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| 1 | State-of-the-art review of soft computing applications in underground excavations显示文摘Soft computing techniques are becoming even more popular and particularly amenable to model the complex behaviors of most geotechnical engineering systems since they have demonstrated superior predictive capacity,compared to the traditional methods.This paper presents an overview of some soft computing techniques as well as their applications in underground excavations.A case study is adopted to compare the predictive performances of soft computing techniques including eXtreme Gradient Boosting(XGBoost),Multivariate Adaptive Regression Splines(MARS),Artificial Neural Networks(ANN),and Support Vector Machine(SVM) in estimating the maximum lateral wall deflection induced by braced excavation.This study also discusses the merits and the limitations of some soft computing techniques,compared with the conventional approaches available. | Wengang Zhang Runhong Zhang Chongzhi Wu Anthony Teck Chee Goh Suzanne Lacasse Zhongqiang Liu Hanlong Liu | 2020 | Geoscience Frontiers2020，11，4： | 33 |
| 2 | Design and 3D Printing of Scaffolds and Tissues显示文摘A growing number of three-dimensional(3D)-print- ing processes have been applied to tissue engineering. This paper presents a state-of-the-art study of 3D-printing technologies for tissue-engineering applications, with particular focus on the development of a computer-aided scaffold design system; the direct 3D printing of functionally graded scaffolds; the modeling of selective laser sintering(SLS) and fused deposition modeling(FDM) processes; the indirect additive manufacturing of scaffolds, with both micro and macro features; the development of a bioreactor; and 3D/4D bioprinting. Technological limitations will be discussed so as to highlight the possibility of future improvements for new 3D-printing methodologies for tissue engineering. | Jia An Joanne Ee Mei Teoh Ratima Suntornnond Chee Kai Chua | 2015 | Engineering2015，1，2： | 21 |
| 3 | 澳大利亚精神卫生主流服务模式介绍显示文摘墨尔本大学ST Vincent's精神卫生部承担着西太平洋地区国家的精神卫生服务人员的培训,中国也曾多次派出专业人员接受过社区精神卫生服务的训练。由于培训时间的限制,有些学员对一些问题尚有不清楚之处,因此,本文试图对澳大利亚维多利亚州的主流精神卫生服务模式做一介绍,以其惠及国内更多的精神卫生服务人员。 | 刘铁桥 马弘 Chee Ng | 2007 | 国际精神病学杂志2007，34，1： | 20 |
| 4 | Two-Way 4D Printing: A Review on the Reversibility of 3D-Printed Shape Memory Materials显示文摘增材制造技术的快速发展和形状记忆材料的进步推动了四维(4D)打印的发展。由于一定程度上的外部刺激,人机交互作用、传感器和电池的需求将被消除,通过使用增材制造技术,可以生产出更复杂的设备和零部件。随着目前对形状记忆机制的理解和对增材制造技术的改进设计,4D打印的可逆性已经被证明是可行的。传统的单向4D打印需要在编程(或定型)阶段进行人机交互,但是可逆的4D打印或双向4D打印将完全消除对人为干预的需求,因为编程阶段被另一种外界刺激所取代。这使得可逆4D打印部件完全依赖外部刺激。零部件在每次回收后都可能被重复利用,甚至在某个周期中可以持续使用——这是一个具有工业运用吸引力的方面。本文综述了影响4D打印的形状记忆材料的机制,目前在合金和聚合物上的4D打印研究结果,以及它们各自存在的一些局限性。对形状记忆材料的可逆性和利用三维(3D)打印技术制作的可行性进行了总结和分析。在对可逆4D打印技术相关内容的介绍中,本文也强调了3D打印技术的方法、相关驱动的机制以及实现可逆性的策略。最后,提出了可逆4D打印技术未来的研究方向。 | Amelia Yilin Lee Jia An Chee Kai Chua | 2017 | Engineering2017，3，5： | 20 |
| 5 | Soliton bursts and deterministic dissipative Kerr soliton generation in auxiliary-assisted microcavities显示文摘Dissipative Kerr solitons in resonant frequency combs offer a promising route for ultrafast mode-locking,precision spectroscopy and time-frequency standards.The dynamics for the dissipative soliton generation,however,are intrinsically intertwined with thermal nonlinearities,limiting the soliton generation parameter map and statistical success probabilities of the solitary state.Here,via use of an auxiliary laser heating approach to suppress thermal dragging dynamics in dissipative soliton comb formation,we demonstrate stable Kerr soliton singlet formation and soliton bursts.First,we access a new soliton existence range with an inverse-sloped Kerr soliton evolution—diminishing soliton energy with increasing pump detuning.Second,we achieve deterministic transitions from Turinglike comb patterns directly into the dissipative Kerr soliton singlet pulse bypassing the chaotic states.This is achieved by avoiding subcomb overlaps at lower pump power,with near-identical singlet soliton comb generation over twenty instances.Third,with the red-detuned pump entrance route