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| 1 | Natural variation in Ghd7.1 plays an important role in grain yield and adaptation in rice显示文摘 | Wenhao Yan Haiyang Liu Xiangchun Zhou Qiuping Li Jia Zhang Li Lu Touming Liu Haijun Liu Chengjun Zhang Zhanyi Zhang Guojing Shen Wen Yao Huaxia Chen Sibin Yu Weibo Xie Yongzhong Xing | 2013 | Cell Research2013，23，7： | 39 |
| 2 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 3 | Emerging role of deep learning-based artificial intelligence in tumor pathology显示文摘The development of digital pathology and progression of state-of-the-art algorithms for computer vision have led to increasing interest in the use of artificial intelligence(AI),especially deep learning(DL)-based AI,in tumor pathology.The DL-based algorithms have been developed to conduct all kinds of work involved in tumor pathology,including tumor diagnosis,subtyping,grading,staging,and prognostic prediction,as well as the identification of pathological features,biomarkers and genetic changes.The applications of AI in pathology not only contribute to improve diagnostic accuracy and objectivity but also reduce the workload of pathologists and subsequently enable them to spend additional time on high-level decision-making tasks.In addition,AI is useful for pathologists to meet the requirements of precision oncology.However,there are still some challenges relating to the implementation of AI,including the issues of algorithm validation and interpretability,computing systems,the unbelieving attitude of pathologists,clinicians and patients,as well as regulators and reimbursements.Herein,we present an overview on how AI-based approaches could be integrated into the workflow of pathologists and discuss the challenges and perspectives of the implementation of AI in tumor pathology. | Yahui Jiang Meng Yang Shuhao Wang Xiangchun Li Yan Sun | 2020 | Cancer Communications2020，40，4： | 15 |
| 4 | Numerical simulation of bubble plumes in overlying water of gas hydrate in the cold seepage active region显示文摘To study the seismic responses produced by gas hydrate bubble plumes in the cold seepage active region, we constructed a plume water body model based on random medium theory and acoustic velocity model of bubble medium. The plume water body model was forward simulated by finite difference. Seismic records of single shot show the scattered waves produced by the plume. The scattered wave energy is strong where the plume exists. Where the scattered wave energy is stronger, the minimum of travel time is always above the plume, which has no relationship with the shot's position. Seismic records of shot gathers were processed by prestack time migration. The migration section shows that the scattered waves produced by plumes can be imaged distinctly with higher accuracy. These researches laid a foundation for further study on the seismic responses produced by plumes and provided a new approach for the identification of gas hydrate. | LI CanPing LIU XueWei GOU LiMin WANG XiangChun YIN JunJie XIE ChengLiang | 2013 | Science China Earth Sciences2013，56，4： | 11 |
| 5 | Experiment of gas diffusion and its diffusion mechanism in coal显示文摘In coal,the gas mainly exists in a free or an adsorption state.When the coal containing gas is damaged,gas desorption and diffusion will occur which can result in gas disaster.This research on gas desorption and diffusion provides a theoretical basis for gas disaster mechanism and prevention.The influence of pressure and temperature on gas diffusion is studied by the experiment.And the mechanism of pressure and temperature on gas diffusion is also analysed.The research results indicate that gas diffusion capacity increases with increasing temperature under the same pressure for the same coal sample.This is mainly because the temperature increases,gas molecular hot motion is severer,kinetic energy of gas molecular increases,and gas desorption quickens,therefore gas diffusion capacity changes stronger.Under other unchanged conditions,the greater gas adsorption balance pressure,the more gas adsorption content,and the higher the initial gas concentration.When gas diffusion begins,the greater the gas concentration gradient,the faster the gas diffusion speeds. | Li Xiangchun Nie Baisheng Zhang Ruming Chi Leilei | 2012 | International Journal of Mining Science and Technology2012，22，6： | 8 |
