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| 1 | Fructus Broussonetae extract improves cognitive function and endoplasmic reticulum stress in Alzheimer's disease models显示文摘This study investigated the effects and possible targets of Fructus Broussonetiae extract,a traditional Chinese medicinal herb,on a model of Alzheimer's disease induced by beta-amyloid peptide 25-35 and D-galactose.The results revealed that intragastric administration of Fructus Broussonetiae significantly increased the expression of immunoglobulin-binding protein,a key factor in the endoplasmic reticulum stress-signaling pathway in rat hippocampus.In contrast,the treatment significantly decreased expression levels of PKR-like endoplasmic reticulum kinase and C/EBP homologous protein,and substantially improved learning,memory and spatial recognition dysfunction in rats.This evidence indicates that Fructus Broussonetiae extract improves spatial learning and memory abilities in rats by affecting the regulation of hippocampal endoplasmic reticulum stress and activation of the apoptosis pathway. | Yinghong Li Li Hu Zhengzhi Wu Zhiling Yu Meiqun Cao Kehuan Sun Yu Jin Anmin Wu Andrew CJ Huang | 2011 | Neural Regeneration Research2011，6，30： | 7 |
| 2 | Isolation, characterization and functional analysis of a cdc48 homologue from tobacco BY-2 cells显示文摘分裂酵母 Schizosaccharomyces pombe 被用来从可以在房间周期规定起作用的烟草 BY-2 房间识别基因。编码对酵母 CDC48 相应的蛋白质的 cDNA 被孤立,基因被指定为 NtCDC48。cDNA 包含为二个 twical ATPase 模块包括的 808 氨基酸的预言的蛋白质编码的一个开的读物框架(一 245-374 并且一 518-646 ) 。NtCDC48in 烟草 BY-2 房间的 Overexpression 在有丝分裂的索引以及到传播有丝分裂的锭子的形成导致了增加。NtCDC48-GFP 熔化蛋白质还通过 G1 无所不在地被散布到 M 阶段的家他们细胞的本地化与房间周期前进一起定期改变了的潜水艇。这些结果显示 NtCDC48 可以在 BY-2 房间在房间周期的规定起一个重要作用。 | CHEN Zhiling Yu Yi LIU Lina XIA Guixian | 2007 | Progress in Natural Science:Materials International2007，17，2： | 6 |
| 3 | An ethanolic extract of Bailian(Radix Ampelopsis Japonicae):demonstration of colorectal cancer treatment efficacy via inhibition of β-catenin signaling in vitro显示文摘OBJECTIVE:To investigate the underlying mechanism of Bailian (Radix Ampelopsis Japonicae,BL) extract action on colorectal cancer (CRC).METHODS:We explored the involvement of β-catenin signaling on the anti-CRC effects of an BL ethanolic extract (BLE) in cell models by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay,immunofluorescent staining,luciferase assay,Western blot analysis and real-time quantitative polymerase chain reaction analysis.Anti-CRC compounds were quantified by high performance liquid chromatography.RESULTS:The contents of gallic acid,catechin,and epicatechin in the BLE were 0.23,1.25,and 0.18 g/kg,respectively.BLE-mediated cytotoxic and apoptotic effects were accompanied by lowered β-catenin/Tcf transcriptional activity,reduced β-catenin nuclear localization,and downregulated protein and mRNA levels of both β-catenin and molecules regulated by β-catenin.CONCLUSION:The mechanism underpinning the anti-CRC effects of BLE may involve inhibition of β-catenin signaling.Further studies are necessary to establish the role of β-catenin signaling in the action of BLE-mediated anti-CRC effects. | Su Tao Wang Xinning Li Chunyu Bai Jingxuan Chi-Yan Cheng Fu Xiuqiong Li Ting Yu Zhiling | 2019 | Journal of Traditional Chinese Medicine2019，39，3： | 3 |
