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1XS0601 REDUCES THE INCIDENCE OF RESTENOSIS: A PROSPECTIVE STUDY OF 335 PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION IN CHINA显示文摘Background XS0601, consisting of active ingredients (Chuangxiongol and paeoniflorin), has been shown to inhibit arterial neointimal hyperplasia in animal models and in preliminary human studies. The objective of this study was to evaluate the safety and efficacy of XS0601 in preventing restenosis following percutaneous coronary intervention (PCI). Methods A multi-center, randomized, double-blind, placebo-controlled trial was conducted. A total of 335 patients were randomized into treatment with the oral administration of XS0601, or a placebo for 6 months after successful PCI. Angiographic follow-up was scheduled at 6 months, and clinical follow-ups performed at 1, 3 and 6 months after PCI. The primary end point was angiographic restenosis. The secondary end points were the combined incidence of death, target lesion nonfatal myocardial infarction, repeat angioplasty, and coronary artery bypass graft surgery. Results A total of 308 patients (91.9%) completed the study and 145 cases (47.1%) received angiographic follow-up. The restenosis rates were significantly reduced in the XS0601 group as compared with the placebo group (26.0% vs. 47.2%, P < 0.05), and the minimum lumen diameter (MLD) was greater [(2.08 ± 0.89) mm for XS0601 vs. (1.73 ± 0.94) mm for placebo, P < 0.05]. XS0601 also significantly reduced the combined incidence of major adverse cardiac event (10.4% in the XS0601 group vs. 22.7% in the placebo group, P < 0.05). The incidence of recurrent angina at 3 and 6 months after PCI was also significantly reduced in XS0601 group (7.1% and 11.0%) as compared with those in placebo group (19.5% and 42.9%) (P < 0.05). No significant side effects occurred within the 6-month follow-up period in the XS0601 group. Conclusion Administration of XS0601 for 6 months is demonstrated to be safe and effective in reducing restenosis in post-PCI patients.CHEN Ke-ji SHI Da-zhuo XU Hao LUE Shu-zheng LI Tian-chang KE Yuan-nan ZHANG Min-zhou LU Xiao-yan SUN Rui-yuan YOU Shi-jie 2006Chinese Medical Journal2006,,1:83
25-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu 2017Cell Research2017,27,10:30
3Transduction of Fas gene or Bcl-2 antisense RNA sensitizes cultured drug resistant gastric cancer cells to chemotherapeutic drugs显示文摘INTRODUCTIONChemotherapyisoneofthemajormethodsintumortreatment,butitoftendoesnotworkduetomultidrugresistance(MDR).Recentstudi...XIAO Bing, SHI Yong Quan, ZHAO Yan Qiu, YOU Han, WANG Zuo You, LIU Xian Ling, YIN Fang, QIAO Tai Dong and FAN Dai Ming 1998World Journal of Gastroenterology1998,4,5:24
4Expression of regulating apoptosis gene and apoptosis index in primary liver cancer显示文摘INTRODUCTIONProgramed cell death plays an important role in thegenesis of cancer.Certain cancer genes canregulate apoptosis.Recently,several proteins thatare structurally related to Bcl-2,an inhibitor ofapoptosis,have been identified.Therefore,novel strategies and agents that target specificmolecular pathways,as well as triggering aHong Yu Xu You Lin Yang Xi Li Guan Guang Song Ai Min Jiang Li Jun Shi 2000World Journal of Gastroenterology2000,6,5:21
5Discharge Characteristics of Long SF6 Gas Gap with and Without Insulator in GIS Under VFTO and LI显示文摘Gas insulator switchgears(GISs),widely used in electric power systems for decades,have many advantages due to their compactness,minimal environmental impact,and long maintenance cycles.However,very fast transient overvoltage(VFTO)increases caused by a rise in voltage levels can lead to GIS insulation failures.In this paper,a generating system of VFTO and standard lightning impulse(LI)is established.The insulation characteristics of SF6 gas with and without insulators under VFTO and standard LI are investigated.Experimental results show that the 50%breakdown voltages of the inhomogeneous electric field rod-plane gap under positive VFTO and standard LI are higher than that under negative VFTO and standard LI.The research shows that the 50%breakdown