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| 1 | 《2013年全球乳房健康共识指南》解读--医院-社区一体化的延续性护理在乳腺癌生存者照护中的重要作用显示文摘乳腺癌发病率在中国呈快速上升趋势,同时其又是可以治愈的疾病,带癌生存者逐年增多;因此,医院-社区一体化的延续性护理势在必行。本文对《2013年全球乳房健康共识指南——中、低等收入国家乳腺癌生存者治疗期后的支持性护理》的内容进行解读,思考医院-社区一体化延续性护理的优势与提供者,介绍指南中专家根据资源分配情况建议相应的护理措施,并且分析我国目前开展医院-社区一体化延续性护理的障碍,旨在为我国护理工作者进行乳腺癌延续性护理提供科学依据。 | 郭奕嫱 李惠平 Soon Lean Keng Azlina Yusuf 雷慧 辛小林 | 2015 | 中国全科医学2015，18，6： | 32 |
| 2 | Identification of differentially expressed long non-coding RNAs in human ovarian cancer cells with different metastatic potentials显示文摘Objective:To identify differentially expressed long non-coding RNAs(lncRNAs) involved in the metastasis of epithelial ovarian cancer.Methods:An in vitro invasion assay was performed to validate the invasive capability of SKOV3 and SKOV3.ip1 cell lines.Total RNA was then extracted,and microarray analysis was performed.Moreover,nine lncRNAs were selected for validation using RT-qPCR.Results:Compared with the SKOV3 cells,the SKOV3.ip1 cells significantly improved in the in vitro invasive activity.Of the 4,956 lncRNAs detected in the microarray,583 and 578 lncRNAs were upregulated and downregulated,respectively,in SKOV3.ip1 cells,compared with the parental SKOV3 cells.Seven of the analyzed lncRNAs(MALAT1,H19,UCA1,CCAT1,LOC645249,LOC100128881,and LOC100292680) confirmed the deregulation found by microarray analysis.Conclusion:LncRNAs clusters were differentially expressed in ovarian cancer cells with varying metastatic potentials.This result indicates that some lncRNAs might exert a partial or key role in epithelial ovarian cancer metastasis.Further studies should be conducted to determine the roles of these lncRNAs in ovarian cancer metastasis. | Shi-Ping Liu Jia-Xin Yang Dong-Yan Cao Keng Shen | 2013 | Cancer Biology & Medicine2013，10，3： | 27 |
| 3 | Factors Associated with Effectiveness of Treatment and Reproductive Outcomes in Patients with Thin Endometrium Undergoing Estrogen Treatment显示文摘 | Si-Miao Liu Yuan-Zheng Zhou Han-Bi Wang Zheng-Yi Sun Jing-Ran Zhen Keng Shen Cheng-Yan Deng Jing-He Lang | 2015 | Chinese Medical Journal2015，，23： | 24 |
| 4 | Aconine inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-KB and NFATcl activation and DC-STAMP expression显示文摘目的: Aconiti Lateralis 根值 Preparata 是过去常对待长期的关节炎的繁体中文药并且对风湿性关节炎是高度有效的。然而, aconine 的效果, aconitum 碱的衍生物在骨破折,它能吸收骨头上,仍然保持未知。这里,我们在 vitro.Methods 在骨破折区别和骨头再吞上调查了 aconine 的效果: 老鼠的生存能力白血病的单核白血球 / 巨噬细胞房间线 RAW264.7 用 CCK-8 试金被测量。骨破折区别被 RAW264.7 房间的孵化面对 RANKL 导致,并且与陷井染色估计了试金。骨头再吞与骨头再吞坑试金被检验。相关基因和蛋白质的表示用 RT-PCR 和西方的污点被分析。 NF-κ 的激活; B 和激活的T房间( NFAT )的原子因素用稳定的 NF-κ 被检验; B 和 NFATc1 酶记者基因系统, RT-PCR 和西方的污点 analysis.Results : Aconine ( 0.125 , 0.25 μ ; mol/L )没影响 RAW264.7 房间的生存能力,但是 dose-dependently 禁止了 导致RANKL 的骨破折形成和骨头再吸收的活动。而且, aconine dose-dependently 禁止了 NF-κ 的 导致RANKL 的激活;在 RAW264.7 房间的 B 和 NFATc1 ,并且随后减少了骨破折特定的基因的表示( c-Src , β ; 3-Integrin ,组织蛋白酶 K 和 MMP-9 )并且树枝状的房间特定的 transmembrane 蛋白质(DC邮票)的表示,它在房间房间 fusion.Conclusion 起了一个重要作用:这些调查结果建议 aconine 由压制在 RAW264.7 房间禁止 导致RANKL | Xiang-zhou ZENG Long-gang HE Song WANG Keng WANG Yue-yang ZHANG Lei TAO Xiao-juan LI Shu-wen LIU | 2016 | Acta Pharmacologica Sinica2016，37，2： | 20 |