| 6 | Some equalities and inequalities of g-continuous frames显示文摘In this paper,we derive some equalities and inequalities about g-continuous frames,which are an extension to g-frames and continuous frames.We also discuss the stability of the perturbation of a g-continuous frame. | XIAO XiangChun & ZENG XiaoMing Department of Mathematics,Xiamen University,Xiamen 361005,China | 2010 | Science China Mathematics2010，53，10： | 8 |
| 7 | Gene diagnosis and targeted breeding for blast-resistant Kongyu 131without changing regional adaptability显示文摘The fungus Magnaporthe oryzae threatens the rice production of Kongyu 131 (KY131),a leading japonica variety in Northeast China.In this study,two rice lines,KP1 and KP2-Hd1,were obtained by introgressing the blast resistance genes Pi1 and Pi2 into KY131,respectively.However,both lines headed later than KY131.RICE60K SNP array analysis showed that Hd1 closely linked to Pi2 was introgressed into KP2-Hd1,and the linkage drag of Hd1 was broken by recombination.On the other hand,no known flowering genes were introgressed into KP1.Gene diagnosis by resequencing six flowering genes showed that KP1 carried functional Hd16 and Ghd8 alleles.Due to its suppression role in heading under long-day conditions,Ghd8 was chosen as the target for gene editing to disrupt its function.Four sgRNAs targeting different sites within Ghd8 were utilized to induce large-deletion mutations,which were easy to detect via agarose gel electrophoresis.All the ghd8-mutated KP1 lines were resistant to rice blast disease and headed earlier than the control KP1,even than KY131,under natural long-day conditions,which ensures its growth in Northeast China.This study confirmed that a combination of gene diagnosis and targeted gene editing is a highly efficient way to quickly eliminate undesired traits in a breeding line. | Xiangchun Zhou Gonghao Jiang Longwei Yang Lei Qiu Ping He Chunxiao Nong Yunyue Wang Yuqing He Yongzhong Xing | 2018 | Journal of Genetics and Genomics2018，45，10： | 7 |
| 8 | 3-D acoustic wave equation forward modeling with topography显示文摘以便与表面地形学为震波地建模,我们在场转变的一个方法在二个不同坐标系统弄弯格子进矩形的格子。然后,在转变坐标系统的 3D 波浪方程被导出。波浪地在转变坐标系统用有限差别的方法被建模。模型计算证明这个方法能与波动的表面地形学为震波地建模并且完成好结果。最后,直接、反映的波浪的精力曲线被分析证明表面地形学在震波的动态性质上有大影响。 | Wang Xiangchun Liu Xuewei | 2007 | Applied Geophysics2007，4，1： | 6 |
| 9 | Global analysis of CCT family knockout mutants identifies four genes involved in regulating heading date in rice显示文摘Many genes encoding CCT domain-containing proteins regulate flowering time. In rice(Oryza sativa), 41 such genes have been identified, but only a few have been shown to regulate heading date. Here, to test whether and how additional CCT family genes regulate heading date in rice, we classified these genes into five groups based on their diurnal expression patterns. The expression patterns of genes in the same subfamily or in close phylogenetic clades tended to be similar. We generated knockout mutants of the entire gene family via CRISPR/Cas9. The heading dates of knockout mutants of only 4 of 14 genes previously shown to regulate heading date were altered, pointing to functional redundancy of CCT family genes in regulating this trait. Analysis of mutants of four other genes showed that OsCCT22, OsCCT38, and OsCCT41 suppress heading under long-day conditions and promote heading under short-day conditions. OsCCT03 promotes heading under both conditions and upregulates the expression of Hd1 and Ehd1, a phenomenon not previously reported for other such genes. To date, at least 18 CCT domaincontaining genes involved in regulating heading have been identified, providing diverse, flexible gene combinations for generating rice varieties with a given heading date. | Jia Zhang Xiaowei Fan Yong Hu Xiangchun Zhou Qin He Liwen Liang Yongzhong Xing | 2021 | Journal of Integrative Plant Biology2021，63，5： | 6 |
| 10 | Assessment of the MT1-MMP expression level of different cell lines by the naked eye显示文摘Membrane type 1 matrix metalloproteinase(MT1-MMP) is expressed in most tumors and is believed to play a key role in the development, invasion and metastasis of tumors. There is an urgent need to develop a simple method to detect the MT1-MMP expression level on cells. In this current study, we demonstrated a red emission Au cluster probes with the specific targeting of MT1-MMP on human dopaminergic neuroblastoma(SH-SY5 Y) cells. More importantly, utilizing the intrinsic enzyme-like activity of the Au cluster probes, the expression level of MT1-MMP on the SH-SY5 Y cells could be assessed by the naked eye without cell lysis and protein extraction process. Furthermore, SH-SY5 