| 4 | Atacamite and Nantokite in Kaerqueka Copper Deposit of Qimantag Area:Evidence for Cenozoic Climate Evolution of the Qaidam Basin显示文摘Using a mineralogy method to reflect climate evolution is a new approach to research Cenozoic environmental progression of the Qaidam Basin. In this paper, we present the chemical composition and crystallographic parameter of atacamite, nantokite, and tenorite in cryptocrystalline aggregates from the Kaerqueka copper deposit of Qimantag metallogenic belt by means of electron microprobe and in-situ X-ray diffraction analyses. Atacamite and nantokite occur in an intimate intergrowth as the secondary precipitation of chalcopyrite and bornite filling in the interstitial space of andradite in the Kaerqueka copper deposit, with an average composition of Cl: 12.38 wt.%, Cu: 63.76 wt.%, O: 21.46 wt.%. X-ray microdiffraction shows that the intergrowth contains nantokite with a cubic unit cell a=5.403(2) ? and atacamite with an orthorhombic unit cell a=6.030(3), b=6.883(2), c=9.114(1) ?. XRD quantitative calculation shows that the nanometric aggregate contains 36.07 wt.% tenorite, 18.41 wt.% atacamite, and 45.52 wt.% nantokite. The presence of nantokite and atacamite requires saline solutions for their formation and hyper-arid climate conditions for their preservation. Combined with the data of salt lakes and the pollen sequence of western China, we suggest that during the uplift of the Tibetan Plateau and the retreat of the Paratethys, saline water was forced to the surface through a basal fracture zone. In the hyper-arid climate of the Qaidam Basin, the recharge of groundwater by direct precipitation is negligible, and groundwater is derived from inflow from the salt lakes. Thus, atacamite is preserved. In addition, spertiniite in the edge and fractures of atacamite and nantokite may represent wetter climate after the formation of atacamite and nantokite. | Liwen Yi Xiangping Gu Anhuai Lu Xiangyu Li Dexian Zhang Zhiling Wang Jianping Liu Shuai Li Zhengxiang Shu Cui Yu Hongyan Zuo Can Shen | 2017 | Journal of Earth Science2017，28，3： | 3 |
| 5 | Major and Trace Elements of Magnetite from the Qimantag Metallogenic Belt: Insights into Evolution of Ore–forming Fluids显示文摘Magnetite, as a genetic indicator of ores, has been studied in various deposits in the world. In this paper, we present textural and compositional data of magnetite from the Qimantag metallogenic belt of the Kunlun Orogenic Belt in China, to provide a better understanding of the formation mechanism and genesis of the metallogenic belt and to shed light on analytical protocols for the in situ chemical analysis of magnetite. Magnetite samples from various occurrences, including the ore–related granitoid pluton, mineralised endoskarn and vein–type iron ores hosted in marine carbonate intruded by the pluton, were examined using scanning electron microscopy and analysed for major and trace elements using electron microprobe and laser ablation–inductively coupled plasma–mass spectrometry. The field and microscope observation reveals that early–stage magnetite from the Hutouya and Kendekeke deposits occurs as massive or banded assemblages, whereas late–stage magnetite is disseminated or scattered in the ores. Early–stage magnetite contains high contents of Ti, V, Ga, Al and low in Mg and Mn. In contrast, late–stage magnetite is high in Mg, Mn and low in Ti, V, Ga, Al. Most magnetite grains from the Qimantag metallogenic belt deposits except the Kendekeke deposit plot in the ' Skarn ' field in the Ca+Al+Mn vs Ti+V diagram, far from typical magmatic Fe deposits such as the Damiao and Panzhihua deposits. According to the(Mg O+Mn O)–Ti O2–Al2O3 diagram, magnetite grains from the Kaerqueka and Galingge deposits and the No.7 ore body of the Hutouya deposit show typical characteristics of skarn magnetite, whereas magnetite grains from the Kendekeke deposit and the No.2 ore body of the Hutouya deposit show continuous elemental variation from magmatic type to skarn type. This compositional contrast indicates that chemical composition of magnetite is largely controlled by the compositions of magmatic fluids and host rocks of the ores that have reacted with the fluids. Moreover, a combination of petrography and magnetite geochemistry indicates that the formation of those ore deposits in the Qimantag metallogenic belt involved a magmatic–hydrothermal process. | YI Liwen GU Xiangping LU Anhuai LIU Jianping LEI Hao WANG Zhiling CUI Yu ZUO Hongyan SHEN Can | 2015 | Acta Geologica Sinica(English Edition)2015，89，4： | 2 |
