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| 1 | Design and 3D Printing of Scaffolds and Tissues显示文摘A growing number of three-dimensional(3D)-print- ing processes have been applied to tissue engineering. This paper presents a state-of-the-art study of 3D-printing technologies for tissue-engineering applications, with particular focus on the development of a computer-aided scaffold design system; the direct 3D printing of functionally graded scaffolds; the modeling of selective laser sintering(SLS) and fused deposition modeling(FDM) processes; the indirect additive manufacturing of scaffolds, with both micro and macro features; the development of a bioreactor; and 3D/4D bioprinting. Technological limitations will be discussed so as to highlight the possibility of future improvements for new 3D-printing methodologies for tissue engineering. | Jia An Joanne Ee Mei Teoh Ratima Suntornnond Chee Kai Chua | 2015 | Engineering2015，1，2： | 21 |
| 2 | Effect of L-NAME on nitric oxide and gastrointestinal motility alterations in cirrhotic rats显示文摘AIM: To invsstigare the effect of L-NAME on nitric oxide andgastriubtestubal motility alterations in cirrhotic ratsMETHODS: Rats with cirrhosis induced by carbontetrachloride were randomly divided into two groups, one( n= 13) receiving 0. 5 mg@ kg-1 per clay of NG-nitro-L-argininemethyl ester (L-NAME), a nitric oxide synthase inhibitor,for 10 days, whereas the other group ( n = 13) and control( n = 10) rats were administrated the same volume of 9 g@ L-1saline.Half gastric emptying time and 2 h residual rate weremeasured by SPECT, using 99m Tc-DTPA-labeled bariumsuifate as test meal. Gastrointestinal transition time wasrecorded simultaneously. Serum concentration of nitrcoxide (NO) was determined by the kinetic cadmiunreduction and colorimetric methods. ImmunohistochemicalSABC method was used to observe the expression anddistribution of three types of nitric oxide synthase (NOS)isoforms in the mt gastrointestinal tract. Western blot wasused to detect expression of gastrointestinal NOS isoforms.RESULTS: Half gastric emptying time and trans-gastrointestinal time were significantly prolonged( 124.0 ± 26.4min; 33.7± 8.9min;72.1 ± 15.3 min; P<0.01), (12.4±0.5h; 9.5±0.3 h; 8.2±0.8 h; P<0.01), 2h residual rate wasraised in cirrhotic rots than in controls and cirrhotic ratstreated with L-NAME(54.9± 7.6 % ,13.7 ± 3.2 %, 34.9± 10.3%, P< 0.01). Serum concentration of NO was significantlyincreased in cirrhotic rots than in the other groups (8.20 ± 2.48)μmol@L-1, (5.94± 1.07) μmol@L-1 ,and control (5.66± 1.60) tμmol@L-1, P< 0.01. NOS staining intensities which weremainly located in the gastrointestinal tissues were markedlylower in cirrhotic rats than in the controls and cirrhotic ratsafter treated with L- NAME.CONCLUSION: Gastrointestinal motility was remarkablyinhibited in cirrhotic rats, which could he alleviated by L-NAME. Nitric oxide may play an important role in theinhibition of gastrointestinal motility in cirrhotic rats. | Xin Wang Zong-You Zhang Mei Lan Ji-Yan Miao Xue-Gang Guo Yong-Quan Shi Yan-Qiu Zhao Jie Ding Kai-Cun Wu Dai-Ming Fan,Institute of Digestive disease,Xijing Hospital,Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China Yue-Xia Zhong,Emergency Department,Tangdu Hospital,Fourth Military Medical University,Xi’an 710038,Shaanxi Province,China Ju Lu,Class EE 87,Department of Electronic Engineering,Tsinghua University,Beijing 100084,China Bo-Rong Pan,Oncology Center,Xijing Hospital,Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China | 2002 | World Journal of Gastroenterology2002，8，2： | 19 |