| 5 | Age-specific prevalence of human papillomavirus by grade of cervical cytology in Tibetan women显示文摘背景人的乳头状瘤病毒(HPV ) 被相信是最普通的性播送的感染。然而,很少在中国对 HPV 类型的流行和分发被知道。我们试图在居住在 China.Methods A 的西藏的自治区域的女人为反常颈的细胞学象风险一样估计流行和 HPV 类型的分发代表性的学习被执行包含 3036 个女人的一件样品。一张流行病学的问询表被使用,颈的标本为基于液体的细胞学和 HPV DNA 察觉被获得。统计分析在这张人口包括了 chi 平方和逻辑回归 model.Results,(111/3036 )3.66% 有未经决定的意义(子囊) 的不正常的有鳞的房间, 1.45%(44/3036 ) 低档有鳞的 intraepithelial 损害(LSIL ) 并且(33/3036 )1.09% 有高级有鳞的 intraepithelial 损害(HSIL ) 。西藏的女人(5.74% , 137/2387 ) 展出更低的反常细胞学比非西藏的女人评价(8.01% , 52/649, P=0.03 ) 。HPV 感染的全面流行是 9.19%(279/3036 ) 。我们没能到年龄在 HPV 流行识别任何差别。在有正常,子囊, LSIL 和 HSIL 的组,全面 HPV 流行是 7.41%(211/2847 ) , 24.32%(27/111 ) , 56.82%(25/44 ) 并且 45.45%(15/33 ) 分别地。HPV 16 (1.52%,46/3036 ) 是最普通的类型,并且在有子囊的女人也是最流行的(8.11% , 9/111 ) 并且 HSIL (15.15% , 5/33 ) 。为西藏的女人的最普通的 HPV 类型是 HPV 16 (1.42% , 34/2387 ) 而为非西藏的个人它是 HPV 33 (2.31% , 15/649 ) 。279 个感染 HPV 的女人, 40 个个人(14.34%) 与多重 HPV 确实介绍了。有二怀孕的女人是更可能的有反常细胞学油迹(OR=1.67; 95% CI:1.07-2.61 ).Conclusions HPV 确实的低流行在居住在中国的西藏的自治区域的女人被观察。反常颈的细胞学和 HPV 类型分布的流行在西藏、非西藏的女人之间是不同的。 | JIN Qiong SHEN Keng LI Hui ZHOU Xian-rong HUANG Hui-fang LENG Jin-hua | 2010 | Chinese Medical Journal2010，，15： | 19 |
| 6 | 石油组分高分辨质谱分析进展与展望显示文摘石油是一种复杂体系,研究石油分子组成是分析化学领域的经典难题.近年来,傅里叶变换离子回旋共振质谱技术(Fourier transform ion cyclotron resonance mass spectrometry,FT-ICR MS)的发展,为从分子水平认识石油组成提供了机会,引起了石油化学界的高度关注,并被期待能在石油、石化领域的相关研究中实现重大突破.本文从质谱分辨率和电离技术方面介绍了石油样品的分析需求,总结了近几年基于FT-ICR MS技术对石油分子组成的研究进展,分析了其在应用中存在的关键技术问题及下一步研究方向,并对FT-ICR MS的发展前景给予展望. | 史权 张亚和 徐春明 赵锁奇 CHUNG Keng H | 2014 | 中国科学:化学2014，44，5： | 16 |
| 7 | Athabasca油砂沥青中重组分的分子模拟显示文摘利用分子模拟技术对加拿大Athabasca油砂沥青超临界萃取分馏残渣组分的化学分子结构进行了研究 ,首先选用长度不同的桥链构建了其三维平均结构 ,然后采用分子力学 (MM)和分子动力学 (MD)方法得到能量最低也即最稳定的构象 .研究发现 ,即使分子的二维结构相同 ,其三维结构差别也很大 ,由此可见仅用二维模型来表征重质油大分子的结构和物理化学性质远远不够 .另外 ,分子模拟还可以预测沥青质残渣中最有可能存在的桥链长度 .Athabasca沥青残渣组分中长度为C5到C7的桥链存在的可能性最大 ,而C1和C2桥链则由于其总能量相对较高 。 | 高金森 徐春明 Luba S.KOTLYAR Keng H.CHUNG | 2003 | 化工学报2003，54，1： | 14 |
| 8 | Gold-patched graphene nano-stripes for high-responsivity and ultrafast photodetection from the visible to infrared regime显示文摘Graphene is a very attractive material for broadband photodetection in hyperspectral imaging and sensing systems.However,its potential use has been hindered by tradeoffs between the responsivity,bandwidth,and operation speed of existing graphene photodetectors.Here,we present engineered photoconductive nanostructures based on goldpatched graphene nano-stripes,which enable simultaneous broadband and ultrafast photodetection with high responsivity.These nanostructures merge the advantages of broadband optical absorption,ultrafast photocarrier transport,and carrier multiplication within graphene nano-stripes with the ultrafast transport of photocarriers to gold patches before recombination.Through this approach,high-responsivity operation is realized without the use of