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| 1 | Reprogramming of phytopathogen transcriptome by a non-bactericidal pesticide residue alleviates its virulence in rice显示文摘Bacteria equipped with virulence systems based on highly bioactive small molecules can circumvent their host's defense mechanisms.Pathogens employing this strategy are currently threatening global rice production.In the present study,variations in the virulence of the highly destructive Barkholderiaplantarii were observed in different rice-producing regions.The environment-linked variation was not attributable to any known host-related or external factors.Co-occurrence analyses indicated a connection between reduced virulence and 5-Amino-l,3,4-thiadiazole-2-thiol(ATT),a non-bactericidal organic compound.ATT,which accumulates in rice plants during metabolization of specific agrochemicals,was found to reduce virulence factor secretion by B.plantarii up to 88.8%and inhibit pathogen virulence by hijacking an upstream signaling cascade.Detailed assessment of the newly discovered virulence inhibitor resulted in mechanistic insights into positive effects of ATT accumulation in plant tissues.Mechanisms of virulence alleviation were deciphered by integrating high-throughput data,gene knockout mutants,and molecular interaction assays.TroK,a histidine protein kinase in a two-component system that regulates virulence factor secretion,is likely the molecular target antagonized by ATT.Our findings provide novel insights into virulence modulation in an important plant-pathogen system that relies on the host's metabolic activity and subsequent signaling interference. | Haruna Matsumoto Yuan Qian Xiaoyan Fan Sunlu Chen Yanxia Nie Kun Qiao Dandan Xiang Xinzhong Zhang Meng Li Bo Guo Peilin Shen Qiangwei Wang Yunlong Yu Tomislav Cemava Mengcen Wang | 2022 | Fundamental Research2022，2，2： | 2 |
| 2 | Intestinal immune system modulating polysaccharides from rhizomes of Atractylodes lancea显示文摘 | YU K W KIYOHARA H MATSUMOTO T | 1998 | Planta Med1998，64，： | 1 |
| 3 | Characterization of pectic polysaccharides having intestinal immune system modulating activity from rhizomes of Atractylodes lancea DC显示文摘 | Yu K Kiyohara W Matsumoto H | 2001 | Carbohydr Polymers2001，46，2： | 1 |
| 4 | Laparoscopic Management of Advanced Renal Cell Carcinoma with Renal Vein and Inferior Vena Cava Thrombus显示文摘 | Rahul Kumar Bansal Hin Yu Vincent Tu Darrel Drachenberg Bobby Shayegan Edward Matsumoto J Paul Whelan Anil Kapoor | 2013 | Urology2013，，： | 1 |
| 5 | In testinal Immune System Modulating Polysaccharides from Rhi romes of Atractylodes lancea显示文摘 | Yu KW Kiyohara H Matsumoto T | 1998 | Planta Med1998，64，8： | 1 |
| 6 | Sodium orthovanadate enhances proliferation of progenitor cells in the adult rat subventricular zone after focal cerebral ischemia显示文摘 | Jun Matsumoto Motohiro Morioka Yu Hasegawa | | J Pharmacol Exp Ther0，3，3： | 1 |
| 7 | Structural characterization of intestinal immune system modulating new arabino-3 ,6-galactan from rhizomes of Atractylodes lancea DC显示文摘 | YU K W’KIYOHARA H MATSUMOTO T | | Carbohydrate Polymers0，200，6： | 1 |
| 8 | Structural characterization of intestinal immune system modulating new arabino-3,6-galactan from rhizomes of Atractylodes lancea DC 显示文摘 | Yu K W Kiyohara H Matsumoto T | 2001 | Carbohydr Polym2001，46，： | 1 |
