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| 1 | Clinical utility of Epstein-Barr virus DNA and other liquid biopsy markers in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is a malignant epithelial tumor ubiquitously associated with the Epstein-Barr virus(EBV),which is highly prevalent in South China,Southeast Asia,and North Africa.Despite being a highly radio-sensitive and treatable cancer,a majority of NPC patients are diagnosed in their advanced stage,and locoregional and distant relapses following definitive treatment contribute largely to cancer-specific mortality among these patients.Given that EBV-driven NPC is the predominant variant seen in endemic regions,various EBV detection methods have been developed and are utilized in screening,prognostication,and post-treatment surveillance of NPC patients.While the Immunoglobulin A(IgA)serology assay is the most extensively studied EBV detection method,the detection of plasma EBV DNA released during replication or cellular apoptosis has shown superior outcomes in endemic population screening,prognostication,and detection of distant relapse.Furthermore,there is emerging evidence on the use of circulating tumor cells,microRNAs,DNA hypermethylation,and combination assays in various clinical scenarios.Herein,this paper provides a comprehensive overview of the relevant studies using various EBV detection techniques in the management of NPC.Specifically,the recent advances,clinical evidence,and challenges associated with the clinical application of EBV liquid biopsies in population screening,prognostication,and surveillance of NPC are presented. | Rong Tan Sean Kean Ann Phua Yoke Lim Soong Lynette Lin Ean Oon Kian Sing Chan Sasidharan Swarnalatha Lucky Jamie Mong Min Han Tan Chwee Ming Lim | 2020 | Cancer Communications2020，40，11： | 8 |
| 2 | 菜蓟提取复合物对罗非鱼生长性能和肝脏保护效果的评价显示文摘菜蓟为双子叶植物药菊科菜蓟的叶,有利胆和保肝作用,并有抗脂肪肝功效。试验采用的菜蓟提取复合物,其有效成分主要包括菜蓟提取物和氯化胆碱等,试验验证菜蓟提取复合物对尼罗罗非鱼生长性能、肝脏抗氧化机能、血浆生化指标和肝细胞的影响等。试验分为3组:空白对照组、黄曲霉毒素B(1AFB,100 mg/kg)攻毒阳性组和菜蓟提取复合物添加组(300 mg/kg菜蓟提取复合物+AFB 100 mg/kg)。8周的养殖试验结果表明:饲料中含AFB后,罗非鱼的增重率、特定生长率、成活率比对照组显著降低(P<0.05),成活率显著降低至50%,而饵料系数则显著提高1倍多(P<0.05);但在含AFB的饲料中补充了菜蓟提取复合物后,其增重率、特定生长率、成活率和饵料系数得到明显改善,与对照组相比没有显著差异(P>0.05);AFB的添加导致罗非鱼肌肉水分和肝脏粗脂肪含量显著增加和肌肉粗蛋白含量的显著下降(P<0.05),而在含AFB的饲料中补充了菜蓟提取复合物后,其肌肉水分、粗蛋白和肝脏粗脂肪含量与对照组相比无显著差异(P>0.05);AFB的添加使罗非鱼的SOD和CAT活性及MDA生成量较对照组显著提高(P<0.05);补充菜蓟提取复合物后,MDA生成量较AFB组又显著降低(P<0.05);罗非鱼的Hct因AFB的添加而显著降低(P<0.05),而ALT、AST和AGP则显著提高(P<0.05);菜蓟提取复合物补充后,上述指标又恢复至与对照组相比无显著差异;饲喂含AFB日粮的罗非鱼细胞质空泡化,出现明显的核偏位和严重的脂肪浸润,在含AFB的日粮中补充菜蓟提取复合物后,罗非鱼肝脏组织中形成大量的嗜碱性细胞包围着坏死的细胞,但并未形成明显结节。结果表明,含一定剂量的黄曲霉毒素B(1AFB)的日粮对罗非鱼的生长会造成显著的负面影响,同时导致明显的肝损伤,而菜蓟提取复合物的补充能够减少罗非鱼的死亡,有效地保护其肝脏,并促进罗非鱼的生长。 | 饶瑞 桂庆平 郑宗林 Claire Yew Yoke Ching 刘鸿艳 | 2013 | 饲料工业2013，34，14： | 4 |
| 3 | 对CAD患者实施出院后健康教育的效果评价显示文摘为评价出院后健康教育课对冠状动脉疾病 (CAD)患者掌握相关知识和自我促进健康行为的效果 ,对行心导管检查并诊断为 CAD的 5 3例患者进行出院后健康教育授课 2 h(实验组 ) ,课后 40~ 142 d使用心脏病患者健康状况调查表 (HHQ)和促进健康生活方式量表 (HPL P)进行调查 ,并与未参加授课者 (对照组 )进行比较。结果 :实验组患者 HHQ和 HPL P得分明显高于对照组。提示 :实验组懂得较多的 CAD相关知识及较频繁实施促进健康的行为 。 | 黄雪斐 Wang Xin Yee Yip Yoke Ying | 2000 | 护理学杂志(综合版)2000，15，9： | 3 |
| 4 | 我国专利保护制度下涉及重大公共健康问题高价药品的经济可及性显示文摘目的通过典型案例分析,研究我国专利制度下涉及重大公共健康问题高价药品的可及性,提出促进这部分药物经济可及性的政策建议。方法通过文献分析和市场调查,以我国疾病负担较重,对社会、经济和政治影响较大的八类疾病临床必需的专利药物为例,测算专利制度下高价药品对个人及医保的药物治疗直接经济负担。结果化合物专利强化了专利药品的价格垄断。目标药品对我国居民,尤其是农村居民的个人经济负担十分沉重。突破化合物专利,实现平行进口或国内仿制药上市,可节约巨额药品采购费用,惠及广大国人。结论制定并实施具有公共健康视角的药品注册和知识产权保护策略,配以不断稳步扩大和加强的基本医疗保险制度,可有效促进对公共健康有重要意义,对社会、政治和经济影响重大的高价专利药品的经济可及性。 | 孙静 赵红艳 马丽平 董四平 杨婷婷 Yoke Ling Paul Cowthrone 陈惜平 陈又丁 | 2014 | 中国循证医学杂志2014，14，5： | 3 |