| 6 | Construction of CdSe/ZnS quantum dot microarray in a microfluidic chip显示文摘Microarray technology has been proved to be greatly helpful for biomedical and biological diagnosis. And the evaluation of its biological applications lies in the detection sensitivity, which requires high intensity and stability of the signal. Recently, several nanomaterials, especially semiconductor nanomaterials, due to their excellent fluorescence properties, have been widely used to construct microarrays for biosensors. Here, we presented an approach for constructing CdSe/ZnS quantum dot (QD) microarray in microfluidic channels on a glass slide by photolithography. The conditions for immobilizing stable and uniform QD microarray on the glass slide were optimized. Several types of QD microarrays with different emission wavelengths and modified groups were constructed using silanization and lithography technology. Based on the fluorescence quenching effect of Cu2+ on QDs, the microfluidic chip with QD microarray was applied for the determination of Cu2+. 1 nmol/L Cu2+ could be detected by this method. | LIU HongWei JING YingYing YU Xu PANG DaiWen ZHANG ZhiLing | 2012 | Science China Chemistry2012，55，4： | 2 |
| 7 | Young Yum pill inhibits inflammatory mediators and nuclear factor-kappa B signaling in lipopolysaccharide-stimulated RAW 264.7 macrophages显示文摘OBJECTIVE: To investigate the effect of Young Yum pill (YYP) on inflammatory mediators in cultured RAW 264.7 cells and elucidate the nuclear factor- kappa B (NF-κB)-related mechanism behind the action. METHODS: YYP was extracted with 95% ethanol Lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages were used to evaluate the effect of YYP on inflammatory mediators. Production of nitric oxide (NO) and prostaglandin E2 (PGE2) were measured by Griess test and enzyme-linked immunosorbent assay, respectively. The levels of genes and proteins involved in the generation of inflammatory mediators were examined using real-time polymerase chain reaction and Western blotting, respectively. RESULTS: YYP dose-dependently suppressed LPS-induced production of NO, PGE2 and tumor necrosis factor-α(TNF-α), and elevation of mRNA and protein levels of inducible NO synthase and cyclooxygenase- 2 in RAW 264.7 macrophages. These observations were associated with decreased NF-κB p65 phosphorylation and nuclear localization, enhanced Akt (protein kinase B) phosphorylation, as well as reduced inhibitor of κB (IκB)α degradation and IκB kinase α/β phosphorylation. CONCLUSION: The present study demonstrated an inhibitory effect of YYP on the NF-κB-regulated inflammatory mediators NO, PGE2 and TNF-α in LPS-stimulated RAW 264.7 macrophages, providing a pharmacological basis for the use of YYP in treating inflammatory disorders. | Yin Chengle Muhammad Jahangir Hossen Anfernee Kai-Wing Tse Su Tao Fu Xiuqiong Li Ting Guo Hui Zhu Peili Li Junkui Chou Jiyao Wang Yaping Yu Zhiling | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 2 |
| 8 | Comparison of rawand processed Radix Polygoni Multiflori ( Heshouwu) by high per-formance liquid chromatography and mass spectrometry 显示文摘 | Liang Zhi tao Chen Hubiao Yu Zhiling | 2010 | ChinMed2010，5，： | 1 |