voltage under VFTO could be lower than that under standard LI at 0.5 MPa for the negative polarity.Moreover,the polarity effect of the insulator without defect is different from that with defect.Similarly,the breakdown voltage of the defective insulator under VFTO could be lower than that under standard LI by 8%.The flashover channel under VFTO is seen as more than that under standard LI.Based on the analysis of discharge images and experimental results,it is concluded that the polarity effect is related to the distortion effect of ion clusters formed by SF6 on the electric field.Additionally,the steepness and front time of impulse plays an important role in the initiation and further development of discharge on insulator surface.Finally,the research shows that different discharge characteristics between VFTO and standard LI may be caused by different wave fronts and oscillation on the tails of the impulses.Tao Wen Qiaogen Zhang Jingtan Ma Can Guo Haoyang You Yifan Qin Yu Yin Weidong Shi Weijiang Chen 2015CSEE Journal of Power and Energy Systems2015,1,3:17
6The Antagonistic Action of Abscisic Acid and Cytokinin Signaling Mediates Drought Stress Response in Arabidopsis显示文摘Xiaozhen Huang Lingyan Hou Jingjing Meng Huiwen You Zhen Li Zhizhong Gong Shuhua Yang Yiting Shi 2018Molecular Plant2018,11,7:15
7Role of CyclinD1 and CDK4 in the Carcinogenesis Induced by Silica显示文摘Objective To study the role of cyclinD1 and CDK4 in malignant transformation of human fetal lung diploid fibroblast cell line(2BS) induced by silica. Methods Recombination vectors with sense and antisense pXJ41-cyclinD1 and pXJ41-CDK4 were constructed, and then transfected into the malignant transformed cells induced by silica, respectively. At the same time, pXJ41-neo was used as the control. Results During the progress of the malignant transformation of 2BS cells induced by silica, cyclinD1 and CDK4 were overexpressed. Antisense RNA suppressed cyclinD1 and CDK4 gene expression in the antisense pXJ41-cyclinD1 and pXJ41-CDK4 transfected cells. Antisense RNA led to cell cycle arrest, resulting in lengthened G1 phase (the percentages of cells in the G1 phase changed from 45.1% to 52.7% and 58.0% for cyclinD1 and CDK4 transfected cells, respectively), and eventually attenuated the increase of the proliferation of malignant transformed cells induced by silica. Compared with malignant transformed cells induced by silica, cells transfected with antisense pXJ41-cyclinD1 and pXJ41-CDK4 showed obviously reduced growth rates. On the 8th day, the suppression rates were 58.69 and 77.43% (the growth rate of malignant transformed cells induced by silica was 100%), doubling time changed from 21.0 h to 31.4 h and 21.0 h to 42.7 h, respectively, the growth capacities on soft agar of cells transfected by antisense pXJ41-cyclinD1 and pXJ41-CDK4 decreased obviously. Conclusion CyclinD1 and CDK4 play an important role in maintaining transformed phenotype of the cancer cells.KE-XIA YAN BING-CI LIU XIANG-LIN SHI BAO-RONG YOU MING XU 2005Biomedical and Environmental Sciences2005,18,5:14
8Situation Awareness of Active Distribution Network:Roadmap,Technologies,and Bottlenecks显示文摘With the rapid development of local generation and demand response,the active distribution network(ADN),which aggregates and manages miscellaneous distributed resources,has moved from theory to practice.Secure and optimal operations now require an advanced situation awareness(SA)system so that operators are aware of operation states and potential risks.Current solutions in distribution supervisory control and data acquisition(DSCADA)as well as the distribution automation system(DAS)generally are not able to meet the technology requirements of SA.In this paper,the authors’participation in the project of developing an SA system as the basic component of a practical active distribution management system(ADMS)deployed in Beijing,China,is presented.This paper reviews the ADN’s development roadmap by illustrating the changes that are made in elements,topology,structure,and control scheme.Taking into consideration these hardware changes,a systematic framework is proposed for the main components and the functional hierarchy of an SA system for the ADN.The SA system’s implementation bottlenecks are also presented,including,but not limited to issues in big data platform,distribution forecasting,and security evaluation.Potential technology solutions are also provided.Jin Lin Can Wan Yonghua Song Renle Huang Xiaoshuang Chen Wanfang Guo Yi Zong You Shi 2016CSEE Journal of Power and Energy Systems2016,2,3:13