| 3 | 非维生素K拮抗与维生素K拮抗口服抗凝剂与脑出血患者住院死亡之间的关系显示文摘尽管非维生素K拮抗口服抗凝剂(non-vitamin K antagonist oral anticoagulants, NOACs)越来越多地应用于预防血栓栓塞性疾病,但关于NOACs相关性脑出血的数据仍然有限。 | 刘青 叶鹏 Inohara T Xian Y Liang L Matsouaka RA Saver JL Smith EE Schwamm LH Reeves MJ Hernandez AF Bhatt DL Peterson ED Fonarow GC | 2018 | 中华高血压杂志2018，26，2： | 16 |
| 4 | 腹腔镜胃袖套状切除减肥术(附1例报告)显示文摘目的:探讨腹腔镜胃袖套状切除术(laparoscopic sleeve gastrectomy,LSG)的减肥效果、术后并发症及其在临床中的应用。方法:分析2006年12月我院1例病态肥胖患者行腹腔镜胃袖套状切除术的临床资料。结果:该例病态肥胖患者行腹腔镜胃袖套状切除术后减重明显,无头晕、乏力等身体不适,未出现胃肠功能紊乱、营养障碍等并发症。结论:腹腔镜胃袖套状切除术是安全可行的,具有减重效果明显、并发症少等优点,可作为病态肥胖患者的理想手术方式。 | 胡三元 Frezza EE 李峰 陈波 | 2007 | 腹腔镜外科杂志2007，12，5： | 15 |
| 5 | 溶栓时间(入院到用药时间)的延迟及其对脑卒中治疗时间与预后的影响显示文摘尽管美国心脏协会/美国脑卒中协会关于脑卒中的治疗均提出了倡议,大量急性缺血性脑卒中患者仍然在到达就诊60min后才开始启动组织型纤溶酶原激活剂(阿替普酶)溶栓治疗。该研究旨在描述延迟的原因及其与患者预后之间的关系。 | 刘莉 叶鹏 Kamal N Sheng S Xian Y Matsouaka R Hill MD Bhatt DL Saver JL Reeves MJ Fonarow GC Schwamm LH Smith EE | 2017 | 中华高血压杂志2017，25，4： | 15 |
| 6 | 非饱和土弹塑性应力应变特性模拟显示文摘简单地回顾了非饱和土应力应变本构模型的研究概况,就非饱和膨胀性土、黄土和击实土等的变形特性作简介。在此基础上,根据硬化塑性理论和临界状态概念,提出了一个描述非饱和土应力应变特性的一般本构理论框架。该理论框架包含了几个不同的模型。 | Alon.,EE 杨代泉 | 1995 | 岩土工程学报1995，17，6： | 13 |
| 7 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 8 | 聚乙烯醇及磷酸酯气相润滑下氮化硅的磨损特性研究显示文摘采用球-三盘磨损试验机在370℃,聚乙烯醇及磷酸三甲苯基酯气相润滑下研究了Si3N4与M50工具钢对磨时的磨损特性.结果表明:在气相润滑下聚乙烯醇可以有效地降低Si3N4的磨损;在聚乙烯醇中添加少量的三甲苯基磷酸酯可以进一步降低Si3N4的磨损.X射线光电子能谱分析发现,Si3N4的摩擦表面形成了主要由元素碳、氧和磷组成的固体润滑膜,Si3N4发生了氧化并生成了SiO2和—SiNO等化合物,而三甲苯基磷酸酯则在摩擦过程中发生了降解. | 刘维民 Klaus,EE | 1998 | 摩擦学学报1998，18，2： | 10 |
| 9 | 吉非替尼结合化放疗治疗局部晚期头颈癌显示文摘该文旨在评价表皮生长因子受体抑制剂吉非替尼结合同期放化疗治疗局部晚期头颈癌(LA—HNC)的效果及毒性.研究治疗效果和EGFR基因拷贝数目的关系。方法:Ⅲ-Ⅳ期LA—HNC患者先行卡铂及紫杉醇诱导化疗,再给以5-FU及羟基脲(FHX)同期放化疗。同时给以吉非替尼,持续2a。初步疗效终点为肿瘤临床CR。EGFR基因的拷贝数应用荧光原位杂交确定。 | Cohen EE Haraf DJ Kunnavakkam R | 2010 | 中国口腔颌面外科杂志2010，8，4： | 10 |
| 10 | 中国基层医疗二型糖尿病人中阳痿的普遍性,相互关联,患者态度和寻求治疗的行为显示文摘本研究探讨在基层医疗二型糖尿病人中,阳痿的普遍性、相互关联、患者态度和寻求治疗的行为。我们将一份结构性匿名自填问卷发放到十所普通科门诊诊所进行横断性调查。在603位参与者(91%回应率)中,以国际勃起功能指数(iief)作定义之阳痿的普遍性为79.1%。多数参与者患轻度阳痿(28.9%),随后为轻至中度阳痿(27.9%)、中度阳痿(13.4%)及严重阳痿(9%)。接近55%的阳痿患者并不自觉患有此症。少于10%的患者曾寻求医生治疗,76.1%的参与者表示若被确诊为阳痿,会期望得到医生治理。他们认为最重要的医生治理是临床评估(41.7%),其次是治理潜在因素(37.8%)、转介专科医生(27.5%)、教育(23.9%)、处方磷酸二酯酶5型抑制剂(16.9%),及转介辅导服务(6.7%)。与诊断阳痿最密切关联的因素是自觉患有阳痿(OR=90.49(20.00—409.48,P〈0.001))、以及较年长的组别(OR=1.043(1.011-1.076,P=0.008))。总体而言,阳痿在二型糖尿病人中非常普遍。其中大部分病人如患上阳痿都希望得到医生救治,但只有少数会真正提出此要求。建议医护人员使用结构性问卷筛选二型糖尿病人中的阳痿患者,有助于找出未被诊断的阳痿个案。 | Wai Hon Lo Sau Nga Fu Carlos King Ho Wong Ee San Chen | 2014 | Asian Journal of Andrology2014，16，5： | 8 |
| 11 | 生物技术的好处——以美国为例——孟山都的经验显示文摘十多年来,孟山都人致力于开发和推广用遗传工程方法改良的新的作物品种。在这一阶段里,已积累了涉及生物技术的科研、开发、管理(审批)、市场验证等各方面的经验。经过长期艰苦的工作,孟山都公司已将早期研究的阶段性成果经过田间实验、种子生产阶段,到现在形成了商... | 陈笑瑜 Debu.,EE | 1999 | 生物技术通报1999，15，1： | 7 |
