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| 1 | Recent advances in diagnostic upper endoscopy显示文摘BACKGROUND Esophageo-gastro-duodenoscopy(EGD)is an important procedure used for detection and diagnosis of esophago-gastric lesions.There exists no consensus on the technique of examination.AIM To identify recent advances in diagnostic EGDs to improve diagnostic yield.METHODS We queried the PubMed database for relevant articles published between January 2001 and August 2019 as well as hand searched references from recently published endoscopy guidelines.Keywords used included free text and MeSH terms addressing quality indicators and technological innovations in EGDs.Factors affecting diagnostic yield and EGD quality were identified and divided into the follow segments:Pre endoscopy preparation,sedation,examination schema,examination time,routine biopsy,image enhanced endoscopy and future developments.RESULTS We identified 120 relevant abstracts of which we utilized 67 of these studies in our review.Adequate pre-endoscopy preparation with simethicone and pronase increases gastric visibility.Proper sedation,especially with propofol,increases patient satisfaction after procedure and may improve detection of superficial gastrointestinal lesions.There is a movement towards mandatory picture documentation during EGD as well as dedicating sufficient time for examination improves diagnostic yield.The use of image enhanced endoscopy and magnifying endoscopy improves detection of squamous cell carcinoma and gastric neoplasm.The magnifying endoscopy simple diagnostic algorithm is useful for diagnosis of early gastric cancer.CONCLUSION There is a steady momentum in the past decade towards improving diagnostic yield,quality and reporting in EGDs.Other interesting innovations,such as Raman spectroscopy,endocytoscopy and artificial intelligence may have widespread endoscopic applications in the near future. | Jun-Liang Teh Asim Shabbir Soon Yuen Jimmy Bok-Yan So | 2020 | World Journal of Gastroenterology2020，26，4： | 15 |
| 2 | On Density-Based Data Streams Clustering Algorithms: A Survey显示文摘Clustering data streams has drawn lots of attention in the last few years due to their ever-growing presence. Data streams put additional challenges on clustering such as limited time and memory and one pass clustering. Furthermore, discovering clusters with arbitrary shapes is very important in data stream applications. Data streams are infinite and evolving over time, and we do not have any knowledge about the number of clusters. In a data stream environment due to various factors, some noise appears occasionally. Density-based method is a remarkable class in clustering data streams, which has the ability to discover arbitrary shape clusters and to detect noise. Furthermore, it does not need the number of clusters in advance. Due to data stream characteristics, the traditional density-based clustering is not applicable. Recently, a lot of density-based clustering algorithms are extended for data streams. The main idea in these algorithms is using densitybased methods in the clustering process and at the same time overcoming the constraints, which are put out by data stream's nature. The purpose of this paper is to shed light on some algorithms in the literature