9Baseline Hepatitis B Virus DNA Level is a Promising Factor for Predicting the 3^rd Month Virological Response to Entecavir Therapy: A Study of Strict Defined Hepatitis B virus Induced Cirrhosis显示文摘Yang Xu Xiao-Ning Wu Yi-Wen Shi Wei Wei Ai-Ting Yang Ya-Meng Sun Wen-Shan Zhao Hong You 2015Chinese Medical Journal2015,,14:11
10AI for 5G: research directions and paradigms显示文摘Wireless communication technologies such as fifth generation mobile networks(5 G) will not only provide an increase of 1000 times in Internet traffic in the next decade but will also offer the underlying technologies to entire industries to support Internet of things(IOT) technologies. Compared to existing mobile communication techniques, 5 G has more varied applications and its corresponding system design is more complicated. The resurgence of artificial intelligence(AI) techniques offers an alternative option that is possibly superior to traditional ideas and performance. Typical and potential research directions related to the promising contributions that can be achieved through AI must be identified, evaluated, and investigated.To this end, this study provides an overview that first combs through several promising research directions in AI for 5 G technologies based on an understanding of the key technologies in 5 G. In addition, the study focuses on providing design paradigms including 5 G network optimization, optimal resource allocation, 5 G physical layer unified acceleration, end-to-end physical layer joint optimization, and so on.Xiaohu YOU Chuan ZHANG Xiaosi TAN Shi JIN Hequan WU 2019Science China(Information Sciences)2019,62,2:10
11Wrist-ankle acupuncture and Fluoxetine in the treatment of post-stroke depression: a randomized controlled clinical trial显示文摘OBJECTIVE: To investigate the effects of WAA combined with fluoxetine in the clinical treatment of post-stroke depression(PSD).METHODS: In this randomized, controlled and single-blind trial, 105 PSD patients who met the inclusion criteria were randomly divided into three equal groups: Thin wrist-ankle acupuncture(WAA)group(Thin WAA needle + Fluoxetine), Thick WAA group(Thick WAA needle + Fluoxetine), and Sham WAA group(sham WAA needle + Fluoxetine). In this trial, the primary outcome was Hamilton Depression Scale(HAMD), while the secondary outcomes included Zung self-rating depression scale(SDS) and World Health Organization Quality of Life BREF(QQL).RESULTS: Ninety nine PSD patients completed all the treatment. The HAMD scores and SDS scores of all the three groups decreased after treatment(P <0.05);thick WAA group and thin WAA group decreased more obviously than the sham WAA group(P < 0.05). There was no significant difference between the QQL scores of the three groups(P >0.05). There was no significant difference in the scores of the three scales between the thick wrist ankle needles and the thin wrist ankle needles(P >0.05).CONCLUSION: The present study showed that WAA combined with fluoxetine can relieve the symptoms of depression after stroke. WAA therapy could improve the antidepressant effect of fluoxetine.You Yanli Zhang Tianfang Shu Shi Qian Xiaolu Zhou Shuang Yao Fei 2020Journal of Traditional Chinese Medicine2020,40,3:10
12PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented.CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua 2014Science China(Physics,Mechanics & Astronomy)2014,57,8:9