enabled,we uncover unique spontaneous soliton bursts in the direct formation of low-noise optical frequency combs from continuum background noise.The burst dynamics are due to the rapid entry and mutual attraction of the pump laser into the cavity mode,aided by the auxiliary laser and matching well with our numerical simulations.Enabled by the auxiliary-assisted frequency comb dynamics,we demonstrate an application of automatic soliton comb recovery and long-term stabilization against strong external perturbations.Our findings hold potential to expand the parameter space for ultrafast nonlinear dynamics and precision optical frequency comb stabilization. | Heng Zhou Yong Geng Wenwen Cui Shu-Wei Huang Qiang Zhou Kun Qiu Chee Wei Wong | 2019 | Light(Science & Applications)2019，8，1： | 16 |
| 6 | Microbleeds in fronto-subcortical circuits are predictive of dementia conversion in patients with vascular cognitive impairment but no dementia显示文摘Cerebral small vessel disease(CSVD) is a common etiology of vascular cognitive impairment with no dementia(V-CIND). Studies have revealed that cerebral microbleeds(CMBs), a feature of CSVD, contribute to cognitive impairment. However, the association between CMBs and dementia conversion in individuals with V-CIND is still unclear. Here, we analyzed the predictive role of CMBs in the conversion from V-CIND to dementia in CSVD patients. We recruited and prospectively assessed 85 patients with CSVD and V-CIND. V-CIND was evaluated using a series of comprehensive neuropsychological scales, including the Chinese version of the Montreal Cognitive Assessment and the Clinical Dementia Rating. MRI assessments were used to quantify lacunar infarcts, white matter hyperintensities, CMBs, and medial temporal lobe atrophy. Eighty-two of the 85 patients completed the assessment for dementia conversion at a 1-year follow-up assessment. Multivariate logistic regression analyses were conducted to examine independent clinical and MRI variables associated with dementia conversion. Twenty-four patients(29.3%) had converted to dementia at the 1-year follow-up, and these individuals had significantly more CMBs in the fronto-subcortical circuits. Multivariate logistic regression analyses revealed that the patients with CMBs in the fronto-subcortical circuits(odds ratio = 4.4; 95% confidence interval: 1.602–12.081, P = 0.004) and 5 or more CMBs overall(odds ratio = 17.6, 95% confidence interval: 3.23–95.84, P = 0.001) had a significantly increased risk of dementia at the 1-year follow-up. These findings indicate that CMBs in the fronto-subcortical circuits may be predictive of dementia conversion in CSVD patients with V-CIND, and thus extend the clinical significance of CMBs. | Yang-Kun Chen Wei-Min Xiao Wei Li Zhuo-Xin Ni Yong-Lin Liu Li Xu Jian-Feng Qu Chee H.Ng Yu-Tao Xiang | 2018 | Neural Regeneration Research2018，13，11： | 12 |
| 7 | Therapeutic and prevention strategies against human enterovirus 71 infection显示文摘Human enterovirus 71(HEV71) is the cause of hand,foot and mouth disease and associated neurological complications in children under five years of age.There has been an increase in HEV71 epidemic activity throughout the Asia-Pacific region in the past decade,and it is predicted to replace poliovirus as the extant neurotropic enterovirus of highest global public health significance. To date there is no effective antiviral treatment and no vaccine is available to prevent HEV71 infection. The increase in prevalence, virulence and geographic spread of HEV71 infection over the past decade provides increasing incentive for the development of new therapeutic and prevention strategies against this emerging viral infection. The current review focuses on the potential, advantages and disadvantages of these strategies. Since the explosion of outbreaks leading to large epidemics in China, research in natural therapeutic products has identified several groups of compounds with anti-HEV71 activities. Concurrently, the search for effective synthetic antivirals has produced promising results. Other therapeutic strategies including immunotherapy and the use of oligonucleotides have also been explored. A sound prevention strategy is crucial in order to control the spread of HEV71. To this end the ultimate goal is the rapid development, regulatory approval and widespread implementation of a safe and effective vaccine. The various forms of HEV71 vaccine designs are highlighted in this review. Given the rapid progress of research in this area, eradication of the virus is likely to be achieved. | Chee Choy Kok | 2015 | World Journal of Virology2015，4，2： | 12 |