bandwidth-limiting and speed-limiting quantum dots,defect states,or tunneling barriers.We demonstrate highresponsivity photodetection from the visible to infrared regime(0.6 A/W at 0.8μm and 11.5 A/W at 20μm),with operation speeds exceeding 50 GHz.Our results demonstrate improvement of the response times by more than seven orders of magnitude and an increase in bandwidths of one order of magnitude compared to those of higherresponsivity graphene photodetectors based on quantum dots and tunneling barriers. | Semih Cakmakyapan Ping Keng Lu Aryan Navabi Mona Jarrahi | 2018 | Light(Science & Applications)2018，7，1： | 12 |
| 9 | Selective separation of Cu(Ⅱ),Zn(Ⅱ),and Cd(Ⅱ)by solvent extraction显示文摘试验性的调查在分离上被介绍 Cu (II ) , Zn (II ) ,和从锌的富有的硫酸盐 leachate 的 Cd (II ) 由溶剂抽取起炉渣。直角的实验的结果显示 LIX 984N 在 Cu ( II )的抽取高度选择、很有效,并且变化的分析显示参数的顺序根据他们对分离效率的影响是阶段比率> LIX 984N 集中> pH 价值>抽取时间。为铜抽取的最佳的条件作为 25% LIX 984N 集中,抽取时间的 7 min,阶段比率记帐的 3:2,和 pH = 被获得 1.7。Zn (II ) 和 Cd (II ) 的分离从 raffinate 在铜抽取以后被执行。有 di-2-ethylhexyl 的分离的比较分析磷的酸(D2EHPA ) , D2EHPA- tributylphosophate (TBP ) synergistic 提取系统,和 2-ethylhexyl 单音的 2-ethylhexyl 酉旨(HEHEHP ) 在 pH = 被做的磷的酸 2.0。有 D2EHPA 的抽取效率在被钠氢氧化物,并且 D2EHPA-TBP synergistic 提取以及 HEHEHP 皂化以后被改进,这被表明,在 Cd (II ) 上有一种优异选择到 Zn (II ) 。 | XIE Keng WEN Jiankang HUA Yixin RUAN Renman | 2008 | Rare Metals2008，27，3： | 11 |
| 10 | Pretreatment neutrophil-to-lymphocyte and platelet-to- lymphocyte ratios do not predict survival in patients with cervical cancer treated with neoadjuvant chemotherapy and radical hysterectomy显示文摘 | WANG Dan WU Ming FENG Feng-zhi HUANG Hui-fang YANG Jia-xin SHEN Keng XIANG Yang | 2013 | Chinese Medical Journal2013，，8： | 10 |
| 11 | URETERAL INJURY DURING GYNECOLOGICAL LAPAROSCOPIC SURGERIES: REPORT OF TWELVE CASES显示文摘Objective To investigate ureteral injury during gynecological laparoscopic surgeries.Methods From January 1990 to December 2005, 12868 gynecological laparoscopic surgeries were conducted in Peking Union Medical College Hospital with 12 ureteral injuries reported. The present study investigated several aspects, including surgical indications, uterine size, pelvic adhesion, operative procedures, symptoms, diagnostic time and methods, injury site and type, subsequent treatment, and prognosis. Results The incidence of ureteral injury was 0.093% (12/12868) in all cases, 0.42% (11/2586) in laparoscopic hysterectomy [laparoscopically assisted vaginal hysterectomy (LAVH) or total laparoscopic hysterectomy (TLH)], and 0.01% (1/10282) in non-LAVH surgeries. Enlarged uterus, pelvic adhesion, and endometrosis were risk factors associated with ureteral injury. Only one injury was found intraoperatively while others were found postoperatively. The injury sites were at the pelvic brim (2 cases) or the lower part of ureter (10 cases). Patients were treated with ureteral stenting (effective in 2 cases) or laparotomy and open repair. Prognoses were favorable in most cases. Conclusions Most laparoscopic ureteral injuries occur during laparoscopic hysterectomy. Further evaluation is required when ureteral injury is suspected, and surgical repair is the major treatment for ureteral injury. | Jin-song Gao Jin-hua Leng Zhu-feng Liu Keng Shen Jing-he Lang | 2007 | Chinese Medical Sciences Journal2007，22，1： | 9 |