13Structural Modulation of Gut Microbiota in Rats with Allergic Bronchial Asthma Treated with Recuperating Lung Decoction显示文摘Objective To investigate whether recuperating lung decoction(RLD) can modulate the composition of gut microbiota in rats during asthma treatment.Methods Fifteen Sprague-Dawley rats were divided randomly and equally into control group,model group,dexamethasone(DEX) group,RLD medium-dose group,and RLD high-dose group.The asthma model was established in all groups,except for the control group.The rats in the DEX and RLD groups were treated orally with DEX and RLD,respectively.The rats in the control and model groups were treated orally with 0.9% saline.The intestinal bacterial communities were compared among groups using 16 S r RNA gene amplification and 454 pyrosequencing.Results The microbial flora differed between the control and model groups,but the flora in the RLD groups was similar to that in the control group.No significant differences were observed between the RLD high-dose and medium-dose groups.RLD treatment resulted in an increase in the level beneficial bacteria in the gut,such as Lactobacillus and Bifidobacterium spp.Conclusion Oral administration of RLD increased the number of intestinal lactic acid-producing bacteria,such as Lactobacillus and Bifidobacterium,in asthma model rats.KONG Yan Hua SHI Qi HAN Na ZHANG Ling ZHANG Yuan Yuan GAO Tong Xin CHEN Chen LI You Lin 2016Biomedical and Environmental Sciences2016,29,8:9
14Application and Experiment on the Least-action Principle of Explosive Welding of Stainless Steel/Steel显示文摘In nature,many physical phenomena follow the least-action principle,which is also abided by the course of explosive welding of stainless steel/steel.The optimal welding interface can be obtained with the least explosive charge by theoretical analysis and interface test.The bonding energy can be acknowledged as the'action'in explosive welding.To minimize the bonding energy,these rules must be followed such as the lower limit of explosive charge,the upper limit of span and the explosive of critical explosion velocity.The principle of least-action is achieved in the course of explosive welding,and the interface will be optimum.Chang-gen SHI Yu WANG Si-jing LI Jun YOU 2014Journal of Iron and Steel Research(International)2014,21,6:8
15Two VOZ transcription factors link an E3 ligase and an NLR immune receptor to modulate immunity in rice显示文摘Nucleotide-binding leucine-rich repeat(NLR)proteins play critical roles in plant immunity.However,how NLRs are regulated and activate defense signaling is not fully understood.The rice(Oryza sativa)NLR receptor Piz-t confers broad-spectrum resistance to the fungal pathogen Magnaporthe oryzae and the RING-type E3 ligase AVRPIZ-T INTERACTING PROTEIN 10(APIP10)negatively regulates Piz-t accumulation.In this study,we found that APIP10 interacts with two rice transcription factors,VASCULAR PLANT ONEZINC FINGER 1(OsVOZ1)and OsVOZ2,and promotes their degradation through the 26S proteasome pathway.OsVOZ1 displays transcriptional repression activity while OsVOZ2 confers transcriptional activation activity in planta.The osvoz1 and osvoz2 single mutants display modest but opposite M.oryzae resistance in the non-Piz-t background.However,the osvoz1 osvoz2 double mutant exhibits strong dwarfism and cell death,and silencing of both genes via RNA interference also leads to dwarfism,mild cell death,and enhanced resistance to M.oryzae in the non-Piz-t background.Both OsVOZ1 and OsVOZ2 interact with Piz-t.Double silencing of OsVOZ1 and OsVOZ2 in the Piz-t background decreases Piz-t protein accumulation and transcription,reactive oxygen species-dependent cell death,and resistance to M.oryzae containing AvrPiz-t.Taken together,these results indicate that OsVOZ1 and OsVOZ2 negatively regulate basal defense but contribute positively to Piz-t-mediated immunity.Jiyang Wang Ruyi Wang Hong Fang Chongyang Zhang Fan Zhang Zeyun Hao Xiaoman You Xuetao Shi Chan Ho Park Kangyu Hua Feng He Maria Bellizzi Kieu Thi Xuan Vo Jong-Seong Jeon Yuese Ning Guo-Liang Wang 2021Molecular Plant2021,14,2:8