| 8 | Risk assessment for the daily intake of polycyclic aromatic hydrocarbons from the ingestion of cockle (Anadara granosa) and exposure to contaminated water and sediments along the west coast of Peninsular Malaysia显示文摘The concentration of carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) present in the sediment and water of Peninsular Malaysia as well as in the cockle Anadara granosa was investigated.Samples were extracted and analysed with gas chromatographymass spectrometry.The concentrations of total carcinogenic polycyclic aromatic hydrocarbons (t-PAHs) were measured between 0.80 ± 0.04 to 162.96 ± 14.74 ng/g wet weight (ww) in sediment,between 21.85 ± 2.18 to 76.2 ± 10.82 ng/L in water samples and between 3.34 ± 0.77 to 46.85 ± 5.50 ng/g ww in the cockle tissue.The risk assessment of probable human carcinogens in the Group B2 PAHs was calculated and assessed in accordance with the standards of the United States Environmental Protection Agency (US EPA).Case I in the toxicity assessment analysed the cancer risk to consumers of Malaysian blood cockle.Case II assessed the risk of cancer from exposure to PAHs from multiple pathways.The average cancer risk of case I and case II were found to be classifiable as unsafe according to the US EPA standard.The cancer risk due to c-PAHs acquired by the ingestion of blood cockle was (8.82 ± 0.54) × 10-6 to (2.67 ± 0.06) × 10-2,higher than the US EPA risk management criterion.The non-cancer risks associated with multiple pathways in Kuala Gula,Kuala Juru and Kuala Perlis were higher than the US EPA safe level,but the non-cancer risk for eating blood cockle was below the level of US EPA concern. | Seiedeh Aghileh Mirsadeghi Mohamad Pauzi Zakaria Chee Kong Yap Azadeh Shahbazi | 2011 | Journal of Environmental Sciences2011，23，2： | 11 |
| 9 | Mapping of long-range chromatin interactions by proximity ligation-assisted ChlP-seq显示文摘 | Rongxin Fang Miao Yu Guoqiang Li Sora Chee Tristin Liu Anthony D Schmitt Bing Ren | 2016 | Cell Research2016，26，12： | 8 |
| 10 | Biochemical sensing in graphene-enhanced microfiber resonators with individual molecule sensitivity and selectivity显示文摘Photonic sensors that are able to detect and track biochemical molecules offer powerful tools for information acquisition in applications ranging from environmental analysis to medical diagnosis.The ultimate aim of biochemical sensing is to achieve both quantitative sensitivity and selectivity.As atomically thick films with remarkable optoelectronic tunability,graphene and its derived materials have shown unique potential as a chemically tunable platform for sensing,thus enabling significant performance enhancement,versatile functionalization and flexible device integration.Here,we demonstrate a partially reduced graphene oxide(prGO)inner-coated and fiber-calibrated Fabry-Perot dye resonator for biochemical detection.Versatile functionalization in the prGO film enables the intracavity fluorescent resonance energy transfer(FRET)to be chemically selective in the visible band.Moreover,by measuring the intermode interference via noise canceled beat notes and locked-in heterodyne detection with Hz-level precision,we achieved individual molecule sensitivity for dopamine,nicotine and single-strand DNA detection.This work combines atomic-layer nanoscience and high-resolution optoelectronics,providing a way toward high-performance biochemical sensors and systems. | Zhongxu Cao Baicheng Yao Chenye Qin Run Yang Yanhong Guo Yufeng Zhang Yu Wu Lei Bi Yuanfu Chen Zhenda Xie Gangding Peng Shu-Wei Huang Chee Wei Wong Yunjiang Rao | 2019 | Light(Science & Applications)2019，8，1： | 8 |