| 12 | A review on photo-thermal catalytic conversion of carbon dioxide显示文摘The conversion of carbon dioxide into value-added products is of great industrial and environmental interest. However, as carbon dioxide is relatively stable, the input energy required for this conversion is a significant limiting factor in the system's performance. By utilising energy from the sun, through a range of key routes, this limitation can be overcome. In this review, we present a comprehensive and critical overview of the potential routes to harvest the sun's energy, primarily through solar-thermal technologies and plasmonic resonance effects. Focusing on the localised heating approach, this review shortlists and compares viable catalysts for the photo-thermal catalytic conversion of carbon dioxide.Further, the pathways and potential products of different carbon dioxide conversion routes are outlined with the reverse water gas shift,methanation, and methanol synthesis being of key interest. Finally, the challenges in implementing such systems and the outlook to the future are detailed. | Ee Teng Kho Tze Hao Tan Emma Lovell Roong Jien Wong Jason Scott Rose Amal | 2017 | Green Energy & Environment2017，2，3： | 7 |
| 13 | Estrogen deficiency leads to telomerase inhibition, telomere shortening and reduced cell proliferation in the adrenal gland of mice显示文摘雌激素缺乏调停变老,但是内在的机制尚待充分坚定。我们这里报导 aromatase 的指向的混乱在老鼠引起的雌激素缺乏在 vivo 在肾上腺导致 telomerase 活动的重要抑制。基因表示分析证明当雌激素不在时, telomerase 颠倒 transcriptase (TERT ) 基因表示在肾上腺外皮和肾的萎缩与损害房间增长联合被减少。在 c 工具包积极的干细胞被识别在肾的外皮的实质占据。telomeres 的分析表明那雌激素缺乏比那在肾的外皮导致显著地更短的 telomeres 在野类型(WT ) 控制鼠标。为了推进,建立雌激素的原因的效果,我们在这些雌激素缺乏的动物进行了雌激素代替治疗。为 3 个星期的雌激素的管理在雌激素缺乏的老鼠恢复 TERT 基因表示, telomerase 活动和房间增长。因此,我们第一次,那雌激素缺乏在 vivo 在鼠标的肾上腺引起 TERT 基因表示, telomerase 活动, telomere 维护,和房间增长的抑制的数据表演,建议那 telomerase 抑制并且 telomere 弄短可以调停在肾上腺的房间增长拘捕,因此贡献雌激素在生理的条件下面的导致缺乏的老化。 | Sharyn Bayne Margaret EE Jones He Li Alex R Pinto Evan R Simpson Jun-Ping Liu | 2008 | Cell Research2008，18，11： | 6 |
| 14 | China’s Changing Economic Structure and Implications for Regional Patterns of Trade,Production and Integration显示文摘Without intending to do so, China has in recent years played a major role in East Asia’s economic integration. It has done so mainly through the production and supply chain networks it has spun across the region. This paper argues that given the developmental trends in the Chinese economy, the Chinese government should pursue a more active strategy towards a broader and more balanced economic integration with the region. The emergence of a multi-track production structure, increased importance of domestic consumption and the services sector, together with faster integration of the domestic economy, will fundamentally change China’s trade and investment relationships with the rest of East Asia and necessitate a review of China’s economic integration strategy. The paper also argues that ASEAN can play a useful role in facilitating the region-wide integration process. | Kim Song Tan Hoe Ee Khor | 2006 | China & World Economy2006，14，6： | 5 |
| 15 | Gorenstein平坦模显示文摘 | Enoc.,EE Jen.,OMG | 1993 | 南京大学学报(数学半年刊)1993，10，1： | 5 |
| 16 | 缺血性脑卒中患者血压与住院临床结局的相关性显示文摘高血压是脑卒中的主要危险因素。研究表明,在缺血性脑卒中患者中,由于压力依赖性的脑血液流向缺血区域,脑卒中后高血压有益。然而,其他研究显示,脑卒中后的高血压与短期再发性脑卒中、脑出血性转化和脑水肿发生率升高有关。关于血压与脑卒中短期临床结局相关性的观察性研究结论相互矛盾。此外,关于血压的搏动组分(脉压)或稳定组分(平均动脉压)与临床结局相关性的数据有限。 | Bangalore S Schwamm L Smith EE Hellkamp AS Suter RE Xian Y Schulte PJ Fonarow GC Bhatt DL 练桂丽 叶鹏 | 2017 | 中华高血压杂志2017，25，11： | 5 |