on density-based clustering over data streams. We not only summarize the main density-based clustering algorithms on data streams, discuss their uniqueness and limitations, but also explain how they address the challenges in clustering data streams. Moreover, we investigate the evaluation metrics used in validating cluster quality and measuring algorithms' performance. It is hoped that this survey will serve as a steppingstone for researchers studying data streams clustering, particularly density-based algorithms. | Amineh Amini Teh Ying Wah Hadi Saboohi | 2014 | Journal of Computer Science & Technology2014，29，1： | 9 |
| 3 | Elucidation of the ‘Honeycrisp’ pedigree through haplotype analysis with a multi-family integrated SNP linkage map and a large apple (Malus×domestica) pedigree-connected SNP data set显示文摘The apple(Malus×domestica)cultivar Honeycrisp has become important economically and as a breeding parent.An earlier study with SSR markers indicated the original recorded pedigree of‘Honeycrisp’was incorrect and‘Keepsake’was identified as one putative parent,the other being unknown.The objective of this study was to verify‘Keepsake’as a parent and identify and genetically describe the unknown parent and its grandparents.A multi-family based dense and high-quality integrated SNP map was created using the apple 8 K Illumina Infinium SNP array.This map was used alongside a large pedigree-connected data set from the RosBREED project to build extended SNP haplotypes and to identify pedigree relationships.‘Keepsake’was verified as one parent of‘Honeycrisp’and‘Duchess of Oldenburg’and‘Golden Delicious’were identified as grandparents through the unknown parent.Following this finding,siblings of‘Honeycrisp’were identified using the SNP data.Breeding records from several of these siblings suggested that the previously unreported parent is a University of Minnesota selection,MN1627.This selection is no longer available,but now is genetically described through imputed SNP haplotypes.We also present the mosaic grandparental composition of‘Honeycrisp’for each of its 17 chromosome pairs.This new pedigree and genetic information will be useful in future pedigree-based genetic studies to connect‘Honeycrisp’with other cultivars used widely in apple breeding programs.The created SNP linkage map will benefit future research using the data from the Illumina apple 8 and 20 K and Affymetrix 480 K SNP arrays. | Nicholas P Howard Eric van de Weg David S Bedford Cameron P Peace Stijn Vanderzande Matthew D Clark Soon Li Teh Lichun Cai James J Luby | 2017 | Horticulture Research2017，4，1： | 9 |
| 4 | 考虑不确定性扰动的含海量资源配电网弹性研究综述显示文摘分布式电源、微电网、储能装置等海量灵活资源接入配电网使得弹性配电网成为可能。然而,上述资源在协同抵御外界冲击、恢复电网正常运行方面的潜力有待进一步挖掘。配电网中,海量资源的时空深度耦合使得其结构与控制日趋复杂,源网荷任意侧的波动都可能引发连锁故障,影响配电网安全运行。为此,文中提出考虑不确定性扰动的含海量资源配电网弹性研究框架,将抵御外部灾害与平抑内部波动纳入研究范畴。首先,拓展配电网弹性内涵,总结配电网现有灵活资源,提出含海量资源高弹性配电网结构并对其特征进行分析;其次,分别从静态拓扑与动态响应角度提出结构弹性指标、系统弹性指标实现定量分析;然后,将不确定性扰动划分为外部冲击与内部波动,并提出配电网弹性研究框架,对其数据基础、理论支撑与弹性提升技术、应用场景进行了详细梳理与讨论;最后,对含海量资源高弹性配电网进行了展望。 | 苏译 Jiashen TEH 柏智 胡长华 吴芳榕 | 2022 | 电力系统自动化2022，46，16： | 8 |