| 5 | The performance of superhydrophobic and superoleophilic carbon nanotube meshes in water–oil filtration显示文摘 | Chee Huei Lee Nick Johnson Jaroslaw Drelich Yoke Khin Yap | 2010 | Carbon2010，，2： | 2 |
| 6 | Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines显示文摘 | Yoke Keong Yong Jun Jie Tan Soek Sin Teh Siau Hui Mah Gwendoline Cheng Lian Ee Hoe Siong Chiong Zuraini Ahmad José Luis Ríos | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 2 |
| 7 | Computer Game as Learning and Teaching Tool for Object Oriented Programming in Higher Education Institution显示文摘 | Wong Yoke Seng Maizatul Hayati Mohamad Yatim | 2014 | Procedia-Social and Behavioral Sciences2014，123，3： | 1 |
| 8 | Multi-category Micro-milling Tool Wear Monitoring with Continu-ous Hidden Markov Models 显示文摘 | ZHU Kunpeng WONG Yoke San HONG Geok Soon | 2009 | Mechanical Systems andSignal Processing2009，23，2： | 1 |
| 9 | Controlling chaos显示文摘 | Ott E Grebogy G Yoke J A | 1990 | Phy Rev Lett1990，64，： | 1 |
| 10 | Typical Dioxin concentrations in agriculture soils of Washington state and potential sources Environ显示文摘 | Godowsky D L Yoke W | 2005 | Sci Technol2005，，39： | 1 |
| 11 | Parvalbumin – the major tropical fish allergen显示文摘 | Dawn Li‐ChernLim Keng HweeNeo Fong ChengYi Kaw YanChua Denise Li‐MengGoh Lynette Pei‐ChiShek Yoke ChinGiam Hugo PSVan Bever Bee WahLee | 2008 | Pediatric Allergy and Immunology2008，，5： | 1 |
| 12 | Bayesian-inference-based neural networks for tool wear estimation显示文摘 | Dong Jianfei Subrahmanyam K V R Wong Yoke San | 2006 | The International Journal of Advanced Manufacturing Technology2006，30，910： | 1 |
| 13 | Potential of FTIR for the authentication of vegetable oils 显示文摘 | YOKE W LAI E KEMSLEY K | 1994 | Agric Food Chem1994，42，： | 1 |
| 14 | Optimized tool path generation for fast tool servo diamond turning of micro-structured surfaces显示文摘 | De Ping Yu Sze Wei Gan Yoke San Wong Geok Soon Hong Mustafizur Rahman Jin Yao | 2012 | The International Journal of Advanced Manufacturing Technology2012，，9： | 1 |
| 15 | Robust nonlinear coordinated generator excitation and SVC control for power systems显示文摘 | Wang Youji Yoke Lin Tan Guo Guoxiao | 2000 | International Journal of Electrical Power and Energy Systems2000，22，3： | 1 |
| 16 | A randomized controlled trial to compare steroid with cyclosporine for theopical treatment of oral lichen planus显示文摘 | Yoke PC Tin GB Kim M J | 2006 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2006，102，1： | 1 |
| 17 | Pterygopalatine fossa and maxillary nerve infiltration in nasopharyngeal carcinoma显示文摘 | Yoke FF | 1997 | Head Neck1997，19，1： | 1 |
| 18 | Controlling chaos显示文摘 | Ott E Grebogy C Yoke J A | 1990 | Phys Rev Lett1990，64，： | 1 |
| 19 | Multiscale Singularity Analysis of Cutting Forces for Micromilling Tool-Wear Monitoring显示文摘 | Zhu Kunpeng lfong Geok Soon Wong Yoke San | 2011 | IEEE Transactions on Industrial Electronics2011，58，6： | 1 |
| 20 | Full Band Waveguide-to-Micros- trip Probe Transitions 显示文摘 | YOKE C L SANDER W | 1999 | IEEE Transactions on Microwave Theory and Techniques1999，47，9： | 1 |
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