| 12 | Helicobacter pylori acquisition of metronidazole resistance by natural transformation in vitro显示文摘INTRODUCTIONGenetictransformationisaprocesbywhichaceltakesupnakedDNAfromthesurroundingmediumandincorporatesitintoitsowngenomi... | HUA Jiesong 1, ZHENG Peng Yuan 1, Teo Keng Fong 1, Khin Mar Mar 2 and HO Bow 1 | 1998 | World Journal of Gastroenterology1998，4，5： | 8 |
| 13 | Comparison between peritoneal tuberculosis and primary peritoneal carcinoma: a 16-year, single-center experience显示文摘 | WANG Dan ZHANG Jun-ji HUANG Hui-fang SHEN Keng CUI Quan-cai XIANG Yang | 2012 | Chinese Medical Journal2012，，18： | 7 |
| 14 | Primary sarcoma of the ovary: clinicopathological characteristics, prognostic factors and evaluation of therapy显示文摘背景主要卵巢的肉瘤是很稀罕的恶意。这研究的目的是进一步与在 1988 和 2007 之间的 ovary.Methods 的主要肉瘤在病人调查 clinicopathologic 特征和结果,在北京联合医药医院经历了治疗的有主要卵巢的肉瘤的 24 个病人回顾地被考察。对治疗,前进和全面幸存的反应是 analyzed.Results 病人,卵巢的肉瘤有吝啬的年龄(54. | DAI Yi SHEN Keng LANG Jing-he HUANG Hui-fang PAN Ling-ya WU Ming YANG Jia-xin ZHONG Ding-rong | 2011 | Chinese Medical Journal2011，，9： | 6 |
| 15 | Clinicopathological analysis of mullerian adenosarcoma of the uterus显示文摘 | HAN Xiao-yan XIANG Yang GUO Li-na SHEN Keng WAN Xi-run HUANG Hui-fang PAN Ling-ya | 2010 | Chinese Medical Journal2010，，6： | 6 |
| 16 | Human CD34loCD133lo fetal liver cells support the expansion of human CD34hiCD133hi hematopoietic stem cells显示文摘 | Kylie Su Mei Yong Choong Tat Keng Shu Qi Tan Eva Loh Kenneth TE Chang Thiam Chye Tan Wanjin Hong Qingfeng Chen | 2016 | Cellular & Molecular Immunology2016，13，5： | 5 |
| 17 | Microencapsulation improves inhibitory effects of transplanted olfactory ensheathing cells on pain after sciatic nerve injury显示文摘Olfactory bulb tissue transplantation inhibits P2X2/3 receptor-mediated neuropathic pain. However, the olfactory bulb has a complex cellular composition, and the mechanism underlying the action of purified transplanted olfactory ensheathing cells(OECs) remains unclear. In the present study, we microencapsulated OECs in alginic acid, and transplanted free and microencapsulated OECs into the region surrounding the injured sciatic nerve in rat models of chronic constriction injury. We assessed mechanical nociception in the rat models 7 and 14 days after surgery by measuring paw withdrawal threshold, and examined P2X2/3 receptor expression in L4–5 dorsal root ganglia using immunohistochemistry. Rats that received free and microencapsulated OEC transplants showed greater withdrawal thresholds than untreated model rats, and weaker P2X2/3 receptor immunoreactivity in dorsal root ganglia. At 14 days, paw withdrawal threshold was much higher in the microencapsulated OEC-treated animals. Our results confirm that microencapsulated OEC