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    题名 作者 年代 出处 被引量
1Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines显示文摘Yoke Keong Yong Jun Jie Tan Soek Sin Teh Siau Hui Mah Gwendoline Cheng Lian Ee Hoe Siong Chiong Zuraini Ahmad José Luis Ríos 2013Evidence-Based Complementary and Alternative Medicine2013,,:2
2Conditions for know ledge sharing in competitive alliances 显示文摘SOEK IJAD MAU RA ANDRIESSEN ERIK 2003European Management Journal2003,21,5:1
3Characterization of genetic alteration patterns in human esophageal squamous cell carcinoma using selected microsatellite markers spanning multiple loci 显示文摘Cai YC Soek Nie AY 2007Int J Oncol2007,30,5:1
4Cerebral embolism following N-butyl-2-cyanoacrylate injection for esophageal postbanding ulcer bleed: a case report显示文摘Asmarani Abdullah Sharmila Sachithanandan Ooi Keat Tan Yee Ming Chan Dennise Khoo Faizal Mohamed Zawawi Haniza Omar Soek Siam Tan Hamed Oemar 2009Hepatology International2009,,3:1
5Effect of zeolite media for the treatment of textile wastewater in a biological aerated filter 显示文摘Won - Seok Chang Soek - WonHong JoonkyuPark 2002Process Biochemistry2002,37,:1
6Design of the 3 phase 60 MVA HTS trans- former with YBCO coated conductor windings 显示文摘LEE C SOEK B Y 20051EEE Transac- tion on Applied Superconductivity2005,15,2:1
7You Don't Win the Silver-You Miss the Gold显示文摘Janwillem Soek 2000International Sports Law Journal2000,,9:1
8Effect of zeolite media for the treatment of textile wastewater in a biological aerated filter显示文摘Won Seok Chang Soek WonHong 2002Process Biochemistry2002,37,:1
9Models of Sport Gov- ernance in the European Union: TheRelationship between State and Sport Authorities 显示文摘Robert Siekmann Janwillem Soek 2010The International Sports LAW Journal2010,3,4:1
10Models of Sport Governance in the European Union: The Relationship between State and Sport Authorities显示文摘ROBERT SIEKMANN JANWILLEM SOEK 2010Int Sports Law J2010,,5:1
11The Legal Nature of Doping Law 显示文摘Matthew Hard Janwillem Soek 2002The International Sports Law Journal2002,,2:1
12Design of the 3 phase 60 MVA HTS transformer with YBCO coated conductor windings显示文摘Lee C Soek B Y 2005IEEE Transactions on Applied Superconductivity2005,15,2:1
13Models of Sport Gover- naneein the European Union: The Relationship between State and Sport Authorities显示文摘Robert Siekmann Janwillem Soek 2010International Sports Law Journal2010,,4:1
14Models of Sport Governance in theEuropean Union:The Relationship between State and Sport Authorities显示文摘Robert Siekmann Janwillem Soek 2008The International Sports Law Journal2008,34,:1
15Tissue factor and cancer matastsis:The role of intracellular and extracellular signaling pathways显示文摘Versteeg HH Soek A Peooelenbosch MP 2004Molecular medicine2004,10,16:1
16Boceprevir early-access for advanced-fibrosis/cirrhosis in Asia-pacific hepatitis C virus genotype 1 non-responders/relapsers显示文摘AIM:To examined the efficacy and safety of treatment with boceprevir,PEGylated-interferon and ribavirin(PR)in hepatitis C virus genotype 1(HCVGT1) PR treatmentfailures in Asia.METHODS:The Boceprevir Named-Patient Program provided boceprevir to HCVGT1 PR treatment-failures.Participating physicians were invited to contribute data from their patients:baseline characteristics,ontreatment responses,sustained virological response at week 12(SVR12),and safety were collected and analysed.Multivariate analysis was performed to determine predictors of response.RESULTS:150 patients were enrolled from Australia,Malaysia,Singapore and Thailand(Asians = 86,Caucasians = 63).Overall SVR12 was 61%(Asians= 59.3%,Caucasians = 63.5%).SVR12 was higher in relapsers(78%) compared with non-responders(34%).On-treatment responses predicted SVR,with undetectable HCVRNA at week 4,8 and 12 leading to SVR12 s of 100%,87%,and 82%respectively,and detectable HCVRNA at week 4,8 and 12,leading to SVR12 s of 58%,22%and 6%respectively.Asian patients were similar to Caucasian patients with regards to on-treatment responses.Patients with cirrhosis(n= 69) also behaved in the same manner with regards to on-treatment responses.Those with the IL28 B CC genotype(80%) had higher SVRs than those with the CT/TT(56%) genotype(P = 0.010).Multivariate analysis showed that TW8 and TW12 responses were independent predictors of SVR.Serious adverse events occurred in 18.6%:sepsis(2%),decompensation(2.7%) and blood transfusion(14%).Discontinuations occurred in 30.7%,with 18.6%fulfilling stopping rules.CONCLUSION:Boceprevir can be used successfully in PR treatment failures with a SVR12 > 80%if they have good on-treatment responses;however,discontinuations occurred in 30%because of virological failure or adverse events.Wattana Sukeepaisarnjaroen Tri Pham Tewesak Tanwandee Saroja Nazareth Sam Galhenage Lindsay Mollison Leanne Totten Alan Wigg Rosalie Altus Anton Colman Brenda Morales Sue Mason Tracey Jones Nadine Leembruggen Vince Fragomelli Cheryl Sendall Richard Guan Dede Sutedja Soek Siam Tan Yock Young Dan Yin Mei Lee Widjaja Luman Eng Kiong Teo Yin Min Than Teerha Piratvisuth Seng Gee Lim 2015World Journal of Gastroenterology2015,21,28:0
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