| 11 | 人肺组织内源性显微荧光特性研究显示文摘采用新型显微荧光分光光度系统 ,实现激光诱导人肺组织内源性显微荧光光谱与图像的测量 ,获得不同组织层 (即上皮层 ,粘膜层和软骨层 )的荧光分布和荧光特性 ,为探索癌与正常组织自体荧光光谱特征差异的根源 。 | 郑蔚 黄志伟 谢树森 S.M.Krishnan Chia Teck Chee | 2001 | 中国激光2001，28，7： | 7 |
| 12 | Effects of Enriched Biochars Containing Magnetic Iron Nanoparticles on Mycorrhizal Colonisation,Plant Growth,Nutrient Uptake and Soil Quality Improvement显示文摘At present, there is little commercial sale of biochar, since farmers find they can not gain a return on their investment in this amendment in the first few years after its application, because of the high cost associated with large application rates. To overcome this constraint, development of artificially aged enriched biochar-mineral complexes(BMCs), having a higher mineral content, surface functionality, exchangeable cations, high concentration of magnetic iron(Fe) nanoparticles, and higher water-extractable organic compounds has been undertaken by a combined team of researchers and a commercial company. Two biochars produced under different pyrolysis conditions were activated with a phosphoric acid treatment. A mixture of clay, chicken litter, and minerals were added to the biochar, and then this composite was torrefied at either 180 or 220?C. In this study a pot experiment was carried out in glasshouse conditions to determine the effects of four different BMCs, with different formulations applied at rates of 100 and 200 kg ha-1, on the mycorrhizal colonisation, wheat growth and nutrient uptake, and soil quality improvement. It was found that the phosphorus(P) and nitrogen uptake in wheat shoots were significantly greater for a low application rate of BMCs(100 kg ha-1). The present formulation of BMC was effective in enhancing growth of wheat at low application rate(100 kg ha-1). The increase in growth appeared due to an increase in P uptake in the plants that could be partly attributed to an increase in mycorrhizal colonisation and partly due to the properties of the BMC. | Stephen JOSEPH Hossain M.ANAWAR Paul STORER Paul BLACKWELL Chee CHIA Yun LIN Paul MUNROE Scott DONNE Josip HORVAT Jianli WANG Zakaria M.SOLAIMAN | 2015 | Pedosphere2015，25，5： | 7 |
| 13 | Attenuation of rock blasting induced ground vibration in rock-soil interface显示文摘Blasting has been widely used in mining and construction industries for rock breaking.This paper presents the results of a series of field tests conducted to investigate the ground wave propagation through mixed geological media.The tests were conducted at a site in the northwestern part of Singapore composed of residual soil and granitic rock.The field test aims to provide measurement data to better understand the stress wave propagation in soil/rock and along their interface.Triaxial accelerometers were used for the free field vibration monitoring.The measured results are presented and discussed,and empirical formulae for predicting peak particle velocity (PPV) attenuation along the ground surface and in soil/rock were derived from the measured data.Also,the ground vibration attenuation across the soil-rock interface was carefully examined,and it was found that the PPV of ground vibration was decreased by 37.2% when it travels from rock to soil in the vertical direction. | Bhagya Jayasinghe Zhiye Zhao Anthony Goh Teck Chee Hongyuan Zhou Yilin Gui | 2019 | Journal of Rock Mechanics and Geotechnical Engineering2019，11，4： | 7 |
| 14 | Large range step method for acoustic waveguide with two layer media显示文摘A numerical method is developed for solving the two-dimensional Helmholtz equation in a two-layer region bounded by a flat top, a flat bottom and a curved interface. A better local orthogonal transformation is used to flatten the curved interface of the waveguide. The one-way re-formulation based on the Dirichlet-to-Neumann (DtN) map is then used to reduce the boundary value problem to an initial value problem. Numerical implemetation of the resulting operator Riccati equation uses a large range step method for discretizing the range variable and a truncated local eigenfunction expansion for approximating the operators. This method is particularly useful for solving long range wave propagation problems in slowly varying waveguides. | ZHU Jianxin and LU Yayan(1. Department of Mathematics, Zhejiang University, Hangzhou 310027, China 2. Department of Mathematics, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China) | 2002 | Progress in Natural Science:Materials International2002，12，11： | 7 |