transplantation suppresses P2X2/3 receptor expression in L4–5 dorsal root ganglia in rat models of neuropathic pain and reduces allodynia, and also suggest that transplantation of microencapsulated OECs is more effective than transplantation of free OECs for the treatment of neuropathic pain. | Hao Zhao Bao-lin Yang Zeng-xu Liu Qing Yu Wen-jun Zhang Keng Yuan Hui-hong Zeng Gao-chun Zhu De-ming Liu Qing Li | 2015 | Neural Regeneration Research2015，10，8： | 5 |
| 18 | Characterization of heavy petroleum fraction by positive-ion electrospray ionization FT-ICR mass spectrometry and collision induced dissociation: Bond dissociation behavior and aromatic ring architecture of basic nitrogen compounds显示文摘This paper examined the bond dissociation behavior and aromatic ring architecture of basic nitrogen compounds in Sudan heavy petroleum fraction. Both broadband and quadrupole isolation modes positive-ion electrospray ionization (ESI) Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) coupled with collision induced dissociation (CID) techniques were used to characterize a low sulfur crude oil derived vacuum residuum (VR). The appropriate CID operating condition was selected by comparing the molecular weight distributions of the basic nitrogen compounds under various CID operating conditions. Both oddand even-electron fragment ions were observed from the mass spectrum, indicating that the heterolytic and homolytic bond cleavages occurred simultaneously during the CID process. The odd-electron fragment ions were predominant in each class species, indicating preferential heterolytic bond cleavages. At the optimal CID condition, the alkyl groups decomposed deeply and just left the aromatic cores of the nitrogen compounds. No significant variation in double bond equivalent (DBE) value was observed between the fragment and parent ions, revealing that the domination of single core structure. | ZHANG LinZhou ZHANG YaHe ZHAO SuoQi XU ChunMing CHUNG Keng H. SHI Quan | 2013 | Science China Chemistry2013，56，7： | 5 |
| 19 | 转移性乳腺癌生存者应对方式的研究进展显示文摘阐述了应对的概念,介绍了国内外转移性乳腺癌生存者应对方式的特点、影响因素和干预方法,并提出对转移性乳腺癌生存者应对方式实践与研究的思考与展望。 | 郭奕嫱 鞠庆梅 尤渺宁 Azlina Yusuf 辛小林 李惠平 Soon Lean Keng | 2017 | 护理研究(中旬版)2017，31，1： | 5 |
| 20 | HIV/AIDS in Asia:The Shape of Epidemics and Their Molecular Epidemiology显示文摘The Asia-Pacific region is a home to 60% of the population in the world and to approximately one quarter of people with HIV/AIDS. Close to a million of people has been infected and a half million people died of AIDS annually in Asia,becoming the second largest epicenter of global AIDS epidemic. Molecular epidemiology has been useful tool to track a course of HIV spread. In-depth knowledge from the studies on molecular epidemiology elucidates the dynamics of HIV spread and the interrelationship of epidemics in the different regions in Asia. | Rie Uenishi Saiki Hase Tee Kok Keng Shigeru Kusagawa Yutaka Takebe | 2007 | Virologica Sinica2007，22，6： | 4 |
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