| 9 | Comprehensive chemical analysis of Venenum Bufonis by using liquid chromatog- raphy/electrospray ionization tandem mass spectrometry 显示文摘 | Hu Yongmei Yu Zhiling Yang Zhijun | 2011 | J Pharm Biomed Anal2011，56，： | 1 |
| 10 | The activation and differential signalling of the growth hormone receptor induced by pGH or anti-idiotypic monoclonal antibodies in primary rat hepatocytes显示文摘 | Wei Li Hainan Lan Huimin Liu Zhiling Fu Yanhong Yang Weiwei Han Feng Guo Yu Liu Hui Zhang Jingsheng Liu Xin Zheng | 2013 | Molecular and Cellular Endocrinology (-)2013，，1： | 1 |
| 11 | Variable valence Mo^(5+)/Mo^(6+)ionic bridge in hollow spherical g-C_(3)N_(4)/Bi_(2)MoO_(6) catalysts for promoting selective visible light-driven CO_(2)photoreduction into CO显示文摘Herein,the catalysts of ultrathin g-C_(3)N_(4)surface-modified hollow spherical Bi2MoO6(g-C_(3)N_(4)/Bi2MoO6,abbreviated as CN/BMO)were fabricated by the co-solvothermal method.The variable valence Mo^(5+)/Mo^(6+)ionic bridge in CN/BMO catalysts can boost the rapid transfer of photogenerated electrons from Bi2MoO6to g-C_(3)N_(4).And the synergy effect of g-C_(3)N_(4)and Bi2MoO6components remarkably enhance CO_(2)adsorption capability.CN/BMO-2 catalyst has the best performances for visible light-driven CO_(2)reduction compared with single Bi2MoO6and g-C_(3)N_(4),i.e.,its amount and selectivity of CO product are 139.50μmol g-1and 96.88%for 9 h,respectively.Based on the results of characterizations and density functional theory calculation,the photocatalytic mechanism for CO_(2)reduction is proposed.The high-efficient separation efficiency of photogenerated electron-hole pairs,induced by variable valence Mo^(5+)/Mo^(6+)ionic bridge,can boost the rate-limiting steps(COOH*-to-CO*and CO*desorption)of selective visible light-driven CO_(2)conversion into CO.It inspires the establishment of efficient photocatalysts for CO_(2)conversion. | Wenjie He Yuechang Wei Jing Xiong Zhiling Tang Yingli Wang Xiong Wang Hui Xu Xiao Zhang Xiaolin Yu Zhen Zhao Jian Liu | 2023 | Journal of Energy Chemistry2023，，5： | 1 |
| 12 | SDF-1/CXCR4-Mediated Migration of Transplanted Bone Marrow Stromal Cells Toward Areas of Heart Myocardial Infarction Through Activation of PI3K/Akt显示文摘 | Jun Yu Mincai Li Zhiling Qu Dan Yan Dujuan Li Qiurong Ruan | 2010 | Journal of Cardiovascular Pharmacology2010，，5： | 1 |
| 13 | Comprehensive chemi- cal analysis of Venenum Bufonis by using liquid chromatography/ electrospray ionization tandem mass spectrometry 显示文摘 | Hu Yongmei Yu Zhiling Yang Z J | 2011 | J Pharm Bi- omed Anal2011，56，： | 1 |
| 14 | Pairwise Interactions of the Six Human MCM Protein Subunits显示文摘 | Zhiling Yu Daorong Feng Chun Liang | 2004 | Journal of Molecular Biology2004，，5： | 1 |
| 15 | Activation of an apoptotic signal transduction pathway involved in the upregulation of calpain and apoptosis-inducing factor in aldosterone-induced primary cultured cardiomyocytes显示文摘 | Xiao Tingting Zhang Yan Wang Yuanyuan Xu Yini Yu Zhiling Shen Xiangchun | 2012 | Food and Chemical Toxicology2012，，： | 1 |
| 16 | Vitreous VEGF Clearance Is Increased after Vitrectomy显示文摘 | Lee SS Ghosn C Zhiling Yu | | 0，，04： | 1 |
| 17 | Synthesis, Structural Characterization,and Electrochemical Properties of Binuclear Copper(Ⅱ) Complexes Containing Tetradentate Schiff Base Ligand显示文摘Two binuclear copper(Ⅱ) complexes, [Cu2(saloph)2 (μ-O)2]-2(DMF)[H2saloph=N,N′-o-phenylenebis(salicylideneaminato)] (a) and [Cu2(salen)2(μ-O)2] [H2salen=N,N′-bis(salicylic-deneaminato) ethylene] (b)were synthesized and characterized by X-ray crystallography. Both of them have distorted rectangular pyramidal geometry around Cu(Ⅱ). The complete series of complexes show bridging phenoxo groups between the copper centers, together with hydroxo-bridges in these complexes. The complexes have also been characterized by elemental analysis, IR, TG-DTA, and electrochemical results. | DING Yu HU Xiaoxia SUN Xiaoli ZUO Zhiling | 2010 | Wuhan University Journal of Natural Sciences2010，15，2： | 0 |