| 9 | Structural characterization of intestinal immune system modulating new arabino-3, 6-galactan from rhizomes of Atractylodes lancea DC.显示文摘 | K.-W Yu H Kiyohara T Matsumoto H.-C Yang H Yamada | 2001 | Carbohydrate Polymers2001，，2： | 1 |
| 10 | Structural characterization of intestinal immune system modulating new ambino-3,6-galactan from rhizomes of Atractylodes lancea显示文摘 | Yu KW Kiyohara H Matsumoto T | 2001 | Carbohydrate Polymers2001，，46： | 1 |
| 11 | Characterization of pectic polysaccharides having intestinal immune system modulating activity from rhizomes of Atractylodes lancea DC显示文摘 | Yu KW Kiyohara H Matsumoto T | 2001 | Carbohydrate Polymers2001，46，： | 1 |
| 12 | Yamada Intestinal Immune Systemmodulating Polysaccarides from Rhizomes of Atractylodes lancea显示文摘 | Yu K W Kiyohara H Matsumoto T | 1998 | Planta Med1998，64，： | 1 |
| 13 | A large-scale genetic association study of ossification of the posterior longitudinal ligament of the spine显示文摘 | Taizo Horikoshi Koichi Maeda Yoshiharu Kawaguchi Kazuhiro Chiba Kanji Mori Yu Koshizuka Shigeru Hirabayashi Kazuhito Sugimori Morio Matsumoto Hiroshi Kawaguchi Makoto Takahashi Hisashi Inoue Tomoatsu Kimura Yoshitaka Matsusue Itsuro Inoue Hisatoshi Baba K | 2006 | Human Genetics2006，，6： | 1 |
| 14 | Application of PCR for selection of grampositive bacteria with high DNA G + C content among new isolates显示文摘 | Yu L Takahashi Y Matsumoto A Seino A Iwai Y Omura S | | 0，，01： | 1 |
| 15 | Random sheared fosmid library as a new genomic tool to accelerate complete finishing of rice (Oryza sativa spp. Nipponbare) genome sequence: sequencing of gap-specific fosmid clones uncovers new euchromatic portions of the genome显示文摘 | Jetty S. S. Ammiraju Yeisoo Yu Meizhong Luo Dave Kudrna HyeRan Kim Jose L. Goicoechea Yuichi Katayose Takashi Matsumoto Jianzhong Wu Takuji Sasaki Rod A. Wing | 2005 | Theoretical and Applied Genetics2005，，8： | 1 |
| 16 | Prognostic value of B-type natriuretic peptide and its amino-terminal proBNP fragment for cardiovascular events with stratification by renal function显示文摘 | Manabu Horii Takaki Matsumoto Shiro Uemura Yu Sugawara Akihiro Takitsume Tomoya Ueda Hitoshi Nakagawa Taku Nishida Tsunenari Soeda Satoshi Okayama Satoshi Somekawa Kenichi Ishigami Yukiji Takeda Hiroyuki Kawata Rika Kawakami Yoshihiko Saito | 2013 | Journal of Cardiology2013，，6： | 1 |
| 17 | High-density lipoprotein is a potential growth factor for adrenocortical cells显示文摘 | Koji Murao Hitomi Imachi Wenming Cao Xiao Yu Junhua Li Kazuya Yoshida Rania A.M. Ahmed Kensuke Matsumoto Takamasa Nishiuchi Norman C.W. Wong Toshihiko Ishida | 2006 | Biochemical and Biophysical Research Communications2006，，1： | 1 |
| 18 | Structuralcharacterization of intestinal immune system modulating new arabino-3, 6-galactan from rhizomes of atractylodes lancea dc 显示文摘 | Yu K W Kiyohara H Matsumoto T | 2001 | Carbohydrate Polymers2001，46，： | 1 |
| 19 | Yamada Intestinal immune systemmodtdating polysaccarides from Rhizomes of Atractylodes lancea显示文摘 | KW Yu Kiyohara H Matsumoto T | 1998 | Planta Med1998，64，： | 1 |
| 20 | Y‐box binding protein 1 is correlated with lymph node metastasis in intestinal‐type gastric cancer显示文摘 | TianTian Guo YingNan Yu George Wai‐Cheong Yip Gyeong Hun Baeg Aye Aye Thike Tony Kiat‐Hon Lim Puay Hoon Tan Ken Matsumoto Boon Huat Bay | 2015 | Histopathology2015，，4： | 1 |
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