Y, human breast cancer(MCF-7), and human bronchial epithelial(16-HBE) cell lines with different MT1-MMP expression level could be distinguished using the Au cluster probes by the naked eye. Meanwhile, fluorescence intensity and Au count determined by inductively coupled plasma mass spectrometry(ICP-MS) were used to verify the feasibility of this simple analytical method. Our proposed method is rapid, convenient, and accurate and could be assessed by the naked eye. This visual assessment method of tumor-associated proteins has immense implications in sorting tumor cells. | Xiangchun Zhang Qing Yuan Xueyun Gao | 2018 | Science China(Life Sciences)2018，61，4： | 5 |
| 11 | Discovery of the ancient Ordovician oil-bearing karst cave in Liuhuanggou,North Tarim Basin,and its significance显示文摘A typical ancient karst cave is found in the Yijianfang Formation of Ordovician at Liuhuanggou,North Tarim Basin.With an entrance of 4.8 m wide and 20 m high,the Liuhuanggou ancient karst cave extends to NW 315° and has been filled by sediments,which can be classified into three types according to their nature and origin:clastic sediments(gravels),chemical sediments(palaeotravertine),and mixed sediments.Among them,the Paleotravertine and gravels are most common.The palaeotravertine is laminated type and yellowish brown or black in color due to oil inside.When saturated with oil,the palaeotravertine is black.Under microscope,oil mainly accumulates in the cracks between calcite crystals.The filling period of the Liuhuanggou karst cave can be divided into three stages:mixed filling,chemical filling,and clastic(palaeotravertine breccia) filling.Numerous fractures are distributed on one side of the karst cave.The fractures can be as wide as 40 cm and over 40 m long.Fractures of different periods and sizes constitute a fracture network and are all filled with calcite veins.Oil can be found inside the fractures.In the chemical fillings,sulfur is also found,which can indicate the magma influence on karst caves.The existence of sulfur also confirms that the Liuhunggou karst cave was formed in ancient times rather than recently or nowadays.Different from normal sedimentary limestone,the ancient Liuhuanggou karst cave has a distinct isotope fractionation and the depletion of heavy carbon and oxygen isotope.Controlled by the northwest oriented vertical strike-slip shear fault,the karst cave is actually a dissolved vertical fault belt. | ZHONG JianHua MAO Cui LI Yong LI Yang YUAN XiangChun NIU YongBin CHEN Xin HuANG ZhiJuan SHAO ZhuFu WANG PeiJun LI Jia ZHANG DanFeng | 2012 | Science China Earth Sciences2012，55，9： | 4 |
| 12 | Effect of NaOH treatment on combustion performance of Xilinhaote lignite显示文摘The combustion characteristics of NaOH treated and untreated Xilihaote lignite was investigated by thermogravimetric analysis.The relationship between physico-chemical properties,including the ash content,oxygen-containing functional groups,mean pore diameter and specific surface area and combustion performance,was also studied in this paper.Combustion kinetic parameters were calculated through Coasts Redfern Method.The results show that ignition of treated samples takes place at higher temperature compared to raw lignite,and peak temperature also occurs at higher temperature.The maximum combustion rate of the sample,which was treated by 0.01 mol/L NaOH lignite,was the biggest.Reaction orders of 0.6,2.0,and 0.8 were found to be effective mechanism for definite three temperature regions.Average activation energies of these three temperature regions of XLHTR,XLHT0.01,XLHT0.50 and XLTH1.00 are 19.17,23.87,10.77,and 10.93 kJ/mol,respectively.Treatment of lignite with NaOH can reduce the reactivity of lignite at proper concentration. | Liu Xiangchun Feng Li Song Lingling Wang Xinhua Zhang Ying | 2014 | International Journal of Mining Science and Technology2014，24，1： | 4 |