| 15 | Carbon-based perovskite solar cells: From single-junction to modules显示文摘Perovskite solar cells(PSCs)have attracted more and more attention in the scientific community due to their high performance and simple fabrication process.In the past few years,emerging technologies have made manufacturing large-scale PSC modules possible.However,stability and fabrication issues still limit the modularization and commercialization of PSCs.Carbon materials have been widely used in PSCs to overcome these challenges due to their excellent optical,electrical,and mechanical properties.In addition,the hydrophobic properties of certain carbon materials are highly effective at protecting the perovskite film from moisture and improving the stability of PSCs.All these superior properties have made carbon one of the most promising materials to fabricate future highperformance PSC modules with long service lifetimes.In this review,recent developments of carbon-based materials in different layers of single-junction PSCs will first be discussed,with an emphasis on functionalities related to PSCs’stability and modularization.Then,current improvements and future discussions in the manufacturing of monolithic PSC modules will be reviewed in detail. | Rui He Xiaozhou Huang Mason Chee Feng Hao Pei Dong | 2019 | Carbon Energy2019，1，1： | 6 |
| 16 | Gastric peritoneal carcinomatosis-a retrospective review显示文摘AIM To characterize patients with gastric peritoneal carcinomatosis(PC) and their typical clinical and treatment course with palliative systemic chemotherapy as the current standard of care.METHODS We performed a retrospective electronic chart review of all patients with gastric adenocarcinoma with PC diagnosed at initial metastatic presentation between January 2010 and December 2014 in a single tertiary referral centre.RESULTS We studied a total of 271 patients with a median age of 63.8 years and median follow-up duration of 5.1 mo. The majority(n = 217, 80.1%) had the peritoneum as the only site of metastasis at initial presentation. Palliative systemic chemotherapy was eventually planned for 175(64.6%) of our patients at initial presentation, of which 171 were initiated on it. Choice of first-line regime was in accordance with the National Comprehensive Cancer Network Guidelines for Gastric Cancer Treatment. Thesepatients underwent a median of one line of chemotherapy, completing a median of six cycles in total. Chemotherapy disruption due to unplanned hospitalizations occurred in 114(66.7%), while cessation of chemotherapy occurred in 157(91.8%), with 42 cessations primarily attributable to PC-related complications. Patients who had initiation of systemic chemotherapy had a significantly better median overall survival than those who did not(10.9 mo vs 1.6 mo, P < 0.001). Of patients who had initiation of systemic chemotherapy, those who experienced any disruptions to chemotherapy due to unplanned hospitalizations had a significantly worse median overall survival compared to those who did not(8.7 mo vs 14.6 mo, P < 0.001).CONCLUSION Gastric PC carries a grim prognosis with a clinical course fraught with disease-related complications which may attenuate any survival benefit which palliative systemic chemotherapy may have to offer. As such, investigational use of regional therapies is warranted and required validation in patients with isolated PC to maximize their survival outcomes in the long run. | Hwee Leong Tan Claramae Shulyn Chia Grace Hwei Ching Tan Su Pin Choo David Wai-Meng Tai Clarinda Wei Ling Chua Matthew Chau Hsien Ng Khee Chee Soo Melissa Ching Ching Teo | 2017 | World Journal of Gastrointestinal Oncology2017，9，3： | 6 |