| 17 | Intracellular interferon signalling pathways as potential regulators of covalently closed circular DNA in the treatment of chronic hepatitis B显示文摘250 million people worldwide continue to be chronically infected with the virus.While patients may be treated with nucleoside/nucleotide analogues,this only suppresses HBV titre to sub-detection levels without eliminating the persistent HBV covalently closed circular DNA(cccDNA)genome.As a result,HBV infection cannot be cured,and the virus reactivates when conditions are favorable.Interferons(IFNs)are cytokines known to induce powerful antiviral mechanisms that clear viruses from infected cells.They have been shown to induce cccDNA clearance,but their use in the treatment of HBV infection is limited as HBVtargeting immune cells are exhausted and HBV has evolved multiple mechanisms to evade and suppress IFN signalling.Thus,to fully utilize IFN-mediated intracellular mechanisms to effectively eliminate HBV,instead of direct IFN administration,novel strategies to sustain IFN-mediated anti-cccDNA and antiviral mechanisms need to be developed.This review will consolidate what is known about how IFNs act to achieve its intracellular antiviral effects and highlight the critical interferon-stimulated gene targets and effector mechanisms with potent anti-cccDNA functions.These include cccDNA degradation by APOBECs and cccDNA silencing and transcription repression by epigenetic modifications.In addition,the mechanisms that HBV employs to disrupt IFN signalling will be discussed.Drugs that have been developed or are in the pipeline for components of the IFN signalling pathway and HBV targets that detract IFN signalling mechanisms will also be identified and discussed for utility in the treatment of HBV infections.Together,these will provide useful insights into design strategies that specifically target cccDNA for the eradication of HBV. | Zhi Yi Goh Ee Chee Ren Hui Ling Ko | 2021 | World Journal of Gastroenterology2021，27，14： | 5 |
| 18 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 19 | Wash water in waterworks:contaminants and process options for reclamation显示文摘Reclamation of clean water from filter backwash water was studied through pilot-scale experiments.The pilot plant consisted of clarification,sand-filtration,and ultrafiltration modules in sequence,with a provision to bypass the sand filter.Clean water that conformed to World Health Organization (WHO) guidelines on Potable Quality was reclaimed.Turbidity,aluminum and iron were found to be critical contaminants in process selection and design.Clarification,followed by sand filtration,was found to be the minimum requirement for recycling filter backwash.However,membrane filtration would enhance reclaimed water quality as the membrane acts as an additional barrier against Giardia and Cryptosporidium. | C B Chidambara Raj Tan Ee Kwong Soh Hoo Tiong Paul Stefan Klose | 2008 | Journal of Environmental Sciences2008，20，11： | 4 |
| 20 | 阿片剂量递增对疼痛强度的影响:一项回顾性队列研究显示文摘开具处方的医师常需面临这样的决策:是否需要增加阿片类药物的剂量,以达到足够的镇痛效果。因此了解剂量增加对疼痛强度的影响是必要的。本文作者采用回顾性队列研究设计,确定患有慢性疼痛并使用慢性阿片类药物长期治疗的退伍军人,阿片类药物剂量逐渐递增。在连续2个6个月的窗口期,将平均毫克当量日剂量增加吗啡20%与维持剂量组(吗啡平均毫克当量日剂量变化±20%)进行比较。疼痛强度采用数字评分法(NRS)进行测量。主要分析使用线性重复测量模型,在1:1剂量增加和剂量维持的样本匹配的倾向评分和在指数日期的±180天。敏感性分析采用调整的线性重复测量模型进行,并在模型中加入或不加入稳定的处理权重逆概率。尽管在随访期间NRS疼痛评分存在一致的显著差异,但差异幅度不大,随着时间的推移,NRS疼痛评分的这些差异并无明显的临床意义。敏感性分析提供了与主要分析相似的结果。表明阿片类药物剂量的增加与疼痛的改善无关,无论当前剂量如何,临床医师应仔细评估增加阿片类药物剂量的必要性。在确定是否逐步增加剂量时,决策重心应更多地集中在其他潜在获益和风险之间,而并非集中于改善疼痛强度。 | Hayesa CJ Krebsc EE Hudsona T 黑光(译) 马柯(校) | 2020 | 中国疼痛医学杂志2020，26，10： | 3 |
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