of about 4.0 km. Beneath the Nanting River fault, Longling-Ruili fault, Dayingjiang fault and Tengchong volcano, the basement velocity structure, 2D crustal P-wave velocity structure, distribution of average profile velocity and intracrustal interface spreading also show significant changes from the basement to the top of the Moho, indicating that the crustal velocity and medium physical properties beneath the fault tectonic belt are apparently different from the crustal materials on its both sides, which suggests that these faults should be in a certain scale and may extend to the lower crust or the top of the upper mantle. The earthquakes in the region mainly occurred at a depth of 10–20 km, and the seismic activity is related to the intracrustal medium velocity difference and fault belt distribution. The results can serve as the important data of the crust-mantle structure for the analysis of the deep tectonic setting, earthquake precise positioning, seismogenic structure modeling of the seismic activities in Southwest Yunnan, as well as the important reference for the evaluation of seismic hazard and the planning of earthquake disaster mitigation of this region. | WANG ShuaiJun LIU BaoJin ZHANG JianShi LIU BaoFeng DUAN YuLing SONG XiangHui DENG XiaoGuo MA CeJun ZANG YiRan | 2015 | Science China Earth Sciences2015，58，12： | 13 |
| 17 | Characterizing CO_2 fluxes for growing and non-growing seasons in a shrub ecosystem on the Qinghai-Tibet Plateau显示文摘To assess carbon budget for shrub ecosystems on the Qinghai-Tibet Plateau, CO2flux was measured with an open-path eddy covariance system for an alpine shrub ecosystem during growing and non-growing seasons. CO2 flux dynamics was distinct between the two seasons. During the growing season from May to September, the ecosystem exhibited net CO2uptake from 08:00 to 19:00 (Beijing Standard Time), but net CO2 emission from 19:00 to 08:00.Maximum CO2 uptake appeared around 12:00 with values of 0.71, 1.19, 1.46 and 0.67 g CO2m-2 h-1 for June, July, August and September, respectively. Diurnal fluctuation of CO2 flux showed higher correlation with photosynthetic photon flux density than temperature. The maximum net CO2 influx occurred in August with a value of 247 g CO2 m-2. The total CO2 uptake by the ecosystem was up to 583 g CO2 m-2 for the growing season. During the non-growing season from January to April and from October to December, CO2 flux showed small fluctuation with the largest net CO2 efflux of 0.30 g CO2 m-2 h-1 in April. The diurnal CO2 flux was close to zero during most time of the day, but showed a small net CO2 efflux from 11:00 to 18:00. Diurnal CO2 flux, is significantly correlated to diurnal temperature in the non-growing season. The maximum monthly net CO2 efflux appeared in April, with a value of 105 g CO2 m-2. The total net CO2 efflux for the whole non-growing season was 356 g CO2 m-2. | XU Shixiao, ZHAO Xinquan, FU Yuling, ZHAO Liang, LI Yingnian, CAO Guangmin, GU Song, WANG Qinxue & DU Mingyuan Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810001, China Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China Graduate School of the Chinese Academy of Sciences, Beijing 100136, China National Institute for Environmental Studies, Tsukuba 305-8569, Japan National Institute for Agro-Environmental Science, Tsukuba 305-8604, Japan | 2005 | Science China Earth Sciences2005，48，z1： | 12 |
| 18 | Mechanistic insights into sequestration of U(VI) toward magnetic biochar: Batch, XPS and EXAFS techniques显示文摘The magnetic iron oxide(Fe_3O_4) nanoparticles stabilized on the biochar were synthesized by fast pyrolysis of Fe(II)-loaded hydrophyte biomass under N_2 conditions. The batch experiments showed that magnetic biochar presented a large removal capacity(54.35 mg/g)at pH 3.0 and 293 K. The reductive co-precipitation of U(VI) to U(IV) by magnetic biochar was demonstrated according to X-ray diffraction, X-ray photoelectron spectroscopy and X-ray absorption near edge structure analysis. According to extended X-ray absorption fine structure analysis, the occurrence of U-Fe and U-U shells indicated that high effective removal of uranium was primarily inner-sphere coordination and then reductive co-precipitation at low pH. These observations provided the further understanding of uranium removal by magnetic materials in environmental remediation. | Qingyuan Hu Yuling Zhu Baowei Hu Songhua Lu Guodong Sheng | 2018 | Journal of Environmental Sciences2018，30，8： | 9 |
| 19 | Spatial correlation analysis of sea-bottom backscattering显示文摘The principle of the spatial correlation characteristics of sea-bottom backscattering was expounded.The Kirchhoff model is introduced to simulate sea-bottom backscattering and the spatial correlation is calculated.Some sediment characteristic parameters,such as the ratio of sediment mass density to water mass density,the ratio of sediment sound speed to water sound speed,the attenuation coefficient of sound waves,the strength and exponent of seabottom interface roughness spectrum,are considered while simulating and their influences on spatial correlation are analyzed.By establishing the expressions of the sediment characteristic parameters with the logarithmic sediment grain size,the variation tendency of the spatial correlation versus the logarithmic sediment grain size is obtained.The width of the major lobe of the spatial correlation function narrows as the logarithmic sediment grain size increases.The comparisons between simulated data and in-situ data collected in October 2007 have proven that their spatial correlation function waveforms agree well under the same sediment characteristics. | KUAI Duojie WANG Changhong FENG Lei WANG Yuling QIU Wei YI Huiqin CHEN Long | 2012 | Chinese Journal of Acoustics2012，31，3： | 9 |
| 20 | Targeted delivery of chlorogenic acid by mannosylated liposomes to effectively promote the polarization of TAMs for the treatment of glioblastoma显示文摘Tumor-associated macrophages(TAMs)generally display an immunosuppressive M2 phenotype and promote tumor progression and metastasis,suggesting their potential value as a target in cancer immunotherapy.Chlorogenic acid(CHA)has been identified as a potent immunomodulator that promotes the polarization of TAMs from an M2 to an M1 phenotype.However,rapid clearance in vivo and low tumor accumulation have compromised the immunotherapeutic efficacy of CHA in clinical trials.In this study,mannosylated liposomes are developed for targeted delivery of CHA to TAMs.The immunoregulatory effects of CHA,along with the overall antitumor efficacy of CHA-encapsulated mannosylated liposomes,are investigated through in vitro and in vivo experiments.The prepared CHA-encapsulated mannosylated liposomes exhibit an ideal particle size,favorable stability,and preferential accumulation in tumors via the mannose receptor-mediated TAMs-targeting effects.Further,CHA-encapsulated mannosylated liposomes inhibit G422 glioma tumor growth by efficiently promoting the polarization of the pro-tumorigenic M2 phenotype to the anti-tumorigenic M1 phenotype.Overall,these findings indicate that CHA-encapsulated mannosylated liposomes have great potential to enhance the immunotherapeutic efficacy of CHA by inducing a shift from the M2 to the M1 phenotype. | Jun Ye Yanfang Yang Jing Jin Ming Ji Yue Gao Yu Feng Hongliang Wang Xiaoguang Chen Yuling Liu | 2020 | Bioactive Materials2020，5，3： | 9 |
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