| 18 | The underappreciated role of fugitive VOCs in ozone formation and health risk assessment emitted from seven typical industries in China显示文摘Fugitive emission from industrial sources may result in ozone formation and health risk,while the exact contribution of this source remains incompletely understood.In this study,emission characteristics,ozone formation potential(OFP)and health risk of fugitive VOCs in7 representative industries were investigated.Chemical material industry was the dominant contributor to VOCs of fugitive emission in comparison with other industries.The OFP of VOCs from fugitive emission was in the range of 1.45×10^(3)-3.98×10^(5)μg/m^(3),with a higher value than that of organized emission in seven industries except for the coking industry and the chemical material industry,suggesting that fugitive VOCs should be taken into account while developing control strategies.Acetaldehyde,m,p-xylene,n-nonane,ethylene,vinyl chloridethe and other high OFP-contributing species were the major reactive species that should be targeted.Health risk assessment investigated non-cancer and cancer risks of fugitive VOCs in 7 industries were all above safe level(HR>1 and LCR>1×10^(-4)),posing remarkable health threats to human health.OVOCs were the main contributor to non-cancer risk,while halohydrocarbons and aromatics contributed most to cancer risks,posing remarkable health threat on human health.Our findings highlighted the contribution of fugitive VOCs on ozone formation and health risk was underestimated,indicating which should be considered in emission control strategies of industrial sources. | Zhiling Liang Yunjiang Yu Bingbing Sun Qian Yao Xihua Lin Yongsheng Wang Jianping Zhang Yingzi Li Xuefeng Wang Zhengzheng Tang Shexia Ma | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 19 | The Expression of Hypoxia-regulated MicroRNAs (HRMs) Induced by Hypoxia Preconditioning in hMSCs显示文摘 | ZhiXin Shan Qiu Xiong Lin XiYong Yu XiaoHong Li ZhiLing zhou Chun YU deng Hong Hong Tan Shu Guang Lin | 2008 | 中国药理通讯2008，25，2： | 0 |
| 20 | Development of Neural Network for BLSOM Clustering of HA Genes of Avian Influenza Viruses Isolated in Guangdong Province显示文摘A neural network classification method,and a batch-learning self-organizing map(BLSOM),was established using trinucleotide and tetranucleotide in the hemagglutinin gene sequences of 25 avian influenza viruses isolated in Guangdong Province. Statistical analysis and normalization of the fragment number were done and MATLAB function was used to simulate the human brain thinking for self-organizing learning. When the number of training steps was 100 and above,the strains could be successfully clustered. H_1,H_3,H_5,H_7 and H_9 subtype strains fell within different classes,respectively,and the HA gene cluster map of H_3N_2 and H_7N_9strains was quite similar,suggesting that these strains shared the same origin; H_5N_1 strain was quite different in different years; H_1N_1 and H_9N_2 strains could be clustered into one group,indicating the natural recombinant variation in the two kinds of viruses,thereby providing a reference for high-risk strain screening and traceability. | Chunjian TIAN Qiong LUO Jiahui GAO Zhixiong LIN Haiqiong YU Zhiling LIU Ru CHEN Xiaowei WU | 2016 | Asian Agricultural Research2016，8，11： | 0 |
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