| 5 | siRNA, miRNA and HIV: promises and challenges显示文摘Small interfering RNA (siRNA) and microRNA (miRNA) are small RNAs of 18-25 nucleotides (nt) in length that play important roles in regulating gene expression. They are incorporated into an RNA-induced silencing complex (RISC) and serve as guides for silencing their corresponding target mRNAs based on complementary base-pairing. The promise of gene silencing has led many researchers to consider siRNA as an anti-viral tool. However, in long-term settings, many viruses appear to escape from this therapeutical strategy. An example of this may be seen in the case of human immunodeficiency virus type-1 (HIV-1) which is able to evade RNA silencing by either mutating the siRNA- targeted sequence or by encoding for a partial suppressor of RNAi (RNA interference). On the other hand, because miRNA targeting does not require absolute complementarity of base-pairing, mutational escape by viruses from miRNA- specified silencing may be more difficult to achieve. In this review, we discuss stratagems used by various viruses to avoid the cells’ antiviral si/mi-RNA defenses and notions of how viruses might control and regulate host cell genes by encoding viral miRNAs (vmiRNAs). | Man Lung YEUNG Yamina BENNASSER Shu Yun LE Kuan Teh JEANG | 2005 | Cell Research2005，15，11： | 7 |
| 6 | Leptin in hepatocellular carcinoma显示文摘The risk factors for hepatocellular carcinoma (HCC) development have been established,and include chronic hepatitis B and C,heavy alcohol consumption,and aflatoxins.In fact,5%-30% of patients with HCC still lack a readily identifiable risk factor.It has been reported that the majority of 'cryptogenic' HCC may be attributed to nonalcoholic fatty liver disease,the hepatic presentation of the metabolic syndrome (MS).Obesity is associated with the development of the MS.Recently,adipose tissue has been considered as an endocrine organ because of its capacity to secrete a variety of cytokines,which are collectively known as the adipokines.Leptin,the product of the obese gene,is mainly produced by adipose tissue.Since leptin was first characterized in 1994,accumulated literature has demonstrated the involvement of this adipokine in several areas of human physiology.After binding to its receptor,leptin initiates a cascade of signaling events and subsequent cellular effects.In addition to being the regulatory mediator of energy homeostasis,several in vitro studies have demonstrated the fibrogenic role of leptin in the liver.Furthermore,the deregulated expression of leptin and its receptor have been demonstrated to be associated with a variety of metabolic disorders as well as human cancers.Most importantly,direct evidence supporting the inhibitory and/or activating role of leptin in the process of carcinogenesis and progression of human HCC has been accumulating rapidly.This review aims to provide important insights into the potential mechanisms of leptin in the development of HCC.Hopefully,further investigations will shed light on a new therapeutic target in HCC. | Shen-Nien Wang King Teh Lee Chen-Guo Ker | 2010 | World Journal of Gastroenterology2010，16，46： | 7 |