| 13 | Compositional heterogeneity of crude oil and its origin in the Linnan subsag,Linyi County,Shandong Province显示文摘The Linnan subsag is the main oil producer of the Linpan oil zone. Based on the oil group composition,gas chromatography data and biomarker analysis,it was indicated that crude oils from different oilfields varied greatly in group composition and showed obvious heterogeneities in the aspects of precursor type,crude oil maturity and hydrocarbon depositional environment. According to the characteristics of source rocks,three oil populations can be distinguished,i.e.,the southern,northern and transitional oil populations. Furthermore,on the basis of post-reservoir reworking processes,the medium conditions of hydrocarbon-generating environment and differences in maturity,six oil families and twelve sub-families were distinquished. An integrated study suggested that the fac-tors leading to such heterogeneities in crude oil composition mainly include different source rocks,multi-stage oil/gas charging,geo-chromatographic effects during oil/gas migration,reservoir heterogeneities and various post-reservoir secondary alterations. | CHANG Xiangchun DUAN Yunge CHEN Qingchun MA Lixin | 2008 | Chinese Journal Of Geochemistry2008，27，4： | 3 |
| 14 | Creep behaviour and constitutive model of coal filled with gas显示文摘Coal exhibits different creep behaviours when filled with different amounts of gas. Creep tests of coal filled with 0 and 0.5 MPa gas were performed, and strain under different axial stress was compared.The three creep constitutive models which were analysed using the method fitting experimental data for determining which creep model can reflect the creep process of the test best. The results show that the deformation of coal filled with 0.5 MPa gas is more higher than that of coal filled with 0 MPa gas under the same axial stress. Gas plays a positive effect on the deformation of coal process and will accelerate creep process. And gas will reduce coal intensity and change coal creep properties.Compared with Nishihara Model and Extensional Nishihara Model, Burgers Model can reflect the three stages of creep process of coal filled with gas better. The research results can contribute to reveal coal and gas outburst mechanism. | Li Xiangchun Yang Chunli Ren Ting Nie Baisheng Zhao Caihong Liu Shuiwen Jiang Tao | 2017 | International Journal of Mining Science and Technology2017，27，5： | 3 |
| 15 | Ultrahigh energy density and improved discharged efficiency in bismuth sodium titanate based relaxor ferroelectrics with A-site vacancy显示文摘Novel A-site deficient(1-x-y)Bi_(0.5)Na_(0.5)TiO_(3-x)BaTiO_(3-y)Bi_(0.2)Sr_(0.7)TiO_(3)lead-free relaxor ferroelectrics have been explored for energy storage property.Particularly slim polarization hysteresis(P-E)loops are observed in 0.655Bi_(0.5)Na_(0.5)TiO_(3)-0.065BaTiO_(3)-0.28Bi_(0.2)Sr_(0.7)□_(0.1)TiO_(3)(6.5BNBT-BST)at ambient temperature resulting in a giant recoverable energy density(W_(rec)=1.5 J cm^(-3))and extremely high efficiency(η=90%)at 100 kV cm^(-1),which are closed related to the track of P-E loops.As the addition of Bi_(0.2)Sr_(0.7)TiO_(3)(BST)content,the ergodic relaxor phase becomes dominant with dynamic polar nanoregions attributed to the absence of ferroelectric domain in the relaxor phase.Furthermore,the recoverable energy density exhibits small variation in elevated temperature where the depressed polarization is compensated by almost hysteresis free loops(ηup to 97%).The achievement of these characteristics in P-E loops provides that Bi_(0.2)Sr_(0.7)TiO_(3)tailoring by A-site vacancies is a potential route when designing new relaxor ferroelectrics for energy-storage applications. | Xiao Liu Jing Shi Fangyuan Zhu Huiling Du Tangyuan Li Xiangchun Liu Hai Lu | 2018 | Journal of Materiomics2018，4，3： | 3 |
| 16 | BSA-seq-based identification of a major additive plant height QTL with an effect equivalent to that of Semi-dwarf 1 in a large rice F_(2) population显示文摘Bulked-segregant analysis is a time-and cost-saving strategy for identifying major quantitative trait loci(QTL) in a mapping population. Bulked-segregant analysis combined with whole-genome sequencing(BSA-seq) was performed to rapidly identify QTL for heading date, plant height, and panicle length in a large F_(2) population derived from two landraces: Chuan 7(C7) and Haoboka(HBK). Twenty plants with extremely low or high phenotypic values for the target traits were selected from an F_(2) population of 940 plants to construct low-and high-value bulks. Three pairs of bulks for the three traits were constructed, resulting in six DNA pools. BSA-seq revealed nine QTL: four for heading date, three for plant height, and two for panicle length. These QTL were validated in a random F_(2) population or BC_(4)F_(2) populations. The major novel plant height QTL, qPH8, acting additively with an effect equivalent to that of semi-dwarf 1(sd1), is potentially valuable for hybrid rice breeding. qPH8 controls mainly the elongation of basal internodes. The C7 allele of qPH8 reduces plant height and increases lodging resistance without yield penalty, suggesting a potential role for qPH8 in improving rice plant architecture. | Bo Zhang Feixiang Qi Gang Hu Yikai Yang Li Zhang Jianghu Meng Zhongmin Han Xiangchun Zhou Haiyang Liu Mohammed Ayaad Yongzhong Xing | 2021 | The Crop Journal2021，9，6： | 3 |
