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| 1 | The Value of Shashen Maidong Decoction in the Treatment of Advanced Lung Cancer显示文摘Objective:This study mainly explores the clinical effect of Shashen Maidong Decoction in the treatment of advanced lung cancer.Methods:Twelve patients with advanced lung cancer from Inner Mongolia Baicaotang Qin's Zhong Meng Medical Hospital were randomly selected from February 2016 to February 2021.They were divided into two groups:the reference group and study group by the digital table method.The reference group was treated with conventional chemotherapy while the study group was treated with Shashen Maidong Decoction plus conventional chemotherapy.Results:The remission rate of the study group was higher than that of the reference group,and the incidence of adverse reactions was lower than that of the reference group,P<0.05.The levels of CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)in the study group were higher than those in the reference group(P<0.05).After treatment,the quality of life score of the study group was higher than that of the reference group(P<0.05).Conclusion:Shashen Maidong Decoction can effectively reduce adverse reactions and improve the condition of patients in the treatment of advanced lung cancer. | Limei Qin | 2021 | Proceedings of Anticancer Research2021，5，5： | 0 |
| 2 | Clinical Effect of Lung Qi-Diffusing and Tumor-Clearing Decoction in the Treatment of Advanced Lung Cancer显示文摘Objective:The main purpose of this study is to explore the efficacy of lung qi-diffusing and tumor-clearing decoction in the treatment of advanced lung cancer.Methods:Eight patients with advanced lung cancer in Inner Mongolia Baicaotang Qin's Zhong Meng Medical Hospital from February 2017 to October 2020 were randomly selected and divided into two groups,a control group and a study group,by the digital table method.The control group was treated with conventional chemotherapy,while the study group was treated with lung qi-diffusing and tumor-clearing decoction on this basis.The therapeutic effects of the two groups were observed.Results:The improvement in symptoms of the patients in the study group was higher than that of the reference group,and the incidence of adverse reactions was lower among patients in the study group compared to the reference group,P<0.05.The serum immunological indexes,CD3^(+),CD4^(+),and CD4^(+)/CD8^(+),of study group were higher than those of the reference group,and the quality-of-life score of the study group was higher than that of the reference group,P<0.05.Conclusion:The clinical effect of lung qi-diffusing and tumor-clearing decoction in the treatment of patients with advanced lung cancer is significant.It effectively improves the immune indicators and reduces adverse reactions. | Limei Qin | 2021 | Proceedings of Anticancer Research2021，5，6： | 0 |
| 3 | 白蔹乙酸乙酯部位体内抗肿瘤的药效作用机制及其成分分析研究显示文摘目的 探究白蔹乙酸乙酯部位对H22实体瘤的抑制作用及机制,以及对正常小鼠的急性毒性,并分析其药效物质基础。方法 对40只KM小鼠皮下注射H22细胞悬液复制H22皮下移植瘤小鼠模型,随机分为模型组、氟尿嘧啶组(5-Fu,25 mg·kg^(-1))和白蔹乙酸乙酯部位低、中、高(1.5、4.5、13.5 g·kg^(-1),生药量)剂量组,每组8只。白蔹乙酸乙酯部位灌胃给药,每日1次,连续10 d。测定肿瘤体积、质量,计算抑瘤率;计算肝脏、脾脏、胸腺的脏器指数;采用ELISA法检测血清中肿瘤坏死因子α(TNF-α)、白细胞介素2(IL-2)和白细胞介素6(IL-6)的水平;HE染色法观察肿瘤组织病理变化;Western Blot法测定肿瘤组织中Bax、Bcl-2、Caspase-3、Caspase-9蛋白表达水平。以最大给药剂量灌胃(30 mL·kg^(-1))1次并连续观察14 d,考察白蔹水提物、醇提物、乙酸乙酯部位(4.00、5.14、23.22 g·mL(-1))对正常小鼠的急性毒性作用。采用超高效液相色谱-四极杆-飞行时间串联质谱(UPLC-QTOF-MS/MS)法分析白蔹乙酸乙酯部位的化学成分。结果 与模型组相比,白蔹乙酸乙酯部位高剂量组的肿瘤体积明显减小(P<0.05),各给药组的肿瘤质量均显著降低(P<0.01),低、中、高剂量组的抑瘤率分别为64.42%、72.00%、78.24%,肝脏、脾脏、胸腺的脏器指数均明显升高(P<0.05,P<0.01);低剂量组小鼠的血清TNF-α、IL-2、IL-6水平均显著升高(P<0.01),高剂量组小鼠的血清IL-6水平显著升高(P<0.01);各给药组小鼠肿瘤组织中Bcl-2蛋白表达均显著下调(P<0.01),Bax、Caspase-3及Caspase-9蛋白表达均明显上调(P<0.05,P<0.01);白蔹乙酸乙酯部位高剂量组的Bax/Bcl-2蛋白比值显著升高(P<0.01)。小鼠在给药剂量相当于生药量696.6 g·kg^(-1)·d-1(约相当于临床使用最大剂量的462.8倍)的白蔹乙酸乙酯部位时,无明显毒副反应。UPLC-QTOF-MS/MS分析共鉴定出16个化学成分,以酚酸类为主。结论 白蔹乙酸乙酯部位具有明显抗H22实体瘤的作用,且安全性较高,其机制可能与调控Bax/Bcl-2/Caspase-9/Caspase-3途径相关,酚酸类成分是其潜在的药效物质基础。 | 韩思婕 潘翔 张梦美 魏琼 叶晓川 | 2022 | 中药新药与临床药理2022，33，12： | 0 |
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