| 7 | Influence of grain size on strength of polymineralic crystalline rock: New insights from DEM grain-based modeling显示文摘Grain size effect on rock strength is a topic of great interest in geotechnical engineering.A consensus obtained from earlier laboratory tests is that rock strength generally decreases with the increase of grain size for both silicate and carbonate rocks;however,some recent numerical results conflict with such laboratory test results.To address this intriguing issue,the effect of grain size on strength of polymineralic crystalline rock with low porosity is investigated numerically using the grain-based modeling(GBM)approach in discrete element method(DEM)by interpreting micro-cracking process in response to loading.In agreement with some previous DEM simulation results,the simulated rock strength is found to increase with increasing grain size for both homogeneous and heterogeneous models,even when the number of assembled disks in one mineral grain changes.The mechanism of strength increase with increasing grain size is mainly associated with the number of assembled smooth-joint contacts along grain interfaces and the generation of grain boundary cracks in response to loading.The grain interfaces significantly weaken the integrity of the rock model,which is similar to effects of inherent defects in real rock.As the grain size increases,fewer grain interfaces are built in the model and the rock strength becomes much higher.Hence,by solely changing the mineral grain size in a model,the mechanism of grain size effect as observed in laboratory tests cannot be replicated.To address this issue,a method of degradation of grain boundary strength parameters is used to mimic the possible mechanism of grain size effect.The simulated strength using the method becomes comparable with those obtained from laboratory tests when the heterogeneity in the rock is considered.Degradation of grain boundary parameters with increasing grain size provides a plausible explanation for the grain size effect on rock strength. | Jun Peng Louis Ngai Yuen Wong Cee Ing Teh | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，4： | 6 |
| 8 | The Classical and Regulatory Functions of C1q in Immunity and Autoimmunity显示文摘A classical function of C1q is to bind immune complexes and initiate complement activation producing membrane lytic complexes,opsonins and anaphylatoxins. This classical pathway of complement activation is also elicited when C1q binds some other ligands. Besides complement activation,C1q also regulates cell differentiation,adhesion,migration,activation and survival. C1q deficiency is associated with autoimmunity as well as increased susceptibility to infections. In this article,we discuss the basic properties of C1q,its expression,and classical and regulatory functions. | Jinhua Lu Boon King Teh Linda Wang Yinan Wang Yen Seah Tan Min Chern Lai Kenneth B. M. Reid | 2008 | Cellular & Molecular Immunology2008，5，1： | 5 |
| 9 | 智慧促进健康,健康利增智慧——智慧健康引领医药卫生事业发展显示文摘智慧健康是将人类的智慧应用于人民的健康,将智慧含有的综合知识、技能、思想、方法、仪器、设备、材料等应用于健康事业,应用于药物开发、医疗保健、疾病诊治、养生康复、卫生防疫等诸多方面,并产生前所未有的高效,较为轻松、容易、方便、灵活地实现人类的健康目标。为了加速健康事业的快速发展,当代'智慧健康'研究领域引入了人工智能系统,集合了医学、药学、保健、信息、网络、计算机、远程通信、信号处理等多学科的知识、技能、技术、设备,构成了'智慧健康'的统一体与集约化。智慧地感知、智慧地运用、智慧地运作、智慧地管理、智慧地互动等,已经成为'智慧健康'的基石,具体表现在智能化采集健康信息,智能处理、应用健康知识与健康信息,形成健康的智能决策过程,应用网络和计算机等现代技术,建立起健康资源与健康需求联系的通道,形成云服务系统。在智慧健康条件下,人们可以利用这些互联网和远程通讯设备,多渠道获得更多的卫生保健知识,提高预防疾病和治疗疾病的水平。在智慧健康的时代,可望破解'看病难'、'看病贵'的社会难题。有了智慧健康,社会人群的个性化需求也较易实现,能更好地满足特殊需求,实现医疗服务的多样性和层次性。卫生服务与信息科技紧密结合,将共同为医药产业的发展指路领航。运用智慧健康的思路和方法研究中西医和中西药,寻觅二者之间物质基础的共同点,实现中西药理论会通,为中医药现代化、中西医结合、中西药会通等研究探寻出路,寻找突破方向。 | 王兴华 王光耀 盛良 汪宇 Te Kian Keong Teh Siew Hoon Ooi Ciat Hui | 2015 | 智慧健康2015，1，1： | 4 |