| 17 | TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β显示文摘 | Motozo Yamashita Karoly Fatyol Chaoyang Jin Xiangchun Wang Zhenggang Liu Ying E. Zhang | 2008 | Molecular Cell2008，，6： | 2 |
| 18 | Geochemistry and possible origin of petroleum in Palaeozoic reservoirs from Halahatang Depression显示文摘 | Xiangchun Chang T.-G. Wang Qiming Li Bin Cheng Xiaowan Tao | 2013 | Journal of Asian Earth Sciences2013，，： | 2 |
| 19 | Biodegradation of polycyclic aromatic hydrocarbons in sediments from the Daliao River watershed, China显示文摘The Daliao River, as an important water system in Northeast China, was reported to be heavily polluted by polycyclic aromatic hydrocarbons (PAHs). Aerobic biodegradations of four selected PAHs (naphthalene, phenanthrene, uorene and anthracene) alone or in their mixture in river sediments from the Daliao River water systems were studied in microcosm systems. Eects of additional carbon source, inorganic nitrogen and phosphorus, temperature variation on PAHs degradation were also investigated. Results showed that the degradation of phenanthrene in water alone system was faster than that in water-sediment combined system. Degradation of phenanthrene in sediment was enhanced by adding yeast extract and ammonium, but retarded by adding sodium acetate and not significantly inuenced by adding phosphate. Although PAHs could also be biodegraded in sediment under low temperature (5°C), much lower degradation rate was observed. Sediments from the three main streams of the Daliao River water system (the Hun River, the Taizi River and the Daliao River) demonstrated dierent degradation capacities and patterns to four PAHs. Average removal rates (15 or 19 d) of naphthalene, phenanthrene, uorene and anthracene by sediment were in the range of 0.062-0.087, 0.005-0.066, 0.008- 0.016 and 0-0.059 mg/(L·d), respectively. As a result, naphthalene was most easily degraded compound, anthracene was the hardest one. In multiple PAHs systems, the interactions between PAHs inuenced each PAH biodegradation. | QUAN Xiangchun, TANG Qian, HE Mengchang, YANG Zhifeng, LIN Chunye, GUO Wei State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Beijing Normal University, Beijing 100875, China. | 2009 | Journal of Environmental Sciences2009，21，7： | 2 |
| 20 | Multi-scale pore fractal characteristics of differently ranked coal and its impact on gas adsorption显示文摘Well-developed pores and cracks in coal reservoirs are the main venues for gas storage and migration.To investigate the multi-scale pore fractal characteristics,six coal samples of different rankings were studied using high-pressure mercury injection(HPMI),low-pressure nitrogen adsorption(LPGA-N2),and scanning electron microscopy(SEM)test methods.Based on the Frankel,Halsey and Hill(FHH)fractal theory,the Menger sponge model,Pores and Cracks Analysis System(PCAS),pore volume complexity(D_(v)),coal surface irregularity(Ds)and pore distribution heterogeneity(D_(p))were studied and evaluated,respectively.The effect of three fractal dimensions on the gas adsorption ability was also analyzed with high-pressure isothermal gas adsorption experiments.Results show that pore structures within these coal samples have obvious fractal characteristics.A noticeable segmentation effect appears in the Dv1and Dv2fitting process,with the boundary size ranging from 36.00 to 182.95 nm,which helps differentiate diffusion pores and seepage fractures.The D values show an asymmetric U-shaped trend as the coal metamorphism increases,demonstrating that coalification greatly affects the pore fractal dimensions.The three fractal dimensions can characterize the difference in coal microstructure and reflect their influence on gas adsorption ability.Langmuir volume(V_(L))has an evident and positive correlation with Dsvalues,whereas Langmuir pressure(P_(L))is mainly affected by the combined action of Dvand Dp.This study will provide valuable knowledge for the appraisal of coal seam gas reservoirs of differently ranked coals. | Zhongbei Li Ting Ren Xiangchun Li Ming Qiao Xiaohan Yang Lihai Tan Baisheng Nie | 2023 | International Journal of Mining Science and Technology2023，33，4： | 2 |
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