| 17 | L(j,k)-number of Direct Product of Path and Cycle显示文摘For positive numbers j and k, an L(j,k)-labeling f of G is an assignment of numbers to vertices of G such that |f(u)-f(v)|≥j if uv∈E(G), and |f(u)-f(v)|≥k if d(u,v)=2. Then the span of f is the difference between the maximum and the minimum numbers assigned by f. The L(j,k)-number of G, denoted by λj,k(G), is the minimum span over all L(j,k)-labelings of G. In this paper, we give some results about the L(j,k)-number of the direct product of a path and a cycle for j≤k. | Wai Chee SHIU Qiong WU | 2013 | Acta Mathematica Sinica,English Series2013，29，8： | 6 |
| 18 | Capecitabine with radiation is an effective adjuvant therapy in gastric cancers显示文摘AIM:To analyze the outcome of patients who received concurrent capecitabine(Xeloda) and radiation(XRT) compared to the established concurrent 5-fluorouracil(5-FU) with radiation(5FU-RT) and fluoropyrimidine-based chemotherapy alone as adjuvant treatment in gastric cancers.METHODS:All patients with gastric cancers who received adjuvant treatment at the National Cancer Centre Singapore between 1996 and 2006 were reviewed.Treatment outcomes of patients who received XRT were compared with those who had 5FU-RT or chemotherapy alone as adjuvant therapy for gastric cancers.RESULTS:A total of 108 patients were reviewed.Median age at diagnosis was 60.The majority of the patients(64.8%) had advanced stage Ⅲ and Ⅳ disease(with no distant metastasis).All except 4 patients had D2 gastrectomy.Twenty one patients(19.4%) had positive surgical resection margins.Thirty three patients received XRT compared with 52 who had 5FU-RT and 23 who received chemotherapy alone.For the patients in the chemotherapy-only group,all had fluoropyrimidine-based therapy,with added cisplatin in 7 patients and epirubicin in 2 patients.Median recurrence-free survival was longer for the XRT group(52 mo) compared to the 5FU-RT(35 mo) and chemotherapy-only groups(25 mo)(P=0.48).The patients in the XRT group achieved similar median overall survival(53 mo) as the 5FU-RT(54 mo) and the chemotherapy-only groups(44 mo)(P=0.5).CONCLUSION:Capecitabine with concurrent radiation was as effective as concurrent 5FU with radiation or fluoropyrimidine-based chemotherapy alone when used as adjuvant treatment in patients with gastric cancers. | Chee Kian Tham Su Pin Choo Donald Yew Hee Poon Han Chong Toh Simon Yew Kuang Ong Sze Huey Tan Michael Lian Chek Wang Kian Fong Foo | 2010 | World Journal of Gastroenterology2010，16，29： | 6 |
| 19 | Miscibility of Semi-flexible Thermotropic Liquid Crystalline Copolyesteramide with Polyamide 66显示文摘Liquid crystalline polymer-polyamide 66 (LCP/PA66) blends were compounded by using a Brabender mixing followed by compression moulding. The LCP employed was a semi-flexible liquid crystalline copolyesteramide based on 30% (molar fraction ) of p-amino benzoic acid (ABA ) and 70% (molar fraction) of poly (ethylene terephthalate) (PET). The LCP/PA66 blends were investigated in terms of the thermal and dynamic mechanical properties. It was found that PA66 and LCP components of the blends are miscible in the molten state, but are partially miscible in the solid state. The inclusion of the semi-flexible LCP into PA66 retards the crystallization rate of PA66. Furthermore, the melting temperature and the degree of crystallinity of PA66 are reduced considerably due to the LCP addition. | XIE Xiao-Lin, TJONG S. C. and LI R. K. Y. (Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074 Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong P. R. China) | 2000 | Chemical Research in Chinese Universities2000，16，4： | 6 |
| 20 | Super-edge-graceful Labelings of Some Cubic Graphs显示文摘The notion of super-edge-graceful graphs was introduced by Mitchem and Simoson in 1994.However,few examples except trees are known.In this paper,we exhibit two classes of infinitely manycubic graphs which are super-edge-graceful.A conjecture is proposed. | Wai Chee SHIU | 2006 | Acta Mathematica Sinica,English Series2006，22，6： | 5 |
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