| 10 | Abscisic acid perception and signaling: structura mechanisms and applications显示文摘不利环境条件是对农业产量的威胁因此在生计,健康和经济上施加全球效果。Abscisic 酸(骆驼毛的织物) 是调整不能生活的压力忍耐的重要植物荷尔蒙,从而允许种应付环境压力。以前,试图开发发信号的内在的骆驼毛的织物被困难在真正的骆驼毛的织物受体的鉴定妨碍了的机制的完全的理解。骆驼毛的织物受体的 PYR/PYL/RCAR 家庭的发现因此在克服这些障碍的努力代表了一个主要里程碑;从那以后,许多结构、功能的研究提供了详细卓见进从骆驼毛的织物感觉到骆驼毛的织物应答的基因抄写的激活的过程。这理解骆驼毛的织物感觉的机制并且发信号在压力抵抗的庄稼的遗传工程以及在新合成骆驼毛的织物收缩筋的设计用作最近的、初步的开发的基础,它为应力公差的农业改进保持大诺言。 | Ley Moy NG Karsten MELCHER Bin Tean TEH H Eric XU | 2014 | Acta Pharmacologica Sinica2014，35，5： | 4 |
| 11 | HOXA7在口腔鳞状细胞癌组织中的表达及临床意义显示文摘目的研究同源盒基因A7(homeobox protein hox-A7,HOXA7)mRNA在口腔鳞状细胞癌组织(oral squamous cell carcinoma,OSCC)中的表达。方法收集20例口腔正常粘膜组织及42例OSCC组织,利用实时荧光定量聚合酶链反应(real-time quantitative program control register,Real-Time q PCR)检测HOXA7mRNA的相对表达情况。结果对比口腔黏膜组织,HOXA7mRNA在OSCC中高表达(z=-5.739,P<0.050),不同分化程度(z=-0.863,P<0.05),不同临床分期(z=-0.756,P<0.05),组间差异有统计学意义。不同年龄(z=-0.619,P>0.05)、不同性别(z=-1.801,P>0.05),组间差异无统计学意义。结论 HOXA7mRNA在口腔鳞状细胞癌组织中高表达,并且与肿瘤分化和临床分期有关,HOXA7可能作为口腔癌治疗和口腔鳞癌早期诊断的潜在生物标记物。 | 陈浩 段晓峰 朴正国 欧阳可雄 Muy-Teck Teh 马洪 | 2017 | 贵州医药2017，41，9： | 3 |
| 12 | A Mini Review: Can Graphene Be a Novel Material for Perovskite Solar Cell Applications?显示文摘Perovskite solar cells(PSCs) have raised research interest in scientific community because their power conversion efficiency is comparable to that of traditional commercial solar cells(i.e., amorphous Si, GaAs,and CdTe). Apart from that, PSCs are lightweight, are flexible, and have low production costs. Recently, graphene has been used as a novel material for PSC applications due to its excellent optical, electrical, and mechanical properties. The hydrophobic nature of graphene surface can provide protection against air moisture from the surrounding medium, which can improve the lifetime of devices. Herein, we review recent developments in the use of graphene for PSC applications as a conductive electrode,carrier transporting material, and stabilizer material. By exploring the application of graphene in PSCs, a new class of strategies can be developed to improve the device performance and stability before it can be commercialized in the photovoltaic market in the near future. | Eng Liang Lim Chi Chin Yap Mohammad Hafizuddin Hj Jumali Mohd Asri Mat Teridi Chin Hoong Teh | 2018 | Nano-Micro Letters2018，10，2： | 3 |
| 13 | 提升医学生人文关怀和医患沟通能力的技巧与方法显示文摘为了提升人文关怀和医患沟通的能力,医学生需要加强人文精神熏陶,要学会尊重患者、倾听患者、主动关心患者;学会使用通俗语言解说医学术语,细心观察病情,发现问题及时沟通。对于某些复杂的疾病,可以借助实物或影像资料向患者予以演示和解说。良好的人文关怀与医患沟通,有利于医患合作。本文给出了具体例证,并加以演示和分析。 | 王光耀 王兴华 马勇 吕新华 杨海霞 Teh Siew Hoon Goh Sze Chin Wang Zhi Hang | 2021 | 叙事医学2021，4，3： | 3 |
| 14 | 运用电子鼻检测活血化瘀中药物质基础研究显示文摘目的探讨具有相同功效的中药材是否具有共同的物质基础,运用电子鼻能否对中药的药性进行初步量化。方法运用电子鼻检测常用具有活血化瘀功效的12种中药材,分析其PCA图和特征指纹图谱的相似性,并通过差异指数和判别指数对其作用作进一步说明。结果检测的12种具有活血化瘀功效的中药材具有相似的PCA图和特征指纹图谱。结论 12种活血化瘀的中药具有共同的物质基础。 | 王光耀 盛良 王兴华 汪宇 Te Kian Keong Teh Siew Hoon Ooi Ciat Hui | 2015 | 智慧健康2015，1，1： | 3 |