16THE RADIATION AND DIFFRACTION OF WATER WAVES BY A BOTTOM-MOUNTED CIRCULAR CYLINDER IN A TWO-LAYER FLUID显示文摘An analytical method was proposed to analyze the radiation and diffraction of water waves by a bottom-mounted circular cylinder in a two-layer fluid. Analytical expressions for added mass and damping coefficients, as well as the wave excitation forces of the circular cylinder were obtained by an eigenfunction expansion method. The hydrodynamic forces on the bottom-mounted circular cylinder in a two-layer fluid include not only the added mass and damping coefficients, but also the wave forces of the surface and internal-wave modes. This is different from the case of a homogenous fluid. Some examples were given, showing that density stratification can have a relative large effect on these hydrodynamic forces over a wide range of frequencies.YOU Yun-xiang SHI Qiang MIAO Guo-ping 2007Journal of Hydrodynamics2007,19,1:7
17Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip.Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI 2021Science China(Information Sciences)2021,64,10:7
18Design of Environmental Monitoring and Control System for Large-scale Pig House with Fermentation Bed显示文摘The design and assembly of environmental monitoring and control system for large-scale pig house with fermentation bed helped to solve the problem of environmental automatic control in piggery.The sensors would monitor the temperature,humidity,light,wind direction,wind speed,CO2,NH3and other parameters.On-line real-time data collection was achieved.The expert system was constructed to control the temperature in piggery below 30℃,to control the air and mattress humidities higher than 65%.Under the conditions of different season or different wind speed,even in day and night,the control actuators were different.The actuators included fanning wet curtain,lighting,micro spraying,spraying,propeller fan,electric aluminum alloy shutter and spraying systems on the roof.The actuators were integrated,and they control the piggery environment simultaneously.The system also designed the remote video monitor interface,parameter-monitoring curved interface and operation interface,which provided a good man-machine interface.Bo LIU Huiyong ZHENG Yingzhi LIN Shengbing LIU Hongyi ZHENG Chunzhong YOU Huai SHI Jianglin LAN Zhaolong LI Jianyang TANG Qinlou HUANG 2015Agricultural Science & Technology2015,16,2:6
19以用户为中心的新兴电力市场模式显示文摘随着可再生能源在现代能源产业中的占比不断提高,其对现行电力系统和电力市场的运行机制所带来的影响也日趋明显;同时,通过与数字信息产业深度结合,分布式能量管理手段也处于飞速发展阶段。在这二者的驱动下,一种以用户为中心的新兴电力市场模式正以不同的表现形式出现在世界各地。文章以高度概括的方式介绍了这一新兴电力市场模式,浅析了其在不同表现形式下的机理和特征。基于这一新兴电力市场模式在短期内所取得的发展成就,有理由相信此类新兴电力市场模式将逐步成为未来电力市场中的重要组成部分。Pierre Pinson Thomas Baroche Fabio Moret Tiago Sousa Etienne Sorin Shi You 2017供用电2017,34,12:6
20Evaluating the Accuracy of ERA5 Wave Reanalysis in the Water Around China显示文摘Wave parameters, such as wave height and wave period, are important for human activities, such as navigation, ocean engineering and sediment transport, etc. In this study, wave data from six buoys around Chinese waters, are used to assess the quality of wave height and wave period in the ERA5 reanalysis of the European Centre for Medium-Range Weather Forecasts. Annual hourly data with temporal resolution are used. The difference between the significant wave height(SWH) of ERA 5 and that of the buoy varies from-0.35 m to 0.30 m for the three shallow locations;for the three deep locations, the variation ranges from-0.09 m to 0.09 m. The ERA5 SWH data show positive biases, indicating an overall overestimation for all locations, except for E2 and S1 where underestimation is observed. During the tropical cyclone period, a large(about 32%) underestimation of the maximum SWH in the ERA5 data is observed. Hence, the ERA5 SWH data cannot be used for design applications without site-specific validation. The difference between the annual wave period from ERA5 and the mean wave period from the buoys varies from-1.31 s to 0.4 s. Inter-comparisons suggest that the ERA5 dataset is consistent with the annual mean SWH. However, for the average period, the performance is not good, and half of the correlation coefficients in the four points are less 50%. Overall, the deep water area simulation effect is better than that in the shallow water.SHI Hongyuan CAO Xuefeng LI Qingjie LI Delei SUN Jiacheng YOU Zaijin SUN Qingying 2021Journal of Ocean University of China2021,20,1:5
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