| 15 | Two-stage Optimal Dispatching of AC/DC Hybrid Active Distribution Systems Considering Network Flexibility显示文摘The increasing flexibility of active distribution systems(ADSs)coupled with the high penetration of renewable distributed generators(RDGs)leads to the increase of the complexity.It is of practical significance to achieve the largest amount of RDG penetration in ADSs and maintain the optimal operation.This study establishes an alternating current(AC)/direct current(DC)hybrid ADS model that considers the dynamic thermal rating,soft open point,and distribution network reconfiguration(DNR).Moreover,it transforms the optimal dispatching into a second-order cone programming problem.Considering the different control time scales of dispatchable resources,the following two-stage dispatching framework is proposed.d dispatch uses hourly input data with the goal(1)The day-ahea of minimizing the grid loss and RDG dropout.It obtains the optimal 24-hour schedule to determine the dispatching plans for DNR and the energy storage system.(2)The intraday dispatch uses 15-min input data for 1-hour rolling-plan dispatch but only executes the first 15 min of dispatching.To eliminate error between the actual operation and dispatching plan,the first 15 min is divided into three 5-min step-by-step executions.The goal of each step is to trace the tie-line power of the intraday rolling-plan dispatch to the greatest extent at the minimum cost.The measured data are used as feedback input for the rolling-plan dispatch after each step is executed.A case study shows that the comprehensive cooperative ADS model can release the line capacity,reduce losses,and improve the penetration rate of RDGs.Further,the two-stage dispatching framework can handle source-load fluctuations and enhance system stability. | Yi Su Jiashen Teh | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，1： | 3 |
| 16 | Genotypes and Viremia of Hepatitis B and D Viruses Are Associated With Outcomes of Chronic Hepatitis D Patients显示文摘 | Chien–Wei Su Yi–Hsiang Huang Teh–Ia Huo Hsuan Hui Shih I–Jane Sheen Su–Wen Chen Pui–Ching Lee Shou–Dong Lee Jaw–Ching Wu | 2006 | Gastroenterology2006，，6： | 3 |
| 17 | Hepatic resection of hepatocellular carcinoma in patients with cirrhosis: Model of end-stage liver disease (MELD) score predicts perioperative mortality显示文摘 | Swee H. Teh John Christein John Donohue Florencia Que Michael Kendrick Michael Farnell Stephen Cha Patrick Kamath Raymond Kim David M. Nagorney | 2005 | Journal of Gastrointestinal Surgery2005，，9： | 2 |
| 18 | 蛋白质组学研究的原理、技术与应用显示文摘蛋白质组包括细胞或生物所表达的全部蛋白质,蛋白质组学是在大规模水平上研究蛋白质的特征,包括蛋白质的表达水平、翻译后的修饰、蛋白与蛋白之间的相互作用等。借以探析生命活动的生理基础及其内在规律,了解疾病发生、发展与细胞代谢过程,在蛋白质水平上获得整体而全面的认识,它是蛋白质(多肽)谱研究以及基因产物图谱研究的进一步延伸。蛋白质组学的核心技术是双向电泳、质谱及生物信息学,相关技术还涉及相对和绝对定量同位素标记、蛋白质芯片,多维色谱等。已被广泛应用于生命科学研究的诸多领域,尤其是癌症等危害人类较大的疾病防治,受到越来越多的关注。 | 王兴华 王光耀 Te Kian Keong Teh Siew Hoon Ooi Ciat Hui 叶儒佳 王智航 | 2016 | 智慧健康2016，2，4： | 2 |
| 19 | Zingiber zerumbet (L.) Smith: A Review of Its Ethnomedicinal, Chemical, and Pharmacological Uses显示文摘 | N. J. Yob S. Mohd. Jofrry M. M. R. Meor. Mohd. Affandi L. K. Teh M. Z. Salleh Z. A. Zakaria | 2011 | Evidence-Based Complementary and Alternative Medicine2011，，： | 2 |
| 20 | Identification of Molecular Subtypes of Gastric Cancer with Different Responses to PI3-Kinase Inhibitors and 5-Fluorouracil显示文摘 | Zhengdeng Lei Iain Beehuat Tan Kakoli Das Niantao Deng Hermioni Zouridis Sharon Pattison Clarinda Chua Zhu Feng Yeoh Khay Guan Chia Huey Ooi Tatiana Ivanova Shenli Zhang Minghui Lee Jeanie Wu Anna Ngo Sravanthy Manesh Elisabeth Tan Bin Tean Teh Jimmy Bok | 2013 | Gastroenterology